{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:13:08Z","timestamp":1790737988506,"version":"4.1.0"},"reference-count":186,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00441-018-2832-z","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T05:15:10Z","timestamp":1523682910000},"page":"297-312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Lateralisation in Parkinson disease"],"prefix":"10.1007","volume":"373","author":[{"given":"P.","family":"Riederer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Jellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kolber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sian-H\u00fclsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"issue":"12","key":"2832_CR1","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1093\/brain\/awh607","volume":"128","author":"JR Adams","year":"2005","unstructured":"Adams JR, van Netten H, Schulzer M, Mak E, Mckenzie J, Strongosky A, Sossi V, Ruth TJ, Lee CS, Farrer M, Gasser T, Uitti RJ, Calne DB, Wszolek ZK, Stoessl AJ (2005) PET in LRRK2 mutations: comparison to sporadic Parkinson\u2019s disease and evidence for presymptomatic compensation. Brain 128(12):2777\u20132785 https:\/\/doi.org\/10.1093\/brain\/awh607","journal-title":"Brain"},{"issue":"5","key":"2832_CR2","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1017\/S1355617706060875","volume":"12","author":"MM Amick","year":"2006","unstructured":"Amick MM, Grace J, Chou KL (2006) Body side of motor symptom onset in Parkinson\u2019s disease is associated with memory performance. J Int Neuropsychol Soc 12(5):736\u2013740","journal-title":"J Int Neuropsychol Soc"},{"key":"2832_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/RLU.0000000000000373","volume":"39","author":"F Amtage","year":"2014","unstructured":"Amtage F, Hellwig S, Kreft A, Spehl T, Glauche V, Winkler C, Rijntjes M, Hellwig B, Weiller C, Weber WA, T\u00fcscher O, Meyer PT (2014) Neuronal correlates of clinical asymmetry in progressive supranuclear palsy. Clin Nucl Med 39:319\u2013325","journal-title":"Clin Nucl Med"},{"issue":"Pt 2","key":"2832_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/brain\/awl358","volume":"130","author":"AG Androulidakis","year":"2007","unstructured":"Androulidakis AG, K\u00fchn AA, Chen CC, Blomstedt P, Kempf F, Kupsch A, Schneider GH, Doyle L, Dowsey-Limousin P, Hariz MI, Brown P (2007) Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson\u2019s disease. Brain 130(Pt 2):457\u2013468","journal-title":"Brain"},{"key":"2832_CR5","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00401-014-1261-7","volume":"127","author":"J Attems","year":"2014","unstructured":"Attems J, Walker L, Jellinger KA (2014) Olfactory bulb involvement in neurodegenerative diseases. Acta Neuropathol 127:459\u2013475","journal-title":"Acta Neuropathol"},{"key":"2832_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3174\/ajnr.A4645","volume":"37","author":"M Azuma","year":"2016","unstructured":"Azuma M, Hirai T, Yamada K, Yamashita S, Ando Y, Tateishi M, Iryo Y, Yoneda T, Kitajima M, Wang Y, Yamashita Y (2016) Lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease measured with quantitative susceptibility mapping. AJNR Am J Neuroradiol 37:782\u2013788","journal-title":"AJNR Am J Neuroradiol"},{"key":"2832_CR7","first-page":"241","volume":"94","author":"GS Barolin","year":"1964","unstructured":"Barolin GS, Bernheimer H, Hornykiewicz O (1964) Seitenverschiedenes Verhalten des Dopamins (3-HyHydroxytyramin) im Gehirn eines Falles von Hemiparkinsonismus. Schweizer Archiv f\u00fcr Neurologie undPsychiatrie 94:241","journal-title":"Schweizer Archiv f\u00fcr Neurologie undPsychiatrie"},{"key":"2832_CR8","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1136\/jnnp.2010.209783","volume":"82","author":"MJ Barrett","year":"2011","unstructured":"Barrett MJ, Wylie SA, Harrison MB, Wooten GF (2011) Handedness and motor symptom asymmetry in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 82:1122\u20131124","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR9","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.parkreldis.2013.05.004","volume":"19","author":"A Batla","year":"2013","unstructured":"Batla A, Stamelou M, Mensikova K, Kaiserova M, Tuckova L, Kanovsky P, Quinn N, Bhatia KP (2013) Markedly asymmetric presentation in multiple system atrophy. Parkinsonism Relat Disord 19:901\u2013905","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/mds.25650","volume":"29","author":"CR Baumann","year":"2014","unstructured":"Baumann CR, Held U, Valko PO, Wienecke M, Waldvogel D (2014) Body side and predominant motor features at the onset of Parkinson\u2019s disease are linked to motor and nonmotor progression. Mov Disord 29:207\u2013213","journal-title":"Mov Disord"},{"key":"2832_CR11","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","volume":"119","author":"TG Beach","year":"2010","unstructured":"Beach TG, Adler CH, Sue LI, Vedders L, Lue L, White Iii CL, Akiyama H, Caviness JN, Shill HA, Sabbagh MN, Walker DG, Arizona Parkinson\u2019s Disease Consortium (2010) Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 119:689\u2013702","journal-title":"Acta Neuropathol"},{"key":"2832_CR12","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/1531-8257(200007)15:4<692::AID-MDS1014>3.0.CO;2-V","volume":"15","author":"HT Benamer","year":"2000","unstructured":"Benamer HT, Patterson J, Wyper DJ, Hadley DM, Macphee GJ, Grosset DG (2000) Correlation of Parkinson\u2019s disease severity and duration with 123I-FP-CIT SPECT striatal uptake. Mov Disord 15:692\u2013698","journal-title":"Mov Disord"},{"key":"2832_CR13","doi-asserted-by":"publisher","first-page":"e0137722","DOI":"10.1371\/journal.pone.0137722","volume":"10","author":"VS Beretta","year":"2015","unstructured":"Beretta VS, Gobbi LT, Lirani-Silva E, Simieli L, Orcioli-Silva D, Barbieri FA (2015) Challenging postural tasks increase asymmetry in patients with Parkinson\u2019s disease. PLoS One 10:e0137722","journal-title":"PLoS One"},{"issue":"8","key":"2832_CR14","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/s004150170114","volume":"248","author":"D Berg","year":"2001","unstructured":"Berg D, Siefker C, Becker G (2001) Echogenicity of the substantia nigra in Parkinson\u2019s disease and its relation to clinical findings. J Neurol 248(8):684\u2013689","journal-title":"J Neurol"},{"key":"2832_CR15","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","volume":"20","author":"H Bernheimer","year":"1973","unstructured":"Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20:415\u2013455","journal-title":"J Neurol Sci"},{"key":"2832_CR16","first-page":"793076","volume":"2012","author":"Y Bogdanova","year":"2012","unstructured":"Bogdanova Y, Cronin-Golomb A (2012) Neurocognitive correlates of apathy and anxiety in Parkinson\u2019s disease. Parkinsons Dis 2012:793076","journal-title":"Parkinsons Dis"},{"issue":"9","key":"2832_CR17","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/sj.jcbfm.9600276","volume":"26","author":"NI Bohnen","year":"2006","unstructured":"Bohnen NI, Albin RL, Koeppe RA, Wernette KA, Kilbourn MR, Minoshima S, Frey KA (2006) Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease. J Cereb Blood Flow Metab 2006 Sep 26(9):1198\u20131212","journal-title":"J Cereb Blood Flow Metab"},{"issue":"284","key":"2832_CR18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbr.2015.01.053","volume":"1","author":"J Boix","year":"2015","unstructured":"Boix J, Padel T, Paul G (2015) A partial lesion model of Parkinson\u2019s disease in mice\u2014characterization of a 6-OHDA-induced medial forebrain bundle lesion. Behav Brain Res 1(284):196\u2013206","journal-title":"Behav Brain Res"},{"issue":"1","key":"2832_CR19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0161-813X(02)00156-0","volume":"24","author":"A Bortolozzi","year":"2003","unstructured":"Bortolozzi A, Duffard R, de Duffard AM (2003) Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats. Neurotoxicology 24(1):149\u2013157","journal-title":"Neurotoxicology"},{"key":"2832_CR20","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1212\/01.wnl.0000312279.49272.9f","volume":"70","author":"H Braak","year":"2008","unstructured":"Braak H, Del Tredici K (2008) Invited article: nervous system pathology in sporadic Parkinson disease. Neurology 70:1916\u20131925","journal-title":"Neurology"},{"key":"2832_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"2832_CR22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3389\/fnana.2014.00152","volume":"8","author":"L Brichta","year":"2014","unstructured":"Brichta L, Greengard P (2014) Molecular determinants of selective dopaminergic vulnerability in Parkinson\u2019s disease: an update. Front Neuroanat 8:152","journal-title":"Front Neuroanat"},{"key":"2832_CR23","first-page":"82","volume":"1","author":"DJ Brooks","year":"2009","unstructured":"Brooks DJ, Pavese N (2009) Recent imaging advances in the diagnosis and management of Parkinson\u2019s disease. Med Rep 1:82","journal-title":"Med Rep"},{"issue":"357(6357)","key":"2832_CR24","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1126\/science.aam9080","volume":"22","author":"LF Burbulla","year":"2017","unstructured":"Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Kr\u00fcger R, Surmeier DJ, Krainc D (2017) Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease. Science 22(357(6357)):1255\u20131261","journal-title":"Science"},{"key":"2832_CR25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/mds.26550","volume":"31","author":"ME Caligiuri","year":"2016","unstructured":"Caligiuri ME, Nistic\u00f2 R, Arabia G, Morelli M, Novellino F, Salsone M, Barbagallo G, Lupo A, Cascini GL, Galea D, Cherubini A, Quattrone A (2016) Alterations of putaminal shape in de novo Parkinson\u2019s disease. Mov Disord 31:676\u2013683","journal-title":"Mov Disord"},{"key":"2832_CR26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.etp.2016.12.007","volume":"69","author":"CH Carriere","year":"2017","unstructured":"Carriere CH, Kang NH, Niles LP (2017) Bilateral upregulation of alpha-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment. Exp Toxicol Pathol 69:109\u2013114","journal-title":"Exp Toxicol Pathol"},{"issue":"Suppl 10","key":"2832_CR27","first-page":"55","volume":"58","author":"DE Casey","year":"1997","unstructured":"Casey DE (1997) The relationship of pharmacology to side effects. J Clin Psychiatry 58(Suppl 10):55\u201362","journal-title":"J Clin Psychiatry"},{"key":"2832_CR28","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1136\/jnnp.2004.055079","volume":"76","author":"AL Cheesman","year":"2005","unstructured":"Cheesman AL, Barker RA, Lewis SJ, Robbins TW, Owen AM, Brooks DJ (2005) Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 76:1204\u20131210","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/brb3.573","volume":"6","author":"DO Claassen","year":"2016","unstructured":"Claassen DO, McDonell KE, Donahue M, Rawal S, Wylie SA, Neimat JS, Kang H, Hedera P, Zald D, Landman B, Dawant B, Rane S (2016) Cortical asymmetry in Parkinson\u2019s disease: early susceptibility of the left hemisphere. Brain Behav 6:1\u201310 e00573","journal-title":"Brain Behav"},{"key":"2832_CR30","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1093\/brain\/aws211","volume":"135","author":"SJ Colloby","year":"2012","unstructured":"Colloby SJ, McParland S, O'Brien JT, Attems J (2012) Neuropathological correlates of dopaminergic imaging in Alzheimer\u2019s disease and Lewy body dementias. Brain 135:2798\u20132808","journal-title":"Brain"},{"issue":"25(9)","key":"2832_CR31","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/mds.23072","volume":"15","author":"C Colosimo","year":"2010","unstructured":"Colosimo C, Mart\u00ednez-Mart\u00edn P, Fabbrini G, Hauser RA, Merello M, Miyasaki J, Poewe W, Sampaio C, Rascol O, Stebbins GT, Schrag A, Goetz CG (2010) Task force report on scales to assess dyskinesia in Parkinson\u2019s disease: critique and recommendations. Mov Disord 15(25(9)):1131\u20131142","journal-title":"Mov Disord"},{"key":"2832_CR32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1136\/jnnp.65.2.164","volume":"65","author":"TJ Counihan","year":"1998","unstructured":"Counihan TJ, Penney JB Jr (1998) Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson\u2019s disease brains. J Neurol Neurosurg Psychiatry 65:164\u2013169","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/mds.22896","volume":"25","author":"E Cubo","year":"2010","unstructured":"Cubo E, Mart\u00edn PM, Martin-Gonzalez JA, Rodr\u00edguez-Bl\u00e1zquez C, Kulisevsky J, ELEP Group Members (2010) Motor laterality asymmetry and nonmotor symptoms in Parkinson\u2019s disease. Mov Disord 25:70\u201375","journal-title":"Mov Disord"},{"key":"2832_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/brain\/awh008","volume":"127","author":"RC Dale","year":"2004","unstructured":"Dale RC, Church AJ, Surtees RA, Lees AJ, Adcock JE, Harding B, Neville BG, Giovannoni G (2004) Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain 127:21\u201333","journal-title":"Brain"},{"issue":"Pt 8","key":"2832_CR35","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","volume":"122","author":"P Damier","year":"1999","unstructured":"Damier P, Hirsch EC, Agid Y, Graybiel AM (1999) The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson\u2019s disease. Brain 122(Pt 8):1437\u20131448","journal-title":"Brain"},{"key":"2832_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0166-4328(00)00165-0","volume":"112","author":"R Fuente-Fern\u00e1ndez de la","year":"2000","unstructured":"de la Fuente-Fern\u00e1ndez R, Kishore A, Calne DB, Ruth TJ, Stoessl AJ (2000) Nigrostriatal dopamine system and motor lateralization. Behav Brain Res 112:63\u201368","journal-title":"Behav Brain Res"},{"key":"2832_CR37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/mds.870130213","volume":"13","author":"S Dethy","year":"1998","unstructured":"Dethy S, Van Blercom N, Damhaut P, Wikler D, Hildebrand J, Goldman S (1998) Asymmetry of basal ganglia glucose metabolism and dopa responsiveness in parkinsonism. Mov Disord 13:275\u2013280","journal-title":"Mov Disord"},{"key":"2832_CR38","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/mds.25952","volume":"29","author":"AA Dijkstra","year":"2014","unstructured":"Dijkstra AA, Voorn P, Berendse HW, Groenewegen HJ, Netherlands Brain Bank, Rozemuller AJ, van de Berg WD (2014) Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson\u2019s disease. Mov Disord 29:1244\u20131251","journal-title":"Mov Disord"},{"key":"2832_CR39","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1001\/archneur.1984.04050200041016","volume":"41","author":"LK Direnfeld","year":"1984","unstructured":"Direnfeld LK, Albert ML, Volicer L, Langlais PJ, Marquis J, Kaplan E (1984) Parkinson\u2019s disease. The possible relationship of laterality to dementia and neurochemical findings. Arch Neurol 41:935\u2013941","journal-title":"Arch Neurol"},{"key":"2832_CR40","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/S1474-4422(06)70549-X","volume":"5","author":"R Djaldetti","year":"2006","unstructured":"Djaldetti R, Ziv I, Melamed E (2006) The mystery of motor asymmetry in Parkinson\u2019s disease. Lancet Neurol 5:796\u2013802","journal-title":"Lancet Neurol"},{"key":"2832_CR41","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/mds.23380","volume":"26","author":"R Djaldetti","year":"2011","unstructured":"Djaldetti R, Lorberboym M, Karmon Y, Treves TA, Ziv I, Melamed E (2011) Residual striatal dopaminergic nerve terminals in very long-standing Parkinson's disease: a single photon emission computed tomography imaging study. Mov Disord 26:327\u2013330","journal-title":"Mov Disord"},{"key":"2832_CR42","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1001\/jamaneurol.2013.172","volume":"70","author":"KM Doherty","year":"2013","unstructured":"Doherty KM, Silveira-Moriyama L, Parkkinen L, Healy DG, Farrell M, Mencacci NE, Ahmed Z, Brett FM, Hardy J, Quinn N, Counihan TJ, Lynch T, Fox ZV, Revesz T, Lees AJ, Holton JL (2013) Parkin disease: a clinicopathologic entity? JAMA Neurol 70:571\u2013579","journal-title":"JAMA Neurol"},{"issue":"5","key":"2832_CR43","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/jnen\/nlx021","volume":"76","author":"V Donadio","year":"2017","unstructured":"Donadio V, Incensi A, Rizzo G, Scaglione C, Capellari S, Fileccia E, Avoni P, Liguori R (2017) Spine topographical distribution of skin \u03b1-synuclein deposits in idiopathic Parkinson disease. J Neuropathol Exp Neurol 76(5):384\u2013389","journal-title":"J Neuropathol Exp Neurol"},{"key":"2832_CR44","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1136\/jnnp.55.2.138","volume":"55","author":"RL Doty","year":"1992","unstructured":"Doty RL, Stern MB, Pfeiffer C, Gollomp SM, Hurtig HI (1992) Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 55:138\u2013142","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"suppl 2","key":"2832_CR45","first-page":"1204","volume":"31","author":"NF Durmaz","year":"2016","unstructured":"Durmaz NF, Yorubulut M, Akbostanci CM (2016) May substantia nigra volume asymmetry be an indicator of motor asymmetry in Parkinson\u2019s disease? A retrospective analysis (abstract). Mov Disord 31(suppl 2):1204","journal-title":"Mov Disord"},{"issue":"4","key":"2832_CR46","doi-asserted-by":"publisher","first-page":"387","DOI":"10.5114\/ninp.2013.34557","volume":"47","author":"A Dziadkiewicz","year":"2013","unstructured":"Dziadkiewicz A, Bia\u0142ecka M, Janik P, S\u0142awek J (2013) Hemiparkinsonism-hemiatrophy syndrome\u2014report on two cases and review of the literature. Neurol Neurochir Pol 47(4):387\u2013392 https:\/\/doi.org\/10.5114\/ninp.2013.34557","journal-title":"Neurol Neurochir Pol"},{"key":"2832_CR47","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1007\/s00415-013-7030-z","volume":"260","author":"R Erro","year":"2013","unstructured":"Erro R, Barone P, Vicidomini C, Picillo M, Pappat\u00e0 S (2013) Patients with Parkinson\u2019s disease and scans with (predominant) ipsilateral dopaminergic deficit. J Neurol 260:2405\u20132406","journal-title":"J Neurol"},{"key":"2832_CR48","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.parkreldis.2015.09.052","volume":"21","author":"R Erro","year":"2015","unstructured":"Erro R, Spina E, Barone P, Pellecchia MT (2015) On the relationship between side of onset and cognition in Parkinson disease. Parkinsonism Relat Disord 21:1391\u20131392","journal-title":"Parkinsonism Relat Disord"},{"issue":"76(17)","key":"2832_CR49","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1212\/WNL.0b013e318217e7dd","volume":"26","author":"AJ Espay","year":"2011","unstructured":"Espay AJ, Henderson KK (2011) Postencephalitic parkinsonism and basal ganglia necrosis due to Epstein-Barr virus infection. Neurology 26(76(17)):1529\u20131530","journal-title":"Neurology"},{"key":"2832_CR50","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fnana.2017.00109","volume":"11","author":"K Fabricius","year":"2017","unstructured":"Fabricius K, Barkholt P, Jelsing J, Hansen HH (2017) Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson\u2019s disease. Front Neuroanat 11:109","journal-title":"Front Neuroanat"},{"issue":"Pt 5","key":"2832_CR51","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","volume":"114","author":"JM Fearnley","year":"1991","unstructured":"Fearnley JM, Lees AJ (1991) Ageing and Parkinson\u2019s disease: substantia nigra regional selectivity. Brain 114(Pt 5):2283\u20132301","journal-title":"Brain"},{"key":"2832_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bandc.2007.10.002","volume":"67","author":"ER Foster","year":"2008","unstructured":"Foster ER, Black KJ, Antenor-Dorsey JA, Perlmutter JS, Hershey T (2008) Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain Cogn 67:1\u201310","journal-title":"Brain Cogn"},{"key":"2832_CR53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.parkreldis.2008.02.006","volume":"15","author":"PS Foster","year":"2009","unstructured":"Foster PS, Drago V, Skidmore F, Skoblar BM, Crucian GP, Heilman KM (2009) Greater motor improvement in right hemibody Parkinson\u2019s patients after dopaminergic medications. Parkinsonism Relat Disord 15:20\u201323","journal-title":"Parkinsonism Relat Disord"},{"issue":"9","key":"2832_CR54","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.biopsych.2010.12.018","volume":"69","author":"C Francks","year":"2011","unstructured":"Francks C (2011) Leucine-rich repeat genes and the fine-tuning of synapses. Biol Psychiatry 69(9):820\u2013821. https:\/\/doi.org\/10.1016\/j.biopsych.2010.12.018","journal-title":"Biol Psychiatry"},{"issue":"1","key":"2832_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nyas.12770","volume":"1359","author":"C Francks","year":"2015","unstructured":"Francks C (2015) Exploring human brain lateralization with molecular genetics and genomics. Ann N Y Acad Sci 1359(1):1\u201313. https:\/\/doi.org\/10.1111\/nyas.12770","journal-title":"Ann N Y Acad Sci"},{"key":"2832_CR56","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00415-012-6585-4","volume":"260","author":"G Frazzitta","year":"2013","unstructured":"Frazzitta G, Pezzoli G, Bertotti G, Maestri R (2013) Asymmetry and freezing of gait in parkinsonian patients. J Neurol 260:71\u201376","journal-title":"J Neurol"},{"key":"2832_CR57","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ana.410260403","volume":"26","author":"DC German","year":"1989","unstructured":"German DC, Manaye K, Smith WK, Woodward DJ, Saper CB (1989) Midbrain dopaminergic cell loss in Parkinson\u2019s disease: computer visualization. Ann Neurol 26:507\u2013514","journal-title":"Ann Neurol"},{"key":"2832_CR58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0006-8993(82)90472-3","volume":"234","author":"SD Glick","year":"1982","unstructured":"Glick SD, Ross DA, Hough LB (1982) Lateral asymmetry of neurotransmitters in human brain. Brain Res 234:53\u201363","journal-title":"Brain Res"},{"key":"2832_CR59","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.clineuro.2009.12.017","volume":"112","author":"JC G\u00f3mez-Esteban","year":"2010","unstructured":"G\u00f3mez-Esteban JC, Tijero B, Ciordia R, Berganzo K, Somme J, Lezcano E, Zarranz JJ (2010) Factors influencing the symmetry of Parkinson\u2019s disease symptoms. Clin Neurol Neurosurg 112:302\u2013305","journal-title":"Clin Neurol Neurosurg"},{"key":"2832_CR60","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1001\/jamaneurol.2016.3338","volume":"73","author":"SN Gomperts","year":"2016","unstructured":"Gomperts SN, Locascio JJ et al (2016) Tau positron emission tomographic imaging in the Lewy body diseases. JAMA Neurol 73:1334\u20131341","journal-title":"JAMA Neurol"},{"key":"2832_CR61","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1212\/WNL.45.6.1138","volume":"45","author":"JM Gorell","year":"1995","unstructured":"Gorell JM, Ordidge RJ, Brown GG, Deniau JC, Buderer NM, Helpern JA (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson\u2019s disease. Neurology 45:1138\u20131143","journal-title":"Neurology"},{"issue":"12","key":"2832_CR62","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1111\/j.1460-9568.2010.07265.x","volume":"31","author":"S Grealish","year":"2010","unstructured":"Grealish S, Mattsson B, Draxler P, Bj\u00f6rklund A (2010) Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson\u2019s disease. Eur J Neurosci 31(12):2266\u20132278","journal-title":"Eur J Neurosci"},{"key":"2832_CR63","unstructured":"Halliday G, Murphy K (2010) Pathology of Parkinson\u2019s disease\u2014an overview. In: AHV S, AET L et al (eds) Movement disorders, vol 4. Saunders-Elsevier, pp 132\u2013154"},{"key":"2832_CR64","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/mds.26418","volume":"30","author":"JH Ham","year":"2015","unstructured":"Ham JH, Lee JJ, Kim JS, Lee PH, Sohn YH (2015) Is dominant-side onset associated with a better motor compensation in Parkinson\u2019s disease? Mov Disord 30:1921\u20131925","journal-title":"Mov Disord"},{"issue":"4","key":"2832_CR65","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1017\/S1355617715000181","volume":"21","author":"B Hanna-Pladdy","year":"2015","unstructured":"Hanna-Pladdy B, Pahwa R, Lyons KE (2015) Paradoxical effect of dopamine medication on cognition in Parkinson\u2019s disease: relationship to side of motor onset. J Int Neuropsychol Soc 21(4):259\u2013270","journal-title":"J Int Neuropsychol Soc"},{"key":"2832_CR66","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1093\/brain\/aww098","volume":"139","author":"AK Hansen","year":"2016","unstructured":"Hansen AK, Knudsen K, Lillethorup TP, Landau AM, Parbo P, Fedorova T, Audrain H, Bender D, \u00d8stergaard K, Brooks DJ, Borghammer P (2016) In vivo imaging of neuromelanin in Parkinson\u2019s disease using 18F-AV-1451 PET. Brain 139:2039\u20132049","journal-title":"Brain"},{"key":"2832_CR67","first-page":"387","volume":"48","author":"R Hassler","year":"1938","unstructured":"Hassler R (1938) Zur Pathologie der Paralysis agitains und des postenzephalitischen Parkinsonismus. J Psychol Neurol 48:387\u2013476","journal-title":"J Psychol Neurol"},{"key":"2832_CR68","doi-asserted-by":"publisher","first-page":"72","DOI":"10.29333\/ejgm\/82244","volume":"1","author":"JG Heckmann","year":"2004","unstructured":"Heckmann JG, H\u00f6cherl C, Lang C, Platsch G, Hummel T (2004) Hemihyposmia in a case of hemiparkinsonism. Eur J Gen Med 1:72\u201373","journal-title":"Eur J Gen Med"},{"key":"2832_CR69","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.nicl.2017.02.010","volume":"14","author":"E Heinrichs-Graham","year":"2017","unstructured":"Heinrichs-Graham E, Santamaria PM, Gendelman HE, Wilson TW (2017) The cortical signature of symptom laterality in Parkinson\u2019s disease. Neuroimage Clin 14:433\u2013440","journal-title":"Neuroimage Clin"},{"issue":"6","key":"2832_CR70","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0028-3932(97)00156-5","volume":"36","author":"PG Hepper","year":"1998","unstructured":"Hepper PG, McCartney GR, Shannon EA (1998) Lateralised behaviour in first trimester human foetuses. Neuropsychologia 36(6):531\u2013534. https:\/\/doi.org\/10.1016\/S0028-3932(97)00156-5","journal-title":"Neuropsychologia"},{"issue":"2","key":"2832_CR71","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.expneurol.2007.11.011","volume":"210","author":"T Hershey","year":"2008","unstructured":"Hershey T, Wu J, Weaver PM, Perantie DC, Karimi M, Tabbal SD, Perlmutter JS (2008) Unilateral vs. bilateral STN DBS effects on working memory and motor function in Parkinson disease. Exp Neurol 210(2):402\u2013408","journal-title":"Exp Neurol"},{"issue":"3","key":"2832_CR72","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/ana.74","volume":"49","author":"R Hilker","year":"2001","unstructured":"Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius LJ, Lenz O, Vieregge P, Herholz K, Heiss WD, Pramstaller PP (2001) Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Ann Neurol 49(3):367\u2013376. https:\/\/doi.org\/10.1002\/ana.74","journal-title":"Ann Neurol"},{"key":"2832_CR73","doi-asserted-by":"crossref","unstructured":"Hipp G (2015) Das Luxemburger Parkinson-Kohortenprogramm: Neue Strategien f\u00fcr eine umfassende Studie zur Erfassung von Biodaten und klinischen Daten. Basal ganglia [internet]. Elsevier 5(1):XVI","DOI":"10.1016\/j.baga.2015.02.246"},{"issue":"1","key":"2832_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.parkreldis.2011.06.011","volume":"18","author":"DE Hobson","year":"2012","unstructured":"Hobson DE (2012) Asymmetry in parkinsonism, spreading pathogens and the nose. Parkinsonism Relat Disord 18(1):1\u20139","journal-title":"Parkinsonism Relat Disord"},{"issue":"Suppl 1","key":"2832_CR75","first-page":"996","volume":"30","author":"E Hoshiyama","year":"2015","unstructured":"Hoshiyama E, Kadowaki T et al (2015) The decreasing of dopamine-transporter uptake on the right ipsilateral side of tremor in a patient with Parkinson\u2019s disease [abstract]. Mov Disord 30(Suppl 1):996","journal-title":"Mov Disord"},{"key":"2832_CR76","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00401-012-1013-5","volume":"124","author":"H Houlden","year":"2012","unstructured":"Houlden H, Singleton AB (2012) The genetics and neuropathology of Parkinson\u2019s disease. Acta Neuropathol 124:325\u2013338","journal-title":"Acta Neuropathol"},{"key":"2832_CR77","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/mds.27000","volume":"32","author":"P Huang","year":"2017","unstructured":"Huang P, Tan YY, Liu DQ, Herzallah MM, Lapidow E, Wang Y, Zang YF, Gluck MA, Chen SD (2017) Motor-symptom laterality affects acquisition in Parkinson\u2019s disease: a cognitive and functional magnetic resonance imaging study. Mov Disord 32:1047\u20131055","journal-title":"Mov Disord"},{"key":"2832_CR78","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181\u2013184","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR79","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.3174\/ajnr.A4442","volume":"36","author":"I Hwang","year":"2015","unstructured":"Hwang I, Sohn CH, Kang KM, Jeon BS, Kim HJ, Choi SH, Yun TJ, Kim JH (2015) Differentiation of parkinsonism-predominant multiple system atrophy from idiopathic Parkinson disease using 3T susceptibility-weighted MR imaging, focusing on putaminal change and lesion asymmetry. AJNR Am J Neuroradiol 36:2227\u20132234","journal-title":"AJNR Am J Neuroradiol"},{"key":"2832_CR80","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/mds.23795","volume":"27","author":"KA Jellinger","year":"2012","unstructured":"Jellinger KA (2012) Neuropathology of sporadic Parkinson\u2019s disease: evaluation and changes of concepts. Mov Disord 27:8\u201330","journal-title":"Mov Disord"},{"key":"2832_CR81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-319-08046-8_2","volume-title":"Inflammation in Parkinson\u2019s disease: scientific and clinical aspects","author":"KA Jellinger","year":"2014","unstructured":"Jellinger KA (2014) Neuropathology of Parkinson\u2019s disease. In: Thomas M (ed) Inflammation in Parkinson\u2019s disease: scientific and clinical aspects. Springer International Publishing, Switzerland, pp 25\u201374"},{"issue":"68(16)","key":"2832_CR82","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1212\/01.wnl.0000260228.73212.f5","volume":"17","author":"KY Jung","year":"2007","unstructured":"Jung KY, Chung CS, Park KW (2007) Bilateral medial temporal lesions in Japanese encephalitis. Neurology 17(68(16)):1319","journal-title":"Neurology"},{"key":"2832_CR83","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/acn3.268","volume":"3","author":"V Kaasinen","year":"2015","unstructured":"Kaasinen V (2015) Ipsilateral deficits of dopaminergic neurotransmission in Parkinson\u2019s disease. Ann Clin Transl Neurol 3:21\u201326","journal-title":"Ann Clin Transl Neurol"},{"key":"2832_CR84","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cortex.2015.03.003","volume":"67","author":"G Karlebach","year":"2015","unstructured":"Karlebach G, Francks C (2015) Lateralization of gene expression in human language cortex. Cortex 67:30\u201336. https:\/\/doi.org\/10.1016\/j.cortex.2015.03.003","journal-title":"Cortex"},{"key":"2832_CR85","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/jnnp.52.1.72","volume":"52","author":"PA Kempster","year":"1989","unstructured":"Kempster PA, Gibb WR, Stern GM, Lees AJ (1989) Asymmetry of substantia nigra neuronal loss in Parkinson\u2019s disease and its relevance to the mechanism of levodopa related motor fluctuations. J Neurol Neurosurg Psychiatry 52:72\u201376","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR86","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13024-015-0038-3","volume":"10","author":"AP Kiely","year":"2015","unstructured":"Kiely AP, Ling H, Asi YT, Kara E, Proukakis C, Schapira AH, Morris HR, Roberts HC, Lubbe S, Limousin P, Lewis PA, Lees AJ, Quinn N, Hardy J, Love S, Revesz T, Houlden H, Holton JL (2015) Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Mol Neurodegener 10:41","journal-title":"Mol Neurodegener"},{"key":"2832_CR87","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.parkreldis.2014.08.021","volume":"20","author":"JS Kim","year":"2014","unstructured":"Kim JS, Yang JJ, Lee JM, Youn J, Kim JM, Cho JW4 (2014) Topographic pattern of cortical thinning with consideration of motor laterality in Parkinson disease. Parkinsonism Relat Disord 20:1186\u20131190","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR88","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1056\/NEJM198804073181402","volume":"318","author":"SJ Kish","year":"1988","unstructured":"Kish SJ, Shannak K, Hornykiewicz O (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson\u2019s disease. Pathophysiologic and clinical implications. N Engl J Med 318:876\u2013880","journal-title":"N Engl J Med"},{"issue":"1(7755)","key":"2832_CR89","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/S0140-6736(72)90837-9","volume":"15","author":"HL Klawans Jr","year":"1972","unstructured":"Klawans HL Jr (1972) Relationship between handedness and side of onset of parkinsonism. Lancet 15(1(7755)):850","journal-title":"Lancet"},{"key":"2832_CR90","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00259-004-1578-x","volume":"31","author":"GM Knudsen","year":"2004","unstructured":"Knudsen GM, Karlsborg M, Thomsen G, Krabbe K, Regeur L, Nygaard T, Videbaek C, Werdelin L (2004) Imaging of dopamine transporters and D2 receptors in patients with Parkinson\u2019s disease and multiple system atrophy. Eur J Nucl Med Mol Imaging 31:1631\u20131638","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2832_CR91","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1212\/WNL.0b013e318253d5dd","volume":"78","author":"M Kojovic","year":"2012","unstructured":"Kojovic M et al (2012) Functional reorganization of sensorimotor cortex in early Parkinson disease. Neurology 78:1441\u20131448","journal-title":"Neurology"},{"key":"2832_CR92","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1093\/brain\/awt192","volume":"136","author":"JH Kordower","year":"2013","unstructured":"Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, Halliday GM, Bartus RT (2013) Disease duration and the integrity of the nigrostriatal system in Parkinson\u2019s disease. Brain 136:2419\u20132431","journal-title":"Brain"},{"key":"2832_CR93","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/mds.22207","volume":"23","author":"GG Kovacs","year":"2008","unstructured":"Kovacs GG, Milenkovic IJ, Preusser M, Budka H (2008) Nigral burden of alpha-synuclein correlates with striatal dopamine deficit. Mov Disord 23:1608\u20131612","journal-title":"Mov Disord"},{"key":"2832_CR94","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/mds.25975","volume":"29","author":"J Kraemmer","year":"2014","unstructured":"Kraemmer J, Kovacs GG, Perju-Dumbrava L, Pirker S, Traub-Weidinger T, Pirker W (2014) Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Mov Disord 29:1767\u20131773","journal-title":"Mov Disord"},{"issue":"10","key":"2832_CR95","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1212\/WNL.56.10.1355","volume":"56","author":"R Kr\u00fcger","year":"2001","unstructured":"Kr\u00fcger R, Kuhn W, Leenders KL, Sprengelmeyer R, M\u00fcller T, Woitalla D, Portman AT, Maguire RP, Veenma L, Schr\u00f6der U, Sch\u00f6ls L, Epplen JT, Riess O, Przuntek H (2001) Familial parkinsonism with synuclein pathology: Clinical and PET studies of A30P mutation carriers. Neurology 56(10):1355\u20131362. https:\/\/doi.org\/10.1212\/WNL.56.10.1355","journal-title":"Neurology"},{"key":"2832_CR96","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/sj.jcbfm.9600202","volume":"26","author":"Y Kumakura","year":"2006","unstructured":"Kumakura Y, Gjedde A, Danielsen EH, Christensen S, Cumming P (2006) Dopamine storage capacity in caudate and putamen of patients with early Parkinson\u2019s disease: correlation with asymmetry of motor symptoms. J Cereb Blood Flow Metab 26:358\u2013370","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"2832_CR97","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1080\/00207450390231509","volume":"113","author":"S Kumar","year":"2003","unstructured":"Kumar S, Mandal MK (2003) Task-specific motor performance and musculoskeletal response in self-classified right handers. Int J Neurosci 113(11):1487\u20131495","journal-title":"Int J Neurosci"},{"key":"2832_CR98","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1093\/brain\/awg270","volume":"126","author":"A Kumar","year":"2003","unstructured":"Kumar A, Mann S et al (2003) [11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson\u2019s disease. Brain 126:2648\u20132655","journal-title":"Brain"},{"key":"2832_CR99","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/ana.22592","volume":"71","author":"DH Kwon","year":"2012","unstructured":"Kwon DH, Kim JM, Oh SH, Jeong HJ, Park SY, Oh ES, Chi JG, Kim YB, Jeon BS, Cho ZH (2012) Seven-Tesla magnetic resonance images of the substantia nigra in Parkinson disease. Ann Neurol 71:267\u2013277","journal-title":"Ann Neurol"},{"issue":"Suppl 2","key":"2832_CR100","doi-asserted-by":"crossref","first-page":"II110","DOI":"10.1007\/PL00022911","volume":"247","author":"A Laihinen","year":"2000","unstructured":"Laihinen A, Ruottinen H, Rinne JO, Haaparanta M, Bergman J, Solin O, Koskenvuo M, Marttila R, Rinne UK (2000) Risk for Parkinson\u2019s disease: twin studies for the detection of asymptomatic subjects using [18F]6-fluorodopa PET. J Neurol 247(Suppl 2):II110\u2013II113","journal-title":"J Neurol"},{"key":"2832_CR101","doi-asserted-by":"publisher","unstructured":"Larsen SB, Hanss Z, Kr\u00fcger R (2018) The genetic architecture of mitochondrial dysfunction in Parkinson's disease. Cell Tissue Res. https:\/\/doi.org\/10.1007\/s00441-017-2768-8","DOI":"10.1007\/s00441-017-2768-8"},{"key":"2832_CR102","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.parkreldis.2015.02.008","volume":"21","author":"EY Lee","year":"2015","unstructured":"Lee EY, Sen S, Eslinger PJ, Wagner D, Kong L, Lewis MM, Du G, Huang X (2015) Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson\u2019s disease. Parkinsonism Relat Disord 21:465\u2013470","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR103","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/mds.27252","volume":"33","author":"SH Lee","year":"2018","unstructured":"Lee SH, Cho H, Choi JY, Lee JH, Ryu YH, Lee MS, Lyoo CH (2018) Distinct patterns of amyloid-dependent tau accumulation in Lewy body diseases. Mov Disord 33:262\u2013272","journal-title":"Mov Disord"},{"issue":"12","key":"2832_CR104","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1001\/archneur.1990.00530120034007","volume":"47","author":"KL Leenders","year":"1990","unstructured":"Leenders KL, Salmon EP, Tyrrell P, Perani D, Brooks DJ, Sager H, Jones T, Marsden CD, Frackowiak RS (1990) The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson\u2019s disease. Arch Neurol 47(12):1290\u20131298","journal-title":"Arch Neurol"},{"issue":"1","key":"2832_CR105","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/npp.2009.88","volume":"35","author":"SE Leh","year":"2010","unstructured":"Leh SE, Petrides M, Strafella AP (2010) The neural circuitry of executive functions in healthy subjects and Parkinson\u2019s disease. Neuropsychopharmacology. 2010 Jan 35(1):70\u201385","journal-title":"Neuropsychopharmacology"},{"key":"2832_CR106","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/mds.26043","volume":"29","author":"S Leh\u00e9ricy","year":"2014","unstructured":"Leh\u00e9ricy S, Bardinet E, Poupon C, Vidailhet M, Fran\u00e7ois C (2014) 7 Tesla magnetic resonance imaging: a closer look at substantia nigra anatomy in Parkinson\u2019s disease. Mov Disord 29:1574\u20131581","journal-title":"Mov Disord"},{"key":"2832_CR107","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1111\/ene.12760","volume":"22","author":"N Lenfeldt","year":"2015","unstructured":"Lenfeldt N, Larsson A, Nyberg L, Birgander R, Forsgren L (2015) Fractional anisotropy in the substantia nigra in Parkinson\u2019s disease: a complex picture. Eur J Neurol 22:1408\u20131414","journal-title":"Eur J Neurol"},{"key":"2832_CR108","first-page":"11(2)","volume":"22","author":"J Li","year":"2016","unstructured":"Li J, Gu CZ, Su JB, Zhu LH, Zhou Y, Huang HY, Liu CF (2016) Changes in olfactory bulb volume in Parkinson\u2019s disease: a systematic review and meta-analysis. PLoS One 22:11(2)","journal-title":"PLoS One"},{"issue":"6","key":"2832_CR109","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mcp.2016.11.001","volume":"30","author":"CM Lill","year":"2016","unstructured":"Lill CM (2016) Genetics of Parkinson\u2019s disease. Mol Cell Probes 30(6):386\u2013396. https:\/\/doi.org\/10.1016\/j.mcp.2016.11.001","journal-title":"Mol Cell Probes"},{"key":"2832_CR110","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.parkreldis.2015.10.017","volume":"21","author":"SY Liu","year":"2015","unstructured":"Liu SY, Wu JJ, Zhao J, Huang SF, Wang YX, Ge JJ, Wu P, Zuo CT, Ding ZT, Wang J (2015) Onset-related subtypes of Parkinson\u2019s disease differ in the patterns of striatal dopaminergic dysfunction: a positron emission tomography study. Parkinsonism Relat Disord 21:1448\u20131453","journal-title":"Parkinsonism Relat Disord"},{"issue":"11","key":"2832_CR111","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3389\/fncel.2017.00424","volume":"9","author":"KM Lizbinski","year":"2018","unstructured":"Lizbinski KM, Dacks AM (2018) Intrinsic and extrinsic neuromodulation of olfactory processing. Front Cell Neurosci 9(11):424","journal-title":"Front Cell Neurosci"},{"key":"2832_CR112","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/ana.10613","volume":"54","author":"E Lohmann","year":"2003","unstructured":"Lohmann E, Periquet M et al (2003a) How much phenotypic variation can be attributed to parkin genotype? Ann Neurol 54:176\u2013185","journal-title":"Ann Neurol"},{"issue":"2","key":"2832_CR113","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/ana.10613","volume":"54","author":"E Lohmann","year":"2003","unstructured":"Lohmann E, Periquet M, Bonifati V, Wood NW, De Michele G, Bonnet AM, Fraix V, Broussolle E, Horstink MW, Vidailhet M, Verpillat P, Gasser T, Nicholl D, Teive H, Raskin S, Rascol O, Dest\u00e9e A, Ruberg M, Gasparini F, Meco G, Agid Y, Durr A, Brice A, French Parkinson\u2019s Disease Genetics Study Group; European Consortium on Genetic Susceptibility in Parkinson\u2019s Disease (2003b) How much phenotypic variation can be attributed to parkin genotype? Ann Neurol 54(2):176\u2013185. https:\/\/doi.org\/10.1002\/ana.10613","journal-title":"Ann Neurol"},{"key":"2832_CR114","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","volume":"4","author":"VJ Lowe","year":"2016","unstructured":"Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE Kantarci K, Boeve BF, Pandey MK, Bruinsma T, Knopman DS, Jones DT, Petrucelli L, Cook CN, Graff-Radford NR, Dickson DW, Petersen RC, Jack CR Jr, Murray ME (2016) An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol Commun 4:58","journal-title":"Acta Neuropathol Commun"},{"issue":"7265","key":"2832_CR115","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","volume":"461","author":"TA Manolio","year":"2009","unstructured":"Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM (2009) Finding the missing heritability of complex diseases. Nature 461(7265):747\u2013753. https:\/\/doi.org\/10.1038\/nature08494","journal-title":"Nature"},{"key":"2832_CR116","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1212\/WNL.46.1.231","volume":"46","author":"KL Marek","year":"1996","unstructured":"Marek KL, Seibyl JP, Zoghbi SS, Zea-Ponce Y, Baldwin RM, Fussell B, Charney DS, van Dyck C, Hoffer PB, Innis RP (1996) [123I] beta-CIT\/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson\u2019s disease. Neurology 46:231\u2013237","journal-title":"Neurology"},{"issue":"3","key":"2832_CR117","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.mcn.2009.11.009","volume":"43","author":"MA Margeta","year":"2010","unstructured":"Margeta MA, Shen K (2010) Molecular mechanisms of synaptic specificity. Mol Cell Neurosci 43(3):261\u2013267. https:\/\/doi.org\/10.1016\/j.mcn.2009.11.009","journal-title":"Mol Cell Neurosci"},{"key":"2832_CR118","first-page":"180940","volume":"2015","author":"L Marinelli","year":"2015","unstructured":"Marinelli L, Piccardo A, Mori L, Morbelli S, Girtler N, Castaldi A, Picco A, Trompetto C, Ghilardi MF, Abbruzzese G, Nobili F (2015) Orbitofrontal (18) F-DOPA uptake and movement preparation in Parkinson\u2019s disease. Parkinsons Dis 2015:180940","journal-title":"Parkinsons Dis"},{"key":"2832_CR119","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1002\/ana.24517","volume":"78","author":"M Marqui\u00e9","year":"2015","unstructured":"Marqui\u00e9 M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, G\u00f3mez-Isla T (2015) Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol 78:787\u2013800","journal-title":"Ann Neurol"},{"key":"2832_CR120","doi-asserted-by":"publisher","first-page":"e111600","DOI":"10.1371\/journal.pone.0111600","volume":"9","author":"K Martinu","year":"2014","unstructured":"Martinu K, Nagano-Saito A, Fogel S, Monchi O (2014) Asymmetrical effect of levodopa on the neural activity of motor regions in PD. PLoS One 9:e111600","journal-title":"PLoS One"},{"issue":"6","key":"2832_CR121","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1136\/jnnp.51.6.753","volume":"51","author":"C Mattock","year":"1988","unstructured":"Mattock C, Marmot M, Stern G (1988) Could Parkinson\u2019s disease follow intra-uterine influenza?: a speculative hypothesis. J Neurol Neurosurg Psychiatry 51(6):753\u2013756","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR122","doi-asserted-by":"publisher","first-page":"e69190","DOI":"10.1371\/journal.pone.0069190","volume":"8","author":"A McNeill","year":"2013","unstructured":"McNeill A, Wu RM, Tzen KY, Aguiar PC, Arbelo JM, Barone P, Bhatia K, Barsottini O, Bonifati V, Bostantjopoulou S, Bressan R, Cossu G, Cortelli P, Felicio A, Ferraz HB, Herrera J, Houlden H, Hoexter M, Isla C, Lees A, Lorenzo-Betancor O, Mencacci NE, Pastor P, Pappata S, Pellecchia MT, Silveria-Moriyama L, Varrone A, Foltynie T, Schapira AH (2013) Dopaminergic neuronal imaging in genetic Parkinson\u2019s disease: insights into pathogenesis. PLoS One 8:e69190","journal-title":"PLoS One"},{"key":"2832_CR123","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.1002\/hbm.23772","volume":"38","author":"L Minkova","year":"2017","unstructured":"Minkova L, Habich A, Peter J, Kaller CP, Eickhoff SB, Kl\u00f6ppel S (2017) Gray matter asymmetries in aging and neurodegeneration: a review and meta-analysis. Hum Brain Mapp 38:5890\u20135904","journal-title":"Hum Brain Mapp"},{"key":"2832_CR124","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neuropsychologia.2017.06.025","volume":"102","author":"G Mirabella","year":"2017","unstructured":"Mirabella G, Fragola M, Giannini G, Modugno N, Lakens D (2017) Inhibitory control is not lateralized in Parkinson\u2019s patients. Neuropsychologia 102:177\u2013189","journal-title":"Neuropsychologia"},{"key":"2832_CR125","first-page":"7(1)","volume":"19","author":"EJ Modestino","year":"2017","unstructured":"Modestino EJ, Amenechi C, Reinhofer A, O'Toole P (2017) Side-of-onset of Parkinson\u2019s disease in relation to neuropsychological measures. Brain Behav 19:7(1)","journal-title":"Brain Behav"},{"key":"2832_CR126","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1093\/cercor\/bhq202","volume":"21","author":"C Moessnang","year":"2011","unstructured":"Moessnang C, Frank G, Bogdahn U, Winkler J, Greenlee MW, Klucken J (2011) Altered activation patterns within the olfactory network in Parkinson\u2019s disease. Cereb Cortex 21:1246\u20131253","journal-title":"Cereb Cortex"},{"key":"2832_CR127","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.expneurol.2017.02.014","volume":"292","author":"C Monnot","year":"2017","unstructured":"Monnot C, Zhang X, Nikkhou-Aski S, Damberg P, Svenningsson P (2017) Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism. Exp Neurol 292:11\u201320","journal-title":"Exp Neurol"},{"key":"2832_CR128","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.parkreldis.2012.07.008","volume":"19","author":"RP Munhoz","year":"2013","unstructured":"Munhoz RP, Espay AJ, Morgante F, Li JY, Teive HA, Dunn E, Gallin E, Litvan I (2013) Long-duration Parkinson\u2019s disease: role of lateralization of motor features. Parkinsonism Relat Disord 19:77\u201380","journal-title":"Parkinsonism Relat Disord"},{"issue":"9","key":"2832_CR129","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ng.3043","volume":"46","author":"MA Nalls","year":"2014","unstructured":"Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease. Nat Genet 46(9):989\u2013993. https:\/\/doi.org\/10.1038\/ng.3043","journal-title":"Nat Genet"},{"issue":"22","key":"2832_CR130","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1212\/01.wnl.0000335973.66333.58","volume":"71","author":"R Nandhagopal","year":"2008","unstructured":"Nandhagopal R, Mak E, Schulzer M, McKenzie J, McCormick S, Sossi V, Ruth TJ, Strongosky A, Farrer MJ, Wszolek ZK, Stoessl AJ (2008) Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study. Neurology 71(22):1790\u20131795. https:\/\/doi.org\/10.1212\/01.wnl.0000335973.66333.58","journal-title":"Neurology"},{"key":"2832_CR131","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1093\/brain\/awp209","volume":"132","author":"R Nandhagopal","year":"2009","unstructured":"Nandhagopal R, Kuramoto L, Schulzer M, Mak E, Cragg J, Lee CS, McKenzie J, McCormick S, Samii A, Troiano A, Ruth TJ, Sossi V, de la Fuente-Fernandez R, Calne DB, Stoessl AJ (2009) Longitudinal progression of sporadic Parkinson\u2019s disease: a multi-tracer positron emission tomography study. Brain 132:2970\u20132979","journal-title":"Brain"},{"key":"2832_CR132","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1007\/s00415-009-5446-2","volume":"257","author":"I Nestrasil","year":"2010","unstructured":"Nestrasil I, Michaeli S, Liimatainen T, Rydeen CE, Kotz CM, Nixon JP, Hanson T, Tuite PJ (2010) T1rho and T2rho MRI in the evaluation of Parkinson\u2019s disease. J Neurol 257:964\u2013968","journal-title":"J Neurol"},{"key":"2832_CR133","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1093\/brain\/awp044","volume":"132","author":"J Neumann","year":"2009","unstructured":"Neumann J, Bras J, Deas E, O'Sullivan SS, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, Segarane B, Singleton A, Lees A, Hardy J, Houlden H, Revesz T, Wood NW (2009) Glucocerebrosidase mutations in clinical and pathologically proven Parkinson\u2019s disease. Brain 132:1783\u20131794","journal-title":"Brain"},{"key":"2832_CR134","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.3174\/ajnr.A4412","volume":"36","author":"Y Noh","year":"2015","unstructured":"Noh Y, Sung YH, Lee J, Kim EY (2015) Nigrosome 1 detection at 3T MRI for the diagnosis of early-stage idiopathic Parkinson disease: assessment of diagnostic accuracy and agreement on imaging asymmetry and clinical laterality. AJNR Am J Neuroradiol 36:2010\u20132016","journal-title":"AJNR Am J Neuroradiol"},{"key":"2832_CR135","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/jnnp.54.1.30","volume":"54","author":"B Pakkenberg","year":"1991","unstructured":"Pakkenberg B, M\u00f8ller A, Gundersen HJ, Mouritzen Dam A, Pakkenberg H (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson\u2019s disease estimated with an unbiased stereological method. J Neurol Neurosurg Psychiatry 54:30\u201333","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2832_CR136","doi-asserted-by":"publisher","first-page":"e8762","DOI":"10.1371\/journal.pone.0008762","volume":"5","author":"F Pan-Montojo","year":"2010","unstructured":"Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG, Reichmann H, Funk RH (2010) Progression of Parkinson\u2019s disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One 5:e8762","journal-title":"PLoS One"},{"key":"2832_CR137","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.parkreldis.2017.11.334","volume":"46","author":"JW Park","year":"2018","unstructured":"Park JW, Kwon DY, Choi JH, Park MH, Yoon HK (2018) Olfactory dysfunctions in drug-na\u00efve Parkinson\u2019s disease with mild cognitive impairment. Parkinsonism Relat Disord 46:69\u201373","journal-title":"Parkinsonism Relat Disord"},{"issue":"9","key":"2832_CR138","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.parkreldis.2015.07.002","volume":"21","author":"C Pellicano","year":"2015","unstructured":"Pellicano C, Assogna F, Cravello L, Langella R, Caltagirone C, Spalletta G, Pontieri FE (2015) Neuropsychiatric and cognitive symptoms and body side of onset of parkinsonism in unmedicated Parkinson\u2019s disease patients. Parkinsonism Relat Disord 21(9):1096\u20131100","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR139","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1093\/brain\/awq212","volume":"133","author":"P P\u00e9ran","year":"2010","unstructured":"P\u00e9ran P, Cherubini A, Assogna F, Piras F, Quattrocchi C, Peppe A, Celsis P, Rascol O, D\u00e9monet JF, Stefani A, Pierantozzi M, Pontieri FE, Caltagirone C, Spalletta G, Sabatini U (2010) Magnetic resonance imaging markers of Parkinson\u2019s disease nigrostriatal signature. Brain 133:3423\u20133433","journal-title":"Brain"},{"key":"2832_CR140","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/mds.24000","volume":"27","author":"LD Perju-Dumbrava","year":"2012","unstructured":"Perju-Dumbrava LD, Kovacs GG, Pirker S, Jellinger K, Hoffmann M, Asenbaum S, Pirker W (2012) Dopamine transporter imaging in autopsy-confirmed Parkinson\u2019s disease and multiple system atrophy. Mov Disord 27:65\u201371","journal-title":"Mov Disord"},{"key":"2832_CR141","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ana.24291","volume":"76","author":"JS Perlmutter","year":"2014","unstructured":"Perlmutter JS, Norris SA (2014) Neuroimaging biomarkers for Parkinson disease: facts and fantasy. Ann Neurol 76:769\u2013783","journal-title":"Ann Neurol"},{"issue":"5","key":"2832_CR142","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/mds.870110513","volume":"11","author":"F Picard","year":"1996","unstructured":"Picard F, de Saint-Martin A, Salmon E, Hirsch E, Marescaux C (1996) Postencephalitic stereotyped involuntary movements responsive to l-dopa. Mov Disord 11(5):567\u2013570","journal-title":"Mov Disord"},{"key":"2832_CR143","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/13803395.2012.751966","volume":"35","author":"M Poletti","year":"2013","unstructured":"Poletti M, Frosini D, Pagni C, Baldacci F, Giuntini M, Mazzucchi S, Tognoni G, Lucetti C, Del Dotto P, Ceravolo R, Bonuccelli U (2013) The relationship between motor symptom lateralization and cognitive performance in newly diagnosed drug-naive patients with Parkinson\u2019s disease. J Clin Exp Neuropsychol 35:124\u2013131","journal-title":"J Clin Exp Neuropsychol"},{"key":"2832_CR144","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.parkreldis.2012.05.021","volume":"18","author":"BD Prakash","year":"2012","unstructured":"Prakash BD, Sitoh YY, Tan LC, Au WL (2012) Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson\u2019s disease. Parkinsonism Relat Disord 18:1029\u20131033","journal-title":"Parkinsonism Relat Disord"},{"issue":"5","key":"2832_CR145","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1212\/WNL.58.5.808","volume":"58","author":"PP Pramstaller","year":"2002","unstructured":"Pramstaller PP, K\u00fcnig G, Leenders K, Kann M, Hedrich K, Vieregge P, Goetz CG, Klein C (2002) Parkin mutations in a patient with hemiparkinsonism-hemiatrophy: a clinical-genetic and PET study. Neurology 58(5):808\u2013810 Retrieved from http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11889248","journal-title":"Neurology"},{"key":"2832_CR146","doi-asserted-by":"publisher","unstructured":"Prasad S, Stezin A, Lenka A, George L, Saini J, Yadav R, Pal PK (2018) Three-dimensional neuromelanin sensitive magnetic resonance imaging of the substantia nigra in Parkinson's disease. Eur J Neurol 25(4):680\u2013686. https:\/\/doi.org\/10.1111\/ene.13573","DOI":"10.1111\/ene.13573"},{"key":"2832_CR147","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1084\/jem.20160368","volume":"213","author":"NL Rey","year":"2016","unstructured":"Rey NL, Steiner JA, Maroof N, Luk KC, Madaj Z, Trojanowski JQ, Lee VM, Brundin P (2016) Widespread transneuronal propagation of alpha-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson\u2019s disease. J Exp Med 213:1759\u20131778","journal-title":"J Exp Med"},{"key":"2832_CR148","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00702-012-0775-1","volume":"119","author":"P Riederer","year":"2012","unstructured":"Riederer P, Sian-H\u00fclsmann J (2012) The significance of neuronal lateralisation in Parkinson\u2019s disease. J Neural Transm (Vienna) 119:953\u2013962","journal-title":"J Neural Transm (Vienna)"},{"key":"2832_CR149","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/mds.870080203","volume":"8","author":"JO Rinne","year":"1993","unstructured":"Rinne JO, Laihinen A, Rinne UK, N\u00e5gren K, Bergman J, Ruotsalainen U (1993) PET study on striatal dopamine D2 receptor changes during the progression of early Parkinson\u2019s disease. Mov Disord 8:134\u2013138","journal-title":"Mov Disord"},{"issue":"4","key":"2832_CR150","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.neuro.2010.03.006","volume":"31","author":"E Rissanen","year":"2010","unstructured":"Rissanen E, Paavilainen T, Virta J, Marttila RJ, Rinne JO, Airas L (2010) Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET). Neurotoxicology 31(4):403\u2013407","journal-title":"Neurotoxicology"},{"key":"2832_CR151","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1093\/brain\/aww124","volume":"139","author":"M Rolinski","year":"2016","unstructured":"Rolinski M, Griffanti L, Piccini P, Roussakis AA, Szewczyk-Krolikowski K, Menke RA, Quinnell T, Zaiwalla Z, Klein JC, Mackay CE, Hu MT (2016) Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson\u2019s disease. Brain 139:2224\u20132234","journal-title":"Brain"},{"key":"2832_CR152","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00401-008-0352-8","volume":"115","author":"G Rudow","year":"2008","unstructured":"Rudow G, O'Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso JC (2008) Morphometry of the human substantia nigra in ageing and Parkinson\u2019s disease. Acta Neuropathol 115:461\u2013470","journal-title":"Acta Neuropathol"},{"key":"2832_CR153","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fneur.2016.00145","volume":"7","author":"MC Santos","year":"2016","unstructured":"Santos MC, Campos LS, Guimar\u00e3es RP, Piccinin CC, Azevedo PC, Piovesana LG, De Campos BM, Scarparo Amato-Filho AC, Cendes F, D\u2019Abreu A (2016) Does side of onset influence the pattern of cerebral atrophy in Parkinson\u2019s disease? Front Neurol 7:145","journal-title":"Front Neurol"},{"issue":"1","key":"2832_CR154","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1037\/a0013734","volume":"123","author":"HE Schendan","year":"2009","unstructured":"Schendan HE, Amick MM, Cronin-Golomb A (2009) Role of a lateralized parietal-basal ganglia circuit in hierarchical pattern perception: evidence from Parkinson\u2019s disease. Behav Neurosci 123(1):125\u2013136","journal-title":"Behav Neurosci"},{"key":"2832_CR155","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1093\/brain\/aws253","volume":"135","author":"C Scherfler","year":"2012","unstructured":"Scherfler C, Seppi K, Mair KJ, Donnemiller E, Virgolini I, Wenning GK, Poewe W (2012) Left hemispheric predominance of nigrostriatal dysfunction in Parkinson\u2019s disease. Brain 135:3348\u20133354","journal-title":"Brain"},{"issue":"3","key":"2832_CR156","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1365-2990.2008.00952.x","volume":"34","author":"C Schiesling","year":"2008","unstructured":"Schiesling C, Kieper N, Seidel K, Kr\u00fcger R (2008) Review: familial Parkinson\u2019s disease\u2014genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol Appl Neurobiol 34(3):255\u2013271. https:\/\/doi.org\/10.1111\/j.1365-2990.2008.00952.x","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"33(3)","key":"2832_CR157","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0304-3940(82)90385-8","volume":"13","author":"LH Schneider","year":"1982","unstructured":"Schneider LH, Murphy RB, Coons EE (1982) Lateralization of striatal dopamine (D2) receptors in normal rats. Neurosci Lett 13(33(3)):281\u2013284","journal-title":"Neurosci Lett"},{"key":"2832_CR158","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/ana.25060","volume":"82","author":"DR Schonhaut","year":"2017","unstructured":"Schonhaut DR, McMillan CT, Spina S, Dickerson BC, Siderowf A, Devous MD Sr, Tsai R, Winer J, Russell DS, Litvan I, Roberson ED, Seeley WW, Grinberg LT, Kramer JH, Miller BL, Pressman P, Nasrallah I, Baker SL, Gomperts SN, Johnson KA, Grossman M, Jagust WJ, Boxer AL, Rabinovici GD (2017) (18) F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: a multicenter study. Ann Neurol 82:622\u2013634","journal-title":"Ann Neurol"},{"key":"2832_CR159","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/mds.26323","volume":"30","author":"N Seraji-Bozorgzad","year":"2015","unstructured":"Seraji-Bozorgzad N, Bao F, George E, Krstevska S, Gorden V, Chorostecki J, Santiago C, Zak I, Caon C, Khan O (2015) Longitudinal study of the substantia nigra in Parkinson disease: a high-field (1) H-MR spectroscopy imaging study. Mov Disord 30:1400\u20131404","journal-title":"Mov Disord"},{"key":"2832_CR160","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.medcli.2012.11.028","volume":"142","author":"J Shi","year":"2014","unstructured":"Shi J, Liu J, Qu Q (2014) Handedness and dominant side of symptoms in Parkinson\u2019s disease. Med Clin (Barc) 142:141\u2013144","journal-title":"Med Clin (Barc)"},{"key":"2832_CR161","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/ana.410340304","volume":"34","author":"BJ Snow","year":"1993","unstructured":"Snow BJ, Tooyama I, McGeer EG, Yamada T, Calne DB, Takahashi H, Kimura H (1993) Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Ann Neurol 34:324\u2013330","journal-title":"Ann Neurol"},{"key":"2832_CR162","volume-title":"Gray\u2019s anatomy: the anatomical basis of clinical practice","author":"S Standring","year":"2008","unstructured":"Standring S, Gray H (2008) Gray\u2019s anatomy: the anatomical basis of clinical practice. Churchill Livingstone\/Elsevier, Edinburgh"},{"key":"2832_CR163","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3389\/fnagi.2017.00361","volume":"9","author":"Y Sun","year":"2017","unstructured":"Sun Y, Li J, Suckling J, Feng L (2017) Asymmetry of hemispheric network topology reveals dissociable processes between functional and structural brain connectome in community-living elders. Front Aging Neurosci 9:361","journal-title":"Front Aging Neurosci"},{"issue":"7","key":"2832_CR164","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0028-3932(98)00144-4","volume":"37","author":"S Tanaka","year":"1999","unstructured":"Tanaka S, Kanzaki R, Yoshibayashi M, Kamiya T, Sugishita M (1999) Dichotic listening in patients with situs inversus: brain asymmetry and situs asymmetry. Neuropsychologia 37(7):869\u2013874. https:\/\/doi.org\/10.1016\/S0028-3932(98)00144-4","journal-title":"Neuropsychologia"},{"issue":"3","key":"2832_CR165","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1523\/JNEUROSCI.4188-09.2010","volume":"30","author":"CC Tang","year":"2010","unstructured":"Tang CC, Poston KL, Dhawan V, Eidelberg D (2010) Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson\u2019s disease. J Neurosci 30(3):1049\u20131056","journal-title":"J Neurosci"},{"key":"2832_CR166","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1080\/13854046.2016.1251973","volume":"31","author":"JJ Tanner","year":"2017","unstructured":"Tanner JJ, Levy SA, Schwab NA, Hizel LP, Nguyen PT, Okun MS, Price CC (2017) Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson\u2019s disease: a longitudinal analysis. Clin Neuropsychol 31:654\u2013675","journal-title":"Clin Neuropsychol"},{"key":"2832_CR167","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s004150050168","volume":"245","author":"G Tissingh","year":"1998","unstructured":"Tissingh G, Bergmans P, Booij J, Winogrodzka A, van Royen EA, Stoof JC, Wolters EC (1998) Drug-naive patients with Parkinson\u2019s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-CIT SPECT. J Neurol 245:14\u201320","journal-title":"J Neurol"},{"key":"2832_CR168","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrn1009","volume":"4","author":"AW Toga","year":"2003","unstructured":"Toga AW, Thompson PM (2003) Mapping brain asymmetry. Nat Rev Neurosci 4:37\u201348","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2832_CR169","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/ana.410340412","volume":"34","author":"R Tomer","year":"1993","unstructured":"Tomer R, Levin BE, Weiner WJ (1993) Side of onset of motor symptoms influences cognition in Parkinson's disease. Ann Neurol 34(4):579\u2013584","journal-title":"Ann Neurol"},{"key":"2832_CR170","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1212\/01.WNL.0000163993.82388.C8","volume":"64","author":"RJ Uitti","year":"2005","unstructured":"Uitti RJ, Baba Y, Whaley NR, Wszolek ZK, Putzke JD (2005) Parkinson disease: handedness predicts asymmetry. Neurology 64:1925\u20131930","journal-title":"Neurology"},{"key":"2832_CR171","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10334-010-0198-7","volume":"23","author":"N Camp Van","year":"2010","unstructured":"Van Camp N, Vreys R, Van Laere K, Lauwers E, Beque D, Verhoye M, Casteels C, Verbruggen A, Debyser Z, Mortelmans L, Sijbers J, Nuyts J, Baekelandt V, Van der Linden A (2010) Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson\u2019s disease discerned with microSPECT and quantitative MRI. MAGMA 23:65\u201375","journal-title":"MAGMA"},{"key":"2832_CR172","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/mds.24007","volume":"27","author":"A Hoorn van der","year":"2012","unstructured":"van der Hoorn A, Burger H, Leenders KL, de Jong BM (2012) Handedness correlates with the dominant Parkinson side: a systematic review and meta-analysis. Mov Disord 27:206\u2013210","journal-title":"Mov Disord"},{"key":"2832_CR173","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/mds.1256","volume":"16","author":"A Varrone","year":"2001","unstructured":"Varrone A, Marek KL, Jennings D, Innis RB, Seibyl JP (2001) [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson\u2019s disease and multiple system atrophy. Mov Disord 16:1023\u20131032","journal-title":"Mov Disord"},{"key":"2832_CR174","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1002\/mds.26799","volume":"31","author":"D Vilas","year":"2016","unstructured":"Vilas D, Segura B, Baggio HC, Pont-Sunyer C, Compta Y, Valldeoriola F, Jos\u00e9 Mart\u00ed M, Quintana M, Bay\u00e9s A, Hern\u00e1ndez-Vara J, Calopa M, Aguilar M, Junqu\u00e9 C, Tolosa E, the Barcelona LRRK2 Study Group (2016) Nigral and striatal connectivity alterations in asymptomatic LRRK2 mutation carriers: a magnetic resonance imaging study. Mov Disord 31:1820\u20131828","journal-title":"Mov Disord"},{"key":"2832_CR175","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.parkreldis.2015.03.012","volume":"21","author":"J Wang","year":"2015","unstructured":"Wang J, Yang QX, Sun X, Vesek J, Mosher Z, Vasavada M, Chu J, Kanekar S, Shivkumar V, Venkiteswaran K, Subramanian T (2015) MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson\u2019s disease. Parkinsonism Relat Disord 21:590\u2013596","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR176","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1600-0404.1995.tb06998.x","volume":"91","author":"GK Wenning","year":"1995","unstructured":"Wenning GK, Shephard B, Hawkes C, Petruckevitch A, Lees A, Quinn N (1995) Olfactory function in atypical parkinsonian syndromes. Acta Neurol Scand 91:247\u2013250","journal-title":"Acta Neurol Scand"},{"key":"2832_CR177","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1002\/hbm.22743","volume":"36","author":"T Wu","year":"2015","unstructured":"Wu T, Hou Y et al (2015) Lateralization of brain activity pattern during unilateral movement in Parkinson\u2019s disease. Hum Brain Mapp 36:1878\u20131891","journal-title":"Hum Brain Mapp"},{"key":"2832_CR178","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2214\/AJR.14.14052","volume":"206","author":"T Wu","year":"2016","unstructured":"Wu T, Hou Y, Hallett M, Zhang J, Chan P (2016) Proton MR spectroscopy for monitoring pathologic changes in the substantia nigra and globus pallidus in Parkinson disease. AJR Am J Roentgenol 206:385\u2013389","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2832_CR179","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuroimage.2007.11.017","volume":"40","author":"X Xu","year":"2008","unstructured":"Xu X, Wang Q, Zhang M (2008) Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. NeuroImage 40(1):35\u201342","journal-title":"NeuroImage"},{"key":"2832_CR180","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.2967\/jnumed.110.076802","volume":"51","author":"S Yagi","year":"2010","unstructured":"Yagi S, Yoshikawa E, Futatsubashi M, Yokokura M, Yoshihara Y, Torizuka T, Ouchi Y (2010) Progression from unilateral to bilateral parkinsonism in early Parkinson disease: implication of mesocortical dopamine dysfunction by PET. J Nucl Med 51:1250\u20131257","journal-title":"J Nucl Med"},{"issue":"8","key":"2832_CR181","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.parkreldis.2008.01.017","volume":"14","author":"S Yust-Katz","year":"2008","unstructured":"Yust-Katz S, Tesler D, Treves TA, Melamed E, Djaldetti R (2008) Handedness as a predictor of side of onset of Parkinson\u2019s disease. Parkinsonism Relat Disord 14(8):633\u2013635","journal-title":"Parkinsonism Relat Disord"},{"key":"2832_CR182","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4172\/2161-0460.1000319","volume":"7","author":"Z Zheng","year":"2017","unstructured":"Zheng Z, Poon WS (2017) Rodent model of Parkinson\u2019s disease: unilateral or bilateral. J Alzheimers Dis Parkinsonism 7:2","journal-title":"J Alzheimers Dis Parkinsonism"},{"key":"2832_CR183","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11682-013-9251-2","volume":"8","author":"B Zhou","year":"2014","unstructured":"Zhou B, Yuan F, He Z, Tan C (2014) Application of proton magnetic resonance spectroscopy on substantia nigra metabolites in Parkinson\u2019s disease. Brain Imaging Behav 8:97\u2013101","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"2832_CR184","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","volume":"44","author":"A Zimprich","year":"2004","unstructured":"Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Gasser T (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44(4):601\u2013607. https:\/\/doi.org\/10.1016\/j.neuron.2004.11.005","journal-title":"Neuron"},{"key":"2832_CR185","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2466\/pms.2001.92.3.894","volume":"92","author":"G Zucco","year":"2001","unstructured":"Zucco G, Zeni MT, Perrone A, Piccolo I (2001) Olfactory sensitivity in early-stage Parkinson patients affected by more marked unilateral disorder. Percept Mot Skills 92:894\u2013898","journal-title":"Percept Mot Skills"},{"issue":"6","key":"2832_CR186","first-page":"1020","volume":"16","author":"GM Zucco","year":"2015","unstructured":"Zucco GM, Rovatti F, Stevenson RJ (2015) Olfactory asymmetric dysfunction in early Parkinson patients affected by unilateral disorder. Front Psychol 16(6):1020","journal-title":"Front Psychol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-018-2832-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2832-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2832-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T03:37:03Z","timestamp":1693625823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-018-2832-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,14]]},"references-count":186,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2832"],"URL":"https:\/\/doi.org\/10.1007\/s00441-018-2832-z","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,14]]},"assertion":[{"value":"1 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}