{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:23:29Z","timestamp":1792668209721,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,5,10]],"date-time":"2008-05-10T00:00:00Z","timestamp":1210377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00441-008-0612-x","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T06:01:07Z","timestamp":1210312867000},"page":"29-38","source":"Crossref","is-referenced-by-count":32,"title":["Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion"],"prefix":"10.1007","volume":"333","author":[{"given":"Jiu-Zhen","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Darling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,10]]},"reference":[{"key":"612_CR1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ydbio.2004.09.010","volume":"277","author":"SR Alappat","year":"2005","unstructured":"Alappat SR, Zhang Z, Suzuki K, Zhang X, Liu H, Jiang R, Yamada G, Chen Y (2005) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol 277:102\u2013113","journal-title":"Dev Biol"},{"key":"612_CR2","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1242\/dev.126.22.5011","volume":"126","author":"JR Barrow","year":"1999","unstructured":"Barrow JR, Capecchi MR (1999) Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development 126:5011\u20135026","journal-title":"Development"},{"key":"612_CR3","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1091\/mbc.12.5.1457","volume":"12","author":"L Blavier","year":"2001","unstructured":"Blavier L, Lazaryev A, Groffen J, Heisterkamp N, DeClerck YA, Kaartinen V (2001) TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell 12:1457\u20131466","journal-title":"Mol Biol Cell"},{"key":"612_CR4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/dna.1996.15.643","volume":"15","author":"AM Cabanillas","year":"1996","unstructured":"Cabanillas AM, Darling DS (1996) Alternative splicing gives rise to two isoforms of Zfhep, a zinc finger\/homeodomain protein that binds T3-response elements. DNA Cell Biol 15:643\u2013651","journal-title":"DNA Cell Biol"},{"key":"612_CR5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1242\/dev.114.2.379","volume":"114","author":"MJ Carette","year":"1992","unstructured":"Carette MJ, Ferguson MW (1992) The fate of medial edge epithelial cells during palatal fusion in vitro: an analysis by DiI labelling and confocal microscopy. Development 114:379\u2013388","journal-title":"Development"},{"key":"612_CR6","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/dvdy.20821","volume":"235","author":"LM Casey","year":"2006","unstructured":"Casey LM, Lan Y, Cho ES, Maltby KM, Gridley T, Jiang R (2006) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn 235:1830\u20131844","journal-title":"Dev Dyn"},{"key":"612_CR7","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","volume":"235","author":"Y Chai","year":"2006","unstructured":"Chai Y, Maxson RE Jr (2006) Recent advances in craniofacial morphogenesis. Dev Dyn 235:2353\u20132375","journal-title":"Dev Dyn"},{"key":"612_CR8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","volume":"127","author":"Y Chai","year":"2000","unstructured":"Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127:1671\u20131679","journal-title":"Development"},{"key":"612_CR9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2004.10.023","volume":"278","author":"XM Cui","year":"2005","unstructured":"Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas P, Chai Y, Shuler CF (2005) Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol 278:193\u2013202","journal-title":"Dev Biol"},{"key":"612_CR10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(98)00076-8","volume":"139","author":"DS Darling","year":"1998","unstructured":"Darling DS, Gaur NK, Zhu B (1998) A zinc finger homeodomain transcription factor binds specific thyroid hormone response elements. Mol Cell Endocrinol 139:25\u201335","journal-title":"Mol Cell Endocrinol"},{"key":"612_CR11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1567-133X(03)00147-9","volume":"3","author":"DS Darling","year":"2003","unstructured":"Darling DS, Stearman RP, Qi Y, Qiu MS, Feller JP (2003) Expression of Zfhep\/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr Patterns 3:709\u2013717","journal-title":"Gene Expr Patterns"},{"key":"612_CR12","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1242\/dev.02693","volume":"133","author":"F Dong","year":"2006","unstructured":"Dong F, Sun X, Liu W, Ai D, Klysik E, Lu MF, Hadley J, Antoni L, Chen L, Baldini A, Francis-West P, Martin JF (2006) Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development 133:4891\u20134899","journal-title":"Development"},{"issue":"(Suppl)","key":"612_CR13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.103.Supplement.41","volume":"103","author":"MW Ferguson","year":"1988","unstructured":"Ferguson MW (1988) Palate development. Development 103 (Suppl):41\u201360","journal-title":"Development"},{"key":"612_CR14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dev.109.3.585","volume":"109","author":"DR Fitzpatrick","year":"1990","unstructured":"Fitzpatrick DR, Denhez F, Kondaiah P, Akhurst RJ (1990) Differential expression of TGF beta isoforms in murine palatogenesis. Development 109:585\u2013595","journal-title":"Development"},{"key":"612_CR15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0925-4773(91)90048-B","volume":"34","author":"ME Fortini","year":"1991","unstructured":"Fortini ME, Lai ZC, Rubin GM (1991) The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Mech Dev 34:113\u2013122","journal-title":"Mech Dev"},{"key":"612_CR16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1242\/dev.119.2.433","volume":"119","author":"J Funahashi","year":"1993","unstructured":"Funahashi J, Sekido R, Murai K, Kamachi Y, Kondoh H (1993) Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Development 119:433\u2013446","journal-title":"Development"},{"key":"612_CR17","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1128\/MCB.19.12.8581","volume":"19","author":"T Furusawa","year":"1999","unstructured":"Furusawa T, Moribe H, Kondoh H, Higashi Y (1999) Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol 19:8581\u20138590","journal-title":"Mol Cell Biol"},{"key":"612_CR18","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1128\/MCB.14.9.6153","volume":"14","author":"T Genetta","year":"1994","unstructured":"Genetta T, Ruezinsky D, Kadesch T (1994) Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol 14:6153\u20136163","journal-title":"Mol Cell Biol"},{"key":"612_CR19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ydbio.2006.07.042","volume":"301","author":"A Gritli-Linde","year":"2007","unstructured":"Gritli-Linde A (2007) Molecular control of secondary palate development. Dev Biol 301:309\u2013326","journal-title":"Dev Biol"},{"key":"612_CR20","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.185.8.1467","volume":"185","author":"Y Higashi","year":"1997","unstructured":"Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, Kikutani H, Kondoh H (1997) Impairment of T cell development in deltaEF1 mutant mice. J Exp Med 185:1467\u20131479","journal-title":"J Exp Med"},{"key":"612_CR21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1469-7580.2005.00474.x","volume":"207","author":"SA Hilliard","year":"2005","unstructured":"Hilliard SA, Yu L, Gu S, Zhang Z, Chen YP (2005) Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice. J Anat 207:655\u2013667","journal-title":"J Anat"},{"key":"612_CR22","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1101\/gad.12.7.1046","volume":"12","author":"R Jiang","year":"1998","unstructured":"Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T (1998) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev 12:1046\u20131057","journal-title":"Genes Dev"},{"key":"612_CR23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/dvdy.20641","volume":"235","author":"JZ Jin","year":"2006","unstructured":"Jin JZ, Ding J (2006) Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate. Dev Dyn 235:539\u2013546","journal-title":"Dev Dyn"},{"key":"612_CR24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","volume":"11","author":"V Kaartinen","year":"1995","unstructured":"Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (1995) Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11:415\u2013421","journal-title":"Nat Genet"},{"key":"612_CR25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0925-4773(91)90049-C","volume":"34","author":"ZC Lai","year":"1991","unstructured":"Lai ZC, Fortini ME, Rubin GM (1991) The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins. Mech Dev 34:123\u2013134","journal-title":"Mech Dev"},{"key":"612_CR26","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1242\/dev.01175","volume":"131","author":"Y Lan","year":"2004","unstructured":"Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R (2004) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131:3207\u20133216","journal-title":"Development"},{"key":"612_CR27","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0003-9969(01)00044-9","volume":"46","author":"IO Lavrin","year":"2001","unstructured":"Lavrin IO, McLean W, Seegmiller RE, Olsen BR, Hay ED (2001) The mechanism of palatal clefting in the Col11a1 mutant mouse. Arch Oral Biol 46:865\u2013869","journal-title":"Arch Oral Biol"},{"key":"612_CR28","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.01676","volume":"132","author":"W Liu","year":"2005","unstructured":"Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, Martin JF (2005) Distinct functions for Bmp signaling in lip and palate fusion in mice. Development 132:1453\u20131461","journal-title":"Development"},{"key":"612_CR29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1440-169x.2000.00523.x","volume":"42","author":"H Moribe","year":"2000","unstructured":"Moribe H, Takagi T, Kondoh H, Higashi Y (2000) Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation. Dev Growth Differ 42:367\u2013376","journal-title":"Dev Growth Differ"},{"key":"612_CR30","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1172\/JCI200422154","volume":"113","author":"JC Murray","year":"2004","unstructured":"Murray JC, Schutte BC (2004) Cleft palate: players, pathways, and pursuits. J Clin Invest 113:1676\u20131678","journal-title":"J Clin Invest"},{"key":"612_CR31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.devcel.2006.05.011","volume":"11","author":"G Nishimura","year":"2006","unstructured":"Nishimura G, Manabe I, Tsushima K, Fujiu K, Oishi Y, Imai Y, Maemura K, Miyagishi M, Higashi Y, Kondoh H, Nagai R (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell 11:93\u2013104","journal-title":"Dev Cell"},{"key":"612_CR32","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0012-1606(90)90401-4","volume":"141","author":"RW Pelton","year":"1990","unstructured":"Pelton RW, Hogan BL, Miller DA, Moses HL (1990) Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. Dev Biol 141:456\u2013460","journal-title":"Dev Biol"},{"key":"612_CR33","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/emboj\/cdg225","volume":"22","author":"AA Postigo","year":"2003","unstructured":"Postigo AA (2003) Opposing functions of ZEB proteins in the regulation of the TGFbeta\/BMP signaling pathway. EMBO J 22:2443\u20132452","journal-title":"EMBO J"},{"key":"612_CR34","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1093\/emboj\/16.13.3935","volume":"16","author":"AA Postigo","year":"1997","unstructured":"Postigo AA, Dean DC (1997) ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J 16:3935\u20133943","journal-title":"EMBO J"},{"key":"612_CR35","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1073\/pnas.96.12.6683","volume":"96","author":"AA Postigo","year":"1999","unstructured":"Postigo AA, Dean DC (1999) ZEB represses transcription through interaction with the corepressor CtBP. Proc Natl Acad Sci USA 96:6683\u20136688","journal-title":"Proc Natl Acad Sci USA"},{"key":"612_CR36","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/emboj\/cdg226","volume":"22","author":"AA Postigo","year":"2003","unstructured":"Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003) Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 22:2453\u20132462","journal-title":"EMBO J"},{"key":"612_CR37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng1295-409","volume":"11","author":"G Proetzel","year":"1995","unstructured":"Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MW, Doetschman T (1995) Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet 11:409\u2013414","journal-title":"Nat Genet"},{"key":"612_CR38","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/154405910508400608","volume":"84","author":"P Pungchanchaikul","year":"2005","unstructured":"Pungchanchaikul P, Gelbier M, Ferretti P, Bloch-Zupan A (2005) Gene expression during palate fusion in vivo and in vitro. J Dent Res 84:526\u2013531","journal-title":"J Dent Res"},{"key":"612_CR39","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1172\/JCI20384","volume":"113","author":"R Rice","year":"2004","unstructured":"Rice R, Spencer-Dene B, Connor EC, Gritli-Linde A, McMahon AP, Dickson C, Thesleff I, Rice DP (2004) Disruption of Fgf10\/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 113:1692\u20131700","journal-title":"J Clin Invest"},{"key":"612_CR40","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","volume":"124","author":"LP Sanford","year":"1997","unstructured":"Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, Boivin GP, Cardell EL, Doetschman T (1997) TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124:2659\u20132670","journal-title":"Development"},{"key":"612_CR41","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng0494-348","volume":"6","author":"I Satokata","year":"1994","unstructured":"Satokata I, Maas R (1994) Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet 6:348\u2013356","journal-title":"Nat Genet"},{"key":"612_CR42","first-page":"227","volume":"38","author":"RE Seegmiller","year":"1977","unstructured":"Seegmiller RE, Fraser FC (1977) Mandibular growth retardation as a cause of cleft palate in mice homozygous for the chondrodysplasia gene. J Embryol Exp Morphol 38:227\u2013238","journal-title":"J Embryol Exp Morphol"},{"key":"612_CR43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0378-1119(96)00185-0","volume":"173","author":"R Sekido","year":"1996","unstructured":"Sekido R, Takagi T, Okanami M, Moribe H, Yamamura M, Higashi Y, Kondoh H (1996) Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains. Gene 173:227\u2013232","journal-title":"Gene"},{"key":"612_CR44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/meth.2001.1152","volume":"24","author":"MM Shen","year":"2001","unstructured":"Shen MM (2001) Identification of differentially expressed genes in mouse development using differential display and in situ hybridization. Methods 24:15\u201327","journal-title":"Methods"},{"key":"612_CR45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dev.125.1.21","volume":"125","author":"T Takagi","year":"1998","unstructured":"Takagi T, Moribe H, Kondoh H, Higashi Y (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development 125:21\u201331","journal-title":"Development"},{"key":"612_CR46","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1242\/dev.126.17.3869","volume":"126","author":"Y Taya","year":"1999","unstructured":"Taya Y, O\u2019Kane S, Ferguson MW (1999) Pathogenesis of cleft palate in TGF-beta3 knockout mice. Development 126:3869\u20133879","journal-title":"Development"},{"key":"612_CR47","doi-asserted-by":"crossref","first-page":"20489","DOI":"10.1074\/jbc.274.29.20489","volume":"274","author":"K Verschueren","year":"1999","unstructured":"Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, Nelles L, Wuytens G, Su MT, Bodmer R, Smith JC, Huylebroeck D (1999) SIP1, a novel zinc finger\/homeodomain repressor, interacts with Smad proteins and binds to 5\u2032-CACCT sequences in candidate target genes. J Biol Chem 274:20489\u201320498","journal-title":"J Biol Chem"},{"key":"612_CR48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ydbio.2006.05.014","volume":"297","author":"X Xu","year":"2006","unstructured":"Xu X, Han J, Ito Y, Bringas P Jr, Urata MM, Chai Y (2006) Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol 297:238\u2013248","journal-title":"Dev Biol"},{"key":"612_CR49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0169-328X(01)00267-4","volume":"96","author":"G Yen","year":"2001","unstructured":"Yen G, Croci A, Dowling A, Zhang S, Zoeller RT, Darling DS (2001) Developmental and functional evidence of a role for Zfhep in neural cell development. Brain Res Mol Brain Res 96:59\u201367","journal-title":"Brain Res Mol Brain Res"},{"key":"612_CR50","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1242\/dev.02013","volume":"132","author":"L Yu","year":"2005","unstructured":"Yu L, Gu S, Alappat S, Song Y, Yan M, Zhang X, Zhang G, Jiang Y, Zhang Z, Zhang Y, Chen Y (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132:4397\u20134406","journal-title":"Development"},{"key":"612_CR51","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1242\/dev.129.17.4135","volume":"129","author":"Z Zhang","year":"2002","unstructured":"Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development 129:4135\u20134146","journal-title":"Development"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-008-0612-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-008-0612-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-008-0612-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T04:17:31Z","timestamp":1631247451000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-008-0612-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,10]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["612"],"URL":"https:\/\/doi.org\/10.1007\/s00441-008-0612-x","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,10]]}}}