{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:48:36Z","timestamp":1788472116721,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Medical and Healthy Technology Development Program of Shandong Province","award":["2015WS0069"],"award-info":[{"award-number":["2015WS0069"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00441-017-2716-7","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T02:05:33Z","timestamp":1509329133000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of over-expression of SOD2 in bone marrow-derived mesenchymal stem cells on traumatic brain injury"],"prefix":"10.1007","volume":"372","author":[{"given":"Xiaodong","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"2716_CR1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2337\/db08-0180","volume":"57","author":"R Abdi","year":"2008","unstructured":"Abdi R, Fiorina P, Adra CN, Atkinson M, Sayegh MH (2008) Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes 57:1759\u20131767","journal-title":"Diabetes"},{"key":"2716_CR2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4103\/0253-7176.183086","volume":"38","author":"A Barman","year":"2016","unstructured":"Barman A, Chatterjee A, Bhide R (2016) Cognitive impairment and rehabilitation strategies after traumatic brain injury. Indian J Psychol Med 38:172\u2013181","journal-title":"Indian J Psychol Med"},{"key":"2716_CR3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1089\/ars.2012.4981","volume":"19","author":"C Cornelius","year":"2013","unstructured":"Cornelius C, Crupi R, Calabrese V, Graziano A, Milone P, Pennisi G, Radak Z, Calabrese EJ, Cuzzocrea S (2013) Traumatic brain injury: oxidative stress and neuroprotection. Antioxid Redox Signal 19:836\u2013853","journal-title":"Antioxid Redox Signal"},{"issue":"683\u2013700","key":"2716_CR4","first-page":"ix","volume":"22","author":"DH Daneshvar","year":"2011","unstructured":"Daneshvar DH, Riley DO, Nowinski CJ, McKee AC, Stern RA, Cantu RC (2011) Long-term consequences: effects on normal development profile after concussion. Phys Med Rehabil Clin N Am 22(683\u2013700):ix","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"2716_CR5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"2716_CR6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4614-3573-0_6","volume":"748","author":"S Drose","year":"2012","unstructured":"Drose S, Brandt U (2012) Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Biol 748:145\u2013169","journal-title":"Adv Exp Med Biol"},{"key":"2716_CR7","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s10350-005-0133-6","volume":"48","author":"M Gavioli","year":"2005","unstructured":"Gavioli M, Luppi G, Losi L, Bertolini F, Santantonio M, Falchi AM, D'Amico R, Conte PF, Natalini G (2005) Incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer. Dis Colon Rectum 48:1851\u20131857","journal-title":"Dis Colon Rectum"},{"key":"2716_CR8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fneur.2017.00028","volume":"8","author":"A Hasan","year":"2017","unstructured":"Hasan A, Deeb G, Rahal R, Atwi K, Mondello S, Marei HE, Gali A, Sleiman E (2017) Mesenchymal stem cells in the treatment of traumatic brain injury. Front Neurol 8:28","journal-title":"Front Neurol"},{"key":"2716_CR9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/NRE-2007-22502","volume":"22","author":"AA Hyder","year":"2007","unstructured":"Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC (2007) The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation 22:341\u2013353","journal-title":"NeuroRehabilitation"},{"key":"2716_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semarthrit.2016.02.008","volume":"46","author":"K Hynes","year":"2016","unstructured":"Hynes K, Bright R, Proudman S, Haynes D, Gronthos S, Bartold M (2016) Immunomodulatory properties of mesenchymal stem cell in experimental arthritis in rat and mouse models: a systematic review. Semin Arthritis Rheum 46:1\u201319","journal-title":"Semin Arthritis Rheum"},{"key":"2716_CR11","doi-asserted-by":"crossref","first-page":"951512","DOI":"10.1155\/2014\/951512","volume":"2014","author":"C Ikebe","year":"2014","unstructured":"Ikebe C, Suzuki K (2014) Mesenchymal stem cells for regenerative therapy: optimization of cell preparation protocols. Biomed Res Int 2014:951512","journal-title":"Biomed Res Int"},{"key":"2716_CR12","first-page":"935","volume":"15","author":"HM Lazarus","year":"1995","unstructured":"Lazarus HM, Winton EF, Williams SF, Grinblatt D, Campion M, Cooper BW, Gunn H, Manfreda S, Isaacs RE (1995) Phase I multicenter trial of interleukin 6 therapy after autologous bone marrow transplantation in advanced breast cancer. Bone Marrow Transplant 15:935\u2013942","journal-title":"Bone Marrow Transplant"},{"key":"2716_CR13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/089771504772695922","volume":"21","author":"A Mahmood","year":"2004","unstructured":"Mahmood A, Lu D, Chopp M (2004) Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma 21:33\u201339","journal-title":"J Neurotrauma"},{"key":"2716_CR14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nucmedbio.2016.12.003","volume":"46","author":"L Meseguer-Olmo","year":"2017","unstructured":"Meseguer-Olmo L, Montellano AJ, Martinez T, Martinez CM, Revilla-Nuin B, Roldan M, Mora CF, Lopez-Lucas MD, Fuente T (2017) Intraarticular and intravenous administration of 99MTc-HMPAO-labeled human mesenchymal stem cells (99MTC-AH-MSCS): in vivo imaging and biodistribution. Nucl Med Biol 46:36\u201342","journal-title":"Nucl Med Biol"},{"key":"2716_CR15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.etp.2012.06.002","volume":"65","author":"R Moghadasali","year":"2013","unstructured":"Moghadasali R, Mutsaers HA, Azarnia M, Aghdami N, Baharvand H, Torensma R, Wilmer MJ, Masereeuw R (2013) Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Exp Toxicol Pathol 65:595\u2013600","journal-title":"Exp Toxicol Pathol"},{"key":"2716_CR16","doi-asserted-by":"crossref","unstructured":"Nargesi AA, Lerman LO, Eirin A (2017) Mesenchymal stem cell-derived extracellular vesicles for renal repair. Curr Gene Ther 17:29\u201342","DOI":"10.2174\/1566523217666170412110724"},{"key":"2716_CR17","doi-asserted-by":"crossref","first-page":"4798639","DOI":"10.1155\/2016\/4798639","volume":"2016","author":"AJ Peired","year":"2016","unstructured":"Peired AJ, Sisti A, Romagnani P (2016) Mesenchymal stem cell-based therapy for kidney disease: a review of clinical evidence. Stem Cells Int 2016:4798639","journal-title":"Stem Cells Int"},{"key":"2716_CR18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2174\/0929867321666131217153310","volume":"21","author":"A Rodriguez-Rodriguez","year":"2014","unstructured":"Rodriguez-Rodriguez A, Egea-Guerrero JJ, Murillo-Cabezas F, Carrillo-Vico A (2014) Oxidative stress in traumatic brain injury. Curr Med Chem 21:1201\u20131211","journal-title":"Curr Med Chem"},{"key":"2716_CR19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1089\/tea.2007.0260","volume":"14","author":"GE Rooney","year":"2008","unstructured":"Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flugel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP (2008) Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Eng Part A 14:681\u2013690","journal-title":"Tissue Eng Part A"},{"key":"2716_CR20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.aanat.2016.11.010","volume":"210","author":"H Salehi","year":"2017","unstructured":"Salehi H, Amirpour N, Razavi S, Esfandiari E, Zavar R (2017) Overview of retinal differentiation potential of mesenchymal stem cells: a promising approach for retinal cell therapy. Ann Anat 210:52\u201363","journal-title":"Ann Anat"},{"key":"2716_CR21","doi-asserted-by":"crossref","unstructured":"Sevivas N, Teixeira FG, Portugal R, Araujo L, Carrico LF, Ferreira N, Vieira da Silva M, Espregueira-Mendes J, Anjo S, Manadas B, Sousa N, Salgado AJ (2017) Mesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated With Chronic Rotator Cuff Tears. Am J Sports Med 45:179\u2013188","DOI":"10.1177\/0363546516657827"},{"key":"2716_CR22","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/j.1532-5415.2006.00894.x","volume":"54","author":"HJ Thompson","year":"2006","unstructured":"Thompson HJ, McCormick WC, Kagan SH (2006) Traumatic brain injury in older adults: epidemiology, outcomes, and future implications. J Am Geriatr Soc 54:1590\u20131595","journal-title":"J Am Geriatr Soc"},{"key":"2716_CR23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3727\/096368916X694265","volume":"26","author":"WL Tseng","year":"2017","unstructured":"Tseng WL, Chou SJ, Chiang HC, Wang ML, Chien CS, Chen KH, Leu HB, Wang CY, Chang YL, Liu YY, Jong YJ, Lin SZ, Chiou SH, Lin SJ, Yu WC (2017) Imbalanced production of reactive oxygen species and mitochondrial antioxidant SOD2 in Fabry disease-specific human induced Pluripotent stem cell-differentiated vascular endothelial cells. Cell Transplant 26:513\u2013527","journal-title":"Cell Transplant"},{"key":"2716_CR24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","volume":"7","author":"B Uttara","year":"2009","unstructured":"Uttara B, Singh AV, Zamboni P, Mahajan RT (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 7:65\u201374","journal-title":"Curr Neuropharmacol"},{"key":"2716_CR25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/1874467208666150928153758","volume":"9","author":"S Wang","year":"2016","unstructured":"Wang S, Xu P, Li X, Su X, Chen Y, Wan L, Fan L, Yin K, Liu Y, Zhao RC (2016) Mesenchymal stem cells and cell therapy for bone repair. Curr Mol Pharmacol 9:289\u2013299","journal-title":"Curr Mol Pharmacol"},{"key":"2716_CR26","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/glia.20985","volume":"58","author":"L Xu","year":"2010","unstructured":"Xu L, Emery JF, Ouyang YB, Voloboueva LA, Giffard RG (2010) Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia. Glia 58:1042\u20131049","journal-title":"Glia"},{"key":"2716_CR27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4196\/kjpp.2016.20.1.63","volume":"20","author":"HG Yi","year":"2016","unstructured":"Yi HG, Yahng SA, Kim I, Lee JH, Min CK, Kim JH, Kim CS, Song SU (2016) Allogeneic clonal mesenchymal stem cell therapy for refractory graft-versus-host disease to standard treatment: a phase I study. Korean J Physiol Pharmacol 20:63\u201367","journal-title":"Korean J Physiol Pharmacol"},{"key":"2716_CR28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainresbull.2016.09.010","volume":"127","author":"J Yuan","year":"2016","unstructured":"Yuan J, Wang A, He Y, Si Z, Xu S, Zhang S, Wang K, Wang D, Liu Y (2016) Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats. Brain Res Bull 127:171\u2013176","journal-title":"Brain Res Bull"},{"key":"2716_CR29","first-page":"4017","volume":"8","author":"X Zhang","year":"2016","unstructured":"Zhang X, Huang F, Chen Y, Qian X, Zheng SG (2016) Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. Am J Transl Res 8:4017\u20134024","journal-title":"Am J Transl Res"},{"key":"2716_CR30","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.18632\/oncotarget.13954","volume":"8","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Lang J, Cao Z, Li R, Wang X, Wang W (2017) Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue. Oncotarget 8:7791\u20137800","journal-title":"Oncotarget"},{"key":"2716_CR31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/stem.2310","volume":"34","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Gibb SL, Zhao J, Moore AN, Hylin MJ, Menge T, Xue H, Baimukanova G, Potter D, Johnson EM, Holcomb JB, Cox CS Jr, Dash PK, Pati S (2016) Wnt3a, a protein secreted by Mesenchymal stem cells is Neuroprotective and promotes Neurocognitive recovery following traumatic brain injury. Stem Cells 34:1263\u20131272","journal-title":"Stem Cells"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-017-2716-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-017-2716-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-017-2716-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:53:01Z","timestamp":1750967581000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-017-2716-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["2716"],"URL":"https:\/\/doi.org\/10.1007\/s00441-017-2716-7","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,30]]}}}