{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:09:25Z","timestamp":1790680165884,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00441-014-1848-2","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T02:42:41Z","timestamp":1397702561000},"page":"279-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I:C)"],"prefix":"10.1007","volume":"357","author":[{"given":"Kaori","family":"Kanaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Suzukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Kikuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yamasoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,18]]},"reference":[{"key":"1848_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(01)78001-7","volume":"78","author":"S Akira","year":"2001","unstructured":"Akira S (2001) Toll-like receptors and innate immunity. Adv Immunol 78:1\u201356","journal-title":"Adv Immunol"},{"key":"1848_CR2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","volume":"413","author":"L Alexopoulou","year":"2001","unstructured":"Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732\u2013738","journal-title":"Nature"},{"key":"1848_CR3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/eji.1830111013","volume":"11","author":"JM Austyn","year":"1981","unstructured":"Austyn JM, Gordon S (1981) F4\/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 11:805\u2013815","journal-title":"Eur J Immunol"},{"key":"1848_CR4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.902850207","volume":"285","author":"H Baker","year":"1989","unstructured":"Baker H, Grillo M, Margolis FL (1989) Biochemical and immunocytochemical characterization of olfactory marker protein in the rodent central nervous system. J Comp Neurol 285:246\u2013261","journal-title":"J Comp Neurol"},{"key":"1848_CR5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1165\/ajrcmb\/9.4.455","volume":"9","author":"M Bedard","year":"1993","unstructured":"Bedard M, McClure CD, Schiller NL, Francoeur C, Cantin A, Denis M (1993) Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am J Respir Cell Mol Biol 9:455\u2013462","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1848_CR6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cellsig.2008.12.001","volume":"21","author":"J Berube","year":"2009","unstructured":"Berube J, Bourdon C, Yao Y, Rousseau S (2009) Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1\/TLR2, TLR3 or NOD1 activated human airway epithelial cells. Cell Signal 21:448\u2013456","journal-title":"Cell Signal"},{"key":"1848_CR7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/590671","volume":"198","author":"N Boivin","year":"2008","unstructured":"Boivin N, Sergerie Y, Rivest S, Boivin G (2008) Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis. J Infect Dis 198:664\u2013672","journal-title":"J Infect Dis"},{"key":"1848_CR8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0773.1995.tb00107.x","volume":"76","author":"EB Brittebo","year":"1995","unstructured":"Brittebo EB (1995) Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa. Pharmacol Toxicol 76:76\u201379","journal-title":"Pharmacol Toxicol"},{"issue":"Suppl 13","key":"1848_CR9","first-page":"97","volume":"5","author":"S Collet","year":"2009","unstructured":"Collet S, Grulois V, Bertrand B, Rombaux P (2009) Post-traumatic olfactory dysfunction: a cohort study and update. B-ENT 5(Suppl 13):97\u2013107","journal-title":"B-ENT"},{"key":"1848_CR10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1189\/jlb.0409236","volume":"87","author":"JM Daley","year":"2010","unstructured":"Daley JM, Brancato SK, Thomay AA, Reichner JS, Albina JE (2010) The phenotype of murine wound macrophages. J Leukoc Biol 87:59\u201367","journal-title":"J Leukoc Biol"},{"key":"1848_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0196-0709(79)80010-1","volume":"1","author":"RL Doty","year":"1979","unstructured":"Doty RL (1979) A review of olfactory dysfunctions in man. Am J Otolaryngol 1:57\u201379","journal-title":"Am J Otolaryngol"},{"key":"1848_CR12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.otohns.2007.11.029","volume":"138","author":"VA Epstein","year":"2008","unstructured":"Epstein VA, Bryce PJ, Conley DB, Kern RC, Robinson AM (2008) Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in mice. Otolaryngol Head Neck Surg 138:334\u2013339","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1848_CR13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/chemse\/27.6.521","volume":"27","author":"Y Ge","year":"2002","unstructured":"Ge Y, Tsukatani T, Nishimura T, Furukawa M, Miwa T (2002) Cell death of olfactory receptor neurons in a rat with nasosinusitis infected artificially with Staphylococcus. Chem Senses 27:521\u2013527","journal-title":"Chem Senses"},{"key":"1848_CR14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/019262339502300404","volume":"23","author":"MB Genter","year":"1995","unstructured":"Genter MB, Deamer NJ, Blake BL, Wesley DS, Levi PE (1995) Olfactory toxicity of methimazole: dose\u2013response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicol Pathol 23:477\u2013486","journal-title":"Toxicol Pathol"},{"key":"1848_CR15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1165\/rcmb.2002-0055OC","volume":"28","author":"JE Gern","year":"2003","unstructured":"Gern JE, French DA, Grindle KA, Brockman-Schneider RA, Konno S, Busse WW (2003) Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells. Am J Respir Cell Mol Biol 28:731\u2013737","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1848_CR16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/ar.1092310310","volume":"231","author":"ML Getchell","year":"1991","unstructured":"Getchell ML, Getchell TV (1991) Immunohistochemical localization of components of the immune barrier in the olfactory mucosae of salamanders and rats. Anat Rec 231:358\u2013374","journal-title":"Anat Rec"},{"key":"1848_CR17","doi-asserted-by":"crossref","first-page":"G705","DOI":"10.1152\/ajpgi.2001.281.3.G705","volume":"281","author":"HH Ginzberg","year":"2001","unstructured":"Ginzberg HH, Cherapanov V, Dong Q, Cantin A, McCulloch CA, Shannon PT, Downey GP (2001) Neutrophil-mediated epithelial injury during transmigration: role of elastase. Am J Physiol Gastrointest Liver Physiol 281:G705\u2013G717","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1848_CR18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01175561","volume":"8","author":"GA Graziadei","year":"1979","unstructured":"Graziadei GA, Graziadei PP (1979) Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy. J Neurocytol 8:197\u2013213","journal-title":"J Neurocytol"},{"key":"1848_CR19","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/lary.21856","volume":"121","author":"EH Holbrook","year":"2011","unstructured":"Holbrook EH, Wu E, Curry WT, Lin DT, Schwob JE (2011) Immunohistochemical characterization of human olfactory tissue. Laryngoscope 121:1687\u20131701","journal-title":"Laryngoscope"},{"key":"1848_CR20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1096-9861(19981102)400:4<469::AID-CNE3>3.0.CO;2-8","volume":"400","author":"JM Huard","year":"1998","unstructured":"Huard JM, Youngentob SL, Goldstein BJ, Luskin MB, Schwob JE (1998) Adult olfactory epithelium contains multipotent progenitors that give rise to neurons and non-neural cells. J Comp Neurol 400:469\u2013486","journal-title":"J Comp Neurol"},{"key":"1848_CR21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0041-008X(88)90273-6","volume":"94","author":"ME Hurtt","year":"1988","unstructured":"Hurtt ME, Thomas DA, Working PK, Monticello TM, Morgan KT (1988) Degeneration and regeneration of the olfactory epithelium following inhalation exposure to methyl bromide: pathology, cell kinetics, and olfactory function. Toxicol Appl Pharmacol 94:311\u2013328","journal-title":"Toxicol Appl Pharmacol"},{"key":"1848_CR22","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/01.ta.0000217271.25809.a0","volume":"60","author":"Y Inoue","year":"2006","unstructured":"Inoue Y, Tanaka H, Ogura H, Ukai I, Fujita K, Hosotsubo H, Shimazu T, Sugimoto H (2006) A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury. J Trauma 60:936\u2013943, discussion 943","journal-title":"J Trauma"},{"key":"1848_CR23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/viro.1996.0259","volume":"219","author":"BL Jacobs","year":"1996","unstructured":"Jacobs BL, Langland JO (1996) When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219:339\u2013349","journal-title":"Virology"},{"key":"1848_CR24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.me.36.020185.001231","volume":"36","author":"A Janoff","year":"1985","unstructured":"Janoff A (1985) Elastase in tissue injury. Annu Rev Med 36:207\u2013216","journal-title":"Annu Rev Med"},{"key":"1848_CR25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.194.6.863","volume":"194","author":"N Kadowaki","year":"2001","unstructured":"Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194:863\u2013869","journal-title":"J Exp Med"},{"key":"1848_CR26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1471-4159.1975.tb03883.x","volume":"24","author":"A Keller","year":"1975","unstructured":"Keller A, Margolis FL (1975) Immunological studies of the rat olfactory marker protein. J Neurochem 24:1101\u20131106","journal-title":"J Neurochem"},{"key":"1848_CR27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature06281","volume":"450","author":"K Kobayakawa","year":"2007","unstructured":"Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, Ikawa M, Okabe M, Ikeda T, Itohara S, Kikusui T, Mori K, Sakano H (2007) Innate versus learned odour processing in the mouse olfactory bulb. Nature 450:503\u2013508","journal-title":"Nature"},{"key":"1848_CR28","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00441-008-0739-9","volume":"335","author":"K Kondo","year":"2009","unstructured":"Kondo K, Watanabe K, Sakamoto T, Suzukawa K, Nibu K, Kaga K, Yamasoba T (2009) Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman\u2019s glands in mouse olfactory mucosa: age-related progression. Cell Tissue Res 335:489\u2013503","journal-title":"Cell Tissue Res"},{"key":"1848_CR29","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1523\/JNEUROSCI.04-03-00868.1984","volume":"4","author":"RM Kream","year":"1984","unstructured":"Kream RM, Margolis FL (1984) Olfactory marker protein: turnover and transportin normal and regenerating neurons. J Neurosci 4:868\u2013879","journal-title":"J Neurosci"},{"key":"1848_CR30","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1523\/JNEUROSCI.4507-09.2010","volume":"30","author":"AP Lane","year":"2010","unstructured":"Lane AP, Turner J, May L, Reed R (2010) A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. J Neurosci 30:2324\u201323293","journal-title":"J Neurosci"},{"key":"1848_CR31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0165-3806(94)00139-1","volume":"83","author":"VM Lee","year":"1994","unstructured":"Lee VM, Pixley SK (1994) Age and differentiation-related differences in neuron-specific tubulin immunostaining of olfactory sensory neurons. Brain Res Dev Brain Res 83:209\u2013215","journal-title":"Brain Res Dev Brain Res"},{"key":"1848_CR32","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1084\/jem.20042307","volume":"201","author":"HH Lin","year":"2005","unstructured":"Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J (2005) The macrophage F4\/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med 201:1615\u20131625","journal-title":"J Exp Med"},{"key":"1848_CR33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cbi.2004.02.003","volume":"147","author":"G Ling","year":"2004","unstructured":"Ling G, Gu J, Genter MB, Zhuo X, Ding X (2004) Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chem Biol Interact 147:247\u2013258","journal-title":"Chem Biol Interact"},{"key":"1848_CR34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/chemse\/bjn074","volume":"34","author":"N Makino","year":"2009","unstructured":"Makino N, Ookawara S, Katoh K, Ohta Y, Ichikawa M, Ichimura K (2009) The morphological change of supporting cells in the olfactory epithelium after bulbectomy. Chem Senses 34:171\u2013179","journal-title":"Chem Senses"},{"key":"1848_CR35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","volume":"23","author":"A Mantovani","year":"2002","unstructured":"Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549\u2013555","journal-title":"Trends Immunol"},{"key":"1848_CR36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/chemse\/27.8.691","volume":"27","author":"V Matarazzo","year":"2002","unstructured":"Matarazzo V, Zsurger N, Guillemot JC, Clot-Faybesse O, Botto JM, Dal Farra C, Crowe M, Demaille J, Vincent JP, Mazella J, Ronin C (2002) Porcine odorant-binding protein selectively binds to a human olfactory receptor. Chem Senses 27:691\u2013701","journal-title":"Chem Senses"},{"key":"1848_CR37","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1365-2222.2006.02530.x","volume":"36","author":"S Matsukura","year":"2006","unstructured":"Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M (2006) Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and\/or IRF-3 in airway epithelial cells. Clin Exp Allergy 36:1049\u20131062","journal-title":"Clin Exp Allergy"},{"key":"1848_CR38","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","volume":"293","author":"M Matsumoto","year":"2002","unstructured":"Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 293:1364\u20131369","journal-title":"Biochem Biophys Res Commun"},{"key":"1848_CR39","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","volume":"60","author":"M Matsumoto","year":"2008","unstructured":"Matsumoto M, Seya T (2008) TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev 60:805\u2013812","journal-title":"Adv Drug Deliv Rev"},{"key":"1848_CR40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/019459989210600221","volume":"106","author":"TK Mellert","year":"1992","unstructured":"Mellert TK, Getchell ML, Sparks L, Getchell TV (1992) Characterization of the immune barrier in human olfactory mucosa. Otolaryngol Head Neck Surg 106:181\u2013188","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"1848_CR41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(83)91023-5","volume":"262","author":"GA Monti Graziadei","year":"1983","unstructured":"Monti Graziadei GA (1983) Experimental studies on the olfactory marker protein. III. The olfactory marker protein in the olfactory neuroepithelium lacking connections with the forebrain. Brain Res 262:303\u2013308","journal-title":"Brain Res"},{"key":"1848_CR42","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1099\/0022-1317-83-9-2109","volume":"83","author":"I Mori","year":"2002","unstructured":"Mori I, Goshima F, Imai Y, Kohsaka S, Sugiyama T, Yoshida T, Yokochi T, Nishiyama Y, Kimura Y (2002) Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis. J Gen Virol 83:2109\u20132116","journal-title":"J Gen Virol"},{"key":"1848_CR43","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0025-7125(16)30391-1","volume":"75","author":"AE Mott","year":"1991","unstructured":"Mott AE, Leopold DA (1991) Disorders in taste and smell. Med Clin N Am 75:1321\u20131353","journal-title":"Med Clin N Am"},{"key":"1848_CR44","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jemt.10146","volume":"58","author":"H Nagao","year":"2002","unstructured":"Nagao H, Yamaguchi M, Takahash Y, Mori K (2002) Grouping and representation of 4 odorant receptors in domains of the olfactory bulb sensory map. Microsc Res Tech 58:168\u2013175","journal-title":"Microsc Res Tech"},{"key":"1848_CR45","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI115738","volume":"89","author":"H Nakamura","year":"1992","unstructured":"Nakamura H, Yoshimura K, McElvaney NG, Crystal RG (1992) Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Investig 89:1478\u20131484","journal-title":"J Clin Investig"},{"key":"1848_CR46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.taap.2010.09.023","volume":"250","author":"T Ohkuni","year":"2011","unstructured":"Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N (2011) Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinctNF-kappaB pathways in human nasal epithelial cells. Toxicol Appl Pharmacol 250:29\u201338","journal-title":"Toxicol Appl Pharmacol"},{"key":"1848_CR47","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/AAC.36.7.1352","volume":"36","author":"K Oishi","year":"1992","unstructured":"Oishi K, Sonoda F, Iwagaki A, Kobayashi S, Nagatake T, Matsumoto K (1992) Effects of the combination of lipopolysaccharide-specific monoclonal antibodies andsparfloxacin against Pseudomonas aeruginosa pneumonia in neutropenic mice. Antimicrob Agents Chemother 36:1352\u20131357","journal-title":"Antimicrob Agents Chemother"},{"key":"1848_CR48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(93)90145-G","volume":"73","author":"KJ Ressler","year":"1993","unstructured":"Ressler KJ, Sullivan SL, Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73:597\u2013609","journal-title":"Cell"},{"key":"1848_CR49","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1177\/002215540205000710","volume":"50","author":"J Ribera","year":"2002","unstructured":"Ribera J, Ayala V, Esquerda JE (2002) c-Jun-like immunoreactivity in apoptosis is the result of a crossreaction with neoantigenic sites exposed by caspase-3-mediated proteolysis. J Histochem Cytochem 50:961\u2013972","journal-title":"J Histochem Cytochem"},{"key":"1848_CR50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0306-4522(97)00344-8","volume":"83","author":"AJ Roskams","year":"1998","unstructured":"Roskams AJ, Cai X, Ronnett GV (1998) Expression of neuron-specific beta-III tubulin during olfactory neurogenesis in the embryonic and adult rat. Neuroscience 83:191\u2013200","journal-title":"Neuroscience"},{"key":"1848_CR51","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jnr.21155","volume":"85","author":"T Sakamoto","year":"2007","unstructured":"Sakamoto T, Kondo K, Kashio A, Suzukawa K, Yamasoba T (2007) Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway. J Neurosci Res 85:548\u2013557","journal-title":"J Neurosci Res"},{"key":"1848_CR52","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.123.3.513","volume":"123","author":"C Schluter","year":"1993","unstructured":"Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, Gerdes J (1993) The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 123:513\u2013522","journal-title":"J Cell Biol"},{"key":"1848_CR53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ar.10047","volume":"269","author":"JE Schwob","year":"2002","unstructured":"Schwob JE (2002) Neural regeneration and the peripheral olfactory system. Anat Rec 269:33\u201349","journal-title":"Anat Rec"},{"key":"1848_CR54","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/chemse\/26.8.937","volume":"26","author":"JE Schwob","year":"2001","unstructured":"Schwob JE, Saha S, Youngentob SL, Jubelt B (2001) Intranasal inoculation with the olfactory bulb line variant of mouse hepatitis virus causes extensive destruction of the olfactory bulb and accelerated turnover of neurons in the olfactory epithelium of mice. Chem Senses 26:937\u2013952","journal-title":"Chem Senses"},{"key":"1848_CR55","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1523\/JNEUROSCI.12-10-03896.1992","volume":"12","author":"JE Schwob","year":"1992","unstructured":"Schwob JE, Szumowski KE, Stasky AA (1992) Olfactory sensory neurons are trophically dependent on the olfactory bulb for their prolonged survival. J Neurosci 12:3896\u20133919","journal-title":"J Neurosci"},{"key":"1848_CR56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cne.903590103","volume":"359","author":"JE Schwob","year":"1995","unstructured":"Schwob JE, Youngentob SL, Mezza RC (1995) Reconstitution of the rat olfactory epithelium after methyl bromide-induced lesion. J Comp Neurol 359:15\u2013375","journal-title":"J Comp Neurol"},{"key":"1848_CR57","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.otc.2004.06.007","volume":"37","author":"AM Seiden","year":"2004","unstructured":"Seiden AM (2004) Postviral olfactory loss. Otolaryngol Clin N Am 37:1159\u20131166","journal-title":"Otolaryngol Clin N Am"},{"key":"1848_CR58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2003-0388OC","volume":"31","author":"Q Sha","year":"2004","unstructured":"Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP (2004) Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 31:358\u2013364","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1848_CR59","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1172\/JCI114492","volume":"85","author":"CP Sommerhoff","year":"1990","unstructured":"Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH (1990) Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airwaygland serous cells. J Clin Investig 85:682\u2013689","journal-title":"J Clin Investig"},{"key":"1848_CR60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-10-43","volume":"10","author":"NC Stowell","year":"2009","unstructured":"Stowell NC, Seideman J, Raymond HA, Smalley KA, Lamb RJ, Egenolf DD, Bugelski PJ, Murray LA, Marsters PA, Bunting RA, Flavell RA, Alexopoulou L, San Mateo LR, Griswold DE, Sarisky RT, Mbow ML, Das AM (2009) Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Respir Res 10:43","journal-title":"Respir Res"},{"key":"1848_CR61","first-page":"191","volume":"538","author":"M Sugiura","year":"1998","unstructured":"Sugiura M, Aiba T, Mori J, Nakai Y (1998) An epidemiological study of postviral olfactory disorder. Acta Otolaryngol Suppl 538:191\u2013196","journal-title":"Acta Otolaryngol Suppl"},{"key":"1848_CR62","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/cne.22611","volume":"519","author":"K Suzukawa","year":"2011","unstructured":"Suzukawa K, Kondo K, Kanaya K, Sakamoto T, Watanabe K, Ushio M, Kaga K, Yamasoba T (2011) Age-related changes of the regeneration mode in the mouse peripheral olfactory system following olfactotoxic drug methimazole-induced damage. J Comp Neurol 519:2154\u20132174","journal-title":"J Comp Neurol"},{"key":"1848_CR63","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/(SICI)1096-9861(19961223)376:4<509::AID-CNE1>3.0.CO;2-5","volume":"376","author":"Y Suzuki","year":"1996","unstructured":"Suzuki Y, Takeda M, Farbman AI (1996) Supporting cells as phagocytes in the olfactory epithelium after bulbectomy. J Comp Neurol 376:509\u2013517","journal-title":"J Comp Neurol"},{"key":"1848_CR64","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90422-M","volume":"74","author":"R Vassar","year":"1993","unstructured":"Vassar R, Ngai J, Axel R (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74:309\u2013318","journal-title":"Cell"},{"key":"1848_CR65","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1523\/JNEUROSCI.09-02-00683.1989","volume":"9","author":"J Verhaagen","year":"1989","unstructured":"Verhaagen J, Oestreicher AB, Gispen WH, Margolis FL (1989) The expression of the growth associated protein B50\/GAP43 in the olfactory system of neonatal and adult rats. J Neurosci 9:683\u2013691","journal-title":"J Neurosci"},{"key":"1848_CR66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jnr.490260105","volume":"26","author":"J Verhaagen","year":"1990","unstructured":"Verhaagen J, Oestreicher AB, Grillo M, Khew-Goodall YS, Gispen WH, Margolis FL (1990) Neuroplasticity in the olfactory system: differentialeffects of central and peripheral lesions of the primary olfactory pathway on the expression of B-50\/GAP43 and the olfactory marker protein. J Neurosci Res 26:31\u201344","journal-title":"J Neurosci Res"},{"key":"1848_CR67","first-page":"125","volume":"63","author":"A Welge-Lussen","year":"2006","unstructured":"Welge-Lussen A, Wolfensberger M (2006) Olfactory disorders following upper respiratory tract infections. Adv Otorhinolaryngol 63:125\u2013132","journal-title":"Adv Otorhinolaryngol"},{"key":"1848_CR68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/01902140701198500","volume":"33","author":"K Yanagihara","year":"2007","unstructured":"Yanagihara K, Fukuda Y, Seki M, Izumikawa K, Miyazaki Y, Hirakata Y, Tsukamoto K, Yamada Y, Kamhira S, Kohno S (2007) Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia. Exp Lung Res 33:71\u201380","journal-title":"Exp Lung Res"},{"key":"1848_CR69","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1128\/JVI.01410-12","volume":"86","author":"J Zhao","year":"2012","unstructured":"Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB Jr, Perlman S (2012) Intranasal treatment with poly(I*C) protects aged mice from lethal respiratory virus infections. J Virol 86:11416\u201311424","journal-title":"J Virol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-014-1848-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-014-1848-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-014-1848-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T16:18:56Z","timestamp":1565367536000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-014-1848-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,18]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["1848"],"URL":"https:\/\/doi.org\/10.1007\/s00441-014-1848-2","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,18]]}}}