{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:20:46Z","timestamp":1791166846779,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,11,3]],"date-time":"2004-11-03T00:00:00Z","timestamp":1099440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1007\/s00441-004-1003-6","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T13:45:40Z","timestamp":1099403140000},"page":"61-70","source":"Crossref","is-referenced-by-count":45,"title":["TNF\/LT? double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury"],"prefix":"10.1007","volume":"319","author":[{"given":"Belinda","family":"Knight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,11,3]]},"reference":[{"key":"CR1","first-page":"G579","volume":"263","author":"P Akerman","year":"1992","unstructured":"Akerman P, Cote P, Yang SQ, McClain C, Nelson S, Bagby GJ, Diehl AM (1992) Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 263:G579?G585","journal-title":"Am J Physiol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"9302","DOI":"10.1073\/pnas.94.17.9302","volume":"94","author":"MB Alimzhanov","year":"1997","unstructured":"Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, Rajewsky K, Nedospasov SA, Pfeffer K (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci USA 94:9302?9307","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1098\/rstb.1998.0252","volume":"353","author":"M Alison","year":"1998","unstructured":"Alison M, Golding M, Lalani e-N, Sarraf C (1998) Wound healing in the liver with particular reference to stem cells. Philos Trans R Soc Lond Biol 353:877?894","journal-title":"Philos Trans R Soc Lond Biol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.155.4.1685","volume":"155","author":"TA Banks","year":"1995","unstructured":"Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, Bouley DM, Thomas J, Kanangat S, Mucenski ML (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155:1685?1693","journal-title":"J Immunol"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/carcin\/23.10.1685","volume":"23","author":"EJ Croager","year":"2002","unstructured":"Croager EJ, Smith PG, Yeoh GC (2002) Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver. Carcinogenesis 23:1685?1694","journal-title":"Carcinogenesis"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1126\/science.8171322","volume":"264","author":"P Togni De","year":"1994","unstructured":"De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, Smith SC, Carlson R, Shornick LP, Strauss-Schoenberger J, Russell JH, Karr R, Chaplin DD (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264:703?707","journal-title":"Science"},{"key":"CR7","first-page":"142","volume":"16","author":"E Farber","year":"1956","unstructured":"Farber E (1956) Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylaminofluorene and 3-methyl-4-dimethylaminoazobenzene. Cancer Res 16:142?148","journal-title":"Cancer Res"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0925-4773(02)00338-6","volume":"120","author":"N Fausto","year":"2003","unstructured":"Fausto N, Campbell JS (2003) The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech Dev 120:117?130","journal-title":"Mech Dev"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(00)80588-9","volume":"9","author":"A Futterer","year":"1998","unstructured":"Futterer A, Mink K, Luz A, Kosco-Vilbois MH, Pfeffer K (1998) The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59?70","journal-title":"Immunity"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0167-4889(02)00326-9","volume":"1592","author":"E Galun","year":"2002","unstructured":"Galun E, Axelrod JH (2002) The role of cytokines in liver failure and regeneration: potential new molecular therapies. Biochim Biophys Acta 1592:345?358","journal-title":"Biochim Biophys Acta"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.163.3.1516","volume":"163","author":"H Hayder","year":"1999","unstructured":"Hayder H, Blanden RV, Korner H, Riminton DS, Sedgwick JD, Mullbacher A (1999) Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin. J Immunol 163:1516?1520","journal-title":"J Immunol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1111\/j.1432-2277.1994.tb01342.x","volume":"7","author":"D Kahn","year":"1994","unstructured":"Kahn D, Robson SC, Hickman R (1994) The effect of a tumour necrosis factor antibody on the regenerative response after partial hepatectomy in rats. Transpl Int 7:S181?S182","journal-title":"Transpl Int"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni795","volume":"3","author":"HS Kang","year":"2002","unstructured":"Kang HS, Chin RK, Wang Y, Yu P, Wang J, Newell KA, Fu YX (2002) Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol 3:576?582","journal-title":"Nat Immunol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.192.12.1809","volume":"192","author":"B Knight","year":"2000","unstructured":"Knight B, Yeoh GC, Husk KL, Ly T, Abraham LJ, Yu C, Rhim JA, Fausto N (2000) Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 192:1809?1818","journal-title":"J Exp Med"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1002\/eji.1830271020","volume":"27","author":"H Korner","year":"1997","unstructured":"Korner H, Cook M, Riminton DS, Lemckert FA, Hoek RM, Ledermann B, Kontgen F, Fazekas de St Groth B, Sedgwick JD (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27:2600?2609","journal-title":"Eur J Immunol"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0002-9440(10)65299-6","volume":"154","author":"KN Lowes","year":"1999","unstructured":"Lowes KN, Brennan BA, Yeoh GC, Olynyk JK (1999) Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 154:537?541","journal-title":"Am J Pathol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1440-1746.2003.02906.x","volume":"18","author":"KN Lowes","year":"2003","unstructured":"Lowes KN, Croager EJ, Olynyk JK, Abraham LJ, Yeoh GC (2003) Oval cell-mediated liver regeneration: role of cytokines and growth factors. J Gastroenterol Hepatol 18:4?12","journal-title":"J Gastroenterol Hepatol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.271.5253.1289","volume":"271","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD (1996) Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271:1289?1291","journal-title":"Science"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","volume":"276","author":"GK Michalopoulos","year":"1997","unstructured":"Michalopoulos GK, DeFrances MC (1997) Liver regeneration. Science 276:60?66","journal-title":"Science"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.184.1.259","volume":"184","author":"B Neumann","year":"1996","unstructured":"Neumann B, Luz A, Pfeffer K, Holzmann B (1996) Defective Peyer?s patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J Exp Med 184:259?264","journal-title":"J Exp Med"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","volume":"184","author":"M Pasparakis","year":"1996","unstructured":"Pasparakis M, Alexopoulou L, Episkopou V, Kollias G (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184:1397?1411","journal-title":"J Exp Med"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4049\/jimmunol.160.2.943","volume":"160","author":"JJ Peschon","year":"1998","unstructured":"Peschon JJ, Torrance DS, Stocking KL, Glaccum MB, Otten C, Willis CR, Charrier K, Morrissey PJ, Ware CB, Mohler KM (1998) TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160:943?952","journal-title":"J Immunol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0168-8278(98)80065-2","volume":"29","author":"T Roskams","year":"1998","unstructured":"Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, Desmet V (1998) Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol 29:455?463","journal-title":"J Hepatol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.21900","volume":"33","author":"S Sell","year":"2001","unstructured":"Sell S (2001) Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33:738?750","journal-title":"Hepatology"},{"key":"CR25","first-page":"1092","volume":"38","author":"H Shinozuka","year":"1978","unstructured":"Shinozuka H, Lombardi B, Sell S, Iammarino RM (1978) Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet. Cancer Res 38:1092?1098","journal-title":"Cancer Res"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev.immunol.17.1.331","volume":"17","author":"D Wallach","year":"1999","unstructured":"Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP (1999) Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 17:331?367","journal-title":"Annu Rev Immunol"},{"key":"CR27","first-page":"1577","volume":"152","author":"Y Yamada","year":"1998","unstructured":"Yamada Y, Fausto N (1998) Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 152:1577?1589","journal-title":"Am J Pathol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.94.4.1441","volume":"94","author":"Y Yamada","year":"1997","unstructured":"Yamada Y, Kirillova I, Peschon JJ, Fausto N (1997) Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 94:1441?1446","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/hep.510280410","volume":"28","author":"Y Yamada","year":"1998","unstructured":"Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N (1998) Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology 28:959?970","journal-title":"Hepatology"},{"key":"CR30","first-page":"329","volume":"25","author":"O Yasui","year":"1997","unstructured":"Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T (1997) Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 25:329?334","journal-title":"Hepatology"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-004-1003-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-004-1003-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-004-1003-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T21:29:15Z","timestamp":1682803755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-004-1003-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1007\/s00441-004-1003-6","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,3]]}}}