{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:12:06Z","timestamp":1790431926115,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2003,2,25]],"date-time":"2003-02-25T00:00:00Z","timestamp":1046131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1007\/s00441-002-0657-1","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T03:23:38Z","timestamp":1576121018000},"page":"299-313","source":"Crossref","is-referenced-by-count":65,"title":["Enteric motor neurons form synaptic-like junctions with interstitial cells of Cajal in the canine gastric antrum"],"prefix":"10.1007","volume":"311","author":[{"given":"Kazuhide","family":"Horiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,2,25]]},"reference":[{"key":"0657_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1113\/jphysiol.2002.021915","volume":"543","author":"Beckett","year":"1992","unstructured":"Beckett EAH, Horiguchi K, Khoyi M, Sanders KM, Ward SM (1992) Loss of enteric motor neurotransmission in the gastric fundus of Sl\/Sl d mice. J Physiol 543:871--887","journal-title":"J Physiol"},{"key":"0657_CR2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1139\/y90-141","volume":"68","author":"Berezin","year":"1990","unstructured":"Berezin I, Huizinga JD, Daniell EE (1990) Innervation of interstitial cells of Cajal by vasoactive intestinal polypeptide containing nerves in canine colon. Can J Physiol Pharmacol 68:922\u2013932","journal-title":"Can J Physiol Pharmacol"},{"key":"0657_CR3","doi-asserted-by":"crossref","first-page":"12008","DOI":"10.1073\/pnas.93.21.12008","volume":"93","author":"Burns","year":"1996","unstructured":"Burns AJ, Lomax AEJ, Torihashi S, Sanders KM, Ward SM (1996) Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci U S A 93:12008\u201312013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"0657_CR4","first-page":"G305","volume":"246","author":"Daniel","year":"1984","unstructured":"Daniel EE, Posey-Daniel V (1984) Neuromuscular structures in opossum esophagus: role of interstitial cells of Cajal. Am J Physiol 246:G305--G315","journal-title":"Am J Physiol"},{"key":"0657_CR5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1139\/y84-219","volume":"62","author":"Daniel","year":"1984","unstructured":"Daniel EE, Sakai Y, Fox JE, Posey-Daniel V (1984) Structural basis for function of circular muscle of canine corpus. Can J Physiol Pharmacol 62:1304\u20131314","journal-title":"Can J Physiol Pharmacol"},{"key":"0657_CR6","doi-asserted-by":"crossref","first-page":"C529","DOI":"10.1152\/ajpcell.2000.279.2.C529","volume":"279","author":"Epperson","year":"2000","unstructured":"Epperson A, Hatton WJ, Callaghan B, Doherty P, Walker RL, Sanders KM, Ward SM, Horowitz B (2000) Molecular markers expressed in cultured and freshly isolated interstitial cells of Cajal. Am J Physiol 279:C529\u2013C539","journal-title":"Am J Physiol"},{"key":"0657_CR7","first-page":"157","volume":"82","author":"Faussone-Pellegrini","year":"1977","unstructured":"Faussone-Pellegrini MS, Cortesini C, Romagnoli P (1977) Sull'ultrastruttura della tunica muscolare della prozione cardiale dell'esofago e dello stomaco umano con particolare riferimento alle cosiddette cellule inerstiziali di Cajal. Arch Ital Anat Embriol 82:157\u2013177","journal-title":"Arch Ital Anat Embriol"},{"key":"0657_CR8","first-page":"439","volume":"21","author":"Faussone-Pellegrini","year":"1989","unstructured":"Faussone-Pellegrini MS, Pantalone D, Cortesini C (1989) An ultrastructural study of the interstitial cells of Cajal of the human stomach. J Submicrosc Cytol Pathol 21:439\u2013460","journal-title":"J Submicrosc Cytol Pathol"},{"key":"0657_CR9","first-page":"11","volume":"Embryol","author":"Fox","year":"2001","unstructured":"Fox EA, Phillips RJ, Martinson FA, Baronowsky EA, Powley TL (2001) C-Kit mutant mice have a selective loss of vagal intramuscular mechanoreceptors in the forestomach. Anat Embryol (Berl) 204:11\u201326","journal-title":"Anat"},{"key":"0657_CR10","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1523\/JNEUROSCI.16-21-06975.1996","volume":"16","author":"Grady","year":"1996","unstructured":"Grady EF, Baluk P, Bohm S, Gamp PD, Wong H, Payan DG, Ansel J, Portbury AL, Furness JB, McDonald DM, Bunnett NW (1996) Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J Neurosci 16:6975\u20136986","journal-title":"J Neurosci"},{"key":"0657_CR11","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1113\/jphysiol.2002.018614","volume":"541","author":"Hirst","year":"2002","unstructured":"Hirst GDS, Dickens EJ, Edwards FR (2002) Pacemaker shift in the gastric antrum of guinea-pigs produced by excitatory vagal stimulation involves intramuscular interstitial cells. J Physiol 541:917\u2013928","journal-title":"J Physiol"},{"key":"0657_CR12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1469-7793.2001.0237k.x","volume":"537","author":"Horiguchi","year":"2001","unstructured":"Horiguchi K, Semple GS, Sanders KM, Ward SM (2001) Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum. J Physiol 537:237\u2013250","journal-title":"J Physiol"},{"key":"0657_CR13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00968841","volume":"97","author":"Imaizumi","year":"1969","unstructured":"Imaizumi M, Hama K (1969) An electronmicroscopic study on the interstitial cells of the gizzard in the love bird ( Uronloncha domestica). Z Zellforsch Mikrosk Anat 97:351\u2013357","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"0657_CR14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1113\/jphysiol.2002.018796","volume":"541","author":"YC Kim","year":"2002","unstructured":"Kim YC, Koh SD, Sanders KM (2002) Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine. J Physiol 541:797\u2013810","journal-title":"J Physiol"},{"key":"0657_CR15","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1113\/jphysiol.2001.014639","volume":"540","author":"Koh","year":"2002","unstructured":"Koh SD, Jun JY, Kim TW, Sanders KM (2002) A Ca(2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal. J Physiol 540:803\u2013814","journal-title":"J Physiol"},{"key":"0657_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s004180050288","volume":"110","author":"Lavin","year":"1998","unstructured":"Lavin ST, Southwell BR, Murphy R, Jenkinson KM, Furness JB (1998) Activation of neurokinin 1 receptors on interstitial cells of Cajal of the guinea-pig small intestine by substance P. Histochem Cell Biol 110:263\u2013271","journal-title":"Histochem Cell Biol"},{"key":"0657_CR17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1113\/jphysiol.1993.sp019463","volume":"460","author":"Lee","year":"1993","unstructured":"Lee HK, Sanders KM (1993) Comparison of ionic currents from interstitial cells and smooth muscle cells of canine colon. J Physiol 460:135\u2013152","journal-title":"J Physiol"},{"key":"0657_CR18","first-page":"G911","volume":"265","author":"Li","year":"1993","unstructured":"Li Z, Zhou Z, Daniel EE (1993) Expression of gap junction connexin 43 and connexin 43 mRNA in different regional tissues of intestine in dog. Am J Physiol 265:G911--G916","journal-title":"Am J Physiol"},{"key":"0657_CR19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s004410100402","volume":"305","author":"Patterson","year":"2001","unstructured":"Patterson LM, Zheng H, Ward SM, Berthoud HR (2001) Immunohistochemical identification of cholecystokinin A receptors on interstitial cells of Cajal, smooth muscle, and enteric neurons in rat pylorus. Cell Tissue Res 305:11\u201323","journal-title":"Cell Tissue Res"},{"key":"0657_CR20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/(SICI)1096-9861(19960408)367:3<342::AID-CNE2>3.0.CO;2-5","volume":"367","author":"Portbury","year":"1996","unstructured":"Portbury AL, Furness JB, Young HM, Southwell BR, Vigna SR (1996) Localisation of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract. J Comp Neurol 367:342\u2013351","journal-title":"J Comp Neurol"},{"key":"0657_CR21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/aja.1001030105","volume":"103","author":"Richardson","year":"1958","unstructured":"Richardson KC (1958) Electron microscopic observations on Auerbach's plexus in the rabbit, with special reference to the problem of smooth muscle innervation. Am J Anat 103:99\u2013136","journal-title":"Am J Anat"},{"key":"0657_CR22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0016-5085(92)91784-2","volume":"102","author":"Rumessen","year":"1992","unstructured":"Rumessen JJ, Mikkelsen HB, Thuneberg L (1992) Ultrastructure of interstitial cells of Cajal associated with deep muscular plexus of human small intestine. Gastroenterology 102:56\u201368","journal-title":"Gastroenterology"},{"key":"0657_CR23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004410100410","volume":"305","author":"Salmhofer","year":"2001","unstructured":"Salmhofer H, Neuhuber WL, Ruth P, Huber A, Russwurm M, Allescher HD (2001) Pivotal role of the interstitial cells of Cajal in the nitric oxide signaling pathway of rat small intestine. Morphological evidence. Cell Tissue Res 305:331\u2013340","journal-title":"Cell Tissue Res"},{"key":"0657_CR24","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/gast.1996.v111.pm8690216","volume":"111","author":"Sanders","year":"1996","unstructured":"Sanders KM (1996) A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 111:492\u2013515","journal-title":"Gastroenterology"},{"key":"0657_CR25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0016-5085(75)80012-6","volume":"68","author":"Sarna","year":"1975","unstructured":"Sarna SK, Daniel EE (1975) Vagal control of gastric electrical control activity and motility. Gastroenterology 68:301\u2013308","journal-title":"Gastroenterology"},{"key":"0657_CR26","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00441-001-0470-2","volume":"306","author":"Seki","year":"2001","unstructured":"Seki K, Komuro T (2001) Immunocytochemical demonstration of the gap junction proteins connexin 43 and connexin 45 in the musculature of the rat small intestine. Cell Tissue Res 306:417\u2013422","journal-title":"Cell Tissue Res"},{"key":"0657_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S0165-1838(97)00134-3","volume":"68","author":"Seki","year":"1998","unstructured":"Seki K, Zhou DS, Komuro T (1998) Immunohistochemical study of the c-kit expressing cells and connexin 43 in the guinea-pig digestive tract. J Auton Nerv Syst 68:182\u2013187","journal-title":"J Auton Nerv Syst"},{"key":"0657_CR28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0306-4522(93)90350-O","volume":"56","author":"Shuttleworth","year":"1993","unstructured":"Shuttleworth CW, Xue C, Ward SM, de Vente J, Sanders KM (1993) Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: responses to nitric oxide and electrical stimulation of enteric inhibitory neurons. Neuroscience 56:513\u2013522","journal-title":"Neuroscience"},{"key":"0657_CR29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/cne.903580406","volume":"358","author":"Sternini","year":"1995","unstructured":"Sternini C, Su D, Gamp PD, Bunnett NW (1995) Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract. J Comp Neurol 358:531\u2013540","journal-title":"J Comp Neurol"},{"key":"0657_CR30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/(SICI)1096-9861(19970929)386:3<396::AID-CNE5>3.0.CO;2-X","volume":"386","author":"Sternini","year":"1997","unstructured":"Sternini C, Wong H, Wu SV, de Giorgio R, Yang M, Reeve J Jr, Brecha NC, Walsh JH (1997) Somatostatin 2A receptor is expressed by enteric neurons, and by interstitial cells of Cajal and enterochromaffin-like cells of the gastrointestinal tract. J Comp Neurol 386:396\u2013408","journal-title":"J Comp Neurol"},{"key":"0657_CR47","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1113\/jphysiol.2002.033365","volume":"546","author":"Suzuki","year":"2003","unstructured":"Suzuki H, Ward SM, Bayguinov YR, Edwards F, Hirst GDS (2003) Involvement in intramuscular interstitial cells of Cajal in nitrergic inhibition in the mouse gastric antrum. J Physiol 546:751\u2013763","journal-title":"J Physiol"},{"key":"0657_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-68417-3_1","volume":"71","author":"Thuneberg","year":"1982","unstructured":"Thuneberg L (1982) Interstitial cells of Cajal: intestinal pacemaker cells. Adv Anat Embryol Cell Biol 71:1\u2013130","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"0657_CR32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s004410051249","volume":"295","author":"Toma","year":"1999","unstructured":"Toma H, Nakamura K, Kuraoka A, Tanaka M, Kawabuchi M (1999) Three-dimensional structures of c-Kit-positive cellular networks in the guinea pig small intestine and colon. Cell Tissue Res 295:425\u2013436","journal-title":"Cell Tissue Res"},{"key":"0657_CR33","first-page":"G638","volume":"265","author":"Torihashi","year":"1993","unstructured":"Torihashi S, Kobayashi S, Gerthoffer WT, Sanders KM (1993) Interstitial cells in deep muscle muscular plexus of canine small intestine may be specialized smooth muscle cells. Am J Physiol 265:G638\u2013G645","journal-title":"Am J Physiol"},{"key":"0657_CR34","doi-asserted-by":"publisher","first-page":"19191","DOI":"10.1074\/jbc.M201728200","volume":"277","author":"Torihashi","year":"2002","unstructured":"Torihashi S, Fujimoto T, Trost C, Nakayama S (2002) Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localisation of TRP4 in caveolae. J Biol Chem 277:19191\u201319197","journal-title":"J Biol Chem"},{"key":"0657_CR35","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1076\/ejom.37.4.250.4728","volume":"37","author":"Vanderwinden","year":"1999","unstructured":"Vanderwinden JM (1999) Role of interstitial cells of Cajal and their relationship with the enteric nervous system. Eur J Morphol 37:250\u2013256","journal-title":"Eur J Morphol"},{"key":"0657_CR36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1096-9861(19970630)383:2<153::AID-CNE3>3.0.CO;2-#","volume":"383","author":"Vannucchi","year":"1997","unstructured":"Vannucchi MG, de Giorgio R, Faussone-Pellegrini MS (1997) NK1 receptor expression in the interstitial cells of Cajal and neurons and tachykinins distribution in rat ileum during development. J Comp Neurol 383:153\u2013162","journal-title":"J Comp Neurol"},{"key":"0657_CR37","doi-asserted-by":"crossref","first-page":"G533","DOI":"10.1152\/ajpgi.2001.281.2.G533","volume":"281","author":"Wang","year":"2001","unstructured":"Wang YF, Daniel EE (2001) Gap junctions in gastrointestinal muscle contain multiple connexins. Am J Physiol Gastrointest Liver Physiol 281:G533--G543","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"0657_CR38","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s004410051231","volume":"295","author":"Wang","year":"1999","unstructured":"Wang X-Y, Sanders KM, Ward SM (1999) Intimate relationship between interstitial cells of Cajal and enteric nerves in the guinea pig small intestine. Cell Tissue Res 295:247\u2013256","journal-title":"Cell Tissue Res"},{"key":"0657_CR39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004410000272","volume":"302","author":"Wang","year":"2000","unstructured":"Wang XY, Sanders KM, Ward SM (2000) Relationship between interstitial cells of Cajal and enteric motor neurons in the murine proximal colon. Cell Tissue Res 302:331\u2013342","journal-title":"Cell Tissue Res"},{"key":"0657_CR40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/1097-0185(20010101)262:1<125::AID-AR1017>3.0.CO;2-I","volume":"262","author":"Ward","year":"2001","unstructured":"Ward SM, Sanders KM (2001) Interstitial cells of Cajal: primary targets of enteric motor innervation. Anat Rec 262:125\u2013135","journal-title":"Anat Rec"},{"key":"0657_CR41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1994.sp020343","volume":"480","author":"Ward","year":"1994","unstructured":"Ward SM, Burns AJ, Torihashi S, Sanders KM (1994) Mutation of the protooncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 480:91\u201397","journal-title":"J Physiol"},{"key":"0657_CR42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0016-5085(98)70198-2","volume":"115","author":"Ward","year":"1998","unstructured":"Ward SM, Morris G, Reese L, Wang X-Y, Sanders KM (1998) Interstitial cells of Cajal mediate enteric inhibitory neurotransmission in the lower esophageal and pyloric sphincters. Gastroenterology 115:314\u2013329","journal-title":"Gastroenterology"},{"key":"0657_CR43","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1523\/JNEUROSCI.20-04-01393.2000","volume":"20","author":"Ward","year":"2000","unstructured":"Ward SM, Beckett EAH, Wang X-Y, Baker F, Khoyi M, Sanders KM (2000a) Interstitial cells of Cajal mediate enteric excitatory neurotransmission in the murine fundus. J Neurosci 20:1393\u20131403","journal-title":"J Neurosci"},{"key":"0657_CR44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1469-7793.2000.t01-1-00355.x","volume":"525","author":"Ward","year":"2000","unstructured":"Ward SM, Ordog T, Koh SD, Baker SA, Jun JY, Amberg G, Monaghan K, Sanders KM (2000b) Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria. J Physiol 525:355\u2013361","journal-title":"J Physiol"},{"key":"0657_CR45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0306-4522(93)90526-L","volume":"55","author":"Young","year":"1993","unstructured":"Young HM, McConalogue K, Furness JB, de Vente J (1993) Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity. Neuroscience 55:583\u2013596","journal-title":"Neuroscience"},{"key":"0657_CR46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00318788","volume":"268","author":"Zhou","year":"1992","unstructured":"Zhou DS, Komuro T (1992) Interstitial cells associated with the deep muscular plexus of the guinea-pig small intestine, with special reference to the interstitial cells of Cajal. Cell Tissue Res 268:205\u2013216","journal-title":"Cell Tissue Res"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-002-0657-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-002-0657-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-002-0657-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T19:31:03Z","timestamp":1613071863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-002-0657-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,25]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["0657"],"URL":"https:\/\/doi.org\/10.1007\/s00441-002-0657-1","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2,25]]}}}