{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:16:07Z","timestamp":1791407767084,"version":"4.3.3"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,8,26]],"date-time":"2006-08-26T00:00:00Z","timestamp":1156550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1007\/s00441-006-0284-3","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T22:37:01Z","timestamp":1156545421000},"page":"505-516","source":"Crossref","is-referenced-by-count":307,"title":["GABAA receptor diversity and pharmacology"],"prefix":"10.1007","volume":"326","author":[{"given":"H.","family":"M\u00f6hler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,8,26]]},"reference":[{"key":"284_CR1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0166-2236(95)93923-L","volume":"18","author":"BE Alger","year":"1995","unstructured":"Alger BE, Pitler TA (1995) Retrograde signaling at GABAA-receptor synapses in the mammalian CNS. Trends Neurosci 18:333\u2013340","journal-title":"Trends Neurosci"},{"key":"284_CR2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.bjp.0706056","volume":"144","author":"JR Atack","year":"2005","unstructured":"Atack JR, Hutson PH, Collinson N, Marchall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR (2005) Anxiogenic properties of an inverse agonist selective for \u03b13 subunit-containing GABAA receptors. Br J Pharmacol 144:357\u2013366","journal-title":"Br J Pharmacol"},{"key":"284_CR3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.105.089920","volume":"316","author":"JR Atack","year":"2006","unstructured":"Atack JR, Wafford K, Tye SJ, Cook S, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, et al (2006a) TPA023 an agonist selective for \u03b12- and \u03b13-containing GABAA receptors, is a non-sedating anxiolytic in rodents and primates. J Pharm Exp Ther 316:410\u2013422","journal-title":"J Pharm Exp Ther"},{"key":"284_CR4","doi-asserted-by":"crossref","unstructured":"Atack JR, Wafford K, Tye SJ, Cook S, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, et al (2006b) The in vivo properties of pagoclone in rat are most likely mediated by 5\u2032-hydroxy pagoclone. Neuropharmacology (in press)","DOI":"10.1016\/j.neuropharm.2005.11.014"},{"key":"284_CR5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0031-6997(24)01363-2","volume":"50","author":"EA Barnard","year":"1998","unstructured":"Barnard EA, Skolnick P, Olsen RW, M\u00f6hler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) Subtypes of \u03b3-aminobutyric acidA receptors: classification on the bases of subunit structure and receptor function. Pharmacol Rev 50:291\u2013313","journal-title":"Pharmacol Rev"},{"key":"284_CR6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1703","volume":"6","author":"D Belelli","year":"2005","unstructured":"Belelli D, Lambert JJ (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci 6:565\u2013575","journal-title":"Nat Rev Neurosci"},{"key":"284_CR7","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0014-5793(98)00803-5","volume":"431","author":"J Benson","year":"1998","unstructured":"Benson J, L\u00f6w K, Keist R, M\u00f6hler H, Rudolph U (1998) Pharmacology of recombinant GABAA receptors rendered diazepam-insensitive by point-mutated \u03b1-subunits. FEBS Lett 431:400\u2013404","journal-title":"FEBS letters"},{"key":"284_CR8","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1523\/JNEUROSCI.23-34-10934.2003","volume":"23","author":"MT Bianchi","year":"2003","unstructured":"Bianchi MT, McDonald RL (2003) Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. J Neurosci 23:10934\u201310943","journal-title":"J Neurosci"},{"key":"284_CR9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0165-6147(99)01413-3","volume":"21","author":"J Bormann","year":"2000","unstructured":"Bormann J (2000) The \u201cABC\u201d of GABA receptors. Trends Pharmacol Sci 21:16\u201319","journal-title":"Trends Pharmacol Sci"},{"key":"284_CR10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1113\/jphysiol.1996.sp021806","volume":"497","author":"SG Brickley","year":"1996","unstructured":"Brickley SG, Cull-Candy SG, Farrant M (1996) Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J Physiol (Lond) 497:753\u2013759","journal-title":"J Physiol (Lond)"},{"key":"284_CR11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/35051086","volume":"409","author":"SG Brickley","year":"2001","unstructured":"Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M (2001) Adaptive regulation of neuronal excitability by a voltage independent potassium conductance. Nature 409:88\u201392","journal-title":"Nature"},{"key":"284_CR12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/sj.bjp.0704795","volume":"136","author":"N Brown","year":"2002","unstructured":"Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA (2002) Pharmacological characterization of a novel cell line expressing human \u03b14\u03b23\u03b4 GABAA receptors. Br J Pharmacol 136:965\u2013974","journal-title":"Br J Pharmacol"},{"key":"284_CR13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0166-2236(99)01540-4","volume":"23","author":"AB Brussaard","year":"2000","unstructured":"Brussaard AB, Herbison AE (2000) Long-term plasticity of postsynaptic GABAA-receptor function in the adult brain: insights from the oxytocin neurone. Trends Neurosci 23:190\u2013195","journal-title":"Trends Neurosci"},{"key":"284_CR14","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra021261","volume":"348","author":"JA Campagna","year":"2003","unstructured":"Campagna JA, Miller KW, Forman SA (2003) Mechanisms of actions of inhaled anesthetics. N Engl J Med 348:2110\u20132124","journal-title":"N Engl J Med"},{"key":"284_CR15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1476-5381.1992.tb14321.x","volume":"106","author":"MP Caulfield","year":"1992","unstructured":"Caulfield MP, Brown DA (1992) Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. Br J Pharmacol 106:231\u2013232","journal-title":"Br J Pharmacol"},{"key":"284_CR16","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1021\/jm020582q","volume":"46","author":"MS Chambers","year":"2003","unstructured":"Chambers MS, Attack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM (2003) Identification of a novel, selective GABAA \u03b15 receptor inverse agonist which enhances cognition. J Med Chem 46:2227\u20132240","journal-title":"J Med Chem"},{"key":"284_CR17","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1021\/jm040863t","volume":"47","author":"MS Chambers","year":"2004","unstructured":"Chambers MS, Atack JR, Carling RW, Collinson N, Cook SM, Dawson GR, Ferris P, Hobbs SC, O\u2019Connor D, Marshall G et al (2004) An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem 47:5829\u20135832","journal-title":"J Med Chem"},{"key":"284_CR18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0896-6273(03)00235-6","volume":"38","author":"V Chevaleyre","year":"2003","unstructured":"Chevaleyre V, Castillo PE (2003) Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. Neuron 38:461\u2013472","journal-title":"Neuron"},{"key":"284_CR19","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/00000542-200406000-00016","volume":"100","author":"J Cirone","year":"2004","unstructured":"Cirone J, Rosahl TW, Reynolds DS, Newman RJ, O\u2019Meara GF, Hutson PH, Wafford KA (2004) Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology 100:1438\u20131445","journal-title":"Anesthesiology"},{"key":"284_CR20","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1021\/jm0110789","volume":"45","author":"I Collins","year":"2002","unstructured":"Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, et al (2002) 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2\/alpha 3-subtypes of human GABA(A) receptor-ion channels. J Med Chem 45:1887\u20131900","journal-title":"J Med Chem"},{"key":"284_CR21","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1523\/JNEUROSCI.22-13-05572.2002","volume":"22","author":"N Collinson","year":"2002","unstructured":"Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, et al (2002) Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the \u03b15 subunit of the GABAA receptor. J Neurosci 22:5572\u20135580","journal-title":"J Neurosci"},{"key":"284_CR22","doi-asserted-by":"crossref","first-page":"8980","DOI":"10.1073\/pnas.142288699","volume":"99","author":"F Crestani","year":"2002","unstructured":"Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Bluethmann H, M\u00f6hler H, Rudolph U (2002) Trace fear conditioning involves hippocampal a5 GABAA receptors. Proc Natl Acad Sci USA 99:8980\u20138985","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1520-6769(199911\/12)25:3<139::AID-NRC3>3.0.CO;2-W","volume":"25","author":"K D\u00e4mgen","year":"1999","unstructured":"D\u00e4mgen K, L\u00fcddens H (1999) Zaleplon diaplays a selecitvity to recombinant GABAA receptors different from zolpidem, zopiclone and benzodiazepines. Neurosci Res Comm 25:139\u2013148","journal-title":"Neurosci Res Comm"},{"key":"284_CR24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0022-3956(96)00003-9","volume":"30","author":"A Dellini-Stula","year":"1996","unstructured":"Dellini-Stula A, Berdah-Tordjman D (1996) Antipsychotic effects of bretazenil, a partial benzodiazepine agonist in acute schizophrenia\u2014a study group report. J Psychiatr Res 30:239\u2013250","journal-title":"J Psychiatr Res"},{"key":"284_CR25","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1152\/jn.2001.85.4.1686","volume":"85","author":"A Devor","year":"2001","unstructured":"Devor A, Fritschy JM, Yarom Y (2001) Spatial distribution and subunit composition of GABAA receptors in the inferior olivary nucleus. J Neurophysiol 85:1686\u20131696","journal-title":"J Neurophysiol"},{"key":"284_CR26","doi-asserted-by":"crossref","first-page":"10682","DOI":"10.1523\/JNEUROSCI.1166-05.2005","volume":"25","author":"R Dias","year":"2005","unstructured":"Dias R, et al (2005) Evidence for a significant role of alpha3\u2013containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J Neurosci 25:10682\u201310688","journal-title":"J Neurosci"},{"key":"284_CR27","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35094565","volume":"2","author":"AK Engel","year":"2001","unstructured":"Engel AK, Fries P, Singer W (2001) Dynamic predictions: oscillations and synchrony in top-down processing. Nat Rev Neurosci 2:704\u2013716","journal-title":"Nat Rev Neurosci"},{"key":"284_CR28","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0306-4522(03)00288-4","volume":"4","author":"M Ernst","year":"2003","unstructured":"Ernst M, Brauchart D, Boresch S, Sieghart W (2003) Comparative modeling of GABAA receptors: limits, insights, future developments. J Neuroscience 4:933\u2013943","journal-title":"J Neuroscience"},{"key":"284_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/35004582","volume":"404","author":"M Fagiolini","year":"2000","unstructured":"Fagiolini M, Hensch T (2000) Inhibitory threshold for critical-period activation in primary visual cortex. Nature 404:183\u2013186","journal-title":"Nature"},{"key":"284_CR30","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1126\/science.1091032","volume":"303","author":"M Fagiolini","year":"2004","unstructured":"Fagiolini M, Fritschy JM, L\u00f6w K, M\u00f6hler H, Rudolph U, Hensch T (2004) Specific GABAA circuits for visual cortical plasticity. Science 303:1681\u20131683","journal-title":"Science"},{"key":"284_CR31","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1126\/science.1096224","volume":"303","author":"D Ferster","year":"2004","unstructured":"Ferster D (2004) Blocking plasticity in the visual cortex. Science 303:1619\u20131621","journal-title":"Science"},{"key":"284_CR32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.conb.2004.01.011","volume":"14","author":"E Foeller","year":"2004","unstructured":"Foeller E, Feldmann DE (2004) Synaptic basis for developmental plasticity in somatosensory cortex. Curr Opin Neurobiol 14:89\u201395","journal-title":"Curr Opin Neurobiol"},{"key":"284_CR33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1124\/jpet.103.063487","volume":"311","author":"AC Foster","year":"2004","unstructured":"Foster AC, Pelleymounter MA, Cullen MJ, Lewis D, Joppa M, Chen TK, Bozigian HP, Gross RS, Gogas KR (2004) In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. J Pharmacol Exp Ther 311:547\u2013559","journal-title":"J Pharmacol Exp Ther"},{"key":"284_CR34","first-page":"345","volume":"6","author":"TF Freund","year":"1996","unstructured":"Freund TF, Buzsaki G (1996) Interneurons of the hippocampus. Hippocampus 6:345\u2013470","journal-title":"Hippocampus"},{"key":"284_CR36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(03)00037-8","volume":"98","author":"JM Fritschy","year":"2003","unstructured":"Fritschy JM, Br\u00fcnig I (2003) Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications. Pharmacol Ther 98:299\u2013323","journal-title":"Pharmacol Ther"},{"key":"284_CR35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.903590111","volume":"359","author":"JM Fritschy","year":"1995","unstructured":"Fritschy JM, M\u00f6hler H (1995) GABAA receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154\u2013194","journal-title":"J Comp Neurol"},{"key":"284_CR37","first-page":"215","volume-title":"Excitatory inhibitory balance: synapses circuits and systems plasticity","author":"JM Fritschy","year":"2004","unstructured":"Fritschy JM, Crestani F, Rudolph U, M\u00f6hler H (2004) GABAA receptor subtypes with special reference to memory function and neurological disorders. In: Hensch TK, Fagiolini M (eds) Excitatory inhibitory balance: synapses, circuits and systems plasticity. Kluwer Academic\/Plenum, New York, pp\u00a0215\u2013228"},{"key":"284_CR38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0306-4522(93)90582-Z","volume":"54","author":"B Gao","year":"1993","unstructured":"Gao B, Fritschy JM, Benke D, M\u00f6hler H (1993) Neuron-specific expression of GABAA receptor subtypes: differential associations of the \u03b11- and \u03b13-subunits with serotonergic and GABAergic neurons. Neuroscience 54:881\u2013892","journal-title":"Neuroscience"},{"key":"284_CR39","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0896-6273(00)80339-6","volume":"18","author":"JR Geiger","year":"1997","unstructured":"Geiger JR, Lubke J, Roth A, Frotscher M, Jonas P (1997) Submillisecond AMPA receptor-mediated signalling at a principal neuron-interneuron synapse. Neuron 18:1009\u20131023","journal-title":"Neuron"},{"key":"284_CR40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1527-3458.2003.tb00241.x","volume":"9","author":"G Griebel","year":"2003","unstructured":"Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Depoortere H, Francon D, Avenet P, Schoemaker H, Evanno Y, et al (2003) SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms. CNS Drug Rev 9:3\u201320","journal-title":"CNS Drug Rev"},{"key":"284_CR41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1126\/science.287.5451.273","volume":"287","author":"A Gupta","year":"2000","unstructured":"Gupta A, Wang Y, Markam H (2000) Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287:273\u2013278","journal-title":"Science"},{"key":"284_CR42","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0165-6147(90)90126-S","volume":"11","author":"W Haefeli","year":"1990","unstructured":"Haefeli W, Martin JR, Schoch P (1990) Novel anxiolytics that act as partial agonists at benzodiazepine receptors. Trends Pharmacol Sci 11:452\u2013456","journal-title":"Trends Pharmacol Sci"},{"key":"284_CR43","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nature00808","volume":"417","author":"KD Harris","year":"2002","unstructured":"Harris KD, Henze DA, Hirase H, Leinekugel X, Dragoi G, Czurko A, Buzsaki G (2002) Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells. Nature 417:738\u2013741","journal-title":"Nature"},{"key":"284_CR44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.mp.4001554","volume":"10","author":"J Hauser","year":"2005","unstructured":"Hauser J, Rudolph U, Keist R, M\u00f6hler H, Feldon J, Yee B (2005) Hippocampal \u03b15 subunit containing GABAA receptors modulate expression of prepulse inhibition. Mol Psychiatry 10:201\u2013207","journal-title":"Mol Psychiatry"},{"key":"284_CR45","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrn1787","volume":"6","author":"TK Hensch","year":"2005","unstructured":"Hensch TK (2005) Critical period plasticity in local cortical circuits. Nature Rev Neurosci 6:877\u2013888","journal-title":"Nature Rev Neurosci"},{"key":"284_CR46","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.1091031","volume":"303","author":"TK Hensch","year":"2004","unstructured":"Hensch TK, Stryker MP (2004) Columnar architecture sculped by GABA circuits in developing cat visual cortex. Science 303:1678\u20131681","journal-title":"Science"},{"key":"284_CR47","first-page":"766","volume":"5","author":"R Huckle","year":"2004","unstructured":"Huckle R (2004) Gaboxadol Lundbeck\/Merck. Curr Opin Investig Drugs 5:766\u2013773","journal-title":"Curr Opin Investig Drugs"},{"key":"284_CR48","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/science.283.5401.541","volume":"283","author":"MM Huntsmann","year":"1999","unstructured":"Huntsmann MM, Porcello DM, Homanics GE, DeLorey TM, Huguenard JR (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 283:541\u2013543","journal-title":"Science"},{"key":"284_CR49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.2000.t01-5-00003.xm","volume":"522","author":"B Hutcheon","year":"2000","unstructured":"Hutcheon B, Morley P, Poulter MO (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J Pysiol (Lond) 522:3\u201317","journal-title":"J Pysiol (Lond)"},{"key":"284_CR50","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1046\/j.0953-816x.2001.01587.x","volume":"13","author":"R J\u00fcttner","year":"2001","unstructured":"J\u00fcttner R, Meier J, Grantyn R (2001) Slow IPSC kinetics, low levels of \u03b11 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus. Eur J Neurosci 13:2088\u20132098","journal-title":"Eur J Neurosci"},{"key":"284_CR51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1096\/fj.02-0611fje","volume":"17","author":"R Jurd","year":"2003","unstructured":"Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, et al (2003) General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 17:250\u2013252","journal-title":"FASEB J"},{"key":"284_CR52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.conb.2004.01.017","volume":"14","author":"K Kandler","year":"2004","unstructured":"Kandler K (2004) Activity-dependent organization of inhibitory circuits: lessons from the auditory system. Curr Opin Neurobiol 14:96\u2013104","journal-title":"Curr Opin Neurobiol"},{"key":"284_CR53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nm803","volume":"9","author":"S Kathuria","year":"2003","unstructured":"Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76\u201381","journal-title":"Nat Med"},{"key":"284_CR54","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1523\/JNEUROSCI.19-11-04544.1999","volume":"19","author":"I Katona","year":"1999","unstructured":"Katona I, Sperlagh B, Sik A, K\u00e4falvi A, Vizi ES, Mackie K, Freund TF (1999) Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci 19:4544\u20134558","journal-title":"J Neurosci"},{"key":"284_CR55","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.1523\/JNEUROSCI.21-23-09506.2001","volume":"21","author":"I Katona","year":"2001","unstructured":"Katona I, Rancz EA, Acsady L, Ledent C, Mackie K, Hajos N, Freund TF (2001) Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. J Neurosci 21:9506\u20139518","journal-title":"J Neurosci"},{"key":"284_CR56","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1523\/JNEUROSCI.22-07-02513.2002","volume":"22","author":"T Klausberger","year":"2002","unstructured":"Klausberger T, Roberts JD, Somogyi P (2002) Cell type- and input-specific differences in the number and subtypes of synaptic GABAA receptors in the hippocampus. J Neurosci 22:2513\u20132521","journal-title":"J Neurosci"},{"key":"284_CR57","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nature01374","volume":"421","author":"T Klausberger","year":"2003","unstructured":"Klausberger T, Magill PJ, Marton LF, Roberts JDB, Cobden PM, Buzsaki G, Somogyi P (2003) Brain state- and cell type-specific firing of hippocampal interneurons in vivo. Nature 421:844\u2013848","journal-title":"Nature"},{"key":"284_CR58","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1097\/00001756-200410050-00031","volume":"15","author":"C Kopp","year":"2004","unstructured":"Kopp C, Rudolph U, Tobler I (2004a) Sleep EEG changes after zolpidem in mice. Neuroreport 15:2299\u20132302","journal-title":"Neuroreport"},{"key":"284_CR59","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1073\/pnas.0306975101","volume":"101","author":"C Kopp","year":"2004","unstructured":"Kopp C, Rudolph U, L\u00f6w K, Tobler I (2004b) Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci USA 101:3674\u20133679","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR60","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1124\/mol.53.3.530","volume":"53","author":"MD Krasowski","year":"1998","unstructured":"Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL (1998) Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane. Mol Pharmacol 53:530\u2013538","journal-title":"Mol Pharmacol"},{"key":"284_CR61","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0896-6273(01)00246-X","volume":"29","author":"AC Kreitzer","year":"2001","unstructured":"Kreitzer AC, Regehr WG (2001a) Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 29:717\u2013727","journal-title":"Neuron"},{"key":"284_CR62","doi-asserted-by":"crossref","first-page":"RC174","DOI":"10.1523\/JNEUROSCI.21-20-j0005.2001","volume":"21","author":"AC Kreitzer","year":"2001","unstructured":"Kreitzer AC, Regehr WG (2001b) Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci 21:RC174","journal-title":"J Neurosci"},{"key":"284_CR63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2005.04.030","volume":"516","author":"S Lambert","year":"2005","unstructured":"Lambert S, Arras M, Vogt KE, Rudolph U (2005) Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. Eur J Pharmacol 516:23\u201327","journal-title":"Eur J Pharmacol"},{"key":"284_CR64","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/(SICI)1521-3773(19991004)38:19<2852::AID-ANIE2852>3.0.CO;2-Z","volume":"111","author":"M Lancel","year":"1999","unstructured":"Lancel M, Steiger A (1999) Sleep and its modulation by drugs that affect GABAA receptor function. Angew Chem Int Ed 111:2852\u20132864","journal-title":"Angew Chem Int Ed"},{"key":"284_CR65","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1124\/jpet.105.084681","volume":"314","author":"B Langen","year":"2005","unstructured":"Langen B, Egerland U, Bernoster K, Dost R, Unverferth K, Rundfeldt C (2005) Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor. J Pharmacol Exp Ther 314:717\u2013724","journal-title":"J Pharmacol Exp Ther"},{"key":"284_CR66","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrn1648","volume":"6","author":"DA Lewis","year":"2005","unstructured":"Lewis DA, Hashimoto T, Volk DW (2005) Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6:312\u2013324","journal-title":"Nat Rev Neurosci"},{"key":"284_CR67","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1213\/01.ANE.0000154196.86587.35","volume":"101","author":"M Liao","year":"2005","unstructured":"Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI 2nd (2005) Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg 101:412\u2013418","journal-title":"Anesth Analg"},{"key":"284_CR68","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1073\/pnas.0502579102","volume":"102","author":"A Lippa","year":"2005","unstructured":"Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P (2005) Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci USA 102:7380\u20137385","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR69","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0896-6273(91)90059-9","volume":"6","author":"I Llano","year":"1991","unstructured":"Llano I, Leresche N, Marty A (1991) Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 6:565\u2013574","journal-title":"Neuron"},{"key":"284_CR70","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","volume":"290","author":"K L\u00f6w","year":"2000","unstructured":"L\u00f6w K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, M\u00f6hler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131\u2013134","journal-title":"Science"},{"key":"284_CR71","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0896-6273(01)00247-1","volume":"29","author":"T Maejima","year":"2001","unstructured":"Maejima T, Ohno-Shosaku T, Kano M (2001) Endogenous cannabinoid mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29:729\u2013738","journal-title":"Neuron"},{"key":"284_CR72","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nrn1519","volume":"10","author":"H Markram","year":"2004","unstructured":"Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silbergerb G, Wu C (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 10:793\u2013807","journal-title":"Nat Rev Neurosci"},{"key":"284_CR73","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1460-9568.2004.03574.x","volume":"20","author":"A Marowsky","year":"2004","unstructured":"Marowsky A, Fritschy JM, Vogt KE (2004) Functional mapping of GABAA receptor subtypes in the amygdala. Eur J Neurosci 20:1281\u20131289","journal-title":"Eur J Neurosci"},{"key":"284_CR74","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature00839","volume":"418","author":"G Marsicano","year":"2002","unstructured":"Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530\u2013534","journal-title":"Nature"},{"key":"284_CR75","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1523\/JNEUROSCI.18-20-08111.1998","volume":"18","author":"M Martina","year":"1998","unstructured":"Martina M, Schultz JH, Ehmke H, Monyer H, Jonas P (1998) Functional and molecular differences between voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus. J Neurosci 18:1811\u20131825","journal-title":"J Neurosci"},{"key":"284_CR76","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","volume":"3","author":"RM McKernan","year":"2000","unstructured":"McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor \u03b11 subtype. Nat Neurosci 3:587\u2013592","journal-title":"Nat Neurosci"},{"key":"284_CR77","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nature00807","volume":"417","author":"MR Metha","year":"2002","unstructured":"Metha MR, Lee AK, Wilson MA (2002) Role of experience and oscillations in transforming a rate code into a temporal code. Nature 417:741\u2013746","journal-title":"Nature"},{"key":"284_CR78","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/38738","volume":"389","author":"SJ Mihic","year":"1997","unstructured":"Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, et al (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389:385\u2013389","journal-title":"Nature"},{"key":"284_CR79","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tins.2004.07.002","volume":"27","author":"I Mody","year":"2004","unstructured":"Mody I, Pearce RA (2004) Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends Neurosci 27:569\u2013575","journal-title":"Trends Neurosci"},{"key":"284_CR81","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-642-56833-6_3","volume-title":"Pharmacology of GABA and glycine neurotransmission","author":"H M\u00f6hler","year":"2001","unstructured":"M\u00f6hler H (2001) Functions of GABA receptors: pharmacology and pathophysiology. In: M\u00f6hler H (ed) Pharmacology of GABA and glycine neurotransmission. Springer, Berlin Heidelberg New York, pp 101\u2013116"},{"key":"284_CR82","doi-asserted-by":"crossref","first-page":"261","DOI":"10.31887\/DCNS.2002.4.3\/hmoehler","volume":"4","author":"H M\u00f6hler","year":"2002","unstructured":"M\u00f6hler H (2002) Pathophysiological aspects of diversity in neuronal inhibition: a new benzodiazepine pharmacology. Dialogues Clin Neurosci 4:261\u2013269","journal-title":"Dialogues Clin Neurosci"},{"key":"284_CR80","first-page":"97","volume-title":"GABA in the nervous system: the view at fifty years","author":"H M\u00f6hler","year":"2000","unstructured":"M\u00f6hler H, Benke D, Fritschy JM, Benson J (2000) The benzodiazepine site of GABAA receptors, In: Martin DL, Olsen RW (eds) GABA in the nervous system: the view at fifty years. Lippincott, Philadelphia, pp\u00a097\u2013112"},{"key":"284_CR83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.300.1.2","volume":"300","author":"H M\u00f6hler","year":"2002","unstructured":"M\u00f6hler H, Fritschy JM, Rudolph U (2002) A new benzodiazepine pharmacology. J Pharm Exptl Ther 300:2\u20138","journal-title":"J Pharm Exptl Ther"},{"key":"284_CR84","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/3-540-28082-0_9","volume-title":"Anxiety and anxiolytic drugs. Handbook of experimental pharmacology, vol 169","author":"H M\u00f6hler","year":"2005","unstructured":"M\u00f6hler H, Fritschy JM, Vogt K, Crestani F, Rudolph U (2005) Pathophysiology and pharmacology of GABAA receptors. In: Holsboer F, Str\u00f6hle A (eds) Anxiety and anxiolytic drugs. Handbook of experimental pharmacology, vol 169. Springer, Berlin Heidelberg New York, pp\u00a0225\u2013247"},{"key":"284_CR85","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tins.2003.12.008","volume":"27","author":"H Monyer","year":"2004","unstructured":"Monyer H, Markram H (2004) Interneuron Diversity series: Molecular and genetic tools to study GABAergic interneuron diversity and function. Trends Neurosci 27:90\u201397","journal-title":"Trends Neurosci"},{"key":"284_CR86","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/35067500","volume":"2","author":"SJ Moss","year":"2001","unstructured":"Moss SJ, Smart TG (2001) Constructing inhibitory synapses. Nat Rev Neurosci 2:240\u2013250","journal-title":"Nat Rev Neurosci"},{"key":"284_CR87","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0278-5846(02)00305-6","volume":"26","author":"JF Navarro","year":"2002","unstructured":"Navarro JF, Buron E, Martin-Lopez M (2002) Anxiogenic-like activity of L-655,708, a selective ligand for the benzodiazepine site of GABA(A) receptors which contain the alpha-5 subunit, in the elevated plus-maze test. Prog Neuropsychopharmacol Biol Psychiatry 26:1389\u20131392","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"284_CR88","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ab.20032","volume":"30","author":"JF Navarro","year":"2004","unstructured":"Navarro JF, Buron E and Martin-Lopez M (2004) Behavioral profile of L-655 708, a selective ligand for the benzodiazepine site of GABAA receptors which contain the \u03b15 subunit in social encounters between male mice. Aggress Behav 30:319\u2013325","journal-title":"Aggress Behav"},{"key":"284_CR89","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1523\/JNEUROSCI.16-01-00103.1996","volume":"16","author":"Z Nusser","year":"1996","unstructured":"Nusser Z, Sieghart W, Stephenson FA, Somogyi P (1996) The \u03b16 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J Neurosci 16:103\u2013114","journal-title":"J Neurosci"},{"key":"284_CR90","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1523\/JNEUROSCI.18-05-01693.1998","volume":"18","author":"Z Nusser","year":"1998","unstructured":"Nusser Z, Sieghart W and Somogyi P (1998) Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693\u20131703","journal-title":"J Neurosci"},{"key":"284_CR91","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1046\/j.1460-9568.2001.01407.x","volume":"13","author":"G Ny\u00edri","year":"2001","unstructured":"Ny\u00edri G, Freund TF and Somogyi P (2001) Input-dependent synaptic targeting of a2 subunit containing GABAA receptors in hippocampal pyramidal cells of the rat. Eur J Neurosci 13:428\u2013442","journal-title":"Eur J Neurosci"},{"key":"284_CR92","first-page":"477","volume-title":"The hippocampus as a cognitive map","author":"J O\u2019Keefe","year":"1978","unstructured":"O\u2019Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Clarendon, Oxford, pp\u00a0477\u2013543"},{"key":"284_CR93","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hipo.450030307","volume":"3","author":"J O\u2019Keefe","year":"1993","unstructured":"O\u2019Keefe J, Recce ML (1993) Phase relationship between hippocampal place units and the EEG theta rhythm. Hippocampus 3:317\u2013330","journal-title":"Hippocampus"},{"key":"284_CR94","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-2236(97)01205-8","volume":"21","author":"O Paulsen","year":"1998","unstructured":"Paulsen O, Moser EI (1998) A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity. Trends Neurosci 21:273\u2013278","journal-title":"Trends Neurosci"},{"key":"284_CR95","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/cne.10118","volume":"443","author":"H Pawelzik","year":"2002","unstructured":"Pawelzik H, Hughes DI, Thomson AM (2002) Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurons in CA1 of the adult rat hippocampus. J Comp Neurol 443:346\u2013367","journal-title":"J Comp Neurol"},{"key":"284_CR96","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(00)00442-5","volume":"101","author":"S Pirker","year":"2000","unstructured":"Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000) GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815\u2013850","journal-title":"Neuroscience"},{"key":"284_CR97","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1523\/JNEUROSCI.12-10-04122.1992","volume":"12","author":"TA Pitler","year":"1992","unstructured":"Pitler TA, Alger BE (1992) Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells. J Neurosci 12:4122\u20134132","journal-title":"J Neurosci"},{"key":"284_CR98","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/0896-6273(94)90430-8","volume":"13","author":"TA Pitler","year":"1994","unstructured":"Pitler TA, Alger BE (1994) Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. Neuron 13:1447\u20131455","journal-title":"Neuron"},{"key":"284_CR99","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1046\/j.1471-4159.2003.02135.x","volume":"87","author":"A P\u00f6ltl","year":"2003","unstructured":"P\u00f6ltl A, Hauer B, Fuchs K, Tretter V, Sieghart W (2003) Subunit composition and quantitative importance of GABAA receptors subtypes in the cerebellum of mouse and rat. J Neurochem 87:1444\u20131455","journal-title":"J Neurochem"},{"key":"284_CR100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tins.2005.03.010","volume":"28","author":"A Represa","year":"2005","unstructured":"Represa A, Ben-Ari Y (2005) Trophic actions of GABA on neuronal develpment. Trends Neurosci 28:278\u2013283","journal-title":"Trends Neurosci"},{"key":"284_CR101","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1523\/JNEUROSCI.23-24-08608.2003","volume":"23","author":"DS Reynolds","year":"2003","unstructured":"Reynolds DS, Rosahl TW, Cirone J, O\u2019Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, et al (2003) Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci 23:8608\u20138617","journal-title":"J Neurosci"},{"key":"284_CR112","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1523\/JNEUROSCI.1067-04.2004","volume":"24","author":"C Rijnsoever van","year":"2004","unstructured":"Rijnsoever C van, Tauber M, Choulli MK, Keist R, Rudolph U, M\u00f6hler H, Fritschy JM, Crestani F (2004) Requirement of \u03b15 GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. J Neurosci 24:6785\u20136790","journal-title":"J Neurosci"},{"key":"284_CR103","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrn1496","volume":"5","author":"U Rudolph","year":"2004","unstructured":"Rudolph U, Antkowiak B (2004) Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 5:709\u2013720","journal-title":"Nat Rev Neurosci"},{"key":"284_CR104","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.pharmtox.44.101802.121429","volume":"44","author":"U Rudolph","year":"2004","unstructured":"Rudolph U, M\u00f6hler H (2004) Analysis of GABAA receptor function and dissection of pharmacology of benzodiazepines and general anaesthetics by mouse genetics. Annu Rev Pharmacol Toxicol 44:475\u2013498","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"284_CR105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2005.10.003","volume":"6","author":"U Rudolph","year":"2006","unstructured":"Rudolph U, M\u00f6hler H (2006) GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol 6:18\u201323","journal-title":"Curr Opin Pharmacol"},{"key":"284_CR102","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","volume":"401","author":"U Rudolph","year":"1999","unstructured":"Rudolph U, Crestani F, Benke D, Br\u00fcnig I, Benson J, Fritschy JM, Martin JR, Bluethmann H, M\u00f6hler H (1999) Benzodiazepine actions mediated by specific \u03b3-aminobutyric acidA receptor subtypes. Nature 401:796\u2013800","journal-title":"Nature"},{"key":"284_CR106","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2174\/1568026023393507","volume":"2","author":"W Sieghart","year":"2002","unstructured":"Sieghart W, Sperk G (2002) Subunit composition, distribution and function of GABAA receptor subtypes. Curr Top Med Chem 2:795\u2013816","journal-title":"Curr Top Med Chem"},{"key":"284_CR107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1098-1063(1996)6:2<149::AID-HIPO6>3.0.CO;2-K","volume":"6","author":"WE Skaggs","year":"1996","unstructured":"Skaggs WE, McNaughton BL, Wilson MA, Barnes CA (1996) Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences. Hippocampus 6:149\u2013172","journal-title":"Hippocampus"},{"key":"284_CR108","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/jm031076j","volume":"47","author":"F Sternfeld","year":"2004","unstructured":"Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O\u2019Connor D, Sohal B, et al (2004) Selective, orally active gamma-amonobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. J Med Chem 47:2176\u20132179","journal-title":"J Med Chem"},{"key":"284_CR109","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(03)01603-0","volume":"467","author":"S Storustovu","year":"2003","unstructured":"Storustovu S, Ebert B (2003) Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity. Eur J Pharmacol 467:49\u201356","journal-title":"Eur J Pharmacol"},{"key":"284_CR110","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1073\/pnas.111055398","volume":"98","author":"I Tobler","year":"2001","unstructured":"Tobler I, Kopp C, Deboer T, Rudolph U (2001) Diazepam-induced changes in sleep: role of the \u03b11GABAA receptor subtype. Proc Natl Acad Sci USA 98:6464\u20136469","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVNEURO.2002.13.1.1","volume":"13","author":"RD Traub","year":"2002","unstructured":"Traub RD, Draguhn A, Whittington MA, Baldeweg T, Bibbig A, Buhl EH, Schmitz D (2002) Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis. Rev Neurosci 13:1\u201330","journal-title":"Rev Neurosci"},{"key":"284_CR113","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1523\/JNEUROSCI.21-09-03009.2001","volume":"21","author":"S Vicini","year":"2001","unstructured":"Vicini S, Ferguson C, Prybylowski K, Kralic J, Morrow AL, Homanics GE (2001) GABAA receptor \u03b11 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci 21:3009\u20133016","journal-title":"J Neurosci"},{"key":"284_CR114","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0896-6273(93)90118-B","volume":"11","author":"P Vincent","year":"1993","unstructured":"Vincent P, Marty A (1993) Neighboring cerebellar Purkinje cell communicate via retrograde inhibition of common presynaptic interneurons. Neuron 11:885\u2013893","journal-title":"Neuron"},{"key":"284_CR115","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","volume":"100","author":"M Wallner","year":"2003","unstructured":"Wallner M, Hanchar HJ, Olsen RW (2003) Ethanol enhances alpha4 beta3 delta and alpha6 beta3 delta gamma-aminobutyric acid type A receptors at low concentration known to affect humans. Proc Natl Acad Sci USA 100:15218\u201315223","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR117","first-page":"648","volume":"6","author":"PJ Whiting","year":"2003","unstructured":"Whiting PJ (2003) The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Dev 6:648\u2013655","journal-title":"Curr Opin Drug Discov Dev"},{"key":"284_CR116","first-page":"113","volume-title":"GABA in the nervous system: the view at fifty years","author":"P Whiting","year":"2000","unstructured":"Whiting P, Wafford KA, McKernan RM (2000) Pharmacologic subtypes of GABAA receptors based on subunit composition In: Martin DL, Olsen RW (eds) GABA in the nervous system: the view at fifty years. Lippincott, Philadelphia, pp\u00a0113\u2013126"},{"key":"284_CR118","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","volume":"26","author":"TN Wiesel","year":"1963","unstructured":"Wiesel TN, Hubel DH (1963) Single cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26:1003\u20131017","journal-title":"J Neurophysiol"},{"key":"284_CR119","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/35069076","volume":"410","author":"RI Wilson","year":"2001","unstructured":"Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 410:588\u201392 [erratum appears in Nature 2001 411:974]","journal-title":"Nature"},{"key":"284_CR120","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1111\/j.1460-9568.2004.03642.x","volume":"20","author":"BK Yee","year":"2004","unstructured":"Yee BK, Hauser J, Dolgov VV, Keist R, M\u00f6hler H, Rudolph U, Feldon J (2004) GABA receptors containing the \u03b15 subunit mediate the trance effect in aversive and appetitive conditioning and extinction of conditioned fear. Eur J Neurosci 20:1928\u20131936","journal-title":"Eur J Neurosci"},{"key":"284_CR121","doi-asserted-by":"crossref","first-page":"17154","DOI":"10.1073\/pnas.0508752102","volume":"102","author":"BK Yee","year":"2005","unstructured":"Yee BK, et al (2005) A schizophrenia-related sensorimotor deficit links \u03b13-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci USA 102:17154\u201317159","journal-title":"Proc Natl Acad Sci USA"},{"key":"284_CR122","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.04-3443fje","volume":"12","author":"A Zeller","year":"2005","unstructured":"Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U (2005) Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB J 12:1677\u20131679","journal-title":"FASEB J"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-006-0284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-006-0284-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-006-0284-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T16:18:43Z","timestamp":1736525923000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-006-0284-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,26]]},"references-count":122,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["284"],"URL":"https:\/\/doi.org\/10.1007\/s00441-006-0284-3","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,26]]}}}