{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:11:44Z","timestamp":1780582304184,"version":"3.54.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["336267"],"award-info":[{"award-number":["336267"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Reumatikerfonden"},{"name":"Insamlingsstiftelsen f\u00f6r medicinsk forskning, Ume\u00e5 University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00441-018-2938-3","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T02:33:12Z","timestamp":1540261992000},"page":"629-639","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes"],"prefix":"10.1007","volume":"375","author":[{"given":"J.","family":"Prittinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yl\u00e4rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Piltti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Karhula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rieppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Ojanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Saarakkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Lammi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"2938_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/jor.1100040401","volume":"4","author":"S Akizuki","year":"1986","unstructured":"Akizuki S, Mow VC, Muller F, Pita JC, Howell DS, Manicourt DH (1986) Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus. J Orthop Res 4:379\u2013392","journal-title":"J Orthop Res"},{"key":"2938_CR2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fbioe.2017.00076","volume":"5","author":"DE Anderson","year":"2017","unstructured":"Anderson DE, Johnstone B (2017) Dynamic mechanical compression of chondrocytes for tissue engineering: a critical review. Front Bioeng Biotechnol 5:76","journal-title":"Front Bioeng Biotechnol"},{"key":"2938_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1115\/1.2720918","volume":"129","author":"GA Ateshian","year":"2007","unstructured":"Ateshian GA, Ellis BJ, Weiss JA (2007) Equivalence between short-time biphasic and incompressible elastic material responses. J Biomech Eng-Trans ASME 129:405\u2013412","journal-title":"J Biomech Eng-Trans ASME"},{"key":"2938_CR4","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1002\/bit.20828","volume":"93","author":"D Bosnakovski","year":"2006","unstructured":"Bosnakovski D, Mizuno M, Kim G, Takagi S, Okumura M, Fujinaga T (2006) Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis. Biotechnol Bioeng 93:1152\u20131163","journal-title":"Biotechnol Bioeng"},{"key":"2938_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2144\/01301bm06","volume":"30","author":"S Brown","year":"2001","unstructured":"Brown S, Worsfold M, Sharp C (2001) Microplate assay for the measurement of hydroxyproline in acid-hydrolyzed tissue samples. Biotechniques 30:38\u201340, 42","journal-title":"Biotechniques"},{"key":"2938_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1097-0282(2001)62:1<1::AID-BIP10>3.0.CO;2-O","volume":"62","author":"NP Camacho","year":"2001","unstructured":"Camacho NP, West P, Torzilli PA, Mendelsohn R (2001) FTIR microscopic imaging of collagen and proteoglycan in bovine cartilage. Biopolymers 62:1\u20138","journal-title":"Biopolymers"},{"key":"2938_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/ijms18010133","volume":"18","author":"S Cheleschi","year":"2017","unstructured":"Cheleschi S, De Palma A, Pecorelli A, Pascarelli NA, Valacchi G, Belmonte G, Carta S, Galeazzi M, Fioravanti A (2017) Hydrostatic pressure regulates microRNA expression levels in osteoarthritic chondrocyte cultures via the Wnt\/beta-catenin pathway. Int J Mol Sci 18:133","journal-title":"Int J Mol Sci"},{"key":"2938_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0945-053X(03)00004-0","volume":"22","author":"M Chiquet","year":"2003","unstructured":"Chiquet M, Renedo AS, Huber F, Fl\u00fcck M (2003) How do fibroblasts translate mechanical signals into changes in extracellular matrix production? Matrix Biol 22:73\u201380","journal-title":"Matrix Biol"},{"key":"2938_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jbiomech.2017.10.044","volume":"66","author":"A Palma De","year":"2018","unstructured":"De Palma A, Cheleschi S, Pascarelli NA, Giannotti S, Galeazzi M, Fioravanti A (2018) Hydrostatic pressure as epigenetic modulator in chondrocyte cultures: a study on miRNA-155, miRNA-181a and miRNA-223 expression levels. J Biomech 66:165\u2013169","journal-title":"J Biomech"},{"key":"2938_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2164-6-135","volume":"6","author":"L Donaldson","year":"2005","unstructured":"Donaldson L, Vuocolo T, Gray C, Strandberg Y, Reverter A, McWilliam S, Wang Y, Byrne K, Tellam R (2005) Construction and validation of a bovine innate immune microarray. BMC Genomics 6:135","journal-title":"BMC Genomics"},{"key":"2938_CR11","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10439-014-1161-y","volume":"43","author":"GD DuRaine","year":"2015","unstructured":"DuRaine GD, Brown WE, Hu JC, Athanasiou KA (2015) Emergence of scaffold-free approaches for tissue engineering musculoskeletal cartilages. Ann Biomed Eng 43:543\u2013554","journal-title":"Ann Biomed Eng"},{"key":"2938_CR12","doi-asserted-by":"publisher","first-page":"e2341","DOI":"10.1371\/journal.pone.0002341","volume":"3","author":"BD Elder","year":"2008","unstructured":"Elder BD, Athanasiou KA (2008) Synergistic and additive effects of hydrostatic pressure and growth factors on tissue formation. PLoS One 3:e2341","journal-title":"PLoS One"},{"key":"2938_CR13","doi-asserted-by":"publisher","first-page":"e26178","DOI":"10.1371\/journal.pone.0026178","volume":"6","author":"SV Eleswarapu","year":"2011","unstructured":"Eleswarapu SV, Responte DJ, Athanasiou KA (2011) Tensile properties, collagen content, and crosslinks in connective tissues of the immature knee joint. PLoS One 6:e26178","journal-title":"PLoS One"},{"key":"2938_CR14","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0304-4165(86)90306-5","volume":"883","author":"RW Farndale","year":"1986","unstructured":"Farndale RW, Buttle DJ, Barrett AJ (1986) Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883:173\u2013177","journal-title":"Biochim Biophys Acta"},{"key":"2938_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.biomaterials.2005.05.098","volume":"27","author":"L Galois","year":"2006","unstructured":"Galois L, Hutasse S, Cortial D, Rousseau CF, Grossin L, Ronziere MC, Herbage D, Freyria AM (2006) Bovine chondrocyte behaviour in three-dimensional type I collagen gel in terms of gel contraction, proliferation and gene expression. Biomaterials 27:79\u201390","journal-title":"Biomaterials"},{"key":"2938_CR16","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.2106\/JBJS.J.00049","volume":"92","author":"JD Harris","year":"2010","unstructured":"Harris JD, Siston RA, Pan X, Flanigan DC (2010) Autologous chondrocyte implantation: a systematic review. J Bone Joint Surg Am 92:2220\u20132233","journal-title":"J Bone Joint Surg Am"},{"key":"2938_CR17","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/0021-9290(72)90010-3","volume":"5","author":"WC Hayes","year":"1972","unstructured":"Hayes WC, Keer LM, Herrmann G, Mockros LF (1972) A mathematical analysis for indentation tests of articular cartilage. J Biomech 5:541\u2013551","journal-title":"J Biomech"},{"key":"2938_CR18","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1007\/s10529-006-9144-1","volume":"28","author":"J Heyland","year":"2006","unstructured":"Heyland J, Wiegandt K, Goepfert C, Nagel-Heyer S, Ilinich E, Schumacher U, Portner R (2006) Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. Biotechnol Lett 28:1641\u20131648","journal-title":"Biotechnol Lett"},{"key":"2938_CR19","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/art.1780290314","volume":"29","author":"R Holmdahl","year":"1986","unstructured":"Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H (1986) Characterization of the antibody-response in mice with type-II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum 29:400\u2013410","journal-title":"Arthritis Rheum"},{"key":"2938_CR20","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/ten.2006.12.1337","volume":"12","author":"JC Hu","year":"2006","unstructured":"Hu JC, Athanasiou KA (2006) The effects of intermittent hydrostatic pressure on self-assembled articular cartilage constructs. Tissue Eng 12:1337\u20131344","journal-title":"Tissue Eng"},{"key":"2938_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/B:ABME.0000007789.99565.42","volume":"32","author":"CT Hung","year":"2004","unstructured":"Hung CT, Mauck RL, Wang CC, Lima EG, Ateshian GA (2004) A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng 32:35\u201349","journal-title":"Ann Biomed Eng"},{"key":"2938_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.joca.2006.09.010","volume":"15","author":"EB Hunziker","year":"2007","unstructured":"Hunziker EB, Kapfinger E, Geiss J (2007) The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development. Osteoarthr Cartil 15:403\u2013413","journal-title":"Osteoarthr Cartil"},{"key":"2938_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0736-0266(02)00091-8","volume":"21","author":"T Ikenoue","year":"2003","unstructured":"Ikenoue T, Trindade MC, Lee MS, Lin EY, Schurman DJ, Goodman SB, Smith RL (2003) Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro. J Orthop Res 21:110\u2013116","journal-title":"J Orthop Res"},{"key":"2938_CR24","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1177\/00220345900690090401","volume":"69","author":"H Inoue","year":"1990","unstructured":"Inoue H, Hiasa K, Samma Y, Nakamura O, Sakuda M, Iwamoto M, Suzuki F, Kato Y (1990) Stimulation of proteoglycan and DNA syntheses in chondrocytes by centrifugation. J Dent Res 69:1560\u20131563","journal-title":"J Dent Res"},{"key":"2938_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0304-4165(70)90388-0","volume":"215","author":"G Kempson","year":"1970","unstructured":"Kempson G, Muir H, Swanson S, Freeman M (1970) Correlations between stiffness and the chemical constituents of cartilage on the human femoral head. Biochim Biophys Acta 215:70\u201377","journal-title":"Biochim Biophys Acta"},{"key":"2938_CR26","doi-asserted-by":"publisher","first-page":"e0185394","DOI":"10.1371\/journal.pone.0185394","volume":"12","author":"J Kim","year":"2017","unstructured":"Kim J, Montagne K, Nemoto H, Ushida T, Furukawa KS (2017) Hypergravity down-regulates c-fos gene expression via ROCK\/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells. PLoS One 12:e0185394","journal-title":"PLoS One"},{"key":"2938_CR27","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0021-9290(02)00052-0","volume":"35","author":"RK Korhonen","year":"2002","unstructured":"Korhonen RK, Laasanen MS, T\u00f6yr\u00e4s J, Rieppo J, Hirvonen J, Helminen HJ, Jurvelin JS (2002) Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation. J Biomech 35:903\u2013909","journal-title":"J Biomech"},{"key":"2938_CR28","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.arthro.2014.11.018","volume":"31","author":"TS Lynch","year":"2015","unstructured":"Lynch TS, Patel RM, Benedick A, Amin NH, Jones MH, Miniaci A (2015) Systematic review of autogenous osteochondral transplant outcomes. Arthroscopy 31:746\u2013754","journal-title":"Arthroscopy"},{"key":"2938_CR29","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.joca.2014.04.010","volume":"22","author":"JT M\u00e4kel\u00e4","year":"2014","unstructured":"M\u00e4kel\u00e4 JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W, Korhonen RK (2014) Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthr Cartil 22:869\u2013878","journal-title":"Osteoarthr Cartil"},{"key":"2938_CR30","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/s41598-017-16523-x","volume":"7","author":"C Meinert","year":"2017","unstructured":"Meinert C, Schrobback K, Hutmacher DW, Klein TJ (2017a) A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage. Sci Rep 7:1699","journal-title":"Sci Rep"},{"key":"2938_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.actbio.2016.10.011","volume":"52","author":"C Meinert","year":"2017","unstructured":"Meinert C, Schrobback K, Levett PA, Lutton C, Sah RL, Klein TJ (2017b) Tailoring hydrogel surface properties to modulate cellular response to shear loading. Acta Biomater 52:105\u2013117","journal-title":"Acta Biomater"},{"key":"2938_CR32","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1177\/0363546508328414","volume":"37","author":"K Mithoefer","year":"2009","unstructured":"Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR (2009) Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. Am J Sports Med 37:2053\u20132063","journal-title":"Am J Sports Med"},{"key":"2938_CR33","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nmat1822","volume":"6","author":"FT Moutos","year":"2007","unstructured":"Moutos FT, Freed LE, Guilak F (2007) A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater 6:162\u2013167","journal-title":"Nat Mater"},{"key":"2938_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1115\/1.3138202","volume":"102","author":"VC Mow","year":"1980","unstructured":"Mow VC, Kuei SC, Lai WM, Armstrong CG (1980) Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J Biomech Eng 102:73\u201384","journal-title":"J Biomech Eng"},{"key":"2938_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40634-015-0029-x","volume":"2","author":"J Natenstedt","year":"2015","unstructured":"Natenstedt J, Kok AC, Dankelman J, Tuijthof GJ (2015) What quantitative mechanical loading stimulates in vitro cultivation best? J Exp Orthop 2:15","journal-title":"J Exp Orthop"},{"key":"2938_CR36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0021-9258(18)56248-7","volume":"186","author":"RE Neuman","year":"1950","unstructured":"Neuman RE, Logan MA (1950) The determination of collagen and elastin in tissues. J Biol Chem 186:549\u2013556","journal-title":"J Biol Chem"},{"key":"2938_CR37","doi-asserted-by":"publisher","first-page":"e2795","DOI":"10.1371\/journal.pone.0002795","volume":"3","author":"G Ofek","year":"2008","unstructured":"Ofek G, Revell CM, Hu JC, Allison DD, Grande-Allen KJ, Athanasiou KA (2008) Matrix development in self-assembly of articular cartilage. PLoS One 3:e2795","journal-title":"PLoS One"},{"key":"2938_CR38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.joca.2003.08.005","volume":"12","author":"S Park","year":"2004","unstructured":"Park S, Hung CT, Ateshian GA (2004) Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiological stress levels. Osteoarthr Cartil 12:65\u201373","journal-title":"Osteoarthr Cartil"},{"key":"2938_CR39","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1006\/abbi.1993.1062","volume":"300","author":"JJ Parkkinen","year":"1993","unstructured":"Parkkinen JJ, Ikonen J, Lammi MJ, Laakkonen J, Tammi M, Helminen HJ (1993) Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophys 300:458\u2013465","journal-title":"Arch Biochem Biophys"},{"key":"2938_CR40","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/jor.1100100503","volume":"10","author":"JJ Parkkinen","year":"1992","unstructured":"Parkkinen JJ, Lammi MJ, Helminen HJ, Tammi M (1992) Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro. J Orthop Res 10:610\u2013620","journal-title":"J Orthop Res"},{"key":"2938_CR41","doi-asserted-by":"publisher","first-page":"26019","DOI":"10.3390\/ijms161125936","volume":"16","author":"NA Pascarelli","year":"2015","unstructured":"Pascarelli NA, Collodel G, Moretti E, Cheleschi S, Fioravanti A (2015) Changes in ultrastructure and cytoskeletal aspects of human normal and osteoarthritic chondrocytes exposed to interleukin-1beta and cyclical hydrostatic pressure. Int J Mol Sci 16:26019\u201326034","journal-title":"Int J Mol Sci"},{"key":"2938_CR42","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/0363546509357915","volume":"38","author":"L Peterson","year":"2010","unstructured":"Peterson L, Vasiliadis HS, Brittberg M, Lindahl A (2010) Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med 38:1117\u20131124","journal-title":"Am J Sports Med"},{"key":"2938_CR43","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/17453674.2016.1180578","volume":"87","author":"PH Puhakka","year":"2016","unstructured":"Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS, T\u00f6yr\u00e4s J (2016) Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop 87:418\u2013424","journal-title":"Acta Orthop"},{"key":"2938_CR44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00441-012-1366-z","volume":"348","author":"C Qu","year":"2012","unstructured":"Qu C, Lindeberg H, Yl\u00e4rinne JH, Lammi MJ (2012) Five percent oxygen tension is not beneficial for neocartilage formation in scaffold-free cell cultures. Cell Tissue Res 348:109\u2013117","journal-title":"Cell Tissue Res"},{"key":"2938_CR45","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1600-0838.2009.00912.x","volume":"19","author":"L Ramage","year":"2009","unstructured":"Ramage L, Nuki G, Salter DM (2009) Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scand J Med Sci Sports 19:457\u2013469","journal-title":"Scand J Med Sci Sports"},{"key":"2938_CR46","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/05704928.2016.1226182","volume":"52","author":"L Rieppo","year":"2017","unstructured":"Rieppo L, T\u00f6yr\u00e4s J, Saarakkala S (2017) Vibrational spectroscopy of articular cartilage. Appl Spectrosc Rev 52:249\u2013266","journal-title":"Appl Spectrosc Rev"},{"key":"2938_CR47","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1600-0838.2005.00461.x","volume":"15","author":"A Sarasa-Renedo","year":"2005","unstructured":"Sarasa-Renedo A, Chiquet M (2005) Mechanical signals regulating extracellular matrix gene expression in fibroblasts. Scand J Med Sci Sports 15:223\u2013230","journal-title":"Scand J Med Sci Sports"},{"key":"2938_CR48","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1159\/000074630","volume":"175","author":"JC Shelton","year":"2003","unstructured":"Shelton JC, Bader DL, Lee DA (2003) Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs 175:140\u2013150","journal-title":"Cells Tissues Organs"},{"key":"2938_CR49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/jor.1100140110","volume":"14","author":"RL Smith","year":"1996","unstructured":"Smith RL, Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, Caler WE, Sandell LJ, Schurman DJ (1996) In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. J Orthop Res 14:53\u201360","journal-title":"J Orthop Res"},{"key":"2938_CR50","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.joca.2004.08.004","volume":"12","author":"JD Szafranski","year":"2004","unstructured":"Szafranski JD, Grodzinsky AJ, Burger E, Gaschen V, Hung HH, Hunziker EB (2004) Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthr Cartil 12:937\u2013946","journal-title":"Osteoarthr Cartil"},{"key":"2938_CR51","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1089\/ten.teb.2015.0142","volume":"21","author":"PD Tatman","year":"2015","unstructured":"Tatman PD, Gerull W, Sweeney-Easter S, Davis JI, Gee AO, Kim DH (2015) Multiscale biofabrication of articular cartilage: bioinspired and biomimetic approaches. Tissue Eng Part B Rev 21:543\u2013559","journal-title":"Tissue Eng Part B Rev"},{"key":"2938_CR52","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1359\/jbmr.2003.18.5.844","volume":"18","author":"E Tchetina","year":"2003","unstructured":"Tchetina E, Mwale F, Poole AR (2003) Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. J Bone Miner Res 18:844\u2013851","journal-title":"J Bone Miner Res"},{"key":"2938_CR53","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00264-015-3099-6","volume":"40","author":"T Trzeciak","year":"2016","unstructured":"Trzeciak T, Richter M, Suchorska W, Augustyniak E, Lach M, Kaczmarek M, Kaczmarczyk J (2016) Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries. Int Orthop 40:615\u2013624","journal-title":"Int Orthop"},{"key":"2938_CR54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13018-018-0726-0","volume":"13","author":"S Wang","year":"2018","unstructured":"Wang S, Bao Y, Guan Y, Zhang C, Liu H, Yang X, Gao L, Guo T, Chen Q (2018) Strain distribution of repaired articular cartilage defects by tissue engineering under compression loading. J Orthop Surg Res 13:19","journal-title":"J Orthop Surg Res"},{"key":"2938_CR55","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/S0736-0266(03)00030-5","volume":"21","author":"AK Williamson","year":"2003","unstructured":"Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL (2003) Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res 21:872\u2013880","journal-title":"J Orthop Res"},{"key":"2938_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2017.01.036","volume":"57","author":"J Yang","year":"2017","unstructured":"Yang J, Zhang YS, Yue K, Khademhosseini A (2017) Cell-laden hydrogels for osteochondral and cartilage tissue engineering. Acta Biomater 57:1\u201325","journal-title":"Acta Biomater"},{"key":"2938_CR57","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00441-014-1970-1","volume":"358","author":"JH Yl\u00e4rinne","year":"2014","unstructured":"Yl\u00e4rinne JH, Qu C, Lammi MJ (2014) Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures. Cell Tissue Res 358:541\u2013550","journal-title":"Cell Tissue Res"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-018-2938-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2938-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-018-2938-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T13:19:35Z","timestamp":1662297575000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-018-2938-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["2938"],"URL":"https:\/\/doi.org\/10.1007\/s00441-018-2938-3","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"27 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}