{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:12:55Z","timestamp":1773213175387,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00441-014-2104-5","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T04:50:39Z","timestamp":1422679839000},"page":"233-243","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy"],"prefix":"10.1007","volume":"360","author":[{"given":"Lijie","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Nian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiutang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,2,1]]},"reference":[{"key":"2104_CR1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJMe058142","volume":"353","author":"LP Aiello","year":"2005","unstructured":"Aiello LP (2005) Angiogenic pathways in diabetic retinopathy. N Engl J Med 353:839\u2013841","journal-title":"N Engl J Med"},{"key":"2104_CR2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","volume":"331","author":"LP Aiello","year":"1994","unstructured":"Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE et al (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480\u20131487","journal-title":"N Engl J Med"},{"key":"2104_CR3","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1158\/0008-5472.CAN-04-3332","volume":"65","author":"K Beppu","year":"2005","unstructured":"Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ (2005) Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res 65:4775\u20134781","journal-title":"Cancer Res"},{"key":"2104_CR4","doi-asserted-by":"crossref","first-page":"31047","DOI":"10.1074\/jbc.274.43.31047","volume":"274","author":"PN Bernatchez","year":"1999","unstructured":"Bernatchez PN, Soker S, Sirois MG (1999) Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. J Biol Chem 274:31047\u201331054","journal-title":"J Biol Chem"},{"key":"2104_CR5","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1021\/ja209924v","volume":"134","author":"DL Buckley","year":"2012","unstructured":"Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM (2012) Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL\/HIF-1\u03b1 interaction. J Am Chem Soc 134:4465\u20134468","journal-title":"J Am Chem Soc"},{"key":"2104_CR6","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1158\/0008-5472.CAN-05-2519","volume":"66","author":"V Carroll","year":"2006","unstructured":"Carroll V, Ashcroft M (2006) Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res 66:6264\u20136270","journal-title":"Cancer Res"},{"key":"2104_CR7","doi-asserted-by":"crossref","first-page":"39967","DOI":"10.1074\/jbc.M112.397042","volume":"287","author":"K Deacon","year":"2012","unstructured":"Deacon K, Onion D, Kumari R, Watson SA, Knox AJ (2012) Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer. J Biol Chem 287:39967\u201339981","journal-title":"J Biol Chem"},{"key":"2104_CR8","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1210\/en.2009-1439","volume":"151","author":"L Denner","year":"2010","unstructured":"Denner L, Bodenburg YH, Jiang J, Pages G, Urban RJ (2010) Insulin-like growth factor-I activates extracellularly regulated kinase to regulate the p450 side-chain cleavage insulin-like response element in granulosa cells. Endocrinology 151:2819\u20132825","journal-title":"Endocrinology"},{"key":"2104_CR9","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1167\/iovs.08-2286","volume":"49","author":"AK Dilly","year":"2008","unstructured":"Dilly AK, Rajala RV (2008) Insulin growth factor 1 receptor\/PI3K\/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest Ophthalmol Vis Sci 49:4765\u20134773","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2104_CR10","doi-asserted-by":"crossref","first-page":"13329","DOI":"10.1074\/jbc.M409187200","volume":"280","author":"X Dong","year":"2005","unstructured":"Dong X, Shylnova O, Challis JR, Lye SJ (2005) Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor. J Biol Chem 280:13329\u201313340","journal-title":"J Biol Chem"},{"key":"2104_CR11","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1128\/MCB.02144-06","volume":"27","author":"X Dong","year":"2007","unstructured":"Dong X, Sweet J, Challis JR, Brown T, Lye SJ (2007) Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Mol Cell Biol 27:4863\u20134875","journal-title":"Mol Cell Biol"},{"key":"2104_CR12","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1074\/jbc.M110.168377","volume":"286","author":"L Dong","year":"2011","unstructured":"Dong L, Zhang X, Fu X, Zhang X, Gao X, Zhu M, Wang X, Yang Z, Jensen ON, Saarikettu J, Yao Z, Silvennoinen O, Yang J (2011) PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem 286:3451\u20133459","journal-title":"J Biol Chem"},{"key":"2104_CR13","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.4161\/cc.8.22.9909","volume":"8","author":"A Figueroa","year":"2009","unstructured":"Figueroa A, Fujita Y, Gorospe M (2009a) Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF. Cell Cycle 8:3648\u20133651","journal-title":"Cell Cycle"},{"key":"2104_CR14","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1091\/mbc.E08-08-0845","volume":"20","author":"A Figueroa","year":"2009","unstructured":"Figueroa A, Kotani H, Toda Y, Mazan-Mamczarz K, Mueller EC, Otto A, Disch L, Norman M, Ramdasi RM, Keshtgar M, Gorospe M, Fujita Y (2009b) Novel roles of hakai in cell proliferation and oncogenesis. Mol Biol Cell 20:3533\u20133542","journal-title":"Mol Biol Cell"},{"key":"2104_CR15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ncb758","volume":"4","author":"Y Fujita","year":"2002","unstructured":"Fujita Y, Krause G, Scheffner M, Zechner D, Leddy HE, Behrens J, Sommer T, Birchmeier W (2002) Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 4:222\u2013231","journal-title":"Nat Cell Biol"},{"key":"2104_CR16","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1073\/pnas.101113998","volume":"98","author":"A Hellstrom","year":"2001","unstructured":"Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, Albertsson-Wikland K, Carlsson B, Niklasson A, Sjodell L, LeRoith D, Senger DR, Smith LE (2001) Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A 98:5804\u20135808","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2104_CR17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.286.5438.309","volume":"286","author":"CA Joazeiro","year":"1999","unstructured":"Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286:309\u2013312","journal-title":"Science"},{"key":"2104_CR18","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1167\/iovs.02-0410","volume":"44","author":"AC Lambooij","year":"2003","unstructured":"Lambooij AC, van Wely KH, Lindenbergh-Kortleve DJ, Kuijpers RW, Kliffen M, Mooy CM (2003) Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 44:2192\u20132198","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2104_CR19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cellsig.2009.04.008","volume":"21","author":"KE Lukong","year":"2009","unstructured":"Lukong KE, Huot ME, Richard S (2009) BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. Cell Signal 21:1415\u20131422","journal-title":"Cell Signal"},{"key":"2104_CR20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1101\/gad.13.5.505","volume":"13","author":"T Maniatis","year":"1999","unstructured":"Maniatis T (1999) A ubiquitin ligase complex essential for the NF-kappaB, Wnt\/Wingless, and Hedgehog signaling pathways. Genes Dev 13:505\u2013510","journal-title":"Genes Dev"},{"key":"2104_CR21","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/pmic.200800083","volume":"8","author":"K Miyamoto","year":"2008","unstructured":"Miyamoto K, Sakurai H, Sugiura T (2008) Proteomic identification of a PSF\/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. Proteomics 8:2907\u20132910","journal-title":"Proteomics"},{"key":"2104_CR22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2012.04.017","volume":"685","author":"S Nakamura","year":"2012","unstructured":"Nakamura S, Tsuruma K, Shimazawa M, Hara H (2012) Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. Eur J Pharmacol 685:8\u201314","journal-title":"Eur J Pharmacol"},{"key":"2104_CR23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1101\/gad.7.3.393","volume":"7","author":"JG Patton","year":"1993","unstructured":"Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (1993) Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev 7:393\u2013406","journal-title":"Genes Dev"},{"key":"2104_CR24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0092-8674(03)00108-9","volume":"112","author":"M Perez-Moreno","year":"2003","unstructured":"Perez-Moreno M, Jamora C, Fuchs E (2003) Sticky business: orchestrating cellular signals at adherens junctions. Cell 112:535\u2013548","journal-title":"Cell"},{"key":"2104_CR25","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/diacare.46.10.1619","volume":"46","author":"RS Punglia","year":"1997","unstructured":"Punglia RS, Lu M, Hsu J, Kuroki M, Tolentino MJ, Keough K, Levy AP, Levy NS, Goldberg MA, D\u2019Amato RJ, Adamis AP (1997) Regulation of vascular endothelial growth factor expression by insulin-like growth factor I. Diabetes 46:1619\u20131626","journal-title":"Diabetes"},{"key":"2104_CR26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.peptides.2012.07.024","volume":"37","author":"E Schmid","year":"2012","unstructured":"Schmid E, Nogalo M, Bechrakis NE, Fischer-Colbrie R, Tasan R, Sperk G, Theurl M, Beer AG, Kirchmair R, Herzog H, Troger J (2012) Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl\/6\u00a0N mice. Peptides 37:252\u2013257","journal-title":"Peptides"},{"key":"2104_CR27","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1126\/science.1063866","volume":"294","author":"SK Shenoy","year":"2001","unstructured":"Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294:1307\u20131313","journal-title":"Science"},{"key":"2104_CR28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1167\/iovs.02-0309","volume":"44","author":"PE Spoerri","year":"2003","unstructured":"Spoerri PE, Caballero S, Wilson SH, Shaw LC, Grant MB (2003) Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis. Invest Ophthalmol Vis Sci 44:365\u2013369","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2104_CR29","first-page":"2809","volume":"33","author":"T Su","year":"1992","unstructured":"Su T, Gillies MC (1992) A simple method for the in vitro culture of human retinal capillary endothelial cells. Invest Ophthalmol Vis Sci 33:2809\u20132813","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2104_CR30","first-page":"6248","volume":"60","author":"Y Tsuzuki","year":"2000","unstructured":"Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK (2000) Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha hypoxia response element VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res 60:6248\u20136252","journal-title":"Cancer Res"},{"key":"2104_CR31","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1152\/ajpendo.00174.2002","volume":"283","author":"RJ Urban","year":"2002","unstructured":"Urban RJ, Bodenburg Y (2002) PTB-associated splicing factor regulates growth factor-stimulated gene expression in mammalian cells. Am J Physiol Endocrinol Metab 283:E794\u2013E798","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2104_CR32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/mend.14.6.0485","volume":"14","author":"RJ Urban","year":"2000","unstructured":"Urban RJ, Bodenburg Y, Kurosky A, Wood TG, Gasic S (2000) Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response eleiniment. Mol Endocrinol 14:774\u2013782","journal-title":"Mol Endocrinol"},{"key":"2104_CR33","doi-asserted-by":"crossref","first-page":"E423","DOI":"10.1152\/ajpendo.00057.2002","volume":"283","author":"RJ Urban","year":"2002","unstructured":"Urban RJ, Bodenburg YH, Wood TG (2002) NH2 terminus of PTB-associated splicing factor binds to the porcine P450scc IGF-I response element. Am J Physiol Endocrinol Metab 283:E423\u2013E427","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2104_CR34","doi-asserted-by":"crossref","first-page":"E975","DOI":"10.1152\/ajpendo.00520.2003","volume":"286","author":"RJ Urban","year":"2004","unstructured":"Urban RJ, Bodenburg YH, Jiang J, Denner L, Chedrese J (2004) Protein kinase Ciota enhances the transcriptional activity of the porcine P-450 side-chain cleavage insulin-like response element. Am J Physiol Endocrinol Metab 286:E975\u2013E979","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2104_CR35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1167\/iovs.02-0281","volume":"44","author":"F Wang","year":"2003","unstructured":"Wang F, Rendahl KG, Manning WC, Quiroz D, Coyne M, Miller SS (2003) AAV-mediated expression of vascular endothelial growth factor induces choroidal neovascularization in rat. Invest Ophthalmol Vis Sci 44:781\u2013790","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2104_CR36","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1096\/fj.08-125856","volume":"24","author":"FE Wang","year":"2010","unstructured":"Wang FE, Zhang C, Maminishkis A, Dong L, Zhi C, Li R, Zhao J, Majerciak V, Gaur AB, Chen S, Miller SS (2010) MicroRNA-204\/211 alters epithelial physiology. FASEB J 24:1552\u20131571","journal-title":"FASEB J"},{"key":"2104_CR37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0955-0674(03)00101-7","volume":"15","author":"MJ Wheelock","year":"2003","unstructured":"Wheelock MJ, Johnson KR (2003) Cadherin-mediated cellular signaling. Curr Opin Cell Biol 15:509\u2013514","journal-title":"Curr Opin Cell Biol"},{"key":"2104_CR38","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1080\/02713680802416670","volume":"33","author":"XB Xia","year":"2008","unstructured":"Xia XB, Xiong SQ, Xu HZ, Jiang J, Li Y (2008) Suppression of retinal neovascularization by shRNA targeting HIF-1alpha. Curr Eye Res 33:892\u2013902","journal-title":"Curr Eye Res"},{"key":"2104_CR39","first-page":"6050","volume":"61","author":"X Zhang","year":"2001","unstructured":"Zhang X, Gaspard JP, Chung DC (2001) Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 61:6050\u20136054","journal-title":"Cancer Res"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-014-2104-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-014-2104-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-014-2104-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:56:24Z","timestamp":1559134584000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-014-2104-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,1]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["2104"],"URL":"https:\/\/doi.org\/10.1007\/s00441-014-2104-5","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,1]]}}}