{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:00:33Z","timestamp":1780052433114,"version":"3.53.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Society for the Promotion of Science","doi-asserted-by":"crossref","award":["2591675"],"award-info":[{"award-number":["2591675"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00441-018-2914-y","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T01:55:31Z","timestamp":1537926931000},"page":"425-435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Age-dependent differences in response to partial-thickness cartilage defects in a rat model as a measure to evaluate the efficacy of interventions for cartilage repair"],"prefix":"10.1007","volume":"375","author":[{"given":"Yorikazu","family":"Akatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Fukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichiro","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Sasho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"2914_CR1","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s00167-006-0124-8","volume":"14","author":"M Agung","year":"2006","unstructured":"Agung M, Ochi M, Yanada S, Adachi N, Izuta Y, Yamasaki T, Toda K (2006) Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration. Knee Surg Sports Traumatol Arthrosc 14:1307\u20131314","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2914_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/0363546503259345","volume":"32","author":"A Ar\u00f8en","year":"2004","unstructured":"Ar\u00f8en A, L\u00f8ken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L (2004) Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med 32:211\u2013215","journal-title":"Am J Sports Med"},{"key":"2914_CR3","doi-asserted-by":"crossref","unstructured":"Buckwalter JA (2002) Articular cartilage injuries. Clin Orthop Relat Res:21\u201337","DOI":"10.1097\/00003086-200209000-00004"},{"key":"2914_CR4","first-page":"465","volume":"54","author":"JA Buckwalter","year":"2005","unstructured":"Buckwalter JA, Mankin HJ, Grodzinsky AJ (2005) Articular cartilage and osteoarthritis. Instr Course Lect 54:465\u2013480","journal-title":"Instr Course Lect"},{"key":"2914_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1089\/ten.teb.2009.0452","volume":"16","author":"CR Chu","year":"2010","unstructured":"Chu CR, Szczodry M, Bruno S (2010) Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev 16:105\u2013115","journal-title":"Tissue Eng Part B Rev"},{"key":"2914_CR6","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/S0749-8063(97)90124-9","volume":"13","author":"WW Curl","year":"1997","unstructured":"Curl WW, Krome J, Gordon ES, Rushing J, Smith BP, Poehling GG (1997) Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy 13:456\u2013460","journal-title":"Arthroscopy"},{"key":"2914_CR7","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P","volume":"44","author":"C De Bari","year":"2001","unstructured":"De Bari C, Dell\u2019Accio F, Tylzanowski P, Luyten FP (2001) Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 44:1928\u20131942","journal-title":"Arthritis Rheum"},{"key":"2914_CR8","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.1002\/art.21474","volume":"52","author":"C Ding","year":"2005","unstructured":"Ding C, Cicuttini F, Scott F, Boon C, Jones G (2005) Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study. Arthritis Rheum 52:3918\u20133927","journal-title":"Arthritis Rheum"},{"key":"2914_CR9","doi-asserted-by":"publisher","first-page":"e45517","DOI":"10.1371\/journal.pone.0045517","volume":"7","author":"I Futami","year":"2012","unstructured":"Futami I, Ishijima M, Kaneko H, Tsuji K, Ichikawa-Tomikawa N, Sadatsuki R, Muneta T, Arikawa-Hirasawa E, Sekiya I, Kaneko K (2012) Isolation and characterization of multipotential mesenchymal cells from the mouse synovium. PLoS One 7:e45517","journal-title":"PLoS One"},{"key":"2914_CR10","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.2042-3306.1992.tb02860.x","volume":"24","author":"EA Hanie","year":"1992","unstructured":"Hanie EA, Sullins KE, Powers BE, Nelson PR (1992) Healing of full-thickness cartilage compared with full-thickness cartilage and subchondral bone defects in the equine third carpal bone. Equine Vet J 24:382\u2013386","journal-title":"Equine Vet J"},{"key":"2914_CR11","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1634\/stemcells.2008-0616","volume":"27","author":"M Horie","year":"2009","unstructured":"Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E (2009) Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect. Stem Cells 27:878\u2013887","journal-title":"Stem Cells"},{"key":"2914_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11926-008-0004-y","volume":"10","author":"DJ Hunter","year":"2008","unstructured":"Hunter DJ (2008) Are there promising biologic therapies for osteoarthritis? Curr Rheumatol Rep 10:19\u201325","journal-title":"Curr Rheumatol Rep"},{"key":"2914_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrrheum.2010.178","volume":"7","author":"DJ Hunter","year":"2011","unstructured":"Hunter DJ (2011) Pharmacologic therapy for osteoarthritis\u2014the era of disease modification. Nat Rev Rheumatol 7:13\u201322","journal-title":"Nat Rev Rheumatol"},{"key":"2914_CR14","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2106\/00004623-199605000-00012","volume":"78","author":"EB Hunziker","year":"1996","unstructured":"Hunziker EB, Rosenberg LC (1996) Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane. J Bone Joint Surg Am 78:721\u2013733","journal-title":"J Bone Joint Surg Am"},{"key":"2914_CR15","doi-asserted-by":"publisher","first-page":"R84","DOI":"10.1186\/ar2460","volume":"10","author":"H Koga","year":"2008","unstructured":"Koga H, Shimaya M, Muneta T, Nimura A, Morito T, Hayashi M, Suzuki S, Ju YJ, Mochizuki T, Sekiya I (2008) Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect. Arthritis Res Ther 10:R84","journal-title":"Arthritis Res Ther"},{"key":"2914_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00441-004-0893-7","volume":"317","author":"N Kumahashi","year":"2004","unstructured":"Kumahashi N, Ochi M, Kataoka H, Uchio Y, Kakimaru H, Sugawara K, Enomoto K (2004) Involvement of ATP, increase of intracellular calcium and the early expression of c-fos in the repair of rat fetal articular cartilage. Cell Tissue Res 317:117\u2013128","journal-title":"Cell Tissue Res"},{"key":"2914_CR17","first-page":"41","volume":"2","author":"JE Lee","year":"2005","unstructured":"Lee JE, Jeong MH, Ahn HJ, Kim JK, Choi K, Chang CB, Kim HJ, Seong SC, Lee MC (2005) Evaluation of chondrogenesis in collagen\/chitosan\/glycosaminoglycan scaffolds for cartilage tissue engineering. Tissue Engineering Regenerative Medicine 2:41\u201349","journal-title":"Tissue Engineering Regenerative Medicine"},{"key":"2914_CR18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1081\/DCT-120014794","volume":"25","author":"EM Lewis","year":"2002","unstructured":"Lewis EM, Barnett JF, Freshwater L, Hoberman AM, Christian MS (2002) Sexual maturation data for Crl Sprague-Dawley rats: criteria and confounding factors. Drug Chem Toxicol 25:437\u2013458","journal-title":"Drug Chem Toxicol"},{"key":"2914_CR19","doi-asserted-by":"publisher","first-page":"e97293","DOI":"10.1371\/journal.pone.0097293","volume":"9","author":"J Liu","year":"2014","unstructured":"Liu J, Song W, Yuan T, Xu Z, Jia W, Zhang C (2014) A comparison between platelet-rich plasma (PRP) and hyaluronate acid on the healing of cartilage defects. PLoS One 9:e97293","journal-title":"PLoS One"},{"key":"2914_CR20","first-page":"244","volume":"18","author":"J Long","year":"1920","unstructured":"Long J, Evans A (1920) On the attainment of sexual maturity and the character of the first estrous cycle in the rat. Anat Recrd 18:244\u2013245","journal-title":"Anat Recrd"},{"key":"2914_CR21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","volume":"7","author":"MK Lotz","year":"2011","unstructured":"Lotz MK, Caram\u00e9s B (2011) Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol 7:579\u2013587","journal-title":"Nat Rev Rheumatol"},{"key":"2914_CR22","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1002\/art.27528","volume":"62","author":"MK Lotz","year":"2010","unstructured":"Lotz MK, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D\u2019Lima D (2010) Cartilage cell clusters. Arthritis Rheum 62:2206\u20132218","journal-title":"Arthritis Rheum"},{"key":"2914_CR23","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1002\/jor.20249","volume":"24","author":"Y Lu","year":"2006","unstructured":"Lu Y, Markel MD, Swain C, Kaplan LD (2006) Development of partial thickness articular cartilage injury in an ovine model. J Orthop Res 24:1974\u20131982","journal-title":"J Orthop Res"},{"key":"2914_CR24","doi-asserted-by":"publisher","first-page":"424","DOI":"10.2106\/00004623-197052030-00002","volume":"52","author":"HJ Mankin","year":"1970","unstructured":"Mankin HJ, Lippiello L (1970) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J Bone Joint Surg Am 52:424\u2013434","journal-title":"J Bone Joint Surg Am"},{"key":"2914_CR25","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1056\/NEJM197412122912406","volume":"291","author":"HJ Mankin","year":"1974","unstructured":"Mankin HJ (1974) The reaction of articular cartilage to injury and osteoarthritis (first of two parts). N Engl J Med 291:1285\u20131292","journal-title":"N Engl J Med"},{"key":"2914_CR26","doi-asserted-by":"publisher","first-page":"460","DOI":"10.2106\/00004623-198264030-00022","volume":"64","author":"HJ Mankin","year":"1982","unstructured":"Mankin HJ (1982) The response of articular cartilage to mechanical injury. J Bone Joint Surg Am 64:460\u2013466","journal-title":"J Bone Joint Surg Am"},{"key":"2914_CR27","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1053\/joca.2001.0507","volume":"10","author":"AC Marijnissen","year":"2002","unstructured":"Marijnissen AC, van Roermund PM, Verzijl N, Tekoppele JM, Bijlsma JW, Lafeber FP (2002) Steady progression of osteoarthritic features in the canine groove model. Osteoarthr Cartil 10:282\u2013289","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.joca.2004.07.009","volume":"14","author":"SC Mastbergen","year":"2006","unstructured":"Mastbergen SC, Marijnissen AC, Vianen ME, van Roermund PM, Bijlsma JW, Lafeber FP (2006) The canine \u2018groove\u2019 model of osteoarthritis is more than simply the expression of surgically applied damage. Osteoarthr Cartil 14:39\u201346","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR29","first-page":"150","volume":"32","author":"KK Middleton","year":"2012","unstructured":"Middleton KK, Barro V, Muller B, Terada S, Fu FH (2012) Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries. Iowa Orthop J 32:150\u2013163","journal-title":"Iowa Orthop J"},{"key":"2914_CR30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.joca.2012.09.018","volume":"21","author":"Y Mifune","year":"2013","unstructured":"Mifune Y, Matsumoto T, Takayama K, Ota S, Li H, Meszaros LB, Usas A, Nagamune K, Gharaibeh B, Fu FH, Huard J (2013) The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair. Osteoarthr Cartil 21:175\u2013185","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR31","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s00167-006-0277-5","volume":"15","author":"A Miyamoto","year":"2007","unstructured":"Miyamoto A, Deie M, Yamasaki T, Nakamae A, Shinomiya R, Adachi N, Ochi M (2007) The role of the synovium in repairing cartilage defects. Knee Surg Sports Traumatol Arthrosc 15:1083\u20131093","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2914_CR32","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.joca.2004.04.008","volume":"12","author":"H Mizuta","year":"2004","unstructured":"Mizuta H, Kudo S, Nakamura E, Otsuka Y, Takagi K, Hiraki Y (2004) Active proliferation of mesenchymal cells prior to the chondrogenic repair response in rabbit full-thickness defects of articular cartilage. Osteoarthr Cartil 12:586\u2013596","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR33","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00441-014-2041-3","volume":"359","author":"S Mukoyama","year":"2015","unstructured":"Mukoyama S, Sasho T, Akatsu Y, Yamaguchi S, Muramatsu Y, Katsuragi J, Fukawa T, Endo J, Hoshi H, Yamamoto Y, Takahashi K (2015) Spontaneous repair of partial thickness linear cartilage injuries in immature rats. Cell Tissue Res 359:513\u2013520","journal-title":"Cell Tissue Res"},{"issue":"8490489","key":"2914_CR34","first-page":"25","volume":"2018","author":"Y Nam","year":"2018","unstructured":"Nam Y, Rim YA, Lee J, Ju JH (2018) Current therapeutic strategies for stem cell-based cartilage regeneration. Stem Cells Int Mar 2018(8490489):25","journal-title":"Stem Cells Int Mar"},{"key":"2914_CR35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2106\/00004623-199801000-00003","volume":"80","author":"RS Namba","year":"1998","unstructured":"Namba RS, Meuli M, Sullivan KM, Le AX, Adzick NS (1998) Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model. J Bone Joint Surg Am 80:4\u201310","journal-title":"J Bone Joint Surg Am"},{"key":"2914_CR36","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1302\/0301-620X.88B9.17810","volume":"88","author":"M Nishimori","year":"2006","unstructured":"Nishimori M, Deie M, Kanaya A, Exham H, Adachi N, Ochi M (2006) Repair of chronic osteochondral defects in the rat. A bone marrow-stimulating procedure enhanced by cultured allogenic bone marrow mesenchymal stromal cells. J Bone Joint Surg Br 88:1236\u20131244","journal-title":"J Bone Joint Surg Br"},{"key":"2914_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2008.06.001","volume":"58","author":"P Qvist","year":"2008","unstructured":"Qvist P, Bay-Jensen AC, Christiansen C, Dam EB, Pastoureau P, Karsdal MA (2008) The disease modifying osteoarthritis drug (DMOAD): is it in the horizon? Pharmacol Res 58:1\u20137","journal-title":"Pharmacol Res"},{"key":"2914_CR38","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1002\/art.21212","volume":"52","author":"Y Sakaguchi","year":"2005","unstructured":"Sakaguchi Y, Sekiya I, Yagishita K, Muneta T (2005) Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 52:2521\u20132529","journal-title":"Arthritis Rheum"},{"key":"2914_CR39","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.joca.2005.10.011","volume":"14","author":"MB Schmidt","year":"2006","unstructured":"Schmidt MB, Chen EH, Lynch SE (2006) A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthr Cartil 14:403\u2013412","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR40","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1007\/s00167-012-2141-0","volume":"21","author":"CI Serra","year":"2013","unstructured":"Serra CI, Soler C, Carrillo JM, Carillo JM, Sopena JJ, Redondo JI, Cugat R (2013) Effect of autologous platelet-rich plasma on the repair of full-thickness articular defects in rabbits. Knee Surg Sports Traumatol Arthrosc 21:1730\u20131736","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2914_CR41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/jcb.20546","volume":"97","author":"S Shirasawa","year":"2006","unstructured":"Shirasawa S, Sekiya I, Sakaguchi Y, Yagishita K, Ichinose S, Muneta T (2006) In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: optimal condition and comparison with bone marrow-derived cells. J Cell Biochem 97:84\u201397","journal-title":"J Cell Biochem"},{"key":"2914_CR42","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12026-015-8720-7","volume":"63","author":"B Smith","year":"2015","unstructured":"Smith B, Sigal IR, Grande DA (2015) Immunology and cartilage regeneration. Immunol Rea 63:181\u2013186","journal-title":"Immunol Rea"},{"key":"2914_CR43","doi-asserted-by":"publisher","first-page":"R136","DOI":"10.1186\/ar3869","volume":"14","author":"S Suzuki","year":"2012","unstructured":"Suzuki S, Muneta T, Tsuji K, Ichinose S, Makino H, Umezawa A, Sekiya I (2012) Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration. Arthritis Res Ther 14:R136","journal-title":"Arthritis Res Ther"},{"key":"2914_CR44","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.orthres.2005.05.009.1100230617","volume":"23","author":"N Tran-Khanh","year":"2005","unstructured":"Tran-Khanh N, Hoemann CD, McKee MD, Henderson JE, Buschmann MD (2005) Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix. J Orthop Res 23:1354\u20131362","journal-title":"J Orthop Res"},{"key":"2914_CR45","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00441-011-1259-6","volume":"346","author":"H Tsuruoka","year":"2011","unstructured":"Tsuruoka H, Sasho T, Yamaguchi S, Ikegawa N, Saito M, Akagi R, Ochiai N, Nakagawa K, Nakajima A, Fallouh L, Takahashi K (2011) Maturation-dependent spontaneous healing of partial thickness cartilage defects in infantile rats. Cell Tissue Res 346:263\u2013271","journal-title":"Cell Tissue Res"},{"key":"2914_CR46","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1177\/0363546513475345","volume":"41","author":"M Vetrano","year":"2013","unstructured":"Vetrano M, Castorina A, Vulpiani MC, Baldini R, Pavan A, Ferretti A (2013) Platelet-rich plasma versus focused shock waves in the treatment of jumper\u2019s knee in athletes. Am J Sports Med 41:795\u2013803","journal-title":"Am J Sports Med"},{"key":"2914_CR47","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/(SICI)1097-4636(199701)34:1<63::AID-JBM9>3.0.CO;2-L","volume":"34","author":"X Wei","year":"1997","unstructured":"Wei X, Gao J, Messner K (1997) Maturation-dependent repair of untreated osteochondral defects in the rabbit knee joint. J Biomed Mater Res 34:63\u201372","journal-title":"J Biomed Mater Res"},{"key":"2914_CR48","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1089\/ten.1999.5.533","volume":"5","author":"L Weiser","year":"1999","unstructured":"Weiser L, Bhargava M, Attia E, Torzilli PA (1999) Effect of serum and platelet-derived growth factor on chondrocytes grown in collagen gels. Tissue Eng 5:533\u2013544","journal-title":"Tissue Eng"},{"key":"2914_CR49","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00441-006-0308-z","volume":"327","author":"H Yoshimura","year":"2007","unstructured":"Yoshimura H, Muneta T, Nimura A, Yokoyama A, Koga H, Sekiya I (2007) Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 327:449\u2013462","journal-title":"Cell Tissue Res"},{"key":"2914_CR50","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1053\/joca.1997.0093","volume":"6","author":"M Yoshioka","year":"1998","unstructured":"Yoshioka M, Kubo T, Coutts RD, Hirasawa Y (1998) Differences in the repair process of longitudinal and transverse injuries of cartilage in the rat knee. Osteoarthr Cartil 6:66\u201375","journal-title":"Osteoarthr Cartil"},{"key":"2914_CR51","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10735-016-9668-1","volume":"47","author":"K Zhang","year":"2016","unstructured":"Zhang K, Shi J, Li Y, Jiang Y, Tao T, Li W, Gui J (2016a) Chondrogenic cells respond to partial-thickness defects of articular cartilage in adult rats: an in vivo study. J Mol Histol 47:249\u2013258","journal-title":"J Mol Histol"},{"key":"2914_CR52","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00264-015-2759-x","volume":"40","author":"X Zhang","year":"2016","unstructured":"Zhang X, You T, Jiang X, Zhang H, Zhang W (2016b) Characteristic arthroscopic signs of cartilage injuries indicating concomitant occult medial meniscal peripheral tears of posterior horn. Int Orthop 40:191\u2013195","journal-title":"Int Orthop"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-018-2914-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2914-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2914-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T07:19:15Z","timestamp":1755674355000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-018-2914-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["2914"],"URL":"https:\/\/doi.org\/10.1007\/s00441-018-2914-y","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"21 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the institutional Ethics Committee of Chiba University and all experiments were conducted in the animal experiment facility of Chiba University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving animals"}}]}}