{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:26:42Z","timestamp":1759962402681},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s00441-005-0149-1","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T17:43:44Z","timestamp":1138383824000},"page":"347-352","source":"Crossref","is-referenced-by-count":12,"title":["Cytomorphological study on human submandibular gland following treatment with secretagogue drugs"],"prefix":"10.1007","volume":"324","author":[{"given":"Francesca","family":"Testa Riva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Puxeddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Loy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"149_CR1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00213-004-2017-1","volume":"178","author":"MA Davies","year":"2005","unstructured":"Davies MA, Compton-Toth BA, Hufeisen SJ, Meltzer HY, Roth BL (2005) The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine\u2019s actions? Psychopharmacology 178:451\u2013460","journal-title":"Psychopharmacology"},{"key":"149_CR2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1345\/aph.19259","volume":"34","author":"L Davydov","year":"2000","unstructured":"Davydov L, Botts SR (2000) Clozapine-induced hypersalivation. Ann Pharmacother 34:662\u2013665","journal-title":"Ann Pharmacother"},{"key":"149_CR3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1177\/00220345870660022301","volume":"66","author":"J Ekstr\u00f6m","year":"1987","unstructured":"Ekstr\u00f6m J (1987) Neuropeptides and secretion. J Dent Res 66:524\u2013530","journal-title":"J Dent Res"},{"key":"149_CR4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/eph8602199","volume":"86","author":"J Ekstr\u00f6m","year":"2001","unstructured":"Ekstr\u00f6m J (2001) Gustatory-salivary reflexes induce non-adrenergic, non-cholinergic acinar degranulation in the rat parotid gland. Exp Physiol 86:475\u2013480","journal-title":"Exp Physiol"},{"key":"149_CR5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1469-445X.2001.tb00038.x","volume":"86","author":"J Ekstr\u00f6m","year":"2001","unstructured":"Ekstr\u00f6m J, Ekstr\u00f6m PF (2001) Acinar degranulation in the rat parotid gland induced by neuropeptides. Exp Physiol 86:733\u2013738","journal-title":"Exp Physiol"},{"key":"149_CR7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1113\/expphysiol.1996.sp003994","volume":"81","author":"J Ekstr\u00f6m","year":"1996","unstructured":"Ekstr\u00f6m J, Aszt\u00e9ly A, Tobin G (1996) Non-adrenergic, non-cholinergic influences on parotid acinar degranulation in response to stimulation of the parasympathetic innervation in the anaesthetized rat. Exp Physiol 81:935\u2013942","journal-title":"Exp Physiol"},{"issue":"Suppl","key":"149_CR8","first-page":"208","volume":"36","author":"J Ekstr\u00f6m","year":"1998","unstructured":"Ekstr\u00f6m J, Aszt\u00e9ly A, Tobin G (1998) Parasympathetic non-adrenergic, non-cholinergic mechanisms in salivary glands and their role in reflex secretion. Eur J Morphol 36 (Suppl):208\u2013212","journal-title":"Eur J Morphol"},{"key":"149_CR6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/jphysiol.1993.sp019944","volume":"472","author":"J Ekstr\u00f6m","year":"1993","unstructured":"Ekstr\u00f6m J, Helander HF, Tobin G (1993) Parasympathetic non-adrenergic non-cholinergic mechanisms in reflex secretion of parotid acinar granules in conscious rat. J Physiol (Lond) 472:233\u2013244","journal-title":"J Physiol (Lond)"},{"key":"149_CR9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archinte.162.11.1293","volume":"162","author":"RS Fife","year":"2002","unstructured":"Fife RS, Chase WF, Dore RK, Wiesenhutter CW, Lockhart PB, Tindall E, Suen JY (2002) Cevimeline for the treatment of xerostomia in patients with Sj\u00f6gren syndrome: a randomized trial. Arch Intern Med 162:1293\u20131300","journal-title":"Arch Intern Med"},{"key":"149_CR10","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/0024-3205(88)90398-0","volume":"43","author":"E Giraldo","year":"1988","unstructured":"Giraldo E, Martos F, Gomez A, Garcia A, Vigano MA, Ladinsky H, Sanchez de La Cuesta F (1988) Characterization of muscarinic receptor subtypes in human tissues. Life Sci 43:1507\u20131515","journal-title":"Life Sci"},{"key":"149_CR11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-5793(00)01763-4","volume":"477","author":"Y Ishikawa","year":"2000","unstructured":"Ishikawa Y, Skowronski MT, Ishida H (2000) Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011. FEBS Lett 477:253\u2013257","journal-title":"FEBS Lett"},{"key":"149_CR12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(99)00341-6","volume":"376","author":"P Michal","year":"1999","unstructured":"Michal P, Lys\u00edkov\u00e1 M, El-Fakahany EE, Tu\u010dek S (1999) Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors. Eur J Pharmacol 376:119\u2013125","journal-title":"Eur J Pharmacol"},{"key":"149_CR13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/sj.bjp.0701357","volume":"122","author":"MC Olianas","year":"1997","unstructured":"Olianas MC, Maullu C, Onali P (1997) Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor. Br J Pharmacol 122:401\u2013408","journal-title":"Br J Pharmacol"},{"key":"149_CR14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0893-133X(98)00048-7","volume":"20","author":"MC Olianas","year":"1999","unstructured":"Olianas MC, Maullu C, Onali P (1999) Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells. Neuropsychopharmacology 20:263\u2013270","journal-title":"Neuropsychopharmacology"},{"key":"149_CR15","first-page":"229","volume-title":"Trattato di Farmacologia, vol 1","author":"G Pepeu","year":"1996","unstructured":"Pepeu G (1996) Trasmissione colinergica. In: Clementi F, Fumagalli G (eds) Trattato di Farmacologia, vol 1. UTET, Torino, pp 229\u2013244"},{"key":"149_CR16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0143-4160(03)00149-0","volume":"34","author":"S Pochet","year":"2003","unstructured":"Pochet S, Garcia-Marcos M, Fernandez M, Marino A, Dehaye JP (2003) Regulation by clozapine of calcium handling by rat submandibular acinar cells. Cell Calcium 34:465\u2013475","journal-title":"Cell Calcium"},{"issue":"Suppl","key":"149_CR17","first-page":"35","volume":"36","author":"A Riva","year":"1998","unstructured":"Riva A, Loffredo F, Segawa A, Congiu T, Testa Riva F (1998) Human salivary glands parenchymal cells seen by SEM from the cytoplasmic side using a new osmium maceration method. Eur J Morphol 36 (Suppl):35\u201340","journal-title":"Eur J Morphol"},{"key":"149_CR18","first-page":"111","volume":"13","author":"A Riva","year":"1999","unstructured":"Riva A, Faa G, Loffredo F, Piludu M, Testa Riva F (1999) An improved OsO4 maceration method for the visualization of internal structures and surfaces by high resolution scanning electron microscopy. Scanning Microscopy 13:111\u2013122","journal-title":"Scanning Microscopy"},{"key":"149_CR19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1076\/ejom.40.4.227.16694","volume":"40","author":"A Riva","year":"2002","unstructured":"Riva A, Puxeddu R, Loy F, Testa Riva F (2002) Morphofunctional studies on human labial salivary glands. Eur J Morphol 40:227\u2013233","journal-title":"Eur J Morphol"},{"key":"149_CR20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/09243860412331282174","volume":"41","author":"A Riva","year":"2003","unstructured":"Riva A, Puxeddu R, Loy F, Isola M, Cabras T, Testa Riva F (2003) Serous and mucous cells of human submandibular salivary gland stimulated in vitro by isoproterenol, carbachol and clozapine: an LM, TEM, and HRSEM study. Eur J Morphol 41:83\u201387","journal-title":"Eur J Morphol"},{"key":"149_CR21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1076\/ejom.34.3.215.13023","volume":"34","author":"A Segawa","year":"1996","unstructured":"Segawa A, Riva A (1996) Dynamics of salivary secretion studied by confocal laser and scanning electron microscopy. Eur J Morphol 34:215\u2013219","journal-title":"Eur J Morphol"},{"key":"149_CR22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s004410051002","volume":"291","author":"A Segawa","year":"1998","unstructured":"Segawa A, Loffredo F, Puxeddu R, Yamashina S, Testa Riva F, Riva A (1998) Exocytosis in human salivary glands visualized by high-resolution scanning electron microscopy. Cell Tissue Res 291:325\u2013336","journal-title":"Cell Tissue Res"},{"key":"149_CR23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.1984.tb00487.x","volume":"133","author":"K Tanaka","year":"1984","unstructured":"Tanaka K, Mitsushima A (1984) A preparation method for observing intracellular structures by scanning electron microscopy. J Microsc 133:213\u2013222","journal-title":"J Microsc"},{"key":"149_CR24","first-page":"80","volume":"53","author":"T Washio","year":"2003","unstructured":"Washio T, Kohsaka K, Arisawa H, Masunaga H, Nagatsuka S, Satoh Y (2003) Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Arznei Forschung 53:80\u201386","journal-title":"Arznei Forschung"},{"key":"149_CR25","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0922-4106(94)90047-7","volume":"269","author":"SH Zorn","year":"1994","unstructured":"Zorn SH, Jones SB, Ward KM, Liston DR (1994) Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol 269:R1\u2013R2","journal-title":"Eur J Pharmacol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-005-0149-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-005-0149-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-005-0149-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:41:10Z","timestamp":1559086870000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-005-0149-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,27]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["149"],"URL":"https:\/\/doi.org\/10.1007\/s00441-005-0149-1","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,27]]}}}