{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:30:18Z","timestamp":1777534218075,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,9,2]],"date-time":"2012-09-02T00:00:00Z","timestamp":1346544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s00441-012-1488-3","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T20:39:32Z","timestamp":1346531972000},"page":"401-407","source":"Crossref","is-referenced-by-count":8,"title":["Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates"],"prefix":"10.1007","volume":"350","author":[{"given":"Rehana K.","family":"Leak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krassimira A.","family":"Garbett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Dettmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"Mirnics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy L.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,2]]},"reference":[{"key":"1488_CR1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1471-4159.2001.00608.x","volume":"79","author":"D Berg","year":"2001","unstructured":"Berg D, Gerlach M, Youdim MB, Double KL, Zecca L, Riederer P, Becker G (2001) Brain iron pathways and their relevance to Parkinson\u2019s disease. J Neurochem 79:225\u2013236","journal-title":"J Neurochem"},{"key":"1488_CR2","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00415-009-0063-7","volume":"255","author":"KJ Bharucha","year":"2008","unstructured":"Bharucha KJ, Friedman JK, Vincent AS, Ross ED (2008) Lower serum ceruloplasmin levels correlate with younger age of onset in Parkinson\u2019s disease. J Neurol 255:1957\u20131962","journal-title":"J Neurol"},{"key":"1488_CR3","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s11064-008-9610-3","volume":"33","author":"MC Boll","year":"2008","unstructured":"Boll MC, Alcaraz-Zubeldia M, Montes S, Rios C (2008) Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases. Neurochem Res 33:1717\u20131723","journal-title":"Neurochem Res"},{"key":"1488_CR4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.expneurol.2008.04.027","volume":"212","author":"F Ding","year":"2008","unstructured":"Ding F, Luan L, Ai Y, Walton A, Gerhardt GA, Gash DM, Grondin R, Zhang Z (2008) Development of a stable, early stage unilateral model of Parkinson\u2019s disease in middle-aged rhesus monkeys. Exp Neurol 212:431\u2013439","journal-title":"Exp Neurol"},{"key":"1488_CR5","doi-asserted-by":"crossref","DOI":"10.1016\/S0079-6123(08)61883-X","volume-title":"The nucleus accumbens: gateway for limbic structures to reach the motor system?","author":"HJ Groenewegen","year":"1996","unstructured":"Groenewegen HJ, Wright CI, Beijer AVJ (1996) The nucleus accumbens: gateway for limbic structures to reach the motor system? Elsevier, Amsterdam"},{"key":"1488_CR6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3727\/096368908784423256","volume":"17","author":"R Grondin","year":"2008","unstructured":"Grondin R, Zhang Z, Ai Y, Ding F, Walton AA, Surgener SP, Gerhardt GA, Gash DM (2008) Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys. Cell Transplant 17:373\u2013381","journal-title":"Cell Transplant"},{"key":"1488_CR7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1249\/mss.0b013e3180616b27","volume":"39","author":"WL Haskell","year":"2007","unstructured":"Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 39:1423\u20131434","journal-title":"Med Sci Sports Exerc"},{"key":"1488_CR8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0301-0082(98)00041-0","volume":"56","author":"W Hauber","year":"1998","unstructured":"Hauber W (1998) Involvement of basal ganglia transmitter systems in movement initiation. Prog Neurobiol 56:507\u2013540","journal-title":"Prog Neurobiol"},{"key":"1488_CR9","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s11064-011-0537-8","volume":"36","author":"A Hineno","year":"2011","unstructured":"Hineno A, Kaneko K, Yoshida K, Ikeda S (2011) Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity. Neurochem Res 36:2127\u20132135","journal-title":"Neurochem Res"},{"key":"1488_CR10","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1046\/j.1460-9568.2003.02946.x","volume":"18","author":"C Jan","year":"2003","unstructured":"Jan C, Pessiglione M, Tremblay L, Tande D, Hirsch EC, Francois C (2003) Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys. Eur J Neurosci 18:2082\u20132086","journal-title":"Eur J Neurosci"},{"key":"1488_CR11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2008.08.089","volume":"446","author":"K Kaneko","year":"2008","unstructured":"Kaneko K, Hineno A, Yoshida K, Ikeda S (2008) Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice. Neurosci Lett 446:56\u201358","journal-title":"Neurosci Lett"},{"key":"1488_CR12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2460\/javma.239.9.1201","volume":"239","author":"CL Kenyon","year":"2011","unstructured":"Kenyon CL, Basaraba RJ, Bohn AA (2011) Influence of endurance exercise on serum concentrations of iron and acute phase proteins in racing sled dogs. J Am Vet Med Assoc 239:1201\u20131210","journal-title":"J Am Vet Med Assoc"},{"key":"1488_CR13","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1460-9568.2011.07626.x","volume":"33","author":"YS Lau","year":"2011","unstructured":"Lau YS, Patki G, Das-Panja K, Le WD, Ahmad SO (2011) Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson\u2019s disease with moderate neurodegeneration. Eur J Neurosci 33:1264\u20131274","journal-title":"Eur J Neurosci"},{"key":"1488_CR14","doi-asserted-by":"crossref","first-page":"17124","DOI":"10.1016\/S0021-9258(19)47348-1","volume":"266","author":"B Bourdelles Le","year":"1991","unstructured":"Le Bourdelles B, Horellou P, Le Caer JP, Denefle P, Latta M, Haavik J, Guibert B, Mayaux JF, Mallet J (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing. J Biol Chem 266:17124\u201317130","journal-title":"J Biol Chem"},{"key":"1488_CR15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1471-4159.2006.04149.x","volume":"99","author":"RK Leak","year":"2006","unstructured":"Leak RK, Liou AK, Zigmond MJ (2006) Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning. J Neurochem 99:1151\u20131163","journal-title":"J Neurochem"},{"key":"1488_CR16","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1471-4159.2008.05459.x","volume":"106","author":"RK Leak","year":"2008","unstructured":"Leak RK, Zigmond MJ, Liou AK (2008) Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism. J Neurochem 106:860\u2013874","journal-title":"J Neurochem"},{"key":"1488_CR17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jneumeth.2010.06.023","volume":"191","author":"RK Leak","year":"2010","unstructured":"Leak RK, Castro SL, Jaumotte JD, Smith AD, Zigmond MJ (2010) Assaying multiple biochemical variables from the same tissue sample. J Neurosci Methods 191:234\u2013238","journal-title":"J Neurosci Methods"},{"key":"1488_CR18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00430954","volume":"37","author":"H Liesen","year":"1977","unstructured":"Liesen H, Dufaux B, Hollmann W (1977) Modifications of serum glycoproteins the days following a prolonged physical exercise and the influence of physical training. Eur J Appl Physiol Occup Physiol 37:243\u2013254","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"1488_CR19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0006-8993(96)00782-2","volume":"738","author":"DA Loeffler","year":"1996","unstructured":"Loeffler DA, LeWitt PA, Juneau PL, Sima AA, Nguyen HU, DeMaggio AJ, Brickman CM, Brewer GJ, Dick RD, Troyer MD, Kanaley L (1996) Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders. Brain Res 738:265\u2013274","journal-title":"Brain Res"},{"key":"1488_CR20","doi-asserted-by":"crossref","first-page":"20185","DOI":"10.1074\/jbc.272.32.20185","volume":"272","author":"BN Patel","year":"1997","unstructured":"Patel BN, David S (1997) A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J Biol Chem 272:20185\u201320190","journal-title":"J Biol Chem"},{"key":"1488_CR21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.arr.2007.04.004","volume":"7","author":"Z Radak","year":"2008","unstructured":"Radak Z, Chung HY, Koltai E, Taylor AW, Goto S (2008) Exercise, oxidative stress and hormesis. Ageing Res Rev 7:34\u201342","journal-title":"Ageing Res Rev"},{"key":"1488_CR22","first-page":"413","volume":"31","author":"A Resina","year":"1991","unstructured":"Resina A, Gatteschi L, Rubenni MG, Giamberardino MA, Imreh F (1991) Comparison of some serum copper parameters in trained professional soccer players and control subjects. J Sports Med Phys Fitness 31:413\u2013416","journal-title":"J Sports Med Phys Fitness"},{"key":"1488_CR23","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.neuroscience.2010.03.003","volume":"167","author":"IJ Rhyu","year":"2010","unstructured":"Rhyu IJ, Bytheway JA, Kohler SJ, Lange H, Lee KJ, Boklewski J, McCormick K, Williams NI, Stanton GB, Greenough WT, Cameron JL (2010) Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys. Neuroscience 167:1239\u20131248","journal-title":"Neuroscience"},{"key":"1488_CR24","doi-asserted-by":"crossref","first-page":"R1068","DOI":"10.1152\/ajpregu.00617.2009","volume":"298","author":"EL Sullivan","year":"2010","unstructured":"Sullivan EL, Cameron JL (2010) A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. Am J Physiol Regul Integr Comp Physiol 298:R1068\u2013R1074","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1488_CR25","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1042\/BST0361277","volume":"36","author":"SJ Texel","year":"2008","unstructured":"Texel SJ, Xu X, Harris ZL (2008) Ceruloplasmin in neurodegenerative diseases. Biochem Soc Trans 36:1277\u20131281","journal-title":"Biochem Soc Trans"},{"key":"1488_CR26","doi-asserted-by":"crossref","first-page":"e25077","DOI":"10.1371\/journal.pone.0025077","volume":"6","author":"SJ Texel","year":"2011","unstructured":"Texel SJ, Zhang J, Camandola S, Unger EL, Taub DD, Koehler RC, Harris ZL, Mattson MP (2011) Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke. PLoS One 6:e25077","journal-title":"PLoS One"},{"key":"1488_CR27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jns.2010.08.047","volume":"299","author":"G Torsdottir","year":"2010","unstructured":"Torsdottir G, Kristinsson J, Snaedal J, Sveinbjornsdottir S, Gudmundsson G, Hreidarsson S, Johannesson T (2010) Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review. J Neurol Sci 299:51\u201354","journal-title":"J Neurol Sci"},{"key":"1488_CR28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","volume":"75","author":"Q Xu","year":"2010","unstructured":"Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H (2010) Physical activities and future risk of Parkinson disease. Neurology 75:341\u2013348","journal-title":"Neurology"},{"key":"1488_CR29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.conb.2010.06.005","volume":"20","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Barres BA (2010) Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol 20:588\u2013594","journal-title":"Curr Opin Neurobiol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-012-1488-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-012-1488-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-012-1488-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T01:57:28Z","timestamp":1643335048000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-012-1488-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,2]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1488"],"URL":"https:\/\/doi.org\/10.1007\/s00441-012-1488-3","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,2]]}}}