{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:38:35Z","timestamp":1789900715764,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00439-013-1293-4","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T08:50:09Z","timestamp":1364460609000},"page":"793-801","source":"Crossref","is-referenced-by-count":22,"title":["Obesity-related genetic variants, human pigmentation, and risk of melanoma"],"prefix":"10.1007","volume":"132","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengju","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-E","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar A.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,29]]},"reference":[{"key":"1293_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.2003.tb03189.x","volume":"994","author":"RAH Adan","year":"2003","unstructured":"Adan RAH, Hillebrand JJG, Rijke C, Nijenhuis W, Vink T, Garner KM, Kas MJH (2003) Melanocortin system and eating disorders. Ann NY Acad Sci 994:267\u2013274","journal-title":"Ann NY Acad Sci"},{"key":"1293_CR2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1210\/er.2006-0034","volume":"27","author":"RD Cone","year":"2006","unstructured":"Cone RD (2006) Studies on the physiological functions of the melanocortin system. Endocr Rev 27:736\u2013749","journal-title":"Endocr Rev"},{"key":"1293_CR3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/j.1550-8528.1996.tb00518.x","volume":"4","author":"C Danforth","year":"2012","unstructured":"Danforth C (2012) Hereditary adiposity in mice. Obes Res 4:96\u2013100","journal-title":"Obes Res"},{"key":"1293_CR4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/oxfordjournals.jhered.a107129","volume":"53","author":"MM Dickies","year":"1962","unstructured":"Dickies MM (1962) A new viable yellow mutation in the house mouse. J Hered 53:84\u201386","journal-title":"J Hered"},{"key":"1293_CR5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tig.2010.02.006","volume":"26","author":"KA Fawcett","year":"2010","unstructured":"Fawcett KA, Barroso I (2010) The genetics of obesity: FTO leads the way. Trends Genet 26:266\u2013274","journal-title":"Trends Genet"},{"key":"1293_CR6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889","journal-title":"Science"},{"key":"1293_CR7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/ajpa.1330550207","volume":"55","author":"AR Frisancho","year":"1981","unstructured":"Frisancho AR, Wainwright R, Way A (1981) Heritability and components of phenotypic expression in skin reflectance of Mestizos from the Peruvian lowlands. Am J Phys Anthropol 55:203\u2013208","journal-title":"Am J Phys Anthropol"},{"key":"1293_CR8","doi-asserted-by":"crossref","first-page":"E468","DOI":"10.1152\/ajpendo.00434.2002","volume":"284","author":"I Gantz","year":"2003","unstructured":"Gantz I, Fong TM (2003) The melanocortin system. Am J Physiol Endocrinol Metab 284:E468\u2013E474","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1293_CR9","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","volume":"318","author":"T Gerken","year":"2007","unstructured":"Gerken T, Girard CA, Tung YCL, Webby CJ, Saudek V, Hewitson KS, Yeo GSH, McDonough MA, Cunliffe S, McNeill LA (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318:1469","journal-title":"Science"},{"key":"1293_CR10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1755-148X.2010.00730.x","volume":"23","author":"MR Gerstenblith","year":"2010","unstructured":"Gerstenblith MR, Shi J, Landi MT (2010) Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis. Pigment Cell Melanoma Res 23:587\u2013606","journal-title":"Pigment Cell Melanoma Res"},{"key":"1293_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2005.06.022","volume":"111","author":"SJ Getting","year":"2006","unstructured":"Getting SJ (2006) Targeting melanocortin receptors as potential novel therapeutics. Pharmacol Ther 111:1\u201315","journal-title":"Pharmacol Ther"},{"key":"1293_CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1469-1809.1964.tb00457.x","volume":"28","author":"GA Harrison","year":"1964","unstructured":"Harrison GA, Owen J (1964) Studies on the inheritance of human skin colour. Ann Hum Genet 28:27\u201337","journal-title":"Ann Hum Genet"},{"key":"1293_CR13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/ATVBAHA.109.196196","volume":"30","author":"M He","year":"2010","unstructured":"He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L (2010) Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 30:327\u2013332","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1293_CR14","first-page":"969","volume":"26","author":"W Heston","year":"1961","unstructured":"Heston W, Vlahakis G (1961) Influence of the Ay gene on mammary-gland tumors, hepatomas, and normal growth in mice. J Natl Cancer Inst 26:969","journal-title":"J Natl Cancer Inst"},{"key":"1293_CR15","first-page":"1161","volume":"40","author":"W Heston","year":"1968","unstructured":"Heston W, Vlahakis G (1968) C3H-Auv\u2014a high hepatoma and high mammary tumor strain of mice. J Natl Cancer Inst 40:1161\u20131166","journal-title":"J Natl Cancer Inst"},{"key":"1293_CR16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3945\/ajcn.110.000828","volume":"93","author":"TO Kilpel\u00e4inen","year":"2011","unstructured":"Kilpel\u00e4inen TO, den Hoed M, Ong KK, Gr\u00f8ntved A, Brage S (2011) Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr 93:851","journal-title":"Am J Clin Nutr"},{"key":"1293_CR17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/509","volume":"19","author":"H Krude","year":"1998","unstructured":"Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155\u2013157","journal-title":"Nat Genet"},{"issue":"2","key":"1293_CR18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tem.2010.11.001","volume":"22","author":"R Larder","year":"2010","unstructured":"Larder R, Cheung M, Tung Y, Yeo GSH, Coll AP (2010) Where to go with FTO? Trends Endocrinol Metab 22(2):53\u201359","journal-title":"Trends Endocrinol Metab"},{"key":"1293_CR19","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ng.140","volume":"40","author":"RJF Loos","year":"2008","unstructured":"Loos RJF, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768","journal-title":"Nat Genet"},{"key":"1293_CR20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ijc.24327","volume":"125","author":"H Nan","year":"2009","unstructured":"Nan H, Kraft P, Hunter DJ, Han J (2009a) Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. Int J Cancer 125:909\u2013917","journal-title":"Int J Cancer"},{"key":"1293_CR21","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1038\/jid.2009.62","volume":"129","author":"H Nan","year":"2009","unstructured":"Nan H, Kraft P, Qureshi AA, Guo Q, Chen C, Hankinson SE, Hu FB, Thomas G, Hoover RN, Chanock S (2009b) Genome-wide association study of tanning phenotype in a population of European ancestry. J Investig Dermatol 129:2250\u20132257","journal-title":"J Investig Dermatol"},{"key":"1293_CR22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.genet.37.110801.143233","volume":"37","author":"JL Rees","year":"2003","unstructured":"Rees JL (2003) Genetics of hair and skin color. Annu Rev Genet 37:67\u201390","journal-title":"Annu Rev Genet"},{"key":"1293_CR23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1086\/425285","volume":"75","author":"JL Rees","year":"2004","unstructured":"Rees JL (2004) The genetics of sun sensitivity in humans. Am J Hum Genet 75:739\u2013751","journal-title":"Am J Hum Genet"},{"key":"1293_CR24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2091-8-23","volume":"8","author":"L Sanchez-Pulido","year":"2007","unstructured":"Sanchez-Pulido L, Andrade-Navarro M (2007) The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem 8:23","journal-title":"BMC Biochem"},{"key":"1293_CR25","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","volume":"316","author":"LJ Scott","year":"2007","unstructured":"Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341","journal-title":"Science"},{"key":"1293_CR26","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pgen.0030115","volume":"3","author":"A Scuteri","year":"2007","unstructured":"Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orr\u00fa M, Usala G (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3:e115","journal-title":"PLoS Genet"},{"issue":"5","key":"1293_CR27","first-page":"e207","volume":"67","author":"J Shoag","year":"2013","unstructured":"Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q (2013) PGC-1 coactivators regulate MITF and the tanning response. Mol Cell 67(5):e207\u2013e208","journal-title":"Mol Cell"},{"issue":"11","key":"1293_CR28","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ng.686","volume":"42","author":"EK Speliotes","year":"2010","unstructured":"Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, M\u00e4gi R (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat genet 42(11):937\u2013948","journal-title":"Nat genet"},{"key":"1293_CR29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng.274","volume":"41","author":"G Thorleifsson","year":"2008","unstructured":"Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I (2008) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41:18\u201324","journal-title":"Nat Genet"},{"key":"1293_CR30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.embor.7400379","volume":"6","author":"SC Trewick","year":"2005","unstructured":"Trewick SC, McLaughlin PJ, Allshire RC (2005) Methylation: lost in hydroxylation? EMBO Rep 6:315\u2013320","journal-title":"EMBO Rep"},{"key":"1293_CR31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.287","volume":"41","author":"CJ Willer","year":"2008","unstructured":"Willer CJ, Speliotes EK, Loos RJF, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C (2008) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41:25\u201334","journal-title":"Nat Genet"},{"key":"1293_CR32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1096\/fasebj.8.8.8181666","volume":"8","author":"T Yen","year":"1994","unstructured":"Yen T, Gill A, Frigeri L, Barsh G, Wolff G (1994) Obesity, diabetes, and neoplasia in yellow A (vy)\/-mice: ectopic expression of the agouti gene. FASEB J 8:479\u2013488","journal-title":"FASEB J"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-013-1293-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00439-013-1293-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-013-1293-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T13:12:49Z","timestamp":1562850769000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00439-013-1293-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,29]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["1293"],"URL":"https:\/\/doi.org\/10.1007\/s00439-013-1293-4","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,29]]}}}