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Around one third of the variability in the risk of severe and complicated malaria is now explained by additive host genetic effects. Many individual variants have been identified that are associated with malaria protection, but the most important all relate to the structure or function of red blood cells. They include the classical polymorphisms that cause sickle cell trait, \u03b1-thalassaemia, G6PD deficiency, and the major red cell blood group variants. More recently however, with improving technology and experimental design, others have been identified that include the Dantu blood group variant, polymorphisms in the red cell membrane protein\n                    <jats:italic>ATP2B4<\/jats:italic>\n                    , and several variants related to the immune response. Characterising how these genes confer their effects could eventually inform novel therapeutic approaches to combat malaria. Nevertheless, all together, only a small proportion of the heritable component of malaria resistance can be explained by the variants described so far, underscoring its complex genetic architecture and the need for continued research.\n                  <\/jats:p>","DOI":"10.1007\/s00439-020-02142-6","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T06:03:01Z","timestamp":1583301781000},"page":"801-811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Human genetics and malaria resistance"],"prefix":"10.1007","volume":"139","author":[{"given":"Silvia N.","family":"Kariuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-2382","authenticated-orcid":false,"given":"Thomas N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"issue":"4","key":"2142_CR1","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/trstmh\/trw014","volume":"110","author":"MH Abdelraheem","year":"2016","unstructured":"Abdelraheem MH, Albsheer MM, Mohamed HS, Amin M, Hamid MMA (2016) Transmission of Plasmodium vivax in Duffy-negative individuals in central Sudan. 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