{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:35:48Z","timestamp":1771263348253,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00439-016-1727-x","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T11:52:34Z","timestamp":1473940354000},"page":"1355-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways"],"prefix":"10.1007","volume":"135","author":[{"given":"Erin M.","family":"Hagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Sicko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon L.","family":"Rigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabbir","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret H.","family":"Doleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Romitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn L.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Caggana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence C.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Jelliffe-Pawlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"1727_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5935\/abc.20140169","volume":"104","author":"CM Campos","year":"2015","unstructured":"Campos CM, Zanardo EA, Dutra RL, Kulikowski LD, Kim CA (2015) Investigation of copy number variation in children with conotruncal heart defects. Arq Bras Cardiol 104:24\u201331. doi: 10.5935\/abc.20140169","journal-title":"Arq Bras Cardiol"},{"key":"1727_CR2","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1016\/j.febslet.2005.04.070","volume":"579","author":"PT Cohen","year":"2005","unstructured":"Cohen PT, Philp A, Vazquez-Martin C (2005) Protein phosphatase 4\u2013from obscurity to vital functions. FEBS Lett 579:3278\u20133286. doi: 10.1016\/j.febslet.2005.04.070","journal-title":"FEBS Lett"},{"key":"1727_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/j.1365-3016.1991.tb00728.x","volume":"5","author":"LA Croen","year":"1991","unstructured":"Croen LA, Shaw GM, Jensvold NG, Harris JA (1991) Birth defects monitoring in California: a resource for epidemiological research. Paediatr Perinat Epidemiol 5:423\u2013427. doi: 10.1111\/j.1365-3016.1991.tb00728.x","journal-title":"Paediatr Perinat Epidemiol"},{"key":"1727_CR4","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1073\/pnas.1019645108","volume":"108","author":"KA Fakhro","year":"2011","unstructured":"Fakhro KA, Choi M, Ware SM, Belmont JW, Towbin JA, Lifton RP, Khokha MK, Brueckner M (2011) Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci 108:2915\u20132920. doi: 10.1073\/pnas.1019645108","journal-title":"Proc Natl Acad Sci"},{"key":"1727_CR5","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1074\/jbc.M113.526905","volume":"289","author":"Y Feng","year":"2014","unstructured":"Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, Feng XH (2014) Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling. J Biol Chem 289:2072\u20132083. doi: 10.1074\/jbc.M113.526905","journal-title":"J Biol Chem"},{"key":"1727_CR6","unstructured":"Ferencz C, Loffredo CA, Correa-Villase\u00f1or A, Wilson PD (1997) Genetic and environmental risk factors of major cardiovascular malformations. In: The Baltimore-Washington infant study 1981\u20131989, perspectives in pediatric cardiology, vol V. Futura Publishing, Armonk"},{"key":"1727_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ydbio.2011.08.025","volume":"359","author":"TL Gallagher","year":"2011","unstructured":"Gallagher TL, Arribere JA, Geurts PA, Exner CR, McDonald KL, Dill KK, Marr HL, Adkar SS, Garnett AT, Amacher SL, Conboy JG (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Dev Biol 359:251\u2013261. doi: 10.1016\/j.ydbio.2011.08.025","journal-title":"Dev Biol"},{"key":"1727_CR8","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1186\/1471-2164-15-1127","volume":"15","author":"J Geng","year":"2014","unstructured":"Geng J, Picker J, Zheng Z, Zhang X, Wang J, Hisama F, Brown DW, Mullen MP, Harris D, Stoler J, Seman A, Miller DT, Fu Q, Roberts AE, Shen Y (2014) Chromosome microarray testing for patients with congenital heart defects reveals novel disease causing loci and high diagnostic yield. BMC Genom 15:1127. doi: 10.1186\/1471-2164-15-1127","journal-title":"BMC Genom"},{"key":"1727_CR9","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1002\/ajmg.a.31837","volume":"143A","author":"N Ghebranious","year":"2007","unstructured":"Ghebranious N, Giampietro PF, Wesbrook FP, Rezkalla SH (2007) A novel microdeletion at 16p11.2 harbors candidate genes for aortic valve development, seizure disorder, and mild mental retardation. Am J Med Genet A 143A:1462\u20131471. doi: 10.1002\/ajmg.a.31837","journal-title":"Am J Med Genet A"},{"key":"1727_CR10","doi-asserted-by":"publisher","first-page":"e2511","DOI":"10.1371\/journal.pone.0002511","volume":"3","author":"AK Hadjantonakis","year":"2008","unstructured":"Hadjantonakis AK, Pisano E, Papaioannou VE (2008) Tbx6 regulates left\/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One 3:e2511. doi: 10.1371\/journal.pone.0002511","journal-title":"PLoS One"},{"key":"1727_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0925-4773(97)00042-7","volume":"64","author":"H Hartung","year":"1997","unstructured":"Hartung H, Feldman B, Lovec H, Coulier F, Birnbaum D, Goldfarb M (1997) Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart. Mech Dev 64:31\u201339. doi: 10.1016\/S0925-4773(97)00042-7","journal-title":"Mech Dev"},{"key":"1727_CR12","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.devcel.2012.03.001","volume":"22","author":"S Jia","year":"2012","unstructured":"Jia S, Dai F, Wu D, Lin X, Xing C, Xue Y, Wang Y, Xiao M, Wu W, Feng XH, Meng A (2012) Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Dev Cell 22:1065\u20131078. doi: 10.1016\/j.devcel.2012.03.001","journal-title":"Dev Cell"},{"key":"1727_CR13","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1161\/circulationaha.106.649038","volume":"115","author":"MP Kennedy","year":"2007","unstructured":"Kennedy MP, Omran H, Leigh MW, Dell S, Morgan L, Molina PL, Robinson BV, Minnix SL, Olbrich H, Severin T, Ahrens P, Lange L, Morillas HN, Noone PG, Zariwala MA, Knowles MR (2007) Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia. Circulation 115:2814\u20132821. doi: 10.1161\/circulationaha.106.649038","journal-title":"Circulation"},{"key":"1727_CR14","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1007\/s00018-013-1399-9","volume":"70","author":"Y Komatsu","year":"2013","unstructured":"Komatsu Y, Mishina Y (2013) Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos. Cell Mol Life Sci 70:4659\u20134666. doi: 10.1007\/s00018-013-1399-9","journal-title":"Cell Mol Life Sci"},{"key":"1727_CR15","doi-asserted-by":"publisher","unstructured":"Kurkowiak M, Zi\u0119tkiewicz E, Witt M (2015) Recent advances in primary ciliary dyskinesia genetics. J Med Genet 52(1):1\u20139. doi: 10.1136\/jmedgenet-2014-102755","DOI":"10.1136\/jmedgenet-2014-102755"},{"key":"1727_CR16","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.1007\/s00018-009-0120-5","volume":"66","author":"H Kuroyanagi","year":"2009","unstructured":"Kuroyanagi H (2009) Fox-1 family of RNA-binding proteins. Cell Mol Life Sci 66:3895\u20133907. doi: 10.1007\/s00018-009-0120-5","journal-title":"Cell Mol Life Sci"},{"key":"1727_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/15513815.2010.547555","volume":"30","author":"S Lale","year":"2011","unstructured":"Lale S, Yu S, Ahmed A (2011) Complex congenital heart defects in association with maternal diabetes and partial deletion of the A2BP1 gene. Fetal Pediatr Pathol 30:161\u2013166. doi: 10.3109\/15513815.2010.547555","journal-title":"Fetal Pediatr Pathol"},{"key":"1727_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1755-8166-5-18","volume":"5","author":"D Li","year":"2012","unstructured":"Li D, Tekin M, Buch M, Fan YS (2012) Co-existence of other copy number variations with 22q11.2 deletion or duplication: a modifier for variable phenotypes of the syndrome? Mol Cytogenet 5:18. doi: 10.1186\/1755-8166-5-18","journal-title":"Mol Cytogenet"},{"key":"1727_CR19","doi-asserted-by":"publisher","unstructured":"Li Y, Yagi H, Onuoha EO, Damerla RR, Francis R, Furutani Y, Tariq M, King SM, Hendricks G, Cui C, Saydmohammed M, Lee DM, Zahid M, Sami I, Leatherbury L, Pazour GJ, Ware SM, Nakanishi T, Goldmuntz E, Tsang M, Lo CW (2016)\u00a0DNAH6\u00a0and its interactions with PCD genes in heterotaxy and primary ciliary dyskinesia.\u00a0PLoS Genet 12(2). doi: 10.1371\/journal.pgen.1005821","DOI":"10.1371\/journal.pgen.1005821"},{"key":"1727_CR21","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1002\/ajmg.a.36695","volume":"164A","author":"AE Lin","year":"2014","unstructured":"Lin AE, Krikov S, Riehle-Colarusso T, Frias JL, Belmont J, Anderka M, Geva T, Getz KD, Botto LD (2014) Laterality defects in the national birth defects prevention study (1998\u20132007): birth prevalence and descriptive epidemiology. Am J Med Genet A 164A:2581\u20132591. doi: 10.1002\/ajmg.a.36695","journal-title":"Am J Med Genet A"},{"key":"1727_CR22","doi-asserted-by":"publisher","unstructured":"Lobo J, Zariwala MA, Noone PG (2015) Primary ciliary dyskinesia. Semin Respir Crit Care Med 36(2):169\u2013179. doi: 10.1055\/s-0035-1546748","DOI":"10.1055\/s-0035-1546748"},{"key":"1727_CR23","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.ydbio.2006.08.073","volume":"300","author":"T Mizoguchi","year":"2006","unstructured":"Mizoguchi T, Izawa T, Kuroiwa A, Kikuchi Y (2006) Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish. Dev Biol 300:612\u2013622. doi: 10.1016\/j.ydbio.2006.08.073","journal-title":"Dev Biol"},{"key":"1727_CR24","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/hmg\/ddn411","volume":"18","author":"B Mohapatra","year":"2009","unstructured":"Mohapatra B, Casey B, Li H, Ho-Dawson T, Smith L, Fernbach SD, Molinari L, Niesh SR, Jefferies JL, Craigen WJ, Towbin JA, Belmont JW, Ware SM (2009) Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. Hum Mol Genet 18:861\u2013871. doi: 10.1093\/hmg\/ddn411","journal-title":"Hum Mol Genet"},{"key":"1727_CR25","doi-asserted-by":"publisher","first-page":"e1001181","DOI":"10.1371\/journal.pbio.1001181","volume":"9","author":"A Muto","year":"2011","unstructured":"Muto A, Calof AL, Lander AD, Schilling TF (2011) Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol 9:e1001181. doi: 10.1371\/journal.pbio.1001181","journal-title":"PLoS Biol"},{"key":"1727_CR26","doi-asserted-by":"publisher","first-page":"12680","DOI":"10.1074\/jbc.M114.558981","volume":"289","author":"N Nakano","year":"2014","unstructured":"Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S (2014) C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling. J Biol Chem 289:12680\u201312692. doi: 10.1074\/jbc.M114.558981","journal-title":"J Biol Chem"},{"key":"1727_CR27","doi-asserted-by":"publisher","unstructured":"Nakhleh N, Francis R, Giese RA, Tian X, Li Y, Zariwala MA, Yagi H, Khalifa O, Kureshi S, Chatterjee B, Sabol SL, Swisher M, Connelly PS, Daniels MP, Srinivasan A, Kuehl K, Kravitz N, Burns K, Sami I, Omran H, Barmada M, Olivier K, Chawla KK, Leigh M, Jonas R, Knowles M, Leatherbury L, Lo CW (2012) High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.\u00a0Circulation 125(18):2232\u20132242. doi: 10.1161\/CIRCULATIONAHA.111.079780","DOI":"10.1161\/CIRCULATIONAHA.111.079780"},{"key":"1727_CR28","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature07753","volume":"458","author":"JM Neugebauer","year":"2009","unstructured":"Neugebauer JM, Amack JD, Peterson AG, Bisgrove BW, Yost HJ (2009) FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature 458:651\u2013654. doi: 10.1038\/nature07753","journal-title":"Nature"},{"key":"1727_CR29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/gim.2014.112","volume":"17","author":"SL Rigler","year":"2015","unstructured":"Rigler SL, Kay DM, Sicko RJ, Fan R, Liu A, Caggana M, Browne ML, Druschel CM, Romitti PA, Brody LC, Mills JL (2015) Novel copy-number variants in a population-based investigation of classic heterotaxy. Genet Med 17:348\u2013357. doi: 10.1038\/gim.2014.112","journal-title":"Genet Med"},{"key":"1727_CR30","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1161\/circresaha.109.194464","volume":"104","author":"F Rochais","year":"2009","unstructured":"Rochais F, Mesbah K, Kelly RG (2009) Signaling pathways controlling second heart field development. Circ Res 104:933\u2013942. doi: 10.1161\/circresaha.109.194464","journal-title":"Circ Res"},{"key":"1727_CR31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.devcel.2009.02.007","volume":"16","author":"A Rosa","year":"2009","unstructured":"Rosa A, Spagnoli FM, Brivanlou AH (2009) The miR-430\/427\/302 family controls mesendodermal fate specification via species-specific target selection. Dev Cell 16:517\u2013527. doi: 10.1016\/j.devcel.2009.02.007","journal-title":"Dev Cell"},{"key":"1727_CR32","first-page":"91","volume":"108","author":"J Schulman","year":"1993","unstructured":"Schulman J, Hahn JA (1993) Quality control of birth defect registry data: a case study. Public Health Rep 108:91\u201398","journal-title":"Public Health Rep"},{"key":"1727_CR33","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1242\/dev.000166","volume":"134","author":"MM Shen","year":"2007","unstructured":"Shen MM (2007) Nodal signaling: developmental roles and regulation. Development 134:1023\u20131034. doi: 10.1242\/dev.000166","journal-title":"Development"},{"key":"1727_CR34","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1253\/circj.CJ-12-0957","volume":"76","author":"I Shiraishi","year":"2012","unstructured":"Shiraishi I, Ichikawa H (2012) Human heterotaxy syndrome\u2014from molecular genetics to clinical features, management, and prognosis. Circ J 76:2066\u20132075. doi: 10.1253\/circj.CJ-12-0957","journal-title":"Circ J"},{"key":"1727_CR35","doi-asserted-by":"publisher","first-page":"e1002289","DOI":"10.1371\/journal.pgen.1002289","volume":"7","author":"KA Smith","year":"2011","unstructured":"Smith KA, Noel E, Thurlings I, Rehmann H, Chocron S, Bakkers J (2011) Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish. PLoS Genet 7:e1002289. doi: 10.1371\/journal.pgen.1002289","journal-title":"PLoS Genet"},{"key":"1727_CR36","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/35025190","volume":"407","author":"D Srivastava","year":"2000","unstructured":"Srivastava D, Olson EN (2000) A genetic blueprint for cardiac development. Nature 407:221\u2013226. doi: 10.1038\/35025190","journal-title":"Nature"},{"key":"1727_CR37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/ajmg.c.30228","volume":"151C","author":"MJ Sutherland","year":"2009","unstructured":"Sutherland MJ, Ware SM (2009) Disorders of left-right asymmetry: heterotaxy and situs inversus. Am J Med Genet C Semin Med Genet 151C:307\u2013317. doi: 10.1002\/ajmg.c.30228","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"1727_CR38","doi-asserted-by":"publisher","first-page":"a002964","DOI":"10.1101\/cshperspect.a002964","volume":"1","author":"EK Vladar","year":"2009","unstructured":"Vladar EK, Antic D, Axelrod JD (2009) Planar cell polarity signaling: the developing cell\u2019s compass. Cold Spring Harb Perspect Biol 1:a002964. doi: 10.1101\/cshperspect.a002964","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1727_CR39","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/S0140-6736(03)14632-6","volume":"362","author":"H Yagi","year":"2003","unstructured":"Yagi H, Furutani Y, Hamada H, Sasaki T, Asakawa S, Minoshima S, Ichida F, Joo K, Kimura M, Imamura S, Kamatani N, Momma K, Takao A, Nakazawa M, Shimizu N, Matsuoka R (2003) Role of TBX1 in human del22q11.2 syndrome. Lancet 362:1366\u20131373. doi: 10.1016\/S0140-6736(03)14632-6","journal-title":"Lancet"},{"key":"1727_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/sj.ejhg.5201506","volume":"14","author":"L Zhu","year":"2006","unstructured":"Zhu L, Belmont JW, Ware SM (2006) Genetics of human heterotaxias. Eur J Hum Genet 14:17\u201325. doi: 10.1038\/sj.ejhg.5201506","journal-title":"Eur J Hum Genet"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-016-1727-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00439-016-1727-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-016-1727-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T05:25:58Z","timestamp":1476422758000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00439-016-1727-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,15]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1727"],"URL":"https:\/\/doi.org\/10.1007\/s00439-016-1727-x","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,15]]}}}