{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:30:13Z","timestamp":1789079413921,"version":"build-2803163510"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s00441-015-2249-x","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T23:03:35Z","timestamp":1438556615000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Proteomics of post-translational modifications of mammalian spermatozoa"],"prefix":"10.1007","volume":"363","author":[{"given":"Mark A.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"2249_CR1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0014-4827(70)90526-4","volume":"60","author":"G Bahr","year":"1970","unstructured":"Bahr G, Engler W (1970) Considerations of volume, mass, DNA, and arrangement of mitochondria in the midpiece of bull spermatozoa. Exp Cell Res 60:338\u2013340","journal-title":"Exp Cell Res"},{"key":"2249_CR2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/rep.0.1260183","volume":"126","author":"M Bajpai","year":"2003","unstructured":"Bajpai M, Doncel GF (2003) Involvement of tyrosine kinase and cAMP-dependent kinase cross-talk in the regulation of human sperm motility. Reproduction 126:183\u2013195","journal-title":"Reproduction"},{"key":"2249_CR3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/pmic.200401100","volume":"5","author":"MA Baker","year":"2005","unstructured":"Baker MA, Witherdin R, Hetherington L, Cunningham-Smith K, Aitken RJ (2005a) Identification of post-translational modifications that occur during sperm maturation using Difference in 2D-Gel electrophoresis. Proteomics Suppl 5:1003\u20131012","journal-title":"Proteomics Suppl"},{"key":"2249_CR4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/pmic.200401100","volume":"5","author":"MA Baker","year":"2005","unstructured":"Baker MA, Witherdin R, Hetherington L, Cunningham\u2010Smith K, Aitken RJ (2005b) Identification of post\u2010translational modifications that occur during sperm maturation using difference in two\u2010dimensional gel electrophoresis. Proteomics 5:1003\u20131012","journal-title":"Proteomics"},{"key":"2249_CR5","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1242\/jcs.03055","volume":"119","author":"MA Baker","year":"2006","unstructured":"Baker MA, Hetherington L, Aitken RJ (2006) Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa. J Cell Sci 119:3182\u20133192","journal-title":"J Cell Sci"},{"key":"2249_CR6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2009.06.022","volume":"333","author":"MA Baker","year":"2009","unstructured":"Baker MA, Hetherington L, Curry B, Aitken RJ (2009) Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. Dev Biol 333:57\u201366","journal-title":"Dev Biol"},{"key":"2249_CR7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/pr1007224","volume":"10","author":"MA Baker","year":"2010","unstructured":"Baker MA, Smith ND, Hetherington L, Pelzing M, Condina MR, Aitken RJ (2010a) Use of titanium dioxide to find phosphopeptide and total protein changes during epididymal sperm maturation. J Proteome Res 10:1004\u20131017","journal-title":"J Proteome Res"},{"key":"2249_CR8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1021\/pr900513d","volume":"9","author":"MA Baker","year":"2010","unstructured":"Baker MA, Smith ND, Hetherington L, Taubman K, Graham ME, Robinson PJ, Aitken RJ (2010b) Label-free quantitation of phosphopeptide changes during rat sperm capacitation. J Proteome Res 9:718\u2013729","journal-title":"J Proteome Res"},{"key":"2249_CR9","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1021\/pr300468m","volume":"11","author":"MA Baker","year":"2012","unstructured":"Baker MA, Hetherington L, Weinberg A, Naumovski N, Velkov T, Pelzing M, Dolman S, Condina MR, Aitken RJ (2012) Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1. J Proteome Res 11:5252\u20135264","journal-title":"J Proteome Res"},{"key":"2249_CR10","unstructured":"Baker MA, Weinberg A, Hethertington L, Villaverde AIS, Velkov T (2014) Analysis of protein thiol changes occurring during rat sperm epididymal maturation. Biol Reprod 114.123679"},{"key":"2249_CR11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/gb-2007-8-9-227","volume":"8","author":"R Balhorn","year":"2007","unstructured":"Balhorn R (2007) The protamine family of sperm nuclear proteins. Genome Biol 8:227","journal-title":"Genome Biol"},{"key":"2249_CR12","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/molehr\/gau073","volume":"20","author":"M Battistone","year":"2014","unstructured":"Battistone M, Alvau A, Salicioni A, Visconti P, Da Ros V, Cuasnic\u00fa P (2014) Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation. Mol Hum Reprod 20:1054\u20131066","journal-title":"Mol Hum Reprod"},{"key":"2249_CR13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrmicro1344","volume":"4","author":"M Bergman","year":"2006","unstructured":"Bergman M, Del Prete G, van Kooyk Y, Appelmelk B (2006) Helicobacter pylori phase variation, immune modulation and gastric autoimmunity. Nat Rev Microbiol 4:151\u2013159","journal-title":"Nat Rev Microbiol"},{"key":"2249_CR14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fertnstert.2013.09.016","volume":"101","author":"S Bhagwat","year":"2014","unstructured":"Bhagwat S, Dalvi V, Chandrasekhar D, Matthew T, Acharya K, Gajbhiye R, Kulkarni V, Sonawane S, Ghosalkar M, Parte P (2014) Acetylated \u03b1-tubulin is reduced in individuals with poor sperm motility. Fertil Steril 101:95\u2013104.e103","journal-title":"Fertil Steril"},{"key":"2249_CR15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1095\/biolreprod20.2.333","volume":"20","author":"PW Bragg","year":"1979","unstructured":"Bragg PW, Handel MA (1979) Protein synthesis in mouse spermatozoa. Biol Reprod 20:333\u2013337","journal-title":"Biol Reprod"},{"key":"2249_CR16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2605.1982.tb00283.x","volume":"5","author":"D Brooks","year":"1982","unstructured":"Brooks D (1982) Purification of rat epididymal proteinsD \u2018andE\u2019, demonstration of shared immunological determinants, and identification of regional synthesis and secretion. Int J Androl 5:513\u2013524","journal-title":"Int J Androl"},{"key":"2249_CR17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1756-8935-7-2","volume":"7","author":"AM Brunner","year":"2014","unstructured":"Brunner AM, Nanni P, Mansuy IM (2014) Epigenetic marking of sperm by post-translational modification of histones and protamines. Epigenetics Chromatin 7:2","journal-title":"Epigenetics Chromatin"},{"key":"2249_CR18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1095\/biolreprod.111.097477","volume":"86","author":"J Caballero","year":"2012","unstructured":"Caballero J, Frenette G, D'Amours O, Dufour M, Oko R, Sullivan R (2012) ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation. Biol Reprod 86:181","journal-title":"Biol Reprod"},{"key":"2249_CR19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/cm.20525","volume":"68","author":"ME Cabrillana","year":"2011","unstructured":"Cabrillana ME, Monclus MA, Saez Lancellotti TE, Boarelli PV, Clementi MA, Vincenti AE, Yunes RF, Fornes MW (2011) Characterization of flagellar cysteine-rich sperm proteins involved in motility, by the combination of cellular fractionation, fluorescence detection, and mass spectrometry analysis. Cytoskeleton (Hoboken) 68:491\u2013500","journal-title":"Cytoskeleton (Hoboken)"},{"key":"2249_CR20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2014.02.056","volume":"157","author":"JJ Chung","year":"2014","unstructured":"Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE (2014) Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell 157:808\u2013822","journal-title":"Cell"},{"key":"2249_CR21","doi-asserted-by":"crossref","unstructured":"Cornwall GA (2014) Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control. Adv Exp Med Biol 759:159\u2013180","DOI":"10.1007\/978-1-4939-0817-2_8"},{"key":"2249_CR22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1530\/ror.0.0030172","volume":"3","author":"J Cummins","year":"1998","unstructured":"Cummins J (1998) Mitochondrial DNA in mammalian reproduction. Rev Reprod 3:172\u2013182","journal-title":"Rev Reprod"},{"key":"2249_CR23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/j.1939-4640.1998.tb01991.x","volume":"19","author":"E Lamirande de","year":"1998","unstructured":"de Lamirande E, Harakat A, Gagnon C (1998) Human sperm capacitation induced by biological fluids and progesterone, but not by NADH or NADPH, is associated with the production of superoxide anion. J Androl 19:215\u2013225","journal-title":"J Androl"},{"key":"2249_CR24","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1074\/jbc.M206284200","volume":"278","author":"IA Demarco","year":"2003","unstructured":"Demarco IA, Espinosa F, Edwards J, Sosnik J, De La Vega-Beltran JL, Hockensmith JW, Kopf GS, Darszon A, Visconti PE (2003) Involvement of a Na+\/HCO-3 cotransporter in mouse sperm capacitation. J Biol Chem 278:7001\u20137009","journal-title":"J Biol Chem"},{"key":"2249_CR25","doi-asserted-by":"crossref","first-page":"26970","DOI":"10.1074\/jbc.270.45.26970","volume":"270","author":"K Ouagari El","year":"1995","unstructured":"El Ouagari K, Teissi\u00e9 J, Benoist H (1995) Glycophorin A protects K562 cells from natural killer cell attack. Role of oligosaccharides. J Biol Chem 270:26970\u201326975","journal-title":"J Biol Chem"},{"key":"2249_CR26","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1073\/pnas.0400050101","volume":"101","author":"G Esposito","year":"2004","unstructured":"Esposito G, Jaiswal BS, Xie F, Krajnc-Franken MA, Robben TJ, Strik AM, Kuil C, Philipsen RL, van Duin M, Conti M, Gossen JA (2004) Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A 101:2993\u20132998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2249_CR27","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1074\/jbc.M202325200","volume":"278","author":"S Ficarro","year":"2003","unstructured":"Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE (2003) Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein\/p97 during capacitation. J Biol Chem 278:11579\u201311589","journal-title":"J Biol Chem"},{"key":"2249_CR28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.1255023","volume":"345","author":"LJ Gaydos","year":"2014","unstructured":"Gaydos LJ, Wang W, Strome S (2014) H3K27me and PRC2 transmit a memory of repression across generations and during development. Science 345:1515\u20131518","journal-title":"Science"},{"key":"2249_CR29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1095\/biolreprod.112.107078","volume":"88","author":"L Gonz\u00e1lez-Fern\u00e1ndez","year":"2013","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez L, Mac\u00edas-Garc\u00eda B, Loux SC, Varner DD, Hinrichs K (2013) Focal adhesion kinases and calcium\/calmodulin-dependent protein kinases regulate protein tyrosine phosphorylation in stallion sperm. Biol Reprod 88:138","journal-title":"Biol Reprod"},{"key":"2249_CR30","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/humrep\/deq138","volume":"25","author":"M Goto","year":"2010","unstructured":"Goto M, O'Brien D, Eddy E (2010) Speriolin is a novel human and mouse sperm centrosome protein. Hum Reprod 25:1884\u20131894","journal-title":"Hum Reprod"},{"key":"2249_CR31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/dvg.1020160202","volume":"16","author":"NB Hecht","year":"1995","unstructured":"Hecht NB (1995) The making of a spermatozoon: a molecular perspective. Dev Genet 16:95\u2013103","journal-title":"Dev Genet"},{"key":"2249_CR32","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/molehr\/7.10.913","volume":"7","author":"MB Herrero","year":"2001","unstructured":"Herrero MB, de Lamirande E, Gagnon C (2001) Tyrosine nitration in human spermatozoa: a physiological function of peroxynitrite, the reaction product of nitric oxide and superoxide. Mol Hum Reprod 7:913\u2013921","journal-title":"Mol Hum Reprod"},{"key":"2249_CR33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0006-291X(72)90858-3","volume":"48","author":"DD Hoskins","year":"1972","unstructured":"Hoskins DD, Casillas ER, Stephens D (1972) Cyclic AMP-dependent protein kinases of bovine epididymal spermatozoa. Biochem Biophys Res Commun 48:1331\u20131338","journal-title":"Biochem Biophys Res Commun"},{"key":"2249_CR34","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1007\/s11033-012-2397-y","volume":"40","author":"C-C Hou","year":"2013","unstructured":"Hou C-C, Yang W-X (2013) New insights to the ubiquitin\u2013proteasome pathway (UPP) mechanism during spermatogenesis. Mol Biol Rep 40:3213\u20133230","journal-title":"Mol Biol Rep"},{"key":"2249_CR35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature03362","volume":"434","author":"N Inoue","year":"2005","unstructured":"Inoue N, Ikawa M, Isotani A, Okabe M (2005) The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434:234\u2013238","journal-title":"Nature"},{"key":"2249_CR36","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbrc.2008.10.073","volume":"377","author":"N Inoue","year":"2008","unstructured":"Inoue N, Ikawa M, Okabe M (2008) Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun 377:910\u2013914","journal-title":"Biochem Biophys Res Commun"},{"key":"2249_CR37","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/dev.094854","volume":"140","author":"N Inoue","year":"2013","unstructured":"Inoue N, Hamada D, Kamikubo H, Hirata K, Kataoka M, Yamamoto M, Ikawa M, Okabe M, Hagihara Y (2013) Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development 140:3221\u20133229","journal-title":"Development"},{"key":"2249_CR38","doi-asserted-by":"crossref","unstructured":"Khoury GA, Baliban RC, Floudas CA (2011) Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database. Sci Rep 1:90","DOI":"10.1038\/srep00090"},{"key":"2249_CR39","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1074\/jbc.M109.085845","volume":"285","author":"D Krapf","year":"2010","unstructured":"Krapf D, Arcelay E, Wertheimer EV, Sanjay A, Pilder SH, Salicioni AM, Visconti PE (2010) Inhibition of Ser\/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors. J Biol Chem 285:7977\u20137985","journal-title":"J Biol Chem"},{"key":"2249_CR40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ydbio.2012.06.017","volume":"369","author":"D Krapf","year":"2012","unstructured":"Krapf D, Chun Ruan Y, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE (2012) cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit. Dev Biol 369:43\u201353","journal-title":"Dev Biol"},{"key":"2249_CR41","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","volume":"16","author":"A Kuzmichev","year":"2002","unstructured":"Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16:2893\u20132905","journal-title":"Genes Dev"},{"key":"2249_CR42","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1021\/bi00786a015","volume":"10","author":"HA Lardy","year":"1971","unstructured":"Lardy HA, Garbers DL, Lust W, First NL (1971) Effects of phosphodiesterase inhibitors and cyclic nucleotides on sperm respiration and motility. Biochemistry 10:1825\u20131831","journal-title":"Biochemistry"},{"key":"2249_CR43","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1074\/mcp.T500007-MCP200","volume":"4","author":"MR Larsen","year":"2005","unstructured":"Larsen MR, Thingholm TE, Jensen ON, Roepstorff P, Jorgensen TJ (2005) Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Mol Cell Proteomics 4:873\u2013886","journal-title":"Mol Cell Proteomics"},{"key":"2249_CR44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1530\/jrf.0.1010703","volume":"101","author":"B Lassalle","year":"1994","unstructured":"Lassalle B, Testart J (1994) Human zona pellucida recognition associated with removal of sialic acid from human sperm surface. J Reprod Fertil 101:703\u2013711","journal-title":"J Reprod Fertil"},{"key":"2249_CR45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1095\/biolreprod67.1.301","volume":"67","author":"P Leclerc","year":"2002","unstructured":"Leclerc P, Goupil S (2002) Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3',5'-monophosphate and inhibition by Ca(2+). Biol Reprod 67:301\u2013307","journal-title":"Biol Reprod"},{"key":"2249_CR46","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.1073\/pnas.0707723105","volume":"105","author":"LI Leichert","year":"2008","unstructured":"Leichert LI, Gehrke F, Gudiseva HV, Blackwell T, Ilbert M, Walker AK, Strahler JR, Andrews PC, Jakob U (2008) Quantifying changes in the thiol redox proteome upon oxidative stress in vivo. Proc Natl Acad Sci U S A 105:8197\u20138202","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2249_CR47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2010.07.033","volume":"348","author":"T Lerer-Goldshtein","year":"2010","unstructured":"Lerer-Goldshtein T, Bel S, Shpungin S, Pery E, Motro B, Goldstein RS, Bar-Sheshet SI, Breitbart H, Nir U (2010) TMF\/ARA160: A key regulator of sperm development. Dev Biol 348:12\u201321","journal-title":"Dev Biol"},{"key":"2249_CR48","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1095\/biolreprod64.5.1545","volume":"64","author":"B Lewis","year":"2001","unstructured":"Lewis B, Aitken RJ (2001) Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa. Biol Reprod 64:1545\u20131556","journal-title":"Biol Reprod"},{"key":"2249_CR49","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1095\/biolreprod.106.052712","volume":"75","author":"M Lin","year":"2006","unstructured":"Lin M, Lee YH, Xu W, Baker MA, Aitken RJ (2006) Ontogeny of tyrosine phosphorylation-signaling pathways during spermatogenesis and epididymal maturation in the mouse. Biol Reprod 75:588\u2013597","journal-title":"Biol Reprod"},{"key":"2249_CR50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1095\/biolreprod.104.032490","volume":"72","author":"M Luconi","year":"2005","unstructured":"Luconi M, Porazzi I, Ferruzzi P, Marchiani S, Forti G, Baldi E (2005) Tyrosine phosphorylation of the a kinase anchoring protein 3 (AKAP3) and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonate. Biol Reprod 72:22\u201332","journal-title":"Biol Reprod"},{"key":"2249_CR51","doi-asserted-by":"crossref","first-page":"38073","DOI":"10.1074\/jbc.M112.380584","volume":"287","author":"F Ma","year":"2012","unstructured":"Ma F, Wu D, Deng L, Secrest P, Zhao J, Varki N, Lindheim S, Gagneux P (2012) Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. J Biol Chem 287:38073\u201338079","journal-title":"J Biol Chem"},{"key":"2249_CR52","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1095\/biolreprod14.5.632","volume":"14","author":"E Mercado","year":"1976","unstructured":"Mercado E, Carvajal G, Reyes A, Rosado A (1976) Sulfhydryl groups on the spermatozoa membrane. A study with a new fluorescent probe for SH groups. Biol Reprod 14:632\u2013640","journal-title":"Biol Reprod"},{"key":"2249_CR53","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mrd.1120050207","volume":"5","author":"M Miller","year":"1982","unstructured":"Miller M, Masui Y (1982) Changes in the stainabilityand sulfhydryl level in the sperm nucleus during sperm-oocyte interaction in mice. Gamete Res 5:167\u2013179","journal-title":"Gamete Res"},{"key":"2249_CR54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mrd.1080370215","volume":"37","author":"CR Morales","year":"1994","unstructured":"Morales CR, Oko R, Clermont Y (1994) Molecular cloning and developmental expression of an mRNA encoding the 27 kDa outer dense fiber protein of rat spermatozoa. Mol Reprod Dev 37:229\u2013240","journal-title":"Mol Reprod Dev"},{"key":"2249_CR55","first-page":"416a","volume":"70","author":"A Mujica","year":"1976","unstructured":"Mujica A (1976) Mitochondrial protein synthesis in human ejaculated spermatozoa. J Cell Biol 70:416a","journal-title":"J Cell Biol"},{"key":"2249_CR56","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/sj.embor.7400790","volume":"7","author":"N Nakamura","year":"2006","unstructured":"Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S (2006) MARCH\u2010V is a novel mitofusin 2\u2010and Drp1\u2010binding protein able to change mitochondrial morphology. EMBO Rep 7:1019\u20131022","journal-title":"EMBO Rep"},{"key":"2249_CR57","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1095\/biolreprod.108.067561","volume":"79","author":"N Nakamura","year":"2008","unstructured":"Nakamura N, Miranda-Vizuete A, Miki K, Mori C, Eddy EM (2008) Cleavage of disulfide bonds in mouse spermatogenic cell-specific type 1 hexokinase isozyme is associated with increased hexokinase activity and initiation of sperm motility. Biol Reprod 79:537\u2013545","journal-title":"Biol Reprod"},{"key":"2249_CR58","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/jcp.24873","volume":"230","author":"FA Navarrete","year":"2015","unstructured":"Navarrete FA, Garc\u00eda\u2010V\u00e1zquez FA, Alvau A, Escoffier J, Krapf D, S\u00e1nchez\u2010C\u00e1rdenas C, Salicioni AM, Darszon A, Visconti PE (2015) Biphasic role of calcium in mouse sperm capacitation signaling pathways. J Cell Physiol 230:1758\u20131769","journal-title":"J Cell Physiol"},{"key":"2249_CR59","unstructured":"Nikhil G, Pradeepa MM, Anayat BU, Satyanarayana RM (2015) Mapping of post-translational modifications of transition proteins, TP1 and TP2 and identification of protein arginine methyl transferase 4 and lysine methyl transferase 7 as methyl transferase for TP2. J Biol Chem jbc. M114. 620443"},{"key":"2249_CR60","doi-asserted-by":"crossref","first-page":"13483","DOI":"10.1073\/pnas.0405580101","volume":"101","author":"MA Nolan","year":"2004","unstructured":"Nolan MA, Babcock DF, Wennemuth G, Brown W, Burton KA, McKnight GS (2004) Sperm-specific protein kinase A catalytic subunit C{alpha}2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A 101:13483\u201313488","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2249_CR61","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/molehr\/4.4.318","volume":"4","author":"K Ozgur","year":"1998","unstructured":"Ozgur K, Patankar MS, Oehninger S, Clark GF (1998) Direct evidence for the involvement of carbohydrate sequences in human sperm-zona pellucida binding. Mol Hum Reprod 4:318\u2013324","journal-title":"Mol Hum Reprod"},{"key":"2249_CR62","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0015-0282(16)48442-6","volume":"43","author":"IJ Pandya","year":"1985","unstructured":"Pandya IJ, Cohen J (1985) The leukocytic reaction of the human uterine cervix to spermatozoa. Fertil Steril 43:417\u2013421","journal-title":"Fertil Steril"},{"key":"2249_CR63","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/pmic.200700919","volume":"8","author":"J Petrak","year":"2008","unstructured":"Petrak J, Ivanek R, Toman O, Cmejla R, Cmejlova J, Vyoral D, Zivny J, Vulpe CD (2008) Deja vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins. Proteomics 8:1744\u20131749","journal-title":"Proteomics"},{"key":"2249_CR64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.104.2.289","volume":"104","author":"G Piperno","year":"1987","unstructured":"Piperno G, LeDizet M, Chang X (1987) Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J Cell Biol 104:289\u2013302","journal-title":"J Cell Biol"},{"key":"2249_CR65","doi-asserted-by":"crossref","first-page":"29956","DOI":"10.1074\/jbc.M109.052043","volume":"284","author":"MM Pradeepa","year":"2009","unstructured":"Pradeepa MM, Nikhil G, Kishore AH, Bharath GN, Kundu TK, Rao MRS (2009) Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. J Biol Chem 284:29956\u201329967","journal-title":"J Biol Chem"},{"key":"2249_CR66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/newbio240139a0","volume":"240","author":"E Premkumar","year":"1972","unstructured":"Premkumar E, Bhargava PM (1972) Transcription and translation in bovine spermatozoa. Nat New Biol 240:139\u2013143","journal-title":"Nat New Biol"},{"key":"2249_CR67","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2013.04.032","volume":"153","author":"M-X Qian","year":"2013","unstructured":"Qian M-X, Pang Y, Liu CH, Haratake K, Du B-Y, Ji D-Y, Wang G-F, Zhu Q-Q, Song W, Yu Y (2013) Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell 153:1012\u20131024","journal-title":"Cell"},{"key":"2249_CR68","doi-asserted-by":"crossref","first-page":"e50851","DOI":"10.1371\/journal.pone.0050851","volume":"7","author":"KA Redgrove","year":"2012","unstructured":"Redgrove KA, Nixon B, Baker MA, Hetherington L, Baker G, Liu DY, Aitken RJ (2012) The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition. PLoS ONE 7:e50851","journal-title":"PLoS ONE"},{"key":"2249_CR69","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1128\/MCB.24.12.5475-5484.2004","volume":"24","author":"C Rougeulle","year":"2004","unstructured":"Rougeulle C, Chaumeil J, Sarma K, Allis CD, Reinberg D, Avner P, Heard E (2004) Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol 24:5475\u20135484","journal-title":"Mol Cell Biol"},{"key":"2249_CR70","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1101\/gad.11.21.2835","volume":"11","author":"PL Schwartzberg","year":"1997","unstructured":"Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE (1997) Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc\u2212\/\u2212 mutant mice. Genes Dev 11:2835\u20132844","journal-title":"Genes Dev"},{"key":"2249_CR71","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1095\/biolreprod40.5.1037","volume":"40","author":"R Shalgi","year":"1989","unstructured":"Shalgi R, Seligman J, Kosower NS (1989) Dynamics of the thiol status of rat spermatozoa during maturation: analysis with the fluorescent labeling agent monobromobimane. Biol Reprod 40:1037\u20131045","journal-title":"Biol Reprod"},{"key":"2249_CR72","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1095\/biolreprod61.1.240","volume":"61","author":"Y Si","year":"1999","unstructured":"Si Y, Okuno M (1999) Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation. Biol Reprod 61:240\u2013246","journal-title":"Biol Reprod"},{"key":"2249_CR73","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/rep.1.00073","volume":"127","author":"KS Sidhu","year":"2004","unstructured":"Sidhu KS, Mate KE, Gunasekera T, Veal D, Hetherington L, Baker MA, Aitken RJ, Rodger JC (2004) A flow cytometric assay for global estimation of tyrosine phosphorylation associated with capacitation of spermatozoa from two marsupial species, the tammar wallaby (Macropus eugenii) and the brushtail possum (Trichosurus vulpecula). Reproduction 127:95\u2013103","journal-title":"Reproduction"},{"key":"2249_CR74","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0093-691X(96)00268-3","volume":"46","author":"MG Steele","year":"1996","unstructured":"Steele MG, Wishart GJ (1996) Demonstration that the removal of sialic acid from the surface of chicken spermatozoa impedes their transvaginal migration. Theriogenology 46:1037\u20131044","journal-title":"Theriogenology"},{"key":"2249_CR75","doi-asserted-by":"crossref","unstructured":"Sutovsky P (2014) Posttranslational modifications-when the sperm cell meets the egg. Adv Exp Med Biol 759:v\u2013vii","DOI":"10.1007\/978-1-4939-0817-2"},{"key":"2249_CR76","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1095\/biolreprod63.2.582","volume":"63","author":"P Sutovsky","year":"2000","unstructured":"Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G (2000) Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos. Biol Reprod 63:582\u2013590","journal-title":"Biol Reprod"},{"key":"2249_CR77","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","volume":"146","author":"M Tan","year":"2011","unstructured":"Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, Buchou T, Cheng Z, Rousseaux S, Rajagopal N (2011) Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146:1016\u20131028","journal-title":"Cell"},{"key":"2249_CR78","doi-asserted-by":"crossref","unstructured":"Thingholm TE, Larsen MR (2009) The use of titanium dioxide micro-columns to selectively isolate phosphopeptides from proteolytic digests. Methods Mol Biol 527:57\u201366, xi","DOI":"10.1007\/978-1-60327-834-8_5"},{"key":"2249_CR79","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/nprot.2006.185","volume":"1","author":"TE Thingholm","year":"2006","unstructured":"Thingholm TE, Jorgensen TJ, Jensen ON, Larsen MR (2006) Highly selective enrichment of phosphorylated peptides using titanium dioxide. Nat Protoc 1:1929\u20131935","journal-title":"Nat Protoc"},{"key":"2249_CR80","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1095\/biolreprod48.2.417","volume":"48","author":"D Tulsiani","year":"1993","unstructured":"Tulsiani D, Skudlarek MD, Holland MK, Orgebin-Crist M-C (1993) Glycosylation of rat sperm plasma membrane during epididymal maturation. Biol Reprod 48:417\u2013428","journal-title":"Biol Reprod"},{"key":"2249_CR81","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/mrd.20619","volume":"74","author":"JG Velasquez","year":"2007","unstructured":"Velasquez JG, Canovas S, Barajas P, Marcos J, Jimenez-Movilla M, Gallego RG, Ballesta J, Aviles M, Coy P (2007) Role of sialic acid in bovine sperm-zona pellucida binding. Mol Reprod Dev 74:617\u2013628","journal-title":"Mol Reprod Dev"},{"key":"2249_CR82","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/humrep\/des317","volume":"28","author":"M Vigodner","year":"2013","unstructured":"Vigodner M, Shrivastava V, Gutstein LE, Schneider J, Nieves E, Goldstein M, Feliciano M, Callaway M (2013) Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Hum Reprod 28:210\u2013223","journal-title":"Hum Reprod"},{"key":"2249_CR83","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/dev.121.4.1129","volume":"121","author":"PE Visconti","year":"1995","unstructured":"Visconti PE, Bailey JL, Moore GD, Pan D, Olds-Clarke P, Kopf GS (1995a) Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 121:1129\u20131137","journal-title":"Development"},{"key":"2249_CR84","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","volume":"121","author":"PE Visconti","year":"1995","unstructured":"Visconti PE, Moore GD, Bailey JL, Leclerc P, Connors SA, Pan D, Olds-Clarke P, Kopf GS (1995b) Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development 121:1139\u20131150","journal-title":"Development"},{"key":"2249_CR85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ydbio.2006.05.038","volume":"296","author":"F Xie","year":"2006","unstructured":"Xie F, Garcia MA, Carlson AE, Schuh SM, Babcock DF, Jaiswal BS, Gossen JA, Esposito G, van Duin M, Conti M (2006) Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol 296:353\u2013362","journal-title":"Dev Biol"},{"key":"2249_CR86","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s11033-010-0322-9","volume":"38","author":"WJ Xing","year":"2011","unstructured":"Xing WJ, Han BD, Wu Q, Zhao L, Bao XH, Bou S (2011) Molecular cloning and characterization of Izumo1 gene from sheep and cashmere goat reveal alternative splicing. Mol Biol Rep 38:1995\u20132006","journal-title":"Mol Biol Rep"},{"key":"2249_CR87","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/aja.1001350405","volume":"135","author":"R Yanagimachi","year":"1972","unstructured":"Yanagimachi R, Noda Y, Fujimoto M, Nicolson G (1972) The distribution of negative surface charges on mammalian spermatozoa. Am J Anat 135:497\u2013519","journal-title":"Am J Anat"},{"key":"2249_CR88","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/MCB.06158-11","volume":"32","author":"K Yang","year":"2012","unstructured":"Yang K, Meinhardt A, Zhang B, Grzmil P, Adham IM, Hoyer-Fender S (2012) The small heat shock protein ODF1\/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice. Mol Cell Biol 32:216\u2013225","journal-title":"Mol Cell Biol"},{"key":"2249_CR89","doi-asserted-by":"crossref","unstructured":"Yu H, Diao H, Wang C, Lin YF, Yu F, Lu H, Xu W, Li Z, Shi H, Zhao S, Zhou Y, Zhang Y (2015) Acetylproteomic analysis reveals functional implications of lysine acetylation in human sperm. Mol Cell Prot 14:1009\u20131023","DOI":"10.1074\/mcp.M114.041384"},{"key":"2249_CR90","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nsmb.2470","volume":"20","author":"GE Zentner","year":"2013","unstructured":"Zentner GE, Henikoff S (2013) Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 20:259\u2013266","journal-title":"Nat Struct Mol Biol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-015-2249-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-015-2249-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-015-2249-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T05:40:38Z","timestamp":1717998038000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-015-2249-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,4]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["2249"],"URL":"https:\/\/doi.org\/10.1007\/s00441-015-2249-x","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,4]]}}}