{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:38:20Z","timestamp":1791052700280,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,8,12]],"date-time":"2006-08-12T00:00:00Z","timestamp":1155340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2006,11,20]]},"DOI":"10.1007\/s00441-006-0270-9","type":"journal-article","created":{"date-parts":[[2006,8,11]],"date-time":"2006-08-11T10:20:42Z","timestamp":1155291642000},"page":"725-736","source":"Crossref","is-referenced-by-count":154,"title":["Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages"],"prefix":"10.1007","volume":"326","author":[{"given":"Haihong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunliang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongzhu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,8,12]]},"reference":[{"key":"270_CR1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcp.10260","volume":"196","author":"EV Badiavas","year":"2003","unstructured":"Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P (2003) Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 196:245\u2013250","journal-title":"J Cell Physiol"},{"key":"270_CR2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biocel.2003.10.015","volume":"36","author":"SG Ball","year":"2004","unstructured":"Ball SG, Shuttleworth AC, Kielty CM (2004) Direct cell contact influences bone marrow mesenchymal stem cell fate. Int J Biochem Cell Biol 36:714\u2013727","journal-title":"Int J Biochem Cell Biol"},{"key":"270_CR3","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/345542a0","volume":"345","author":"SR Blecher","year":"1990","unstructured":"Blecher SR, Kapalanga J, Lalonde D (1990) Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature 345:542\u2013544","journal-title":"Nature"},{"key":"270_CR4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00441-004-1012-5","volume":"319","author":"D Bosnakovski","year":"2005","unstructured":"Bosnakovski D, Mizuno M, Kim G, Takagi S, Okumura M, Fujinaga T (2005) Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells. Cell Tissue Res 319:243\u2013253","journal-title":"Cell Tissue Res"},{"key":"270_CR5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/ten.2005.11.110","volume":"11","author":"W Deng","year":"2005","unstructured":"Deng W, Han Q, Liao L, Li C, Ge W, Zhao Z, You S, Deng H, Murad F, Zhao RC (2005) Engrafted bone marrow-derived Flk-1(+) mesenchymal stem cells regenerate skin tissue. Tissue Eng 11:110\u2013119","journal-title":"Tissue Eng"},{"key":"270_CR6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1242\/jcs.02784","volume":"119","author":"R Guerriero","year":"2006","unstructured":"Guerriero R, Parolini I, Testa U, Samoggia P, Petrucci E, Sargiacomo M, Chelucci C, Gabbianelli M, Peschle C (2006) Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes. J Cell Sci 119:744\u2013752","journal-title":"J Cell Sci"},{"key":"270_CR7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.200505087","volume":"171","author":"HY Irie","year":"2005","unstructured":"Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS (2005) Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 171:1023\u20131034","journal-title":"J Cell Biol"},{"key":"270_CR8","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1074\/jbc.275.13.9645","volume":"275","author":"RK Jaiswal","year":"2000","unstructured":"Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF (2000) Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275:9645\u20139652","journal-title":"J Biol Chem"},{"key":"270_CR9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/path.1156","volume":"197","author":"SM Janes","year":"2002","unstructured":"Janes SM, Lowell S, Hutter C (2002) Epidermal stem cells. J Pathol 197:479\u2013491","journal-title":"J Pathol"},{"key":"270_CR10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","volume":"418","author":"Y Jiang","year":"2002","unstructured":"Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41\u201349","journal-title":"Nature"},{"key":"270_CR11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/15258160360732704","volume":"12","author":"A Joannides","year":"2003","unstructured":"Joannides A, Gaughwin P, Scott M, Watt S, Compston A, Chandran S (2003) Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. J Hematother Stem Cell Res 12:681\u2013688","journal-title":"J Hematother Stem Cell Res"},{"key":"270_CR12","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0002-9440(10)63482-7","volume":"163","author":"K Kataoka","year":"2003","unstructured":"Kataoka K, Medina RJ, Kageyama T, Miyazaki M, Yoshino T, Makino T, Huh NH (2003) Participation of adult mouse bone marrow cells in reconstitution of skin. Am J Pathol 163:1227\u20131231","journal-title":"Am J Pathol"},{"key":"270_CR13","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1523\/JNEUROSCI.23-21-07742.2003","volume":"23","author":"A Kicic","year":"2003","unstructured":"Kicic A, Shen WY, Wilson AS, Constable IJ, Robertson T, Rakoczy PE (2003) Differentiation of marrow stromal cells into photoreceptors in the rat eye. J Neurosci 23:7742\u20137749","journal-title":"J Neurosci"},{"key":"270_CR14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood-2004-09-3645","volume":"106","author":"M Krampera","year":"2005","unstructured":"Krampera M, Pasini A, Rigo A, Scupoli MT, Tecchio C, Malpeli G, Scarpa A, Dazzi F, Pizzolo G, Vinante F (2005) HB-EGF\/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation. Blood 106:59\u201366","journal-title":"Blood"},{"key":"270_CR30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2174\/1389450053345037","volume":"6","author":"I Kulbatski","year":"2005","unstructured":"Kulbatski I, Mothe AJ, Nomura H, Tator CH (2005) Endogenous and exogenous CNS derived stem\/progenitor cell approaches for neurotrauma.Curr Drug Targets 6:111\u2013126","journal-title":"Curr Drug Targets"},{"key":"270_CR15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0301-472X(03)00110-3","volume":"31","author":"K Blanc Le","year":"2003","unstructured":"Le Blanc K, Tammik C, Rosendahl K, Zetterberg E, Ringden O (2003) HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 31:890\u2013896","journal-title":"Exp Hematol"},{"key":"270_CR16","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ceb.2004.09.007","volume":"16","author":"EA Mayhall","year":"2004","unstructured":"Mayhall EA, Paffett-Lugassy N, Zon LI (2004) The clinical potential of stem cells. Curr Opin Cell Biol 16:713\u2013720","journal-title":"Curr Opin Cell Biol"},{"key":"270_CR17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1369\/jhc.4A6280.2005","volume":"53","author":"Y Oshima","year":"2005","unstructured":"Oshima Y, Watanabe N, Matsuda K, Takai S, Kawata M, Kubo T (2005) Behavior of transplanted bone marrow-derived GFP mesenchymal cells in osteochondral defect as a simulation of autologous transplantation. J Histochem Cytochem 53:207\u2013216","journal-title":"J Histochem Cytochem"},{"key":"270_CR18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143\u2013147","journal-title":"Science"},{"key":"270_CR19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/labinvest.3700204","volume":"85","author":"C Rescan","year":"2005","unstructured":"Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H (2005) EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK\/ERK cascade. Lab Invest 85:65\u201374","journal-title":"Lab Invest"},{"key":"270_CR20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1389450053345028","volume":"6","author":"KM Safford","year":"2005","unstructured":"Safford KM, Rice HE (2005) Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells. Curr Drug Targets 6:57\u201362","journal-title":"Curr Drug Targets"},{"key":"270_CR21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0079-6336(02)80005-5","volume":"37","author":"K Saga","year":"2002","unstructured":"Saga K (2002) Structure and function of human sweat glands studied with histochemistry and cytochemistry. Prog Histochem Cytochem 37:323\u2013386","journal-title":"Prog Histochem Cytochem"},{"key":"270_CR22","doi-asserted-by":"crossref","first-page":"11307","DOI":"10.1073\/pnas.97.21.11307","volume":"97","author":"M Schuldiner","year":"2000","unstructured":"Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N (2000) Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 97:11307\u201311312","journal-title":"Proc Natl Acad Sci USA"},{"key":"270_CR23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jdermsci.2003.09.004","volume":"33","author":"T Shikiji","year":"2003","unstructured":"Shikiji T, Minami M, Inoue T, Hirose K, Oura H, Arase S (2003) Keratinocytes can differentiate into eccrine sweat ducts in vitro: involvement of epidermal growth factor and fetal bovine serum. J Dermatol Sci 33:141\u2013150","journal-title":"J Dermatol Sci"},{"key":"270_CR24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/01.CIR.0000151812.86142.45","volume":"111","author":"GV Silva","year":"2005","unstructured":"Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RV, Oliveira EM, He R, Geng YJ, Willerson JT, Perin EC (2005) Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111:150\u2013156","journal-title":"Circulation"},{"key":"270_CR25","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1634\/stemcells.2005-0176","volume":"24","author":"K Tamama","year":"2005","unstructured":"Tamama K, Fan VH, Griffith LG, Blair HC, Wells A (2005) Epidermal growth factor as candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells 24:686\u2013695","journal-title":"Stem Cells"},{"key":"270_CR26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.yexcr.2003.12.030","volume":"295","author":"P Tropel","year":"2004","unstructured":"Tropel P, Noel D, Platet N, Legrand P, Benabid AL, Bergera F (2004) Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow. Exp Cell Res 295:395\u2013406","journal-title":"Exp Cell Res"},{"key":"270_CR27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1073\/pnas.0406266102","volume":"102","author":"G Wang","year":"2005","unstructured":"Wang G, Bunnell BA, Painter RG, Quiniones BC, Tom S, Lanson NA Jr, Spees JL, Bertucci D, Peister A, Weiss DJ, Valentine VG, Prockop DJ, Kolls JK (2005) Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proc Natl Acad Sci USA 102:186\u2013191","journal-title":"Proc Natl Acad Sci USA"},{"key":"270_CR28","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1158\/0008-5472.CAN-05-3060","volume":"66","author":"W Yang","year":"2006","unstructured":"Yang W, Chen Y, Zhang Y, Wang X, Yang N, Zhu D (2006) Extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression. Cancer Res 66:1320\u20131326","journal-title":"Cancer Res"},{"key":"270_CR29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/sj.cr.7310010","volume":"16","author":"SY Yoon","year":"2006","unstructured":"Yoon SY, Lee YJ, Seo JH, Sung HJ, Park KH, Choi IK, Kim SJ, Oh SC, Choi CW, Kim BS, Shin SW, Kim YH, Kim JS (2006) uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line. Cell Res 16:75\u201381","journal-title":"Cell Res"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-006-0270-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-006-0270-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-006-0270-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:41:17Z","timestamp":1559086877000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-006-0270-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,11,20]]}},"alternative-id":["270"],"URL":"https:\/\/doi.org\/10.1007\/s00441-006-0270-9","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,12]]}}}