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Genet."],"published-print":{"date-parts":[[2026,12]]},"abstract":"Abstract<\/jats:title>\n \n While genetic heritability plays a major role in the development of cognitive impairment, most genetic risk factors are identified from studies of European populations. We conducted a genome-wide association study (GWAS) on cognitive impairment in the Chinese population by sequencing 1,040 matched case-control individuals from a longitudinal cohort of Zhejiang Province, China. We detected 19 SNPs clustered in 15 genomic loci reaching suggestive significance (\n P<\/jats:italic>\n \u2009<\u20091\u2009\u00d7\u200910\n \u2212\u20095<\/jats:sup>\n ). Eleven of these genomic loci are newly associated with Alzheimer\u2019s disease (AD) or cognitive impairment, among which five (\n GRP39<\/jats:italic>\n ,\n FAT1<\/jats:italic>\n ,\n EDIL3<\/jats:italic>\n ,\n ZNF596<\/jats:italic>\n , and\n PDGFD<\/jats:italic>\n ) show nominal evidence of replication in both external GWAS of AD in East-Asian populations and summary statistics of AD in diverse populations. The detected loci are implicated in micronutrient homeostasis including zinc (\n GPR39<\/jats:italic>\n ), iron (\n STEAP1<\/jats:italic>\n ), potassium (\n KCNJ6<\/jats:italic>\n ), and vitamin\n K<\/jats:italic>\n (\n VKORC1L1<\/jats:italic>\n ), cell connections (\n EVPLL<\/jats:italic>\n ) through cadherin regulations (\n PCDH18<\/jats:italic>\n ,\n FAT1<\/jats:italic>\n ), regulating amyloid-beta precursor protein (APP) (\n EDIL3<\/jats:italic>\n ), formation of amyloid-\u03b2 (\n EDEM1<\/jats:italic>\n ) and neurofibrillary tangles (\n PDGFD<\/jats:italic>\n ,\n ZNF596<\/jats:italic>\n ), neuronal growth (\n NEGR1<\/jats:italic>\n ), and phosphatase regulations (\n SETBP1<\/jats:italic>\n ,\n TPTE<\/jats:italic>\n ). This study presents a robust GWAS for cognitive impairment in the Chinese population and highlights a promising set of therapeutic targets for neurodegenerative disorder.\n <\/jats:p>","DOI":"10.1007\/s00439-026-02887-6","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:42:40Z","timestamp":1792215760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals"],"prefix":"10.1007","volume":"145","author":[{"given":"Maggie Haitian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Ka Chun","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ka Kei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny Chung-Ying","family":"Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"2887_CR1","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1007\/s00018-015-1955-6","volume":"72","author":"AF Ahmed","year":"2015","unstructured":"Ahmed AF, de Bock CE, Lincz LF, Pundavela J, Zouikr I, Sontag E, Hondermarck H, Thorne RF (2015) FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation. 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