{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T16:41:56Z","timestamp":1718642516778},"reference-count":47,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2009,5,12]],"date-time":"2009-05-12T00:00:00Z","timestamp":1242086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"DOI":"10.1007\/s00441-009-0807-9","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T08:32:51Z","timestamp":1243585971000},"source":"Crossref","is-referenced-by-count":3,"title":["Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes"],"prefix":"10.1007","author":[{"given":"Emmanuel B.","family":"Menashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Loftus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,5,12]]},"reference":[{"key":"807_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0898-6568(99)00076-5","volume":"12","author":"H Avraham","year":"2000","unstructured":"Avraham H, Park SY, Schinkmann K, Avraham S (2000) RAFTK\/Pyk2-mediated cellular signalling. Cell Signal 12:123\u2013133","journal-title":"Cell Signal"},{"key":"807_CR2","doi-asserted-by":"crossref","first-page":"27742","DOI":"10.1074\/jbc.270.46.27742","volume":"270","author":"S Avraham","year":"1995","unstructured":"Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S, Pasztor LM, White RA, Groopman JE, et al (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem 270:27742\u201327751","journal-title":"J Biol Chem"},{"key":"807_CR3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1006\/jmcc.2001.1369","volume":"33","author":"AL Bayer","year":"2001","unstructured":"Bayer AL, Ferguson AG, Lucchesi PA, Samarel AM (2001) Pyk2 expression and phosphorylation in neonatal and adult cardiomyocytes. J Mol Cell Cardiol 33:1017\u20131030","journal-title":"J Mol Cell Cardiol"},{"key":"807_CR4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0022-2828(03)00228-1","volume":"35","author":"AL Bayer","year":"2003","unstructured":"Bayer AL, Heidkamp MC, Howes AL, Heller Brown J, Byron KL, Samarel AM (2003) Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. J Mol Cell Cardiol 35:1121\u20131133","journal-title":"J Mol Cell Cardiol"},{"key":"807_CR5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cardiores.2005.12.015","volume":"70","author":"M Brancaccio","year":"2006","unstructured":"Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G (2006) Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res 70:422\u2013433","journal-title":"Cardiovasc Res"},{"key":"807_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0955-0674(99)80013-1","volume":"11","author":"A Bretscher","year":"1999","unstructured":"Bretscher A (1999) Regulation of cortical structure by the ezrin-radixin-moesin protein family. Curr Opin Cell Biol 11:109\u2013116","journal-title":"Curr Opin Cell Biol"},{"key":"807_CR7","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1038\/sj.onc.1203082","volume":"18","author":"D Chauhan","year":"1999","unstructured":"Chauhan D, Hideshima T, Pandey P, Treon S, Teoh G, Raje N, Rosen S, Krett N, Husson H, Avraham S, Kharbanda S, Anderson KC (1999) RAFTK\/PYK2-dependent and -independent apoptosis in multiple myeloma cells. Oncogene 18:6733\u20136740","journal-title":"Oncogene"},{"key":"807_CR8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0968-0004(98)01237-7","volume":"23","author":"AH Chishti","year":"1998","unstructured":"Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ Jr, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Hoover KB, et al (1998) The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci 23:281\u2013282","journal-title":"Trends Biochem Sci"},{"key":"807_CR9","doi-asserted-by":"crossref","first-page":"64H","DOI":"10.1016\/S0002-9149(99)00261-1","volume":"83","author":"A Clerk","year":"1999","unstructured":"Clerk A, Sugden PH (1999) Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists. Am J Cardiol 83:64H\u201369H","journal-title":"Am J Cardiol"},{"key":"807_CR10","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1073\/pnas.94.15.8121","volume":"94","author":"DD D\u2019Angelo","year":"1997","unstructured":"D\u2019Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW 2nd (1997) Transgenic G\u03b1q overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA 94:8121\u20138126","journal-title":"Proc Natl Acad Sci USA"},{"key":"807_CR11","first-page":"2977","volume":"114","author":"QS Du","year":"2001","unstructured":"Du QS, Ren XR, Xie Y, Wang Q, Mei L, Xiong WC (2001) Inhibition of PYK2-induced actin cytoskeleton reorganization, PYK2 autophosphorylation and focal adhesion targeting by FAK. J Cell Sci 114:2977\u20132987","journal-title":"J Cell Sci"},{"key":"807_CR12","doi-asserted-by":"crossref","first-page":"45644","DOI":"10.1074\/jbc.M201779200","volume":"277","author":"JM Dunty","year":"2002","unstructured":"Dunty JM, Schaller MD (2002) The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology. J Biol Chem 277:45644\u201345654","journal-title":"J Biol Chem"},{"key":"807_CR13","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1128\/MCB.24.12.5353-5368.2004","volume":"24","author":"JM Dunty","year":"2004","unstructured":"Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD (2004) FERM domain interaction promotes FAK signaling. Mol Cell Biol 24:5353\u20135368","journal-title":"Mol Cell Biol"},{"key":"807_CR14","doi-asserted-by":"crossref","first-page":"H1695","DOI":"10.1152\/ajpheart.2000.278.5.H1695","volume":"278","author":"DM Eble","year":"2000","unstructured":"Eble DM, Strait JB, Govindarajan G, Lou J, Byron KL, Samarel AM (2000) Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase. Am J Physiol Heart Circ Physiol 278:H1695\u2013H1707","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"807_CR15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.RES.87.7.558","volume":"87","author":"KG Franchini","year":"2000","unstructured":"Franchini KG, Torsoni AS, Soares PH, Saad MJ (2000) Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart. Circ Res 87:558\u2013565","journal-title":"Circ Res"},{"key":"807_CR16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/BF03401769","volume":"4","author":"JA Girault","year":"1998","unstructured":"Girault JA, Labesse G, Mornon JP, Callebaut I (1998) Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction. Mol Med 4:751\u2013769","journal-title":"Mol Med"},{"key":"807_CR17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbrc.2004.07.119","volume":"322","author":"D Hayashi","year":"2004","unstructured":"Hayashi D, Kudoh S, Shiojima I, Zou Y, Harada K, Shimoyama M, Imai Y, Monzen K, Yamazaki T, Yazaki Y, Nagai R, Komuro I (2004) Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1. Biochem Biophys Res Commun 322:310\u2013319","journal-title":"Biochem Biophys Res Commun"},{"key":"807_CR18","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/01.RES.0000023201.41774.EA","volume":"90","author":"MC Heidkamp","year":"2002","unstructured":"Heidkamp MC, Bayer AL, Kalina JA, Eble DM, Samarel AM (2002) GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes. Circ Res 90:1282\u20131289","journal-title":"Circ Res"},{"key":"807_CR19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/cm.970210202","volume":"21","author":"LL Hilenski","year":"1992","unstructured":"Hilenski LL, Ma XH, Vinson N, Terracio L, Borg TK (1992) The role of \u03b21 integrin in spreading and myofibrillogenesis in neonatal rat cardiomyocytes in vitro. Cell Motil Cytoskeleton 21:87\u2013100","journal-title":"Cell Motil Cytoskeleton"},{"key":"807_CR20","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.yjmcc.2004.03.002","volume":"36","author":"S Hirotani","year":"2004","unstructured":"Hirotani S, Higuchi Y, Nishida K, Nakayama H, Yamaguchi O, Hikoso S, Takeda T, Kashiwase K, Watanabe T, Asahi M, Taniike M, Tsujimoto I, Matsumura Y, Sasaki T, Hori M, Otsu K (2004) Ca2+-sensitive tyrosine kinase Pyk2\/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy. J Mol Cell Cardiol 36:799\u2013807","journal-title":"J Mol Cell Cardiol"},{"key":"807_CR21","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","volume":"341","author":"JJ Hunter","year":"1999","unstructured":"Hunter JJ, Chien KR (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341:1276\u20131283","journal-title":"N Engl J Med"},{"key":"807_CR22","first-page":"13809","volume":"265","author":"K Iwaki","year":"1990","unstructured":"Iwaki K, Sukhatme VP, Shubeita HE, Chien KR (1990) \u03b1- and \u03b2-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos\/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an \u03b11-mediated response. J Biol Chem 265:13809\u201313817","journal-title":"J Biol Chem"},{"key":"807_CR23","first-page":"7759","volume":"266","author":"KU Knowlton","year":"1991","unstructured":"Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR (1991) Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during \u03b1-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem 266:7759\u20137768","journal-title":"Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem"},{"key":"807_CR24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/jmcc.2001.1496","volume":"34","author":"H Kodama","year":"2002","unstructured":"Kodama H, Fukuda K, Takahashi T, Sano M, Kato T, Tahara S, Hakuno D, Sato T, Manabe T, Konishi F, Ogawa S (2002) Role of EGF Receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes. J Mol Cell Cardiol 34:139\u2013150","journal-title":"J Mol Cell Cardiol"},{"key":"807_CR25","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.HYP.0000069698.11814.F4","volume":"41","author":"H Kodama","year":"2003","unstructured":"Kodama H, Fukuda K, Takahashi E, Tahara S, Tomita Y, Ieda M, Kimura K, Owada KM, Vuori K, Ogawa S (2003) Selective involvement of p130Cas\/Crk\/Pyk2\/c-Src in endothelin-1-induced JNK activation. Hypertension 41:1372\u20131379","journal-title":"Hypertension"},{"key":"807_CR26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/BJ20070665","volume":"410","author":"T Kohno","year":"2008","unstructured":"Kohno T, Matsuda E, Sasaki H, Sasaki T (2008) Protein-tyrosine kinase CAK\u03b2\/PYK2 is activated by binding Ca2+\/calmodulin to FERM F2 \u03b12 helix and thus forming its dimer. Biochem J 410:513\u2013523","journal-title":"Biochem J"},{"key":"807_CR27","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1091\/mbc.12.8.2290","volume":"12","author":"B Kovacic-Milivojevic","year":"2001","unstructured":"Kovacic-Milivojevic B, Roediger F, Almeida EA, Damsky CH, Gardner DG, Ilic D (2001) Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Mol Biol Cell 12:2290\u20132307","journal-title":"Mol Biol Cell"},{"key":"807_CR28","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1074\/jbc.272.7.4500","volume":"272","author":"D Kuppuswamy","year":"1997","unstructured":"Kuppuswamy D, Kerr C, Narishige T, Kasi VS, Menick DR, Gt C (1997) Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J Biol Chem 272:4500\u20134508","journal-title":"J Biol Chem"},{"key":"807_CR29","first-page":"323","volume":"1","author":"CA Lipinski","year":"2003","unstructured":"Lipinski CA, Tran NL, Bay C, Kloss J, McDonough WS, Beaudry C, Berens ME, Loftus JC (2003) Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation. Mol Cancer Res 1:323\u2013332","journal-title":"Mol Cancer Res"},{"key":"807_CR30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.bbrc.2006.08.134","volume":"349","author":"CA Lipinski","year":"2006","unstructured":"Lipinski CA, Tran NL, Dooley A, Pang YP, Rohl C, Kloss J, Yang Z, McDonough W, Craig D, Berens ME, Loftus JC (2006) Critical role of the FERM domain in Pyk2 stimulated glioma cell migration. Biochem Biophys Res Commun 349:939\u2013947","journal-title":"Biochem Biophys Res Commun"},{"key":"807_CR31","doi-asserted-by":"crossref","first-page":"H625","DOI":"10.1152\/ajpcell.1993.264.3.C625","volume":"264","author":"PM McDonough","year":"1993","unstructured":"McDonough PM, Brown JH, Glembotski CC (1993) Phenylephrine and endothelin differentially stimulate cardiac PI hydrolysis and ANF expression. Am J Physiol 264:H625\u2013H630","journal-title":"Am J Physiol"},{"key":"807_CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0959-437X(99)80040-9","volume":"9","author":"TA McKinsey","year":"1999","unstructured":"McKinsey TA, Olson EN (1999) Cardiac hypertrophy: sorting out the circuitry. Curr Opin Genet Dev 9:267\u2013274","journal-title":"Curr Opin Genet Dev"},{"key":"807_CR33","doi-asserted-by":"crossref","first-page":"45203","DOI":"10.1074\/jbc.M204886200","volume":"277","author":"J Melendez","year":"2002","unstructured":"Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA (2002) Activation of pyk2\/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J Biol Chem 277:45203\u201345210","journal-title":"J Biol Chem"},{"key":"807_CR34","doi-asserted-by":"crossref","first-page":"53516","DOI":"10.1074\/jbc.M408475200","volume":"279","author":"J Melendez","year":"2004","unstructured":"Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA (2004) Cardiomyocyte apoptosis triggered by RAFTK\/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 279:53516\u201353523","journal-title":"J Biol Chem"},{"key":"807_CR35","doi-asserted-by":"crossref","first-page":"33315","DOI":"10.1074\/jbc.M313527200","volume":"279","author":"SY Park","year":"2004","unstructured":"Park SY, Avraham HK, Avraham S (2004) RAFTK\/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. J Biol Chem 279:33315\u201333322","journal-title":"J Biol Chem"},{"key":"807_CR36","doi-asserted-by":"crossref","first-page":"H2916","DOI":"10.1152\/ajpheart.2000.279.6.H2916","volume":"279","author":"CG Pham","year":"2000","unstructured":"Pham CG, Harpf AE, Keller RS, Vu HT, Shai SY, Loftus JC, Ross RS (2000) Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am J Physiol Heart Circ Physiol 279:H2916\u2013H2926","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"807_CR37","doi-asserted-by":"crossref","first-page":"C90","DOI":"10.1152\/ajpcell.2001.280.1.C90","volume":"280","author":"P Rocic","year":"2001","unstructured":"Rocic P, Govindarajan G, Sabri A, Lucchesi PA (2001) A role for PYK2 in regulation of ERK1\/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle. Am J Physiol Cell Physiol 280:C90\u2013C99","journal-title":"Am J Physiol Cell Physiol"},{"key":"807_CR38","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/01.RES.82.11.1160","volume":"82","author":"RS Ross","year":"1998","unstructured":"Ross RS, Pham C, Shai SY, Goldhaber JI, Fenczik C, Glembotski CC, Ginsberg MH, Loftus JC (1998) \u03b21 Integrins participate in the hypertrophic response of rat ventricular myocytes. Circ Res 82:1160\u20131172","journal-title":"Circ Res"},{"key":"807_CR39","doi-asserted-by":"crossref","first-page":"21206","DOI":"10.1074\/jbc.270.36.21206","volume":"270","author":"H Sasaki","year":"1995","unstructured":"Sasaki H, Nagura K, Ishino M, Tobioka H, Kotani K, Sasaki T (1995) Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J Biol Chem 270:21206\u201321219","journal-title":"J Biol Chem"},{"key":"807_CR40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35010517","volume":"2","author":"DJ Sieg","year":"2000","unstructured":"Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2:249\u2013256","journal-title":"Nat Cell Biol"},{"key":"807_CR41","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1172\/JCI111023","volume":"72","author":"P Simpson","year":"1983","unstructured":"Simpson P (1983) Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an \u03b1 1 adrenergic response. J Clin Invest 72:732\u2013738","journal-title":"J Clin Invest"},{"key":"807_CR42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.RES.51.6.787","volume":"51","author":"P Simpson","year":"1982","unstructured":"Simpson P, McGrath A, Savion S (1982) Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines. Circ Res 51:787\u2013801","journal-title":"Circ Res"},{"key":"807_CR43","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/01.RES.84.6.633","volume":"84","author":"PH Sugden","year":"1999","unstructured":"Sugden PH (1999) Signaling in myocardial hypertrophy: life after calcineurin? Circ Res 84:633\u2013646","journal-title":"Circ Res"},{"key":"807_CR44","doi-asserted-by":"crossref","first-page":"19250","DOI":"10.1074\/jbc.M909099199","volume":"275","author":"JM Taylor","year":"2000","unstructured":"Taylor JM, Rovin JD, Parsons JT (2000) A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. J Biol Chem 275:19250\u201319257","journal-title":"J Biol Chem"},{"key":"807_CR45","first-page":"30580","volume":"269","author":"J Thorburn","year":"1994","unstructured":"Thorburn J, McMahon M, Thorburn A (1994) Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J Biol Chem 269:30580\u201330586","journal-title":"J Biol Chem"},{"key":"807_CR46","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/emboj\/16.8.1888","volume":"16","author":"J Thorburn","year":"1997","unstructured":"Thorburn J, Xu S, Thorburn A (1997) MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J 16:1888\u20131900","journal-title":"EMBO J"},{"key":"807_CR47","first-page":"3063","volume":"113","author":"J Zhao","year":"2000","unstructured":"Zhao J, Zheng C, Guan J (2000) Pyk2 and FAK differentially regulate progression of the cell cycle. J Cell Sci 113:3063\u20133072","journal-title":"J Cell Sci"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-009-0807-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-009-0807-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-009-0807-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:56:27Z","timestamp":1559134587000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-009-0807-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,12]]},"references-count":47,"alternative-id":["807"],"URL":"https:\/\/doi.org\/10.1007\/s00441-009-0807-9","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,12]]}}}