{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:09:23Z","timestamp":1776290963829,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2753\/20"],"award-info":[{"award-number":["2753\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum Genet"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00439-023-02567-9","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T10:03:05Z","timestamp":1683108185000},"page":"863-878","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gene-based association study reveals a distinct female genetic signal in primary hypertension"],"prefix":"10.1007","volume":"142","author":[{"given":"Roei","family":"Zucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kovalerchik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-4526","authenticated-orcid":false,"given":"Michal","family":"Linial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"2567_CR1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/s41431-021-00919-5","volume":"29","author":"A Arteche-Lopez","year":"2021","unstructured":"Arteche-Lopez A, Alvarez-Mora MI, Sanchez Calvin MT, Lezana Rosales JM, Palma Milla C, Gomez Rodriguez MJ, Gomez Manjon I, Blazquez A, Juarez Rufian A, Ramos Gomez P, Sierra Tomillo O, Hidalgo Mayoral I, Perez de la Fuente R, Posada Rodriguez IJ, Gonzalez Granado LI, Martin MA, Quesada-Espinosa JF, Moreno-Garcia M (2021) Biallelic variants in genes previously associated with dominant inheritance: CACNA1A, RET and SLC20A2. Eur J Hum Genet 29:1520\u20131526. https:\/\/doi.org\/10.1038\/s41431-021-00919-5","journal-title":"Eur J Hum Genet"},{"key":"2567_CR2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006465","author":"MS Bohnen","year":"2017","unstructured":"Bohnen MS, Roman-Campos D, Terrenoire C, Jnani J, Sampson KJ, Chung WK, Kass RS (2017) The impact of heterozygous KCNK3 mutations associated with pulmonary arterial hypertension on channel function and pharmacological recovery. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.117.006465","journal-title":"J Am Heart Assoc"},{"key":"2567_CR3","doi-asserted-by":"publisher","first-page":"6642","DOI":"10.1093\/nar\/gkz546","volume":"47","author":"N Brandes","year":"2019","unstructured":"Brandes N, Linial N, Linial M (2019) Quantifying gene selection in cancer through protein functional alteration bias. Nucl Acids Res 47:6642\u20136655. https:\/\/doi.org\/10.1093\/nar\/gkz546","journal-title":"Nucl Acids Res"},{"key":"2567_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13059-020-02089-x","volume":"21","author":"N Brandes","year":"2020","unstructured":"Brandes N, Linial N, Linial M (2020) PWAS: proteome-wide association study-linking genes and phenotypes by functional variation in proteins. Genome Biol 21:173. https:\/\/doi.org\/10.1186\/s13059-020-02089-x","journal-title":"Genome Biol"},{"key":"2567_CR5","doi-asserted-by":"publisher","first-page":"14901","DOI":"10.1038\/s41598-021-94252-y","volume":"11","author":"N Brandes","year":"2021","unstructured":"Brandes N, Linial N, Linial M (2021) Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition. Sci Rep 11:14901. https:\/\/doi.org\/10.1038\/s41598-021-94252-y","journal-title":"Sci Rep"},{"key":"2567_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-022-02697-9","volume":"23","author":"N Brandes","year":"2022","unstructured":"Brandes N, Weissbrod O, Linial M (2022) Open problems in human trait genetics. Genome Biol 23:1\u201332","journal-title":"Genome Biol"},{"key":"2567_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","volume":"562","author":"C Bycroft","year":"2018","unstructured":"Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O\u2019Connell J, Cortes A, Welsh S, Young A, Effingham M, McVean G, Leslie S, Allen N, Donnelly P, Marchini J (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562:203\u2013209. https:\/\/doi.org\/10.1038\/s41586-018-0579-z","journal-title":"Nature"},{"key":"2567_CR8","doi-asserted-by":"publisher","first-page":"D1056","DOI":"10.1093\/nar\/gky1133","volume":"47","author":"D Carvalho-Silva","year":"2019","unstructured":"Carvalho-Silva D, Pierleoni A, Pignatelli M, Ong C, Fumis L, Karamanis N, Carmona M, Faulconbridge A, Hercules A, McAuley E (2019) Open Targets Platform: new developments and updates two years on. Nucl Acids Res 47:D1056\u2013D1065","journal-title":"Nucl Acids Res"},{"key":"2567_CR9","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"G Consortium","year":"2020","unstructured":"Consortium G (2020) The GTEx consortium atlas of genetic regulatory effects across human tissues. Science 369:1318\u20131330","journal-title":"Science"},{"key":"2567_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac392","author":"Y Dai","year":"2022","unstructured":"Dai Y, Hu R, Liu A, Cho KS, Manuel AM, Li X, Dong X, Jia P, Zhao Z (2022) WebCSEA: web-based cell-type-specific enrichment analysis of genes. Nucl Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkac392","journal-title":"Nucl Acids Res"},{"key":"2567_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/MNH.0000000000000196","volume":"25","author":"BL Dale","year":"2016","unstructured":"Dale BL, Madhur MS (2016) Linking inflammation and hypertension via LNK\/SH2B3. Curr Opin Nephrol Hypertens 25:87\u201393. https:\/\/doi.org\/10.1097\/MNH.0000000000000196","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2567_CR12","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s43587-021-00051-5","volume":"1","author":"HM Donertas","year":"2021","unstructured":"Donertas HM, Fabian DK, Valenzuela MF, Partridge L, Thornton JM (2021) Common genetic associations between age-related diseases. Nat Aging 1:400\u2013412. https:\/\/doi.org\/10.1038\/s43587-021-00051-5","journal-title":"Nat Aging"},{"key":"2567_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/s41577-019-0160-5","volume":"19","author":"GR Drummond","year":"2019","unstructured":"Drummond GR, Vinh A, Guzik TJ, Sobey CG (2019) Immune mechanisms of hypertension. Nat Rev Immunol 19:517\u2013532. https:\/\/doi.org\/10.1038\/s41577-019-0160-5","journal-title":"Nat Rev Immunol"},{"key":"2567_CR14","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/eurheartj\/ehs455","volume":"34","author":"GB Ehret","year":"2013","unstructured":"Ehret GB, Caulfield MJ (2013) Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J 34:951\u2013961","journal-title":"Eur Heart J"},{"key":"2567_CR15","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","volume":"50","author":"E Evangelou","year":"2018","unstructured":"Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 50:1412\u20131425","journal-title":"Nat Genet"},{"key":"2567_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41431-020-00712-w","volume":"29","author":"E Flynn","year":"2021","unstructured":"Flynn E, Tanigawa Y, Rodriguez F, Altman RB, Sinnott-Armstrong N, Rivas MA (2021) Sex-specific genetic effects across biomarkers. Eur J Hum Genet 29:154\u2013163. https:\/\/doi.org\/10.1038\/s41431-020-00712-w","journal-title":"Eur J Hum Genet"},{"key":"2567_CR17","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/S0140-6736(19)30955-9","volume":"394","author":"P Geldsetzer","year":"2019","unstructured":"Geldsetzer P, Manne-Goehler J, Marcus ME, Ebert C, Zhumadilov Z, Wesseh CS, Tsabedze L, Supiyev A, Sturua L, Bahendeka SK, Sibai AM, Quesnel-Crooks S, Norov B, Mwangi KJ, Mwalim O, Wong-McClure R, Mayige MT, Martins JS, Lunet N, Labadarios D, Karki KB, Kagaruki GB, Jorgensen JMA, Hwalla NC, Houinato D, Houehanou C, Msaidie M, Guwatudde D, Gurung MS, Gathecha G, Dorobantu M, Damasceno A, Bovet P, Bicaba BW, Aryal KK, Andall-Brereton G, Agoudavi K, Stokes A, Davies JI, Barnighausen T, Atun R, Vollmer S, Jaacks LM (2019) The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1.1 million adults. Lancet 394:652\u2013662. https:\/\/doi.org\/10.1016\/S0140-6736(19)30955-9","journal-title":"Lancet"},{"key":"2567_CR18","doi-asserted-by":"publisher","first-page":"D1311","DOI":"10.1093\/nar\/gkaa840","volume":"49","author":"M Ghoussaini","year":"2021","unstructured":"Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt EM, Hercules A, Fumis L, Miranda A, Carvalho-Silva D, Buniello A (2021) Open targets genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. Nucleic Acids Res 49:D1311\u2013D1320","journal-title":"Nucleic Acids Res"},{"key":"2567_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2006.12.004","volume":"28","author":"N Gleicher","year":"2007","unstructured":"Gleicher N, Barad DH (2007) Gender as risk factor for autoimmune diseases. J Autoimmun 28:1\u20136","journal-title":"J Autoimmun"},{"key":"2567_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13073-021-00828-8","volume":"13","author":"M Isgut","year":"2021","unstructured":"Isgut M, Sun J, Quyyumi AA, Gibson G (2021) Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later. Genome Med 13:1\u201316","journal-title":"Genome Med"},{"key":"2567_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0092-8674(92)90275-h","volume":"71","author":"X Jeunemaitre","year":"1992","unstructured":"Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM et al (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169\u2013180. https:\/\/doi.org\/10.1016\/0092-8674(92)90275-h","journal-title":"Cell"},{"key":"2567_CR22","doi-asserted-by":"publisher","first-page":"580443","DOI":"10.3389\/fgene.2020.580443","volume":"11","author":"LD Ji","year":"2020","unstructured":"Ji LD, Tang NLS, Xu ZF, Xu J (2020) Genes regulate blood pressure, but \u201cenvironments\u201d cause hypertension. Front Genet 11:580443. https:\/\/doi.org\/10.3389\/fgene.2020.580443","journal-title":"Front Genet"},{"key":"2567_CR23","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.ajhg.2011.10.013","volume":"89","author":"T Johnson","year":"2011","unstructured":"Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O\u2019Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y, Davey Smith G, Day IN, Lawlor DA, Goodall AH, Cardiogenics C, Fowkes FG, Abecasis GR, Elliott P, Gateva V, Global BC, Braund PS, Burton PR, Nelson CP, Tobin MD, van der Harst P, Glorioso N, Neuvrith H, Salvi E, Staessen JA, Stucchi A, Devos N, Jeunemaitre X, Plouin PF, Tichet J, Juhanson P, Org E, Putku M, Sober S, Veldre G, Viigimaa M, Levinsson A, Rosengren A, Thelle DS, Hastie CE, Hedner T, Lee WK, Melander O, Wahlstrand B, Hardy R, Wong A, Cooper JA, Palmen J, Chen L, Stewart AF, Wells GA, Westra HJ, Wolfs MG, Clarke R, Franzosi MG, Goel A, Hamsten A, Lathrop M, Peden JF, Seedorf U, Watkins H, Ouwehand WH, Sambrook J, Stephens J, Casas JP, Drenos F, Holmes MV, Kivimaki M, Shah S, Shah T, Talmud PJ, Whittaker J, Wallace C, Delles C, Laan M, Kuh D, Humphries SE, Nyberg F, Cusi D, Roberts R, Newton-Cheh C, Franke L, Stanton AV et al (2011) Blood pressure loci identified with a gene-centric array. Am J Hum Genet 89:688\u2013700. https:\/\/doi.org\/10.1016\/j.ajhg.2011.10.013","journal-title":"Am J Hum Genet"},{"key":"2567_CR24","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1161\/HYPERTENSIONAHA.121.17796","volume":"78","author":"A Kauko","year":"2021","unstructured":"Kauko A, Aittokallio J, Vaura F, Ji H, Ebinger JE, Niiranen T, Cheng S (2021) Sex differences in genetic risk for hypertension. Hypertension 78:1153\u20131155. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.17796","journal-title":"Hypertension"},{"key":"2567_CR25","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/s41371-019-0253-4","volume":"33","author":"G Kolifarhood","year":"2019","unstructured":"Kolifarhood G, Daneshpour M, Hadaegh F, Sabour S, MozafarSaadati H, Akbar Haghdoust A, Akbarzadeh M, Sedaghati-Khayat B, Khosravi N (2019) Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis. J Hum Hypertens 33:775\u2013785. https:\/\/doi.org\/10.1038\/s41371-019-0253-4","journal-title":"J Hum Hypertens"},{"key":"2567_CR26","first-page":"1","volume":"1","author":"N Kurniansyah","year":"2021","unstructured":"Kurniansyah N, Goodman MO, Kelly T, Elfassi T, Wiggins K, Bis J, Guo XO, Palmas W, Taylor KD, Lin H (2021) A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood. meDrxiv 1:1","journal-title":"meDrxiv"},{"key":"2567_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.compbiomed.2018.11.002","volume":"104","author":"J Leete","year":"2019","unstructured":"Leete J, Layton AT (2019) Sex-specific long-term blood pressure regulation: modeling and analysis. Comput Biol Med 104:139\u2013148. https:\/\/doi.org\/10.1016\/j.compbiomed.2018.11.002","journal-title":"Comput Biol Med"},{"key":"2567_CR28","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/ng.384","volume":"41","author":"D Levy","year":"2009","unstructured":"Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Kottgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O\u2019Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet 41:677\u2013687. https:\/\/doi.org\/10.1038\/ng.384","journal-title":"Nat Genet"},{"key":"2567_CR29","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/ng.3660","volume":"48","author":"C Liu","year":"2016","unstructured":"Liu C, Kraja AT, Smith JA, Brody JA, Franceschini N, Bis JC, Rice K, Morrison AC, Lu Y, Weiss S, Guo X, Palmas W, Martin LW, Chen YD, Surendran P, Drenos F, Cook JP, Auer PL, Chu AY, Giri A, Zhao W, Jakobsdottir J, Lin LA, Stafford JM, Amin N, Mei H, Yao J, Voorman A, Consortium CHDE, Exome BPC, Go TDC, Consortium TDG, Larson MG, Grove ML, Smith AV, Hwang SJ, Chen H, Huan T, Kosova G, Stitziel NO, Kathiresan S, Samani N, Schunkert H, Deloukas P, Myocardial Infarction G, Consortia CAE, Li M, Fuchsberger C, Pattaro C, Gorski M, Consortium CK, Kooperberg C, Papanicolaou GJ, Rossouw JE, Faul JD, Kardia SL, Bouchard C, Raffel LJ, Uitterlinden AG, Franco OH, Vasan RS, O\u2019Donnell CJ, Taylor KD, Liu K, Bottinger EP, Gottesman O, Daw EW, Giulianini F, Ganesh S, Salfati E, Harris TB, Launer LJ, Dorr M, Felix SB, Rettig R, Volzke H, Kim E, Lee WJ, Lee IT, Sheu WH, Tsosie KS, Edwards DR, Liu Y, Correa A, Weir DR, Volker U, Ridker PM, Boerwinkle E, Gudnason V, Reiner AP, van Duijn CM, Borecki IB, Edwards TL, Chakravarti A, Rotter JI, Psaty BM, Loos RJ, Fornage M, Ehret GB, Newton-Cheh C et al (2016) Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet 48:1162\u20131170. https:\/\/doi.org\/10.1038\/ng.3660","journal-title":"Nat Genet"},{"key":"2567_CR30","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/S0140-6736(17)32478-9","volume":"390","author":"J Lu","year":"2017","unstructured":"Lu J, Lu Y, Wang X, Li X, Linderman GC, Wu C, Cheng X, Mu L, Zhang H, Liu J, Su M, Zhao H, Spatz ES, Spertus JA, Masoudi FA, Krumholz HM, Jiang L (2017) Prevalence, awareness, treatment, and control of hypertension in China: data from 1.7 million adults in a population-based screening study (China PEACE Million Persons Project). Lancet 390:2549\u20132558. https:\/\/doi.org\/10.1016\/S0140-6736(17)32478-9","journal-title":"Lancet"},{"key":"2567_CR31","doi-asserted-by":"publisher","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","volume":"45","author":"J MacArthur","year":"2017","unstructured":"MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, Junkins H, McMahon A, Milano A, Morales J (2017) The new NHGRI-EBI catalog of published genome-wide association studies (GWAS Catalog). Nucl Acids Res 45:D896\u2013D901","journal-title":"Nucl Acids Res"},{"key":"2567_CR32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3109\/10641963.2011.618207","volume":"34","author":"VU Mohana","year":"2012","unstructured":"Mohana VU, Swapna N, Surender RS, Vishnupriya S, Padma T (2012) Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension\u2014a case\u2013control study. Clin Exp Hypertens 34:38\u201344. https:\/\/doi.org\/10.3109\/10641963.2011.618207","journal-title":"Clin Exp Hypertens"},{"key":"2567_CR100","doi-asserted-by":"publisher","unstructured":"Patel RS, Masi S, Taddei S (2017) Understanding the role of genetics in hypertension. Eur Heart J 38:2309\u20132312. https:\/\/doi.org\/10.1093\/eurheartj\/ehx273","DOI":"10.1093\/eurheartj\/ehx273"},{"key":"2567_CR33","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1161\/CIRCRESAHA.116.303647","volume":"116","author":"S Padmanabhan","year":"2015","unstructured":"Padmanabhan S, Caulfield M, Dominiczak AF (2015) Genetic and molecular aspects of hypertension. Circ Res 116:937\u2013959. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303647","journal-title":"Circ Res"},{"key":"2567_CR34","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1038\/s41467-019-10936-0","volume":"10","author":"E Porcu","year":"2019","unstructured":"Porcu E, Rueger S, Lepik K, E QC, Consortium B, Santoni FA, Reymond A, Kutalik Z (2019) Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nat Commun 10:3300. https:\/\/doi.org\/10.1038\/s41467-019-10936-0","journal-title":"Nat Commun"},{"key":"2567_CR35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/ajh\/hpy168","volume":"32","author":"B Rodriguez-Iturbe","year":"2019","unstructured":"Rodriguez-Iturbe B, Johnson RJ (2019) Genetic polymorphisms in hypertension: Are we missing the immune connection? Am J Hypertens 32:113\u2013122. https:\/\/doi.org\/10.1093\/ajh\/hpy168","journal-title":"Am J Hypertens"},{"key":"2567_CR36","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nrendo.2016.196","volume":"13","author":"GP Rossi","year":"2017","unstructured":"Rossi GP, Ceolotto G, Caroccia B, Lenzini L (2017) Genetic screening in arterial hypertension. Nat Rev Endocrinol 13:289\u2013298","journal-title":"Nat Rev Endocrinol"},{"key":"2567_CR37","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1161\/HYPERTENSIONAHA.114.04736","volume":"65","author":"NP Rudemiller","year":"2015","unstructured":"Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL (2015) Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Hypertension 65:1111\u20131117. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.04736","journal-title":"Hypertension"},{"key":"2567_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2042-6410-3-7","volume":"3","author":"K Sandberg","year":"2012","unstructured":"Sandberg K, Ji H (2012) Sex differences in primary hypertension. Biol Sex Differ 3:1\u201321","journal-title":"Biol Sex Differ"},{"key":"2567_CR39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41588-020-00757-z","volume":"53","author":"N Sinnott-Armstrong","year":"2021","unstructured":"Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T (2021) Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet 53:185\u2013194","journal-title":"Nat Genet"},{"key":"2567_CR40","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5947","author":"E Sjostedt","year":"2020","unstructured":"Sjostedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Ponten F, Luo Y, Hokfelt T, Uhlen M, Mulder J (2020) An atlas of the protein-coding genes in the human, pig, and mouse brain. Science. https:\/\/doi.org\/10.1126\/science.aay5947","journal-title":"Science"},{"key":"2567_CR41","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/ng.3654","volume":"48","author":"P Surendran","year":"2016","unstructured":"Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M, Mihailov E, Liu C, Kraja AT, Fallgaard Nielsen S, Rasheed A, Samuel M, Zhao W, Bonnycastle LL, Jackson AU, Narisu N, Swift AJ, Southam L, Marten J, Huyghe JR, Stancakova A, Fava C, Ohlsson T, Matchan A, Stirrups KE, Bork-Jensen J, Gjesing AP, Kontto J, Perola M, Shaw-Hawkins S, Havulinna AS, Zhang H, Donnelly LA, Groves CJ, Rayner NW, Neville MJ, Robertson NR, Yiorkas AM, Herzig KH, Kajantie E, Zhang W, Willems SM, Lannfelt L, Malerba G, Soranzo N, Trabetti E, Verweij N, Evangelou E, Moayyeri A, Vergnaud AC, Nelson CP, Poveda A, Varga TV, Caslake M, de Craen AJ, Trompet S, Luan J, Scott RA, Harris SE, Liewald DC, Marioni R, Menni C, Farmaki AE, Hallmans G, Renstrom F, Huffman JE, Hassinen M, Burgess S, Vasan RS, Felix JF, Consortium CH-HF, Uria-Nickelsen M, Malarstig A, Reily DF, Hoek M, Vogt T, Lin H, Lieb W, EchoGen C, Traylor M, Markus HF, Consortium M, Highland HM, Justice AE, Marouli E, Consortium G et al (2016) Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 48:1151\u20131161. https:\/\/doi.org\/10.1038\/ng.3654","journal-title":"Nat Genet"},{"key":"2567_CR42","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1038\/s41588-020-00713-x","volume":"52","author":"P Surendran","year":"2020","unstructured":"Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindstrom J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Muller-Nurasyid M, Pare G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepulveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanakova A, Sulem P, Theriault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E, Aeschbacher S, Asllanaj E, Blankenberg S, Bonnycastle LL, Bork-Jensen J, Brandslund I, Braund PS, Burgess S et al (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet 52:1314\u20131332. https:\/\/doi.org\/10.1038\/s41588-020-00713-x","journal-title":"Nat Genet"},{"key":"2567_CR43","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1038\/s41467-018-07345-0","volume":"9","author":"F Takeuchi","year":"2018","unstructured":"Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, Moon S, Spracklen CN, Chai JF, Kim YJ, Zhang L, Wang C, Li H, Li H, Wu JY, Dorajoo R, Nierenberg JL, Wang YX, He J, Bennett DA, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Rakugi H, Nakashima E, Isono M, Shirota M, Hozawa A, Ichihara S, Matsubara T, Yamamoto K, Kohara K, Igase M, Han S, Gordon-Larsen P, Huang W, Lee NR, Adair LS, Hwang MY, Lee J, Chee ML, Sabanayagam C, Zhao W, Liu J, Reilly DF, Sun L, Huo S, Edwards TL, Long J, Chang LC, Chen CH, Yuan JM, Koh WP, Friedlander Y, Kelly TN, Bin Wei W, Xu L, Cai H, Xiang YB, Lin K, Clarke R, Walters RG, Millwood IY, Li L, Chambers JC, Kooner JS, Elliott P, van der Harst P, International Genomics of Blood Pressure C, Chen Z, Sasaki M, Shu XO, Jonas JB, He J, Heng CK, Chen YT, Zheng W, Lin X, Teo YY, Tai ES, Cheng CY, Wong TY, Sim X, Mohlke KL, Yamamoto M, Kim BJ, Miki T, Nabika T, Yokota M, Kamatani Y, Kubo M, Kato N (2018) Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nat Commun 9:5052. https:\/\/doi.org\/10.1038\/s41467-018-07345-0","journal-title":"Nat Commun"},{"key":"2567_CR44","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1161\/HYPERTENSIONAHA.120.16471","volume":"77","author":"F Vaura","year":"2021","unstructured":"Vaura F, Kauko A, Suvila K, Havulinna AS, Mars N, Salomaa V, FinnGen CS, Niiranen T (2021) Polygenic risk scores predict hypertension onset and cardiovascular risk. Hypertension 77:1119\u20131127","journal-title":"Hypertension"},{"key":"2567_CR45","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/ng.3768","volume":"49","author":"HR Warren","year":"2017","unstructured":"Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP (2017) Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet 49:403\u2013415","journal-title":"Nat Genet"},{"key":"2567_CR46","doi-asserted-by":"publisher","unstructured":"Warren H, Edwards T, Vaez A, Keaton J, Kamali Z, Xie T, Ani A, Evangelou E, Hellwege J, Yengo L et al (2022) Genome-wide analysis in over 1 million individuals reveals over 2000 independent genetic signals for blood pressure. Preprint. https:\/\/doi.org\/10.21203\/rs.3.rs-1409164\/v1","DOI":"10.21203\/rs.3.rs-1409164\/v1"},{"key":"2567_CR47","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1001\/jama.289.18.2363","volume":"289","author":"K Wolf-Maier","year":"2003","unstructured":"Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense H-W, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodr\u00edguez-Artalejo F (2003) Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 289:2363\u20132369","journal-title":"JAMA"},{"key":"2567_CR48","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0140-6736(07)60198-6","volume":"369","author":"TY Wong","year":"2007","unstructured":"Wong TY, Mitchell P (2007) The eye in hypertension. Lancet 369:425\u2013435. https:\/\/doi.org\/10.1016\/S0140-6736(07)60198-6","journal-title":"Lancet"},{"key":"2567_CR49","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1038\/s41467-018-05512-x","volume":"9","author":"C Yao","year":"2018","unstructured":"Yao C, Chen G, Song C, Keefe J, Mendelson M, Huan T, Sun BB, Laser A, Maranville JC, Wu H, Ho JE, Courchesne P, Lyass A, Larson MG, Gieger C, Graumann J, Johnson AD, Danesh J, Runz H, Hwang SJ, Liu C, Butterworth AS, Suhre K, Levy D (2018) Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease. Nat Commun 9:3268. https:\/\/doi.org\/10.1038\/s41467-018-05512-x","journal-title":"Nat Commun"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-023-02567-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00439-023-02567-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-023-02567-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T13:02:10Z","timestamp":1688821330000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00439-023-02567-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["2567"],"URL":"https:\/\/doi.org\/10.1007\/s00439-023-02567-9","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"assertion":[{"value":"1 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author declares that he has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical committee approval: The Hebrew University #13082019 from the University Committee for the Use of Human Subjects in research (dated 07\/2002).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}