{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:35Z","timestamp":1792783295439,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82192874, 82402161, 82071606, 82171842"],"award-info":[{"award-number":["82192874, 82402161, 82071606, 82171842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"The Excellence Research Group Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Shandong Provincial Key Research and Development Program","award":["2024CXPT087"],"award-info":[{"award-number":["2024CXPT087"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Basic Science Center Program of NSFC","award":["32588201"],"award-info":[{"award-number":["32588201"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["ts20190988"],"award-info":[{"award-number":["ts20190988"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"Ningxia Hui Autonomous Region Key Research and Developmental Program","award":["2024BEG02019"],"award-info":[{"award-number":["2024BEG02019"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"name":"China National Postdoctoral Program for Innovative Talent","award":["BX20240172"],"award-info":[{"award-number":["BX20240172"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M751487"],"award-info":[{"award-number":["2024M751487"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Youth Project of Jiangsu Provincial Natural Science Foundation","award":["BK20240375"],"award-info":[{"award-number":["BK20240375"]}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Postdoctoral Research Fund of Gusu School in Nanjing Medical University","award":["GSBSHKY202303"],"award-info":[{"award-number":["GSBSHKY202303"]}],"id":[{"id":"https:\/\/ror.org\/059gcgy73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Shandong University","award":["2023QNTDO04"],"award-info":[{"award-number":["2023QNTDO04"]}],"id":[{"id":"https:\/\/ror.org\/0207yh398","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"name":"The specific research fund of The Innovation Platform for Academicians of Hainan Province","award":["YSPTZX202310"],"award-info":[{"award-number":["YSPTZX202310"]}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"The Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ2083"],"award-info":[{"award-number":["2024JJ2083"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]},{"name":"The science and technology innovation Program of Hunan Province","award":["2023RC3233"],"award-info":[{"award-number":["2023RC3233"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum. Genet."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00439-026-02818-5","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:29:49Z","timestamp":1774067389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human YTHDC2 mutations disturb RNA homeostasis of oocytes and early embryos"],"prefix":"10.1007","volume":"145","author":[{"given":"Wei","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"2818_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.stem.2021.11.012","volume":"29","author":"M Asami","year":"2022","unstructured":"Asami M, Lam BYH, Ma MK et al (2022) Human embryonic genome activation initiates at the one-cell stage. Cell Stem Cell 29:209-216.e4. https:\/\/doi.org\/10.1016\/j.stem.2021.11.012","journal-title":"Cell Stem Cell"},{"key":"2818_CR2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309548121","volume":"121","author":"AS Bailey","year":"2024","unstructured":"Bailey AS, Fuller MT (2024) YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation. Proc Natl Acad Sci U S A 121:e2309548121. https:\/\/doi.org\/10.1073\/pnas.2309548121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2818_CR3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26116","volume":"6","author":"AS Bailey","year":"2017","unstructured":"Bailey AS, Batista PJ, Gold RS et al (2017) The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. eLife 6:e26116. https:\/\/doi.org\/10.7554\/eLife.26116","journal-title":"eLife"},{"key":"2818_CR4","doi-asserted-by":"publisher","first-page":"8557","DOI":"10.1111\/jcmm.15482","volume":"24","author":"Q Cao","year":"2020","unstructured":"Cao Q, Zhao C, Zhang X et al (2020) Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human. J Cell Mol Med 24:8557\u20138566. https:\/\/doi.org\/10.1111\/jcmm.15482","journal-title":"J Cell Mol Med"},{"key":"2818_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00439-024-02650-9","volume":"143","author":"L Cao","year":"2024","unstructured":"Cao L, He X, Ren J et al (2024) Novel compound heterozygous variants in FANCI cause premature ovarian insufficiency. Hum Genet 143:357\u2013369. https:\/\/doi.org\/10.1007\/s00439-024-02650-9","journal-title":"Hum Genet"},{"key":"2818_CR6","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708515","volume":"10","author":"M Christou-Kent","year":"2018","unstructured":"Christou-Kent M, Kherraf Z, Amiri\u2010Yekta A et al (2018) PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice. EMBO Mol Med 10:e8515. https:\/\/doi.org\/10.15252\/emmm.201708515","journal-title":"EMBO Mol Med"},{"key":"2818_CR7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30490","volume":"6","author":"B Fouquet","year":"2017","unstructured":"Fouquet B, Pawlikowska P, Caburet S et al (2017) A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency. eLife 6:e30490. https:\/\/doi.org\/10.7554\/eLife.30490","journal-title":"eLife"},{"key":"2818_CR8","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1080\/15384101.2022.2031427","volume":"21","author":"N Gindi","year":"2022","unstructured":"Gindi N, Grossman H, Bar-Joseph H et al (2022) Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation. Cell Cycle 21:792\u2013804. https:\/\/doi.org\/10.1080\/15384101.2022.2031427","journal-title":"Cell Cycle"},{"key":"2818_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0125-4","author":"C Gu","year":"2019","unstructured":"Gu C, Liu S, Wu Q et al (2019) Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes. Cell Res. https:\/\/doi.org\/10.1038\/s41422-018-0125-4","journal-title":"Cell Res"},{"key":"2818_CR10","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1007\/s43032-022-00958-3","volume":"29","author":"M Hou","year":"2022","unstructured":"Hou M, Zhu L, Jiang J et al (2022) Novel heterozygous mutations in ZP2 cause abnormal zona pellucida and female infertility. Reprod Sci 29:3047\u20133054. https:\/\/doi.org\/10.1007\/s43032-022-00958-3","journal-title":"Reprod Sci"},{"key":"2818_CR11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/cr.2017.99","volume":"27","author":"PJ Hsu","year":"2017","unstructured":"Hsu PJ, Zhu Y, Ma H et al (2017) Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res 27:1115\u20131127. https:\/\/doi.org\/10.1038\/cr.2017.99","journal-title":"Cell Res"},{"key":"2818_CR12","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s10815-022-02412-4","volume":"39","author":"L Huang","year":"2022","unstructured":"Huang L, Wang Y, Lu F et al (2022) Novel mutations in NLRP5 and PATL2 cause female infertility characterized by primarily oocyte maturation abnormality and consequent early embryonic arrest. J Assist Reprod Genet 39:711\u2013718. https:\/\/doi.org\/10.1007\/s10815-022-02412-4","journal-title":"J Assist Reprod Genet"},{"key":"2818_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301538","volume":"10","author":"J Huang","year":"2023","unstructured":"Huang J, Chen P, Jia L et al (2023) Multi-omics analysis reveals translational landscapes and regulations in mouse and human oocyte aging. Adv Sci 10:2301538. https:\/\/doi.org\/10.1002\/advs.202301538","journal-title":"Adv Sci"},{"key":"2818_CR14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30919","volume":"7","author":"D Jain","year":"2018","unstructured":"Jain D, Puno MR, Meydan C et al (2018) Ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. eLife 7:e30919. https:\/\/doi.org\/10.7554\/eLife.30919","journal-title":"eLife"},{"key":"2818_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.12669\/pjms.321.8329","volume":"32","author":"S Jawed","year":"2016","unstructured":"Jawed S, Rehman R, Ali MA et al (2016) Fertilization rate and its determinants in intracytoplasmic sperm injection. Pak J Med Sci 32:3\u20137. https:\/\/doi.org\/10.12669\/pjms.321.8329","journal-title":"Pak J Med Sci"},{"key":"2818_CR16","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41591-022-02194-3","volume":"29","author":"H Ke","year":"2023","unstructured":"Ke H, Tang S, Guo T et al (2023) Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med 29:483\u2013492. https:\/\/doi.org\/10.1038\/s41591-022-02194-3","journal-title":"Nat Med"},{"key":"2818_CR17","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1038\/cr.2014.153","volume":"24","author":"F Li","year":"2014","unstructured":"Li F, Zhao D, Wu J, Shi Y (2014) Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition. Cell Res 24:1490\u20131492. https:\/\/doi.org\/10.1038\/cr.2014.153","journal-title":"Cell Res"},{"key":"2818_CR18","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.molcel.2022.02.034","volume":"82","author":"L Li","year":"2022","unstructured":"Li L, Krasnykov K, Homolka D et al (2022) The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition. Mol Cell 82:1678\u20131690e12. https:\/\/doi.org\/10.1016\/j.molcel.2022.02.034","journal-title":"Mol Cell"},{"issue":"1","key":"2818_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/9278518","volume":"2024","author":"R Li","year":"2024","unstructured":"Li R, Mei M, Zhou L et al (2024) Biallelic recessive mutations in TLE6 and NLRP5 cause female infertility characterized by human early embryonic arrest. Hum Mutat 2024:9278518. https:\/\/doi.org\/10.1155\/2024\/9278518","journal-title":"Hum Mutat"},{"key":"2818_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Yue Y, Han D et al (2014) A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10:93\u201395. https:\/\/doi.org\/10.1038\/nchembio.1432","journal-title":"Nat Chem Biol"},{"key":"2818_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110110","volume":"37","author":"R Liu","year":"2021","unstructured":"Liu R, Kasowitz SD, Homolka D et al (2021) YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis. Cell Reports 37:110110. https:\/\/doi.org\/10.1016\/j.celrep.2021.110110","journal-title":"Cell Reports"},{"key":"2818_CR22","doi-asserted-by":"publisher","DOI":"10.1093\/gpbjnl\/qzad001","volume":"22","author":"W Liu","year":"2023","unstructured":"Liu W, Chen C, Gao Y et al (2023) Transcriptome dynamics and cell dialogs between oocytes and granulosa cells in mouse follicle development. Genomics Proteomics Bioinformatics 22:qzad001. https:\/\/doi.org\/10.1093\/gpbjnl\/qzad001","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2818_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/gpbjnl\/qzad001","volume":"22","author":"W Liu","year":"2024","unstructured":"Liu W, Chen C, Gao Y et al (2024) Transcriptome dynamics and cell dialogs between oocytes and granulosa cells in mouse follicle development. Genomics, Proteomics & Bioinformatics 22:qzad001. https:\/\/doi.org\/10.1093\/gpbjnl\/qzad001","journal-title":"Genomics, Proteomics & Bioinformatics"},{"key":"2818_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1516473","volume":"16","author":"L Liu","year":"2025","unstructured":"Liu L, Ge D, Lin Y et al (2025) Epigenetic regulation in oogenesis and fetal development: insights into m6A modifications. Front Immunol 16:1516473. https:\/\/doi.org\/10.3389\/fimmu.2025.1516473","journal-title":"Front Immunol"},{"key":"2818_CR25","doi-asserted-by":"publisher","first-page":"13834","DOI":"10.1073\/pnas.1412742111","volume":"111","author":"S Luo","year":"2014","unstructured":"Luo S, Tong L (2014) Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain. Proc Natl Acad Sci 111:13834\u201313839. https:\/\/doi.org\/10.1073\/pnas.1412742111","journal-title":"Proc Natl Acad Sci"},{"key":"2818_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13317-9","volume":"10","author":"Y Mao","year":"2019","unstructured":"Mao Y, Dong L, Liu X-M et al (2019) M6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2. Nat Commun 10:5332. https:\/\/doi.org\/10.1038\/s41467-019-13317-9","journal-title":"Nat Commun"},{"key":"2818_CR27","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.154671","volume":"7","author":"SM McGlacken-Byrne","year":"2022","unstructured":"McGlacken-Byrne SM, Del Valle I, Quesne Stabej PL et al (2022) Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency. JCI Insight 7:e154671. https:\/\/doi.org\/10.1172\/jci.insight.154671","journal-title":"JCI Insight"},{"issue":"11","key":"2818_CR28","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf124","volume":"110","author":"SM McGlacken-Byrne","year":"2025","unstructured":"McGlacken-Byrne SM, Suntharalingham JP, Ishida M et al (2025) A tiered approach to exome sequencing analysis in early-onset primary ovarian insufficiency. J Clin Endocrinol Metab dgaf124. https:\/\/doi.org\/10.1210\/clinem\/dgaf124","journal-title":"J Clin Endocrinol Metab"},{"key":"2818_CR29","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/humrep\/deab226","volume":"37","author":"P Ntostis","year":"2021","unstructured":"Ntostis P, Iles D, Kokkali G et al (2021) The impact of maternal age on gene expression during the GV to MII transition in euploid human oocytes. Hum Reprod 37:80\u201392. https:\/\/doi.org\/10.1093\/humrep\/deab226","journal-title":"Hum Reprod"},{"key":"2818_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.tcb.2017.10.001","volume":"28","author":"DP Patil","year":"2018","unstructured":"Patil DP, Pickering BF, Jaffrey SR (2018) Reading m6A in the transcriptome: M6A-binding proteins. Trends Cell Biol 28:113\u2013127. https:\/\/doi.org\/10.1016\/j.tcb.2017.10.001","journal-title":"Trends Cell Biol"},{"key":"2818_CR31","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.molcel.2015.10.011","volume":"60","author":"JR Prabu","year":"2015","unstructured":"Prabu JR, M\u00fcller M, Thomae AW et al (2015) Structure of the RNA helicase MLE reveals the molecular mechanisms for uridine specificity and RNA-ATP coupling. Mol Cell 60:487\u2013499. https:\/\/doi.org\/10.1016\/j.molcel.2015.10.011","journal-title":"Mol Cell"},{"key":"2818_CR32","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41431-018-0141-3","volume":"26","author":"J Qian","year":"2018","unstructured":"Qian J, Nguyen NMP, Rezaei M et al (2018) Biallelic PADI6 variants linking infertility, miscarriages, and hydatidiform moles. Eur J Hum Genet 26:1007\u20131013. https:\/\/doi.org\/10.1038\/s41431-018-0141-3","journal-title":"Eur J Hum Genet"},{"key":"2818_CR33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1101\/gad.349190.121","volume":"36","author":"Y Saito","year":"2022","unstructured":"Saito Y, Hawley BR, Puno MR et al (2022) YTHDC2 control of gametogenesis requires helicase activity but not m6 a binding. Genes Dev 36:180\u2013194. https:\/\/doi.org\/10.1101\/gad.349190.121","journal-title":"Genes Dev"},{"key":"2818_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/cells12151976","volume":"12","author":"D Salimov","year":"2023","unstructured":"Salimov D, Lisovskaya T, Otsuki J et al (2023) Chromatin morphology in human germinal vesicle oocytes and their competence to mature in stimulated cycles. Cells 12:1976. https:\/\/doi.org\/10.3390\/cells12151976","journal-title":"Cells"},{"key":"2818_CR35","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ajhg.2018.02.015","volume":"102","author":"Q Sang","year":"2018","unstructured":"Sang Q, Li B, Kuang Y et al (2018) Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet 102:649\u2013657. https:\/\/doi.org\/10.1016\/j.ajhg.2018.02.015","journal-title":"Am J Hum Genet"},{"key":"2818_CR36","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1126\/science.adf7760","volume":"380","author":"Q Sang","year":"2023","unstructured":"Sang Q, Ray PF, Wang L (2023) Understanding the genetics of human infertility. Science 380:158\u2013163. https:\/\/doi.org\/10.1126\/science.adf7760","journal-title":"Science"},{"key":"2818_CR37","doi-asserted-by":"publisher","first-page":"6582","DOI":"10.1093\/emboj\/19.23.6582","volume":"19","author":"B Schwer","year":"2000","unstructured":"Schwer B, Meszaros T (2000) RNA helicase dynamics in pre-mRNA splicing. EMBO J 19:6582\u20136591. https:\/\/doi.org\/10.1093\/emboj\/19.23.6582","journal-title":"EMBO J"},{"key":"2818_CR38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183758","volume":"134","author":"S Tang","year":"2024","unstructured":"Tang S, Guo T, Song C et al (2024) MGA loss-of-function variants cause premature ovarian insufficiency. J Clin Invest 134:e183758. https:\/\/doi.org\/10.1172\/JCI183758","journal-title":"J Clin Invest"},{"key":"2818_CR39","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2024.0259","author":"F T\u00fcttelmann","year":"2025","unstructured":"T\u00fcttelmann F, Wyrwoll MJ, Steingr\u00f6ver J, Wieacker P (2025) The genetics of female and male infertility. Dtsch Arztebl Int. https:\/\/doi.org\/10.3238\/arztebl.m2024.0259","journal-title":"Dtsch Arztebl Int"},{"key":"2818_CR40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ncb2902","volume":"16","author":"Y Wang","year":"2014","unstructured":"Wang Y, Li Y, Toth JI et al (2014) N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol 16:191\u2013198. https:\/\/doi.org\/10.1038\/ncb2902","journal-title":"Nat Cell Biol"},{"key":"2818_CR41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/humupd\/dmad026","volume":"30","author":"Y Wei","year":"2024","unstructured":"Wei Y, Wang J, Qu R et al (2024) Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review. Hum Reprod Update 30:48\u201380. https:\/\/doi.org\/10.1093\/humupd\/dmad026","journal-title":"Hum Reprod Update"},{"key":"2818_CR42","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.molcel.2017.09.021","volume":"68","author":"MN Wojtas","year":"2017","unstructured":"Wojtas MN, Pandey RR, Mendel M et al (2017) Regulation of m6A transcripts by the 3\u02b9\u21925\u02b9 RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline. Mol Cell 68:374-387.e12. https:\/\/doi.org\/10.1016\/j.molcel.2017.09.021","journal-title":"Mol Cell"},{"key":"2818_CR43","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s43587-024-00607-1","volume":"4","author":"M Wu","year":"2024","unstructured":"Wu M, Tang W, Chen Y et al (2024a) Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. Nat Aging 4:527\u2013545. https:\/\/doi.org\/10.1038\/s43587-024-00607-1","journal-title":"Nat Aging"},{"key":"2818_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05293-6","volume":"22","author":"X Wu","year":"2024","unstructured":"Wu X, Chen H, Li K et al (2024b) The biological function of the N6-methyladenosine reader YTHDC2 and its role in diseases. J Transl Med 22:490. https:\/\/doi.org\/10.1186\/s12967-024-05293-6","journal-title":"J Transl Med"},{"key":"2818_CR45","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","volume":"61","author":"W Xiao","year":"2016","unstructured":"Xiao W, Adhikari S, Dahal U et al (2016) Nuclear m6A reader YTHDC1 regulates mRNA splicing. Mol Cell 61:507\u2013519. https:\/\/doi.org\/10.1016\/j.molcel.2016.01.012","journal-title":"Mol Cell"},{"key":"2818_CR46","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1016\/j.bbapap.2014.07.001","volume":"1844","author":"L Xing","year":"2014","unstructured":"Xing L, Zhao X, Niu M, Kleiman L (2014) Helicase associated 2 domain is essential for helicase activity of RNA helicase a. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844:1757\u20131764. https:\/\/doi.org\/10.1016\/j.bbapap.2014.07.001","journal-title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"},{"key":"2818_CR47","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nchembio.1654","volume":"10","author":"C Xu","year":"2014","unstructured":"Xu C, Wang X, Liu K et al (2014) Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat Chem Biol 10:927\u2013929. https:\/\/doi.org\/10.1038\/nchembio.1654","journal-title":"Nat Chem Biol"},{"key":"2818_CR48","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.ajhg.2016.06.024","volume":"99","author":"Y Xu","year":"2016","unstructured":"Xu Y, Shi Y, Fu J et al (2016) Mutations in PADI6 cause female infertility characterized by early embryonic arrest. Am J Hum Genet 99:744\u2013752. https:\/\/doi.org\/10.1016\/j.ajhg.2016.06.024","journal-title":"Am J Hum Genet"},{"key":"2818_CR49","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00439-019-02059-9","volume":"138","author":"X Yang","year":"2019","unstructured":"Yang X, Zhang X, Jiao J et al (2019) Rare variants in FANCA induce premature ovarian insufficiency. Hum Genet 138:1227\u20131236. https:\/\/doi.org\/10.1007\/s00439-019-02059-9","journal-title":"Hum Genet"},{"key":"2818_CR50","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/humu.23997","volume":"41","author":"Y Yang","year":"2020","unstructured":"Yang Y, Guo T, Liu R et al (2020) FANCL gene mutations in premature ovarian insufficiency. Hum Mutat 41:1033\u20131041. https:\/\/doi.org\/10.1002\/humu.23997","journal-title":"Hum Mutat"},{"key":"2818_CR51","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.fertnstert.2020.11.003","volume":"115","author":"P Yang","year":"2021","unstructured":"Yang P, Chen T, Liu Y et al (2021) The critical role of ZP genes in female infertility characterized by empty follicle syndrome and oocyte degeneration. Fertil Steril 115:1259\u20131269. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.11.003","journal-title":"Fertil Steril"},{"key":"2818_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144810","volume":"753","author":"M Zeng","year":"2020","unstructured":"Zeng M, Dai X, Liang Z et al (2020) Critical roles of mRNA m6A modification and YTHDC2 expression for meiotic initiation and progression in female germ cells. Gene 753:144810. https:\/\/doi.org\/10.1016\/j.gene.2020.144810","journal-title":"Gene"},{"key":"2818_CR53","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.molcel.2018.10.029","volume":"72","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Yan Z, Qin Q et al (2018) Transcriptome landscape of human folliculogenesis reveals oocyte and granulosa cell interactions. Mol Cell 72:1021\u20131034e4. https:\/\/doi.org\/10.1016\/j.molcel.2018.10.029","journal-title":"Mol Cell"},{"key":"2818_CR54","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1101\/gad.331157.119","volume":"34","author":"C Zhang","year":"2020","unstructured":"Zhang C, Chen Z, Yin Q et al (2020) The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes Dev 34:166\u2013178. https:\/\/doi.org\/10.1101\/gad.331157.119","journal-title":"Genes Dev"},{"key":"2818_CR55","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41422-021-00507-8","volume":"31","author":"H Zhang","year":"2021","unstructured":"Zhang H, Chen T, Wu K et al (2021) Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor. Cell Res 31:814\u2013817. https:\/\/doi.org\/10.1038\/s41422-021-00507-8","journal-title":"Cell Res"},{"key":"2818_CR56","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13575","volume":"57","author":"H Zhang","year":"2023","unstructured":"Zhang H, Su W, Zhao R et al (2023a) Epigallocatechin-3\u2010gallate improves the quality of maternally aged oocytes. Cell Prolif 57:e13575. https:\/\/doi.org\/10.1111\/cpr.13575","journal-title":"Cell Prolif"},{"key":"2818_CR57","doi-asserted-by":"publisher","first-page":"ii47","DOI":"10.1093\/humrep\/dead084","volume":"38","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Zhang W, Wu X et al (2023b) Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency. Hum Reprod 38:ii47\u2013ii56. https:\/\/doi.org\/10.1093\/humrep\/dead084","journal-title":"Hum Reprod"},{"key":"2818_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01341-2","volume":"14","author":"Y-L Zhang","year":"2024","unstructured":"Zhang Y-L, Hu Z, Jiang H et al (2024) PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation. Cell Biosci 14:157. https:\/\/doi.org\/10.1186\/s13578-024-01341-2","journal-title":"Cell Biosci"},{"key":"2818_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-04001-1","author":"C Zhang","year":"2025","unstructured":"Zhang C, Zheng W, Zhang H et al (2025a) Genetic architecture and phenotypic diversity of oocyte and early embryo competence defects in female infertility. Nat Med. https:\/\/doi.org\/10.1038\/s41591-025-04001-1","journal-title":"Nat Med"},{"key":"2818_CR60","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2837-9","author":"H Zhang","year":"2025","unstructured":"Zhang H, Su W, Jiang X et al (2025b) GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication. Sci China Life Sci. https:\/\/doi.org\/10.1007\/s11427-024-2837-9","journal-title":"Sci China Life Sci"},{"key":"2818_CR61","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.fertnstert.2018.11.018","volume":"111","author":"S Zhao","year":"2019","unstructured":"Zhao S, Chen T, Yu M et al (2019) Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertil Steril 111:519\u2013526. https:\/\/doi.org\/10.1016\/j.fertnstert.2018.11.018","journal-title":"Fertil Steril"},{"key":"2818_CR62","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajhg.2020.05.010","volume":"107","author":"W Zheng","year":"2020","unstructured":"Zheng W, Zhou Z, Sha Q et al (2020) Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility. Am J Hum Genet 107:24\u201333. https:\/\/doi.org\/10.1016\/j.ajhg.2020.05.010","journal-title":"Am J Hum Genet"},{"key":"2818_CR63","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1007\/s10815-021-02219-9","volume":"38","author":"W Zheng","year":"2021","unstructured":"Zheng W, Hu H, Zhang S et al (2021) The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility. J Assist Reprod Genet 38:2261\u20132272. https:\/\/doi.org\/10.1007\/s10815-021-02219-9","journal-title":"J Assist Reprod Genet"},{"key":"2818_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10:1523. https:\/\/doi.org\/10.1038\/s41467-019-09234-6","journal-title":"Nat Commun"},{"key":"2818_CR65","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/cr.2014.152","volume":"24","author":"T Zhu","year":"2014","unstructured":"Zhu T, Roundtree IA, Wang P et al (2014) Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res 24:1493\u20131496. https:\/\/doi.org\/10.1038\/cr.2014.152","journal-title":"Cell Res"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-026-02818-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00439-026-02818-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-026-02818-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:29:52Z","timestamp":1774067392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00439-026-02818-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,21]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2818"],"URL":"https:\/\/doi.org\/10.1007\/s00439-026-02818-5","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,21]]},"assertion":[{"value":"19 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study received approval from the Institutional Review 468 Board of the Center for Reproductive Medicine, Shandong University (approval 469 number 2016IRB14) and the Reproductive and Genetic Hospital of CITIC-XIANGYA 470 (approval number LLSC-2024-012). The Institutional Review Board of Reproductive Medicine, Shandong University, and the Ethics Committee of the Reproductive and Genetic Hospital of CITIC-Xiangya approved the experiments on mice.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided informed consent, and the recruitment process adhered to 467 local ethical guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors confirm that human research participants have provided informed consent for the publication of the data in Table\n                      \n                      .","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"31"}}