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All other authors declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"CHRIS study was approved by the Ethics Committee of the Healthcare System of the Autonomous Province of Bolzano\/Bozen, South Tyrol (approval number 21-2011). MICROS study was approved by the Provincial Ethics Committee of Bolzano\/Bozen - South Tyrol (23.5 Dr.MVH\/31.05.07.14\/19644) with an update approved by the Ethics Committee of the Healthcare System of the Autonomous Province of Bolzano\/Bozen - South Tyrol (18\/09\/2013). The research involving human stem cell lines was approved by the Ethics Committee of the Province of Bolzano (approval number 1\/2014). SHIP-START and SHIP-TREND were approved by the Ethics Committee at the University Medicine Greifswald (approval number BB 39\/08). The studies conform to the Declaration of Helsinki, and with national and institutional legal and ethical requirements. 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