{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:01:23Z","timestamp":1786122083175,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Major Project of Guangxi Innovation Driven","award":["AA18118016"],"award-info":[{"award-number":["AA18118016"]}]},{"name":"National Key Research and Development Program of China","award":["2017YFC0908000"],"award-info":[{"award-number":["2017YFC0908000"]}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFDA069012"],"award-info":[{"award-number":["2025GXNSFDA069012"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273618"],"award-info":[{"award-number":["82273618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hum. Genet."],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00439-026-02859-w","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:36:15Z","timestamp":1786091775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of novel loci regulating circulating melatonin and its causal relationship with hypertension"],"prefix":"10.1007","volume":"145","author":[{"given":"Lin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boteng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiantu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengnan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"17","key":"2859_CR1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2147\/JMDH.S446521","volume":"2:17","author":"MA Ahmed","year":"2024","unstructured":"Ahmed MA (2024) The Effect of melatonin supplement on high arterial blood pressure: an overview from clinicaltrials.gov. J Multidiscip Healthc 2024 Feb 2:17(17):517\u2013520. https:\/\/doi.org\/10.2147\/JMDH.S446521","journal-title":"J Multidiscip Healthc 2024 Feb"},{"key":"2859_CR2","doi-asserted-by":"publisher","DOI":"10.1177\/00912174241287996","author":"M Atmaca","year":"2024","unstructured":"Atmaca M, Yildiz S, Tabara MF, Gurok MG, Yildirim M, Yildirim H (2024) Reduced pineal gland volume in patients with obsessive-compulsive disorder. Int J Psychiatry Med. https:\/\/doi.org\/10.1177\/00912174241287996","journal-title":"Int J Psychiatry Med"},{"key":"2859_CR3","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.21037\/tlcr-22-467","volume":"11","author":"M Bao","year":"2022","unstructured":"Bao M, Huang Y, Lang Z, Zhao H, Saito Y, Nagano T, Kawagoe I, Divisi D, Hu X, Jiang G (2022) Proteomic analysis of plasma exosomes in patients with non-small cell lung cancer. Translational Lung Cancer Res 11:1434\u20131452. https:\/\/doi.org\/10.21037\/tlcr-22-467","journal-title":"Translational Lung Cancer Res"},{"key":"2859_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0306-4530(02)00003-3","volume":"28","author":"M Bartels","year":"2003","unstructured":"Bartels M, Van den Berg M, Sluyter F, Boomsma DI, de Geus EJ (2003) Heritability of cortisol levels: review and simultaneous analysis of twin studies. Psychoneuroendocrinology 28:121\u2013137. https:\/\/doi.org\/10.1016\/s0306-4530(02)00003-3","journal-title":"Psychoneuroendocrinology"},{"key":"2859_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00586-022-07452-z","volume":"32","author":"S Batin","year":"2023","unstructured":"Batin S, Ekinci Y, Gurbuz K, Payas A, Kurtoglu E, Ucar I, Seber T, Arik M, Yilmaz H, Unur E (2023) The role of pineal gland volume in the development of scoliosis. European spine journal: official publication of the European spine society, the European spinal deformity society, and the European section of the cervical. Spine Res Soc 32:181\u2013189. https:\/\/doi.org\/10.1007\/s00586-022-07452-z","journal-title":"Spine Res Soc"},{"issue":"1","key":"2859_CR6","doi-asserted-by":"publisher","first-page":"17746","DOI":"10.1038\/s41598-017-18016-3","volume":"7","author":"M Benabou","year":"2017","unstructured":"Benabou M, Rolland T, Leblond CS, Millot GA, Huguet G, Delorme R, Leboyer M, Pagan C, Callebert J, Maronde E, Bourgeron T (2017) Heritability of the melatonin synthesis variability in autism spectrum disorders. Sci Rep 7:17746. https:\/\/doi.org\/10.1038\/s41598-017-18016-3","journal-title":"Sci Rep"},{"key":"2859_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003055","volume":"3","author":"HJ Burgess","year":"2008","unstructured":"Burgess HJ, Fogg LF (2008) Individual differences in the amount and timing of salivary melatonin secretion. PLoS One 3:e3055. https:\/\/doi.org\/10.1371\/journal.pone.0003055","journal-title":"PLoS One"},{"key":"2859_CR8","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1101\/gad.17446611","volume":"25","author":"MN Cabili","year":"2011","unstructured":"Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, Rinn JL (2011) Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev 25:1915\u20131927. https:\/\/doi.org\/10.1101\/gad.17446611","journal-title":"Genes Dev"},{"key":"2859_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12961","volume":"76","author":"E Challet","year":"2024","unstructured":"Challet E, Pevet P (2024) Melatonin in energy control: circadian time-giver and homeostatic monitor. J Pineal Res 76:e12961. https:\/\/doi.org\/10.1111\/jpi.12961","journal-title":"J Pineal Res"},{"key":"2859_CR10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1126\/science.adj0217","volume":"381","author":"H Davis","year":"2023","unstructured":"Davis H, Attwell D (2023) Heart failure causes sleepless nights. Sci (New York) 381:270\u2013271. https:\/\/doi.org\/10.1126\/science.adj0217","journal-title":"Sci (New York)"},{"key":"2859_CR11","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1158\/1541-7786.Mcr-20-1066","volume":"19","author":"SE Degan","year":"2021","unstructured":"Degan SE, Gelman IH (2021) Emerging roles for AKT isoform preference in cancer progression pathways. Mol cancer research: MCR 19:1251\u20131257. https:\/\/doi.org\/10.1158\/1541-7786.Mcr-20-1066","journal-title":"Mol cancer research: MCR"},{"key":"2859_CR12","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3390\/antiox9111088","volume":"9","author":"N Ferlazzo","year":"2020","unstructured":"Ferlazzo N, Andolina G, Cannata A, Costanzo MG, Rizzo V, Curro M, Ientile R, Caccamo D (2020) Is melatonin the cornucopia of the 21st century? Antioxid (Basel) 9:1088. https:\/\/doi.org\/10.3390\/antiox9111088","journal-title":"Antioxid (Basel)"},{"key":"2859_CR13","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1093\/bioinformatics\/bty1032","volume":"35","author":"A Gilly","year":"2019","unstructured":"Gilly A, Southam L, Suveges D, Kuchenbaecker K, Moore R, Melloni GEM, Hatzikotoulas K, Farmaki AE, Ritchie G, Schwartzentruber J, Danecek P, Kilian B, Pollard MO, Ge X, Tsafantakis E, Dedoussis G, Zeggini E (2019) Very low-depth whole-genome sequencing in complex trait association studies. Bioinf (Oxford England) 35:2555\u20132561. https:\/\/doi.org\/10.1093\/bioinformatics\/bty1032","journal-title":"Bioinf (Oxford England)"},{"key":"2859_CR14","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1097\/hjh.0000000000000714","volume":"33","author":"Y Gong","year":"2015","unstructured":"Gong Y, McDonough CW, Beitelshees AL, Rouby NE, Hiltunen TP, O\u2019Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SOF, Curry RW, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens 33:2278\u20132285. https:\/\/doi.org\/10.1097\/hjh.0000000000000714","journal-title":"J Hypertens"},{"key":"2859_CR15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1055\/a-0841-6638","volume":"51","author":"A Hadi","year":"2019","unstructured":"Hadi A, Ghaedi E, Moradi S, Pourmasoumi M, Ghavami A, Kafeshani M (2019) Effects of melatonin supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 51:157\u2013164. https:\/\/doi.org\/10.1055\/a-0841-6638","journal-title":"Horm Metab Res"},{"key":"2859_CR16","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.psyneuen.2006.04.004","volume":"31","author":"KT Hallam","year":"2006","unstructured":"Hallam KT, Olver JS, Chambers V, Begg DP, McGrath C, Norman TR (2006) The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. Psychoneuroendocrinology 31:867\u2013875. https:\/\/doi.org\/10.1016\/j.psyneuen.2006.04.004","journal-title":"Psychoneuroendocrinology"},{"key":"2859_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47005-0","volume":"15","author":"AA Hatton","year":"2024","unstructured":"Hatton AA, Cheng FF, Lin T, Shen RJ, Chen J, Zheng Z, Qu J, Lyu F, Harris SE, Cox SR, Jin ZB, Martin NG, Fan D, Montgomery GW, Yang J, Wray NR, Marioni RE, Visscher PM, McRae AF (2024) Genetic control of DNA methylation is largely shared across European and East Asian populations. Nat Commun 15:2713. https:\/\/doi.org\/10.1038\/s41467-024-47005-0","journal-title":"Nat Commun"},{"key":"2859_CR18","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41588-019-0487-7","volume":"51","author":"RD Hernandez","year":"2019","unstructured":"Hernandez RD, Uricchio LH, Hartman K, Ye C, Dahl A, Zaitlen N (2019) Ultrarare variants drive substantial cis heritability of human gene expression. Nat Genet 51:1349\u20131355. https:\/\/doi.org\/10.1038\/s41588-019-0487-7","journal-title":"Nat Genet"},{"key":"2859_CR19","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s00125-022-05747-w","volume":"65","author":"X Huang","year":"2022","unstructured":"Huang X, Qiu Y, Gao Y, Zhou R, Hu Q, He Z, Lv Y, Wang X, Chen W, Deng Y, An Z, Zhang H, Mo Z, Lin R (2022) Gut microbiota mediate melatonin signalling in association with type 2 diabetes. Diabetologia 65:1627\u20131641. https:\/\/doi.org\/10.1007\/s00125-022-05747-w","journal-title":"Diabetologia"},{"key":"2859_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1158\/1055-9965.EPI-23-0860","volume":"33","author":"MC-P Ilkania","year":"2024","unstructured":"Ilkania MC-P, Jane BV, Iona C, Eva SS, Zhike L, Christopher AH, Lo\u00efc LM, Unnur V, Lynne RW, Sarah CM, Lorelei AM (2024) Adiposity, weight change, and urinary melatonin levels among men in the multiethnic cohort. Cancer Epidemiol Biomarkers Prev 33:136\u2013142. https:\/\/doi.org\/10.1158\/1055-9965.EPI-23-0860","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2859_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nrc3418","volume":"13","author":"MM Jacqueline","year":"2013","unstructured":"Jacqueline MM, Krystal L, Soumya J, David JC (2013) LIM-domain-only proteins in cancer. Nat Rev Cancer 13:111\u2013122. https:\/\/doi.org\/10.1038\/nrc3418","journal-title":"Nat Rev Cancer"},{"key":"2859_CR22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/HJH.0b013e3283340c16","volume":"28","author":"PF John","year":"2010","unstructured":"John PF, Gary CC, Eva SS (2010) Urinary melatonin and risk of incident hypertension among young women. J Hypertens 28:446\u2013451. https:\/\/doi.org\/10.1097\/HJH.0b013e3283340c16","journal-title":"J Hypertens"},{"key":"2859_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13073-019-0682-2","volume":"11","author":"RH Julian","year":"2019","unstructured":"Julian RH, Cynthia LN, Gilad M, Alicia YZ, Sekar K, Amit VK (2019) Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores. Genome Med 11:74. https:\/\/doi.org\/10.1186\/s13073-019-0682-2","journal-title":"Genome Med"},{"key":"2859_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24266","volume":"10","author":"WW Kamfar","year":"2024","unstructured":"Kamfar WW, Khraiwesh HM, Ibrahim MO, Qadhi AH, Azhar WF, Ghafouri KJ, Alhussain MH, Aldairi AF, AlShahrani AM, Alghannam AF, Abdulal RH, Al-Slaihat AH, Qutob MS, Elrggal ME, Ghaith MM, Azzeh FS (2024) Comprehensive review of melatonin as a promising nutritional and nutraceutical supplement. Heliyon 10:e24266. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24266","journal-title":"Heliyon"},{"key":"2859_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2022.100168","volume":"2","author":"KJ Karczewski","year":"2022","unstructured":"Karczewski KJ, Solomonson M, Chao KR, Goodrich JK, Tiao G, Lu W, Riley-Gillis BM, Tsai EA, Kim HI, Zheng X, Rahimov F, Esmaeeli S, Grundstad AJ, Reppell M, Waring J, Jacob H, Sexton D, Bronson PG, Chen X, Hu X, Goldstein JI, King D, Vittal C, Poterba T, Palmer DS, Churchhouse C, Howrigan DP, Zhou W, Watts NA, Nguyen K, Nguyen H, Mason C, Farnham C, Tolonen C, Gauthier LD, Gupta N, MacArthur DG, Rehm HL, Seed C, Philippakis AA, Daly MJ, Davis JW, Runz H, Miller MR, Neale BM (2022) Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes. Cell Genom 2:100168. https:\/\/doi.org\/10.1016\/j.xgen.2022.100168","journal-title":"Cell Genom"},{"key":"2859_CR26","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R (2009) The Sequence Alignment\/Map format and SAMtools. Bioinformatics 25:2078\u20132079. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352","journal-title":"Bioinformatics"},{"key":"2859_CR27","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/s41588-020-0676-4","volume":"52","author":"X Li","year":"2020","unstructured":"Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O\u2019Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X (2020) Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet 52:969\u2013983. https:\/\/doi.org\/10.1038\/s41588-020-0676-4","journal-title":"Nat Genet"},{"key":"2859_CR28","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41592-022-01640-x","volume":"19","author":"Z Li","year":"2022","unstructured":"Li Z, Li X, Zhou H, Gaynor SM, Selvaraj MS, Arapoglou T, Quick C, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Auer PL, Bielak LF, Bis JC, Blackwell TW, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Conomos MP, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Franceschini N, Freedman BI, G\u00f6ring HHH, Guo X, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Lin BM, Manichaikul A, Manning AK, Martin LW, Mathias RA, Meigs JB, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O\u2019Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Smith JA, Taylor KD, Taub MA, Vasan RS, Weeks DE, Wilson JG, Yanek LR, Zhao W, Rotter JI, Willer CJ, Natarajan P, Peloso GM, Lin X (2022) A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nat Methods 19:1599\u20131611. https:\/\/doi.org\/10.1038\/s41592-022-01640-x","journal-title":"Nat Methods"},{"key":"2859_CR29","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/s2213-8587(24)00096-2","volume":"12","author":"Y Li","year":"2024","unstructured":"Li Y, Huang T, Redline S, Willett WC, Manson JE, Schernhammer ES, Hu FB (2024) Use of melatonin supplements and risk of type 2 diabetes and cardiovascular diseases in the USA: insights from three prospective cohort studies. Lancet Diabetes Endocrinol 12:404\u2013413. https:\/\/doi.org\/10.1016\/s2213-8587(24)00096-2","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2859_CR30","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1093\/ajh\/hpaa164","volume":"34","author":"M Liu","year":"2021","unstructured":"Liu M, Song X, Wang B, Li Y, Li A, Zhang J, Zhang H, Xiu R (2021) Pancreatic microcirculation profiles in the progression of hypertension in spontaneously hypertensive rats. Am J Hypertens 34:100\u2013109. https:\/\/doi.org\/10.1093\/ajh\/hpaa164","journal-title":"Am J Hypertens"},{"issue":"1","key":"2859_CR31","doi-asserted-by":"publisher","first-page":"8025","DOI":"10.1038\/s41598-022-12084-w","volume":"12","author":"PH Liu","year":"2022","unstructured":"Liu PH, Chuang GT, Hsiung CN, Yang WS, Ku HC, Lin YC, Chen YS, Huang YY, Lin CH, Li WY, Lin JW, Hsu CN, Hwang JJ, Liao KC, Hsieh ML, Lee HL, Shen CY, Chang YC (2022) A genome-wide association study for melatonin secretion. Sci Rep 12:8025. https:\/\/doi.org\/10.1038\/s41598-022-12084-w","journal-title":"Sci Rep"},{"key":"2859_CR32","doi-asserted-by":"publisher","first-page":"5966","DOI":"10.1111\/mec.16077","volume":"30","author":"RN Lou","year":"2021","unstructured":"Lou RN, Jacobs A, Wilder AP, Therkildsen NO (2021) A beginner\u2019s guide to low-coverage whole genome sequencing for population genomics. Mol Ecol 30:5966\u20135993. https:\/\/doi.org\/10.1111\/mec.16077","journal-title":"Mol Ecol"},{"key":"2859_CR33","doi-asserted-by":"publisher","first-page":"e34604","DOI":"10.1016\/j.heliyon.2024.e34604","volume":"10","author":"V Mahdi","year":"2024","unstructured":"Mahdi V, Seyedehelham M, Nooshin N, Fatemeh PFT, Mahsa K, Mahdieh A-F, Beitullah A (2024) Effect of melatonin supplementation on body composition and blood pressure in adults: a systematic review and dose-response meta-analysis of randomized controlled trial. Heliyon 10:e34604. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e34604","journal-title":"Heliyon"},{"key":"2859_CR34","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","volume":"26","author":"A Manichaikul","year":"2010","unstructured":"Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM (2010) Robust relationship inference in genome-wide association studies. Bioinformatics 26:2867\u20132873. https:\/\/doi.org\/10.1093\/bioinformatics\/btq559","journal-title":"Bioinformatics"},{"key":"2859_CR35","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","volume":"461","author":"TA Manolio","year":"2009","unstructured":"Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM (2009) Finding the missing heritability of complex diseases. Nature 461:747\u2013753. https:\/\/doi.org\/10.1038\/nature08494","journal-title":"Nature"},{"key":"2859_CR36","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.ajhg.2021.03.012","volume":"108","author":"AR Martin","year":"2021","unstructured":"Martin AR, Atkinson EG, Chapman SB, Stevenson A, Stroud RE, Abebe T, Akena D, Alemayehu M, Ashaba FK, Atwoli L, Bowers T, Chibnik LB, Daly MJ, DeSmet T, Dodge S, Fekadu A, Ferriera S, Gelaye B, Gichuru S, Injera WE, James R, Kariuki SM, Kigen G, Koenen KC, Kwobah E, Kyebuzibwa J, Majara L, Musinguzi H, Mwema RM, Neale BM, Newman CP, Newton C, Pickrell JK, Ramesar R, Shiferaw W, Stein DJ, Teferra S, van der Merwe C, Zingela Z (2021) Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations. Am J Hum Genet 108:656\u2013668. https:\/\/doi.org\/10.1016\/j.ajhg.2021.03.012","journal-title":"Am J Hum Genet"},{"key":"2859_CR37","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M, DePristo MA (2010) The genome analysis toolkit: a mapreduce framework for analyzing next-generation DNA sequencing data. Genome Res 20:1297\u20131303. https:\/\/doi.org\/10.1101\/gr.107524.110","journal-title":"Genome Res"},{"key":"2859_CR38","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1001\/jama.2013.2710","volume":"309","author":"CJ McMullan","year":"2013","unstructured":"McMullan CJ, Schernhammer ES, Rimm EB, Hu FB, Forman JP (2013) Melatonin secretion and the incidence of type 2 diabetes. Jama-J Am Med Assoc 309:1388\u20131396. https:\/\/doi.org\/10.1001\/jama.2013.2710","journal-title":"Jama-J Am Med Assoc"},{"key":"2859_CR39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s11920-022-01369-6","volume":"24","author":"E Moon","year":"2022","unstructured":"Moon E, Kim K, Partonen T, Linnaranta O (2022) Role of melatonin in the management of sleep and circadian disorders in the context of psychiatric illness. Curr psychiatry Rep 24:623\u2013634. https:\/\/doi.org\/10.1007\/s11920-022-01369-6","journal-title":"Curr psychiatry Rep"},{"key":"2859_CR40","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12935-023-03176-2","volume":"23","author":"LT Na","year":"2023","unstructured":"Na LT, Hyerim K, Cheol-Hee S, Eun K, Seung J, Oh (2023) Artificial intelligence-driven new drug discovery targeting serinethreonine kinase 33 for cancer treatment. Cancer Cell Int 23:321. https:\/\/doi.org\/10.1186\/s12935-023-03176-2","journal-title":"Cancer Cell Int"},{"key":"2859_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/biom15050682","author":"C Ortiz-Placin","year":"2025","unstructured":"Ortiz-Placin C, Salido GM, Gonzalez A (2025) Melatonin interplay in physiology and disease-the fountain of eternal youth revisited. Biomolecules. https:\/\/doi.org\/10.3390\/biom15050682","journal-title":"Biomolecules"},{"key":"2859_CR42","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1365-2265.2007.03079.x","volume":"68","author":"V Panicker","year":"2008","unstructured":"Panicker V, Wilson SG, Spector TD, Brown SJ, Falchi M, Richards JB, Surdulescu GL, Lim EM, Fletcher SJ, Walsh JP (2008) Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort. Clin Endocrinol (Oxf) 68:652\u2013659. https:\/\/doi.org\/10.1111\/j.1365-2265.2007.03079.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2859_CR43","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/ng.610","volume":"42","author":"JH Park","year":"2010","unstructured":"Park JH, Wacholder S, Gail MH, Peters U, Jacobs KB, Chanock SJ, Chatterjee N (2010) Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet 42:570\u2013575. https:\/\/doi.org\/10.1038\/ng.610","journal-title":"Nat Genet"},{"key":"2859_CR44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41588-020-00756-0","volume":"53","author":"S Rubinacci","year":"2021","unstructured":"Rubinacci S, Ribeiro DM, Hofmeister RJ, Delaneau O (2021) Efficient phasing and imputation of low-coverage sequencing data using large reference panels. Nat Genet 53:120\u2013126. https:\/\/doi.org\/10.1038\/s41588-020-00756-0","journal-title":"Nat Genet"},{"key":"2859_CR45","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41588-023-01438-3","volume":"55","author":"S Rubinacci","year":"2023","unstructured":"Rubinacci S, Hofmeister RJ, Sousa da Mota B, Delaneau O (2023) Imputation of low-coverage sequencing data from 150,119 UK Biobank genomes. Nat Genet 55:1088\u20131090. https:\/\/doi.org\/10.1038\/s41588-023-01438-3","journal-title":"Nat Genet"},{"key":"2859_CR46","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3109\/00207459408985994","volume":"76","author":"R Sandyk","year":"1994","unstructured":"Sandyk R, Awerbuch GI (1994) The relationship between melatonin secretion and serum cholesterol in patients with multiple sclerosis. Int J Neurosci 76:81\u201386. https:\/\/doi.org\/10.3109\/00207459408985994","journal-title":"Int J Neurosci"},{"key":"2859_CR47","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.33549\/physiolres.934448","volume":"69","author":"X Song","year":"2020","unstructured":"Song X, Li Y, Wang B, Liu M, Zhang J, Li A, Zhang H, Xiu R (2020) Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis. Physiol Res 69:1039\u20131049. https:\/\/doi.org\/10.33549\/physiolres.934448","journal-title":"Physiol Res"},{"key":"2859_CR48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41586-022-04394-w","volume":"603","author":"BB Sun","year":"2022","unstructured":"Sun BB, Kurki MI, Foley CN, Mechakra A, Chen CY, Marshall E, Wilk JB, Chahine M, Chevalier P, Christ\u00e9 G, Palotie A, Daly MJ, Runz H (2022) Genetic associations of protein-coding variants in human disease. Nature 603:95\u2013102. https:\/\/doi.org\/10.1038\/s41586-022-04394-w","journal-title":"Nature"},{"key":"2859_CR49","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12014-024-09489-2","volume":"21","author":"SE Sung","year":"2024","unstructured":"Sung SE, Lim JH, Kang KK, Choi JH, Lee S, Sung M, Park WT, Kim YI, Seo MS, Lee GW (2024) Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis. Clin Proteomics 21:39. https:\/\/doi.org\/10.1186\/s12014-024-09489-2","journal-title":"Clin Proteomics"},{"key":"2859_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007784","volume":"17","author":"H Susak","year":"2021","unstructured":"Susak H, Serra-Saurina L, Demidov G, Rabionet R, Dom\u00e8nech L, Bosio M, Muyas F, Estivill X, Escaram\u00eds G, Ossowski S (2021) Efficient and flexible integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation. PLoS Comput Biol 17:e1007784. https:\/\/doi.org\/10.1371\/journal.pcbi.1007784","journal-title":"PLoS Comput Biol"},{"key":"2859_CR51","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41586-021-03205-y","volume":"590","author":"D Taliun","year":"2021","unstructured":"Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, K\u00f6ttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O\u2019Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Z\u00f6llner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Abecasis TD (2021) Sequencing of 53,831 diverse genomes from the NHLBI TOPMed program. Nature 590:290\u2013299. https:\/\/doi.org\/10.1038\/s41586-021-03205-y","journal-title":"Nature"},{"key":"2859_CR52","doi-asserted-by":"publisher","first-page":"1386295","DOI":"10.3389\/fnana.2024.1386295","volume":"18","author":"M Vukovic","year":"2024","unstructured":"Vukovic M, Nosek I, Boban J, Kozic D (2024) Pineal gland volume loss in females with multiple sclerosis. Front Neuroanat 18:1386295. https:\/\/doi.org\/10.3389\/fnana.2024.1386295","journal-title":"Front Neuroanat"},{"key":"2859_CR53","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41588-021-00997-7","volume":"54","author":"P Wainschtein","year":"2022","unstructured":"Wainschtein P, Jain D, Zheng Z, Cupples LA, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, Liu CT, Albert CM, Roden D, Chasman DI, Darbar D, Lloyd-Jones DM, Arnett DK, Regan EA, Boerwinkle E, Rotter JI, O\u2019Connell JR, Yanek LR, de Andrade M, Allison MA, McDonald MN, Chung MK, Fornage M, Chami N, Smith NL, Ellinor PT, Vasan RS, Mathias RA, Loos RJF, Rich SS, Lubitz SA, Heckbert SR, Redline S, Guo X, Chen YI, Laurie CA, Hernandez RD, McGarvey ST, Goddard ME, Laurie CC, North KE, Lange LA, Weir BS, Yengo L, Yang J, Visscher PM (2022) Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet 54:263\u2013273. https:\/\/doi.org\/10.1038\/s41588-021-00997-7","journal-title":"Nat Genet"},{"key":"2859_CR54","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-021-03855-y","volume":"597","author":"Q Wang","year":"2021","unstructured":"Wang Q, Dhindsa RS, Carss K, Harper AR, Nag A, Tachmazidou I, Vitsios D, Deevi SVV, Mackay A, Muthas D, H\u00fchn M, Monkley S, Olsson H, Wasilewski S, Smith KR, March R, Platt A, Haefliger C, Petrovski S (2021) Rare variant contribution to human disease in 281,104 UK Biobank exomes. Nature 597:527\u2013532. https:\/\/doi.org\/10.1038\/s41586-021-03855-y","journal-title":"Nature"},{"key":"2859_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1494802","volume":"15","author":"H Wang","year":"2024","unstructured":"Wang H, Tang R, Jiang L, Jia Y (2024) The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies. Front Pharmacol 15:1494802. https:\/\/doi.org\/10.3389\/fphar.2024.1494802","journal-title":"Front Pharmacol"},{"key":"2859_CR56","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1093\/cvr\/cvab269","volume":"118","author":"X Wei","year":"2022","unstructured":"Wei X, Zou S, Xie Z, Wang Z, Huang N, Cen Z, Hao Y, Zhang C, Chen Z, Zhao F, Hu Z, Teng X, Gui Y, Liu X, Zheng H, Zhou H, Chen S, Cheng J, Zeng F, Zhou Y, Wu W, Hu J, Wei Y, Cui K, Li J (2022) EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization. Cardiovascular Res 118:2179\u20132195. https:\/\/doi.org\/10.1093\/cvr\/cvab269","journal-title":"Cardiovascular Res"},{"key":"2859_CR57","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/s41467-018-03371-0","volume":"9","author":"Y Wu","year":"2018","unstructured":"Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z, Lloyd-Jones LR, Marioni RE, Martin NG, Montgomery GW, Deary IJ, Wray NR, Visscher PM, McRae AF, Yang J (2018) Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nat Commun 9:918. https:\/\/doi.org\/10.1038\/s41467-018-03371-0","journal-title":"Nat Commun"},{"key":"2859_CR58","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1097\/hjh.0000000000003220","volume":"40","author":"J Xu","year":"2022","unstructured":"Xu J, Zhong Y, Yin H, Linneman J, Luo Y, Xia S, Xia Q, Yang L, Huang X, Kang K, Wang J, Niu Y, Li L, Gou D (2022) Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB\/PLCgamma1 axis. J Hypertens 40:1795\u20131807. https:\/\/doi.org\/10.1097\/hjh.0000000000003220","journal-title":"J Hypertens"},{"key":"2859_CR59","doi-asserted-by":"publisher","DOI":"10.1101\/2025.03.10.25323654","author":"P Xu","year":"2025","unstructured":"Xu P, Imtiaz MA, Rusman D, Estrada S, Reuter M, Breteler MMB, Aziz NA (2025) Genome-wide association study of human pineal gland volume as proxy for melatonin secretion. medRxiv\u00a0Reprint Serv Health Sci. https:\/\/doi.org\/10.1101\/2025.03.10.25323654","journal-title":"medRxiv\u00a0Reprint Serv Health Sci"},{"key":"2859_CR60","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","volume":"21","author":"I Yanai","year":"2005","unstructured":"Yanai I, Benjamin H, Shmoish M, Chalifa-Caspi V, Shklar M, Ophir R, Bar-Even A, Horn-Saban S, Safran M, Domany E, Lancet D, Shmueli O (2005) Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 21:650\u2013659. https:\/\/doi.org\/10.1093\/bioinformatics\/bti042","journal-title":"Bioinformatics"},{"key":"2859_CR61","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/ng.608","volume":"42","author":"J Yang","year":"2010","unstructured":"Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42:565\u2013569. https:\/\/doi.org\/10.1038\/ng.608","journal-title":"Nat Genet"},{"key":"2859_CR62","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1080\/15548627.2024.2367191","volume":"20","author":"Z Yin","year":"2024","unstructured":"Yin Z, Zhang J, Zhao M, Liu J, Xu Y, Peng S, Pan W, Wei C, Zheng Z, Liu S, Qin JJ, Wan J, Wang M (2024) EDIL3\/Del-1 prevents aortic dissection through enhancing internalization and degradation of apoptotic vascular smooth muscle cells. Autophagy 20:2405\u20132425. https:\/\/doi.org\/10.1080\/15548627.2024.2367191","journal-title":"Autophagy"},{"key":"2859_CR63","first-page":"83","volume":"15","author":"BF Zhou","year":"2002","unstructured":"Zhou BF (2002) Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2013study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci: BES 15:83\u201396","journal-title":"Biomed Environ Sci: BES"},{"key":"2859_CR64","doi-asserted-by":"publisher","first-page":"D1300","DOI":"10.1093\/nar\/gkac966","volume":"51","author":"H Zhou","year":"2023","unstructured":"Zhou H, Arapoglou T, Li X, Li Z, Zheng X, Moore J, Asok A, Kumar S, Blue EE, Buyske S, Cox N, Felsenfeld A, Gerstein M, Kenny E, Li B, Matise T, Philippakis A, Rehm HL, Sofia HJ, Snyder G, Weng Z, Neale B, Sunyaev SR, Lin X (2023) FAVOR: functional annotation of variants online resource and annotator for variation across the human genome. Nucleic Acids Res 51:D1300\u2013d1311. https:\/\/doi.org\/10.1093\/nar\/gkac966","journal-title":"Nucleic Acids Res"},{"key":"2859_CR65","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW, Goddard ME, Wray NR, Visscher PM, Yang J (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48:481\u2013487. https:\/\/doi.org\/10.1038\/ng.3538","journal-title":"Nat Genet"}],"container-title":["Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-026-02859-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00439-026-02859-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00439-026-02859-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:36:18Z","timestamp":1786091778000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00439-026-02859-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["2859"],"URL":"https:\/\/doi.org\/10.1007\/s00439-026-02859-w","relation":{},"ISSN":["0340-6717","1432-1203"],"issn-type":[{"value":"0340-6717","type":"print"},{"value":"1432-1203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"66"}}