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The purpose of this investigation was to identify genetic markers associated with corneal and refractive astigmatism in a large-scale European ancestry cohort (UK Biobank) who underwent keratometry and autorefraction at an assessment centre. Genome-wide association studies for corneal and refractive astigmatism were performed in individuals of European ancestry (<jats:italic>N<\/jats:italic>\u2009=\u200986,335 and 88,005 respectively), with the mean corneal astigmatism or refractive astigmatism in fellow eyes analysed as a quantitative trait (dependent variable). Genetic correlation between the two traits was calculated using LD Score regression. Gene-based and gene-set tests were carried out using MAGMA. Single marker-based association tests for corneal astigmatism identified four genome-wide significant loci (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) near the genes <jats:italic>ZC3H11B<\/jats:italic> (1q41), <jats:italic>LINC00340<\/jats:italic> (6p22.3), <jats:italic>HERC2<\/jats:italic>\/<jats:italic>OCA2<\/jats:italic> (15q13.1) and <jats:italic>NPLOC4<\/jats:italic>\/<jats:italic>TSPAN10<\/jats:italic> (17q25.3). Three of these loci also demonstrated genome-wide significant association with refractive astigmatism: <jats:italic>LINC00340, HERC2<\/jats:italic>\/<jats:italic>OCA2<\/jats:italic> and <jats:italic>NPLOC4<\/jats:italic>\/<jats:italic>TSPAN10<\/jats:italic>. The genetic correlation between corneal and refractive astigmatism was 0.85 (standard error\u2009=\u20090.068, <jats:italic>P<\/jats:italic>\u2009=\u20091.37\u2009\u00d7\u200910<jats:sup>\u221235<\/jats:sup>). Here, we have undertaken the largest genome-wide association studies for corneal and refractive astigmatism to date and identified four novel loci for corneal astigmatism, two of which were also novel loci for refractive astigmatism. These loci have previously demonstrated association with axial length (<jats:italic>ZC3H11B<\/jats:italic>), myopia (<jats:italic>NPLOC4<\/jats:italic>), spherical equivalent refractive error (<jats:italic>LINC00340<\/jats:italic>) and eye colour (<jats:italic>HERC2<\/jats:italic>). The shared role of these novel candidate genes for astigmatism lends further support to the shared genetic susceptibility of myopia and astigmatism.<\/jats:p>","DOI":"10.1007\/s00439-018-1942-8","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T12:22:24Z","timestamp":1539174144000},"page":"881-896","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci"],"prefix":"10.1007","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-8869","authenticated-orcid":false,"given":"Rupal L.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-340X","authenticated-orcid":false,"given":"Jeremy A.","family":"Guggenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"UK Biobank Eye and Vision Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"issue":"4","key":"1942_CR1","doi-asserted-by":"publisher","first-page":"e93766","DOI":"10.1371\/journal.pone.0093766","volume":"9","author":"G Abraham","year":"2014","unstructured":"Abraham G, Inouye M (2014) Fast principal component analysis of large-scale genome-wide data. 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