{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:29:55Z","timestamp":1783002595080,"version":"3.54.5"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Institute of Health","award":["1DP2CA195763-01"],"award-info":[{"award-number":["1DP2CA195763-01"]}]},{"DOI":"10.13039\/100008871","name":"JDRF","doi-asserted-by":"publisher","award":["17-2013-491"],"award-info":[{"award-number":["17-2013-491"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00441-019-03046-2","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T19:02:36Z","timestamp":1560798156000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes"],"prefix":"10.1007","volume":"378","author":[{"given":"Rachel","family":"Stiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egest J.","family":"Pone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-4287","authenticated-orcid":false,"given":"Jonathan R. T.","family":"Lakey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"3046_CR1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/stem.1948","volume":"33","author":"R Abdi","year":"2015","unstructured":"Abdi R, Moore R, Sakai S, Donnelly CB, Mounayar M, Sackstein R (2015) Hcell expression on murine MSC licenses pancreatotropism and confers durable reversal of autoimmune diabetes in nod mice. Stem Cells 33:1523\u20131531","journal-title":"Stem Cells"},{"key":"3046_CR2","first-page":"473","volume":"80","author":"C Almici","year":"1995","unstructured":"Almici C, Carlo-Stella C, Wagner JE, Rizzoli V (1995) Umbilical cord blood as a source of hematopoietic stem cells: from research to clinical application. Haematologica 80:473\u2013479","journal-title":"Haematologica"},{"key":"3046_CR3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","volume":"383","author":"MA Atkinson","year":"2014","unstructured":"Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383:69\u201382","journal-title":"Lancet"},{"key":"3046_CR4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/scd.2008.0017","volume":"18","author":"S Barachini","year":"2009","unstructured":"Barachini S, Trombi L, Danti S, D\u2019Alessandro D, Battolla B, Legitimo A, Nesti C, Mucci I, D\u2019Acunto M, Cascone MG, Lazzeri L, Mattii L, Consolini R, Petrini M (2009) Morpho-functional characterization of human mesenchymal stem cells from umbilical cord blood for potential uses in regenerative medicine. Stem Cells Dev 18:293\u2013305","journal-title":"Stem Cells Dev"},{"key":"3046_CR5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.diff.2011.06.003","volume":"82","author":"DR Bhandari","year":"2011","unstructured":"Bhandari DR, Seo K-W, Sun B, Seo M-S, Kim H-S, Seo Y-J, Marcin J, Forraz N, Roy HL, Larry D, Colin M, Kang K-S (2011) The simplest method for in vitro \u03b2-cell production from human adult stem cells. Differentiation 82:144\u2013152","journal-title":"Differentiation"},{"key":"3046_CR6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","volume":"22","author":"K Bieback","year":"2004","unstructured":"Bieback K, Kern S, Kl\u00fcter H, Eichler H (2004) Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells 22:625\u2013634","journal-title":"Stem Cells"},{"key":"3046_CR7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nature08933","volume":"464","author":"JA Bluestone","year":"2010","unstructured":"Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464:1293\u20131300","journal-title":"Nature"},{"key":"3046_CR8","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1073\/pnas.86.10.3828","volume":"86","author":"HE Broxmeyer","year":"1989","unstructured":"Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem\/progenitor cells. Proc Natl Acad Sci U S A 86:3828\u20133832","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3046_CR9","first-page":"211","volume":"7","author":"A Bruni","year":"2014","unstructured":"Bruni A, Gala-Lopez B, Pepper AR, Abualhassan NS, Shapiro AJ (2014) Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes 7:211\u2013223","journal-title":"Diabetes Metab Syndr Obes"},{"key":"3046_CR10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2337\/dc15-0171","volume":"39","author":"J Cai","year":"2016","unstructured":"Cai J, Wu Z, Xu X, Liao L, Chen J, Huang L, Wu W, Luo F, Wu C, Pugliese A, Pileggi A, Ricordi C, Tan J (2016) Umbilical cord mesenchymal stromal cell with autologous bone marrow cell transplantation in established type 1 diabetes: a pilot randomized controlled open-label clinical study to assess safety and impact on insulin secretion. Diabetes Care 39:149\u2013157","journal-title":"Diabetes Care"},{"key":"3046_CR11","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10875-010-9415-4","volume":"30","author":"S Cappellesso-Fleury","year":"2010","unstructured":"Cappellesso-Fleury S, Puissant-Lubrano B, Apoil P-A, Titeux M, Winterton P, Casteilla L, Bourin P, Blancher A (2010) Human fibroblasts share immunosuppressive properties with bone marrow mesenchymal stem cells. J Clin Immunol 30:607\u2013619","journal-title":"J Clin Immunol"},{"key":"3046_CR12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3727\/096368910X520056","volume":"20","author":"J-W Chang","year":"2011","unstructured":"Chang J-W, Hung S-P, Wu H-H, Wu W-M, Yang A-H, Tsai H-L, Yang L-Y, Lee OK (2011) Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant 20:245\u2013257","journal-title":"Cell Transplant"},{"issue":"8","key":"3046_CR13","doi-asserted-by":"crossref","first-page":"a007716","DOI":"10.1101\/cshperspect.a007716","volume":"2","author":"L. Chatenoud","year":"2012","unstructured":"Chatenoud L, Warncke K, Ziegler A-G (2012) Clinical immunologic interventions for the treatment of type 1 diabetes. Cold Spring Harb Perspect Med 2","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"3046_CR14","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/sctm.16-0492","volume":"6","author":"JE Davies","year":"2017","unstructured":"Davies JE, Walker JT, Keating A (2017) Concise review: Wharton\u2019s jelly: the rich, but enigmatic, source of mesenchymal stromal cells. Stem Cells Transl Med 6:1620\u20131630","journal-title":"Stem Cells Transl Med"},{"key":"3046_CR15","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.ebiom.2015.11.003","volume":"2","author":"E Delgado","year":"2015","unstructured":"Delgado E, Perez-Basterrechea M, Suarez-Alvarez B, Zhou H, Revuelta EM, Garcia-Gala JM, Perez S, Alvarez-Viejo M, Menendez E, Lopez-Larrea C, Tang R, Zhu Z, Hu W, Moss T, Guindi E, Otero J, Zhao Y (2015) Modulation of autoimmune t-cell memory by stem cell educator therapy: phase 1\/2 clinical trial. EBioMedicine 2:2024\u20132036","journal-title":"EBioMedicine"},{"key":"3046_CR16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2184.2007.00439.x","volume":"40","author":"L Denner","year":"2007","unstructured":"Denner L, Bodenburg Y, Zhao JG, Howe M, Cappo J, Tilton RG, Copland JA, Forraz N, McGuckin C, Urban R (2007) Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin. Cell Prolif 40:367\u2013380","journal-title":"Cell Prolif"},{"key":"3046_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"3046_CR18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3727\/000000003108747154","volume":"12","author":"AA Erices","year":"2003","unstructured":"Erices AA, Allers CI, Conget PA, Rojas CV, Minguell JJ (2003) Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion. Cell Transplant 12:555\u2013561","journal-title":"Cell Transplant"},{"key":"3046_CR19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00029330-200805010-00012","volume":"121","author":"F Gao","year":"2008","unstructured":"Gao F, Wu D, Hu Y, Jin G (2008a) Extracellular matrix gel is necessary for in vitro cultivation of insulin producing cells from human umbilical cord blood derived mesenchymal stem cells. Chin Med J 121:811\u2013818","journal-title":"Chin Med J"},{"key":"3046_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.trsl.2008.03.003","volume":"151","author":"F Gao","year":"2008","unstructured":"Gao F, Wu D-Q, Hu Y-H, Jin G-X, Li G-D, Sun T-W, Li F-J (2008b) In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells. Transl Res 151:293\u2013302","journal-title":"Transl Res"},{"key":"3046_CR21","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1056\/NEJM198910263211707","volume":"321","author":"E Gluckman","year":"1989","unstructured":"Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P (1989) Hematopoietic reconstitution in a patient with Fanconi\u2019s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321:1174\u20131178","journal-title":"N Engl J Med"},{"key":"3046_CR22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1053\/bbmt.2001.v7.pm11760145","volume":"7","author":"HS Goodwin","year":"2001","unstructured":"Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA (2001) Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 7:581\u2013588","journal-title":"Biol Blood Marrow Transplant"},{"key":"3046_CR23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.exphem.2008.01.009","volume":"36","author":"MJ Haller","year":"2008","unstructured":"Haller MJ, Viener H-L, Wasserfall C, Brusko T, Atkinson MA, Schatz DA (2008) Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol 36:710\u2013715","journal-title":"Exp Hematol"},{"key":"3046_CR24","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.2337\/dc11-1406","volume":"34","author":"MJ Haller","year":"2011","unstructured":"Haller MJ, Wasserfall CH, Hulme MA, Cintron M, Brusko TM, McGrail KM, Sumrall TM, Wingard JR, Theriaque DW, Shuster JJ, Atkinson MA, Schatz DA (2011) Autologous umbilical cord blood transfusion in young children with type 1 diabetes fails to preserve C-peptide. Diabetes Care 34:2567\u20132569","journal-title":"Diabetes Care"},{"key":"3046_CR25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2016.08.025","volume":"315","author":"Y He","year":"2016","unstructured":"He Y, Li H, Zhang F, Zhang G, Tang X, Zhu T, Huang N, Li X (2016) Immunotherapeutic effects of lymphocytes co-cultured with human cord blood-derived multipotent stem cells transplantation on APP\/PS1 mice. Behav Brain Res 315:94\u2013102","journal-title":"Behav Brain Res"},{"key":"3046_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.trre.2012.11.003","volume":"27","author":"P Hematti","year":"2013","unstructured":"Hematti P, Kim J, Stein AP, Kaufman D (2013) Potential role of mesenchymal stromal cells in pancreatic islet transplantation. Transplant Rev (Orlando) 27:21\u201329","journal-title":"Transplant Rev (Orlando)"},{"key":"3046_CR27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1507\/endocrj.K07E-173","volume":"55","author":"E Hisanaga","year":"2008","unstructured":"Hisanaga E, Park K-Y, Yamada S, Hashimoto H, Takeuchi T, Mori M, Seno M, Umezawa K, Takei I, Kojima I (2008) A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4. Endocr J 55:535\u2013543","journal-title":"Endocr J"},{"key":"3046_CR28","first-page":"255","volume":"8","author":"Y-H Hu","year":"2009","unstructured":"Hu Y-H, Wu D-Q, Gao F, Li G-D, Yao L, Zhang X-C (2009) A secretory function of human insulin-producing cells in vivo. HBPD Int 8:255\u2013260","journal-title":"HBPD Int"},{"key":"3046_CR29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1507\/endocrj.EJ12-0343","volume":"60","author":"J Hu","year":"2013","unstructured":"Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y (2013) Long term effects of the implantation of Wharton\u2019s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocr J 60:347\u2013357","journal-title":"Endocr J"},{"key":"3046_CR30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s12020-014-0219-9","volume":"48","author":"J Hu","year":"2015","unstructured":"Hu J, Wang Y, Wang F, Wang L, Yu X, Sun R, Wang Z, Wang L, Gao H, Fu Z, Zhao W, Yan S (2015) Effect and mechanisms of human Wharton\u2019s jelly-derived mesenchymal stem cells on type 1 diabetes in NOD model. Endocrine 48:124\u2013134","journal-title":"Endocrine"},{"key":"3046_CR31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3727\/096368914X678300","volume":"23","author":"T-H Jaing","year":"2014","unstructured":"Jaing T-H (2014) Umbilical cord blood: a trustworthy source of multipotent stem cells for regenerative medicine. Cell Transplant 23:493\u2013496","journal-title":"Cell Transplant"},{"key":"3046_CR32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","volume":"418","author":"Y Jiang","year":"2002","unstructured":"Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41\u201349","journal-title":"Nature"},{"key":"3046_CR33","doi-asserted-by":"crossref","first-page":"17986","DOI":"10.3390\/ijms140917986","volume":"14","author":"HJ Jin","year":"2013","unstructured":"Jin HJ, Bae YK, Kim M, Kwon S-J, Jeon HB, Choi SJ, Kim SW, Yang YS, Oh W, Chang JW (2013) Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci 14:17986\u201318001","journal-title":"Int J Mol Sci"},{"key":"3046_CR34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/iwj.12849","volume":"15","author":"J-A Jung","year":"2018","unstructured":"Jung J-A, Yoon Y-D, Lee H-W, Kang S-R, Han S-K (2018) Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts. Int Wound J 15:133\u2013139","journal-title":"Int Wound J"},{"key":"3046_CR35","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/cea.12920","volume":"47","author":"S-Y Kang","year":"2017","unstructured":"Kang S-Y, Park D-E, Song W-J, Bae B-R, Lee J-W, Sohn K-H, Lee H-S, Kang H-R, Park H-W, Chang Y-S, Choi S-J, Oh W-I, Min K-U, Cho S-H (2017) Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model. Clin Exp Allergy 47:937\u2013945","journal-title":"Clin Exp Allergy"},{"key":"3046_CR36","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.bbmt.2008.03.012","volume":"15","author":"P Kebriaei","year":"2009","unstructured":"Kebriaei P, Isola L, Bahceci E, Holland K, Rowley S, McGuirk J, Devetten M, Jansen J, Herzig R, Schuster M, Monroy R, Uberti J (2009) Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 15:804\u2013811","journal-title":"Biol Blood Marrow Transplant"},{"key":"3046_CR37","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","volume":"24","author":"S Kern","year":"2006","unstructured":"Kern S, Eichler H, Stoeve J, Kl\u00fcter H, Bieback K (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24:1294\u20131301","journal-title":"Stem Cells"},{"key":"3046_CR38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4252\/wjsc.v2.i2.34","volume":"2","author":"J-Y Kim","year":"2010","unstructured":"Kim J-Y, Jeon HB, Yang YS, Oh W, Chang JW (2010) Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World J Stem Cells 2:34\u201338","journal-title":"World J Stem Cells"},{"key":"3046_CR39","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2013.08.033","volume":"145","author":"H-S Kim","year":"2013","unstructured":"Kim H-S, Shin T-H, Lee B-C, Yu K-R, Seo Y, Lee S, Seo M-S, Hong I-S, Choi SW, Seo K-W, N\u00fa\u00f1ez G, Park J-H, Kang K-S (2013) Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. Gastroenterology 145:1392\u20131403.e1\u20138","journal-title":"Gastroenterology"},{"key":"3046_CR40","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1913","volume":"33","author":"H-S Kim","year":"2015","unstructured":"Kim H-S, Yun J-W, Shin T-H, Lee S-H, Lee B-C, Yu K-R, Seo Y, Lee S, Kang T-W, Choi SW, Seo K-W, Kang K-S (2015) Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-\u03b21 alleviate atopic dermatitis by reducing mast cell degranulation. Stem Cells 33:1254\u20131266","journal-title":"Stem Cells"},{"key":"3046_CR41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1900\/RDS.2005.2.228","volume":"2","author":"T Koblas","year":"2005","unstructured":"Koblas T, Harman SM, Saudek F (2005) The application of umbilical cord blood cells in the treatment of diabetes mellitus. Rev Diabet Stud 2:228\u2013234","journal-title":"Rev Diabet Stud"},{"key":"3046_CR42","first-page":"224","volume":"55","author":"T Koblas","year":"2009","unstructured":"Koblas T, Zacharovov\u00e1 K, Berkov\u00e1 Z, Leontovic I, Dovolilov\u00e1 E, Z\u00e1mecn\u00edk L, Saudek F (2009) In vivo differentiation of human umbilical cord blood-derived cells into insulin-producing beta cells. Folia Biol (Praha) 55:224\u2013232","journal-title":"Folia Biol (Praha)"},{"key":"3046_CR43","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.exphem.2006.07.011","volume":"34","author":"G K\u00f6gler","year":"2006","unstructured":"K\u00f6gler G, Sensken S, Wernet P (2006) Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp Hematol 34:1589\u20131595","journal-title":"Exp Hematol"},{"key":"3046_CR44","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","volume":"371","author":"K Le Blanc","year":"2008","unstructured":"Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, Dini G, Egeler RM, Bacigalupo A, Fibbe W, Ringd\u00e9n O (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371:1579\u20131586","journal-title":"Lancet"},{"key":"3046_CR45","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jcyt.2017.06.007","volume":"19","author":"C Lee","year":"2017","unstructured":"Lee C, Shim S, Jang H, Myung H, Lee J, Bae C-H, Myung JK, Kim M-J, Lee SB, Jang W-S, Lee S-J, Kim H-Y, Lee S-S, Park S (2017a) Human umbilical cord blood-derived mesenchymal stromal cells and small intestinal submucosa hydrogel composite promotes combined radiation-wound healing of mice. Cytotherapy 19:1048\u20131059","journal-title":"Cytotherapy"},{"key":"3046_CR46","first-page":"281","volume":"9","author":"YS Lee","year":"2017","unstructured":"Lee YS, Sah SK, Lee JH, Seo K-W, Kang K-S, Kim T-Y (2017b) Human umbilical cord blood-derived mesenchymal stem cells ameliorate psoriasis-like skin inflammation in mice. Biochem Biophys Rep 9:281\u2013288","journal-title":"Biochem Biophys Rep"},{"key":"3046_CR47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbrc.2012.01.142","volume":"419","author":"X Li","year":"2012","unstructured":"Li X, Li H, Bi J, Chen Y, Jain S, Zhao Y (2012) Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochem Biophys Res Commun 419:110\u2013116","journal-title":"Biochem Biophys Res Commun"},{"key":"3046_CR48","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.2174\/13816128113199990326","volume":"19","author":"X-Y Li","year":"2013","unstructured":"Li X-Y, Zheng Z-H, Li X-Y, Guo J, Zhang Y, Li H, Wang Y-W, Ren J, Wu Z-B (2013) Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies. Curr Pharm Des 19:4893\u20134899","journal-title":"Curr Pharm Des"},{"key":"3046_CR49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12916-015-0331-6","volume":"13","author":"Y Li","year":"2015","unstructured":"Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, Chen Y, Zhang Y, Li W, Zhang J, Wang S, Shen J, Li Y, Guindi E, Zhao Y (2015) Hair regrowth in alopecia areata patients following stem cell educator therapy. BMC Med 13:87","journal-title":"BMC Med"},{"key":"3046_CR50","volume":"6","author":"L Li","year":"2016","unstructured":"Li L, Hui H, Jia X, Zhang J, Liu Y, Xu Q, Zhu D (2016) Infusion with human bone marrow-derived mesenchymal stem cells improves \u03b2-cell function in patients and non-obese mice with severe diabetes. Sci Rep 6:37894","journal-title":"Sci Rep"},{"key":"3046_CR51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bbmt.2010.06.002","volume":"17","author":"M Mabed","year":"2011","unstructured":"Mabed M (2011) The potential utility of bone marrow or umbilical cord blood transplantation for the treatment of type I diabetes mellitus. Biol Blood Marrow Transplant 17:455\u2013464","journal-title":"Biol Blood Marrow Transplant"},{"key":"3046_CR52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/scd.2006.0660","volume":"16","author":"V Markov","year":"2007","unstructured":"Markov V, Kusumi K, Tadesse MG, William DA, Hall DM, Lounev V, Carlton A, Leonard J, Cohen RI, Rappaport EF, Saitta B (2007) Identification of cord blood-derived mesenchymal stem\/stromal cell populations with distinct growth kinetics, differentiation potentials, and gene expression profiles. Stem Cells Dev 16:53\u201373","journal-title":"Stem Cells Dev"},{"key":"3046_CR53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.clim.2015.12.002","volume":"163","author":"P Montanucci","year":"2016","unstructured":"Montanucci P, Alunno A, Basta G, Bistoni O, Pescara T, Caterbi S, Pennoni I, Bini V, Gerli R, Calafiore R (2016) Restoration of t cell substes of patients with type 1 diabetes mellitus by microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells: an in vitro study. Clin Immunol 163:34\u201341","journal-title":"Clin Immunol"},{"key":"3046_CR54","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1172\/JCI8296","volume":"105","author":"T Murohara","year":"2000","unstructured":"Murohara T, Ikeda H, Duan J, Shintani S, Sasaki K i, Eguchi H, Onitsuka I, Matsui K, Imaizumi T (2000) Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 105:1527\u20131536","journal-title":"J Clin Invest"},{"key":"3046_CR55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cellimm.2008.04.003","volume":"251","author":"W Oh","year":"2008","unstructured":"Oh W, Kim D-S, Yang YS, Lee JK (2008) Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 251:116\u2013123","journal-title":"Cell Immunol"},{"key":"3046_CR56","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.diabres.2012.09.034","volume":"98","author":"JH Park","year":"2012","unstructured":"Park JH, Hwang I, Hwang SH, Han H, Ha H (2012) Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action. Diabetes Res Clin Pract 98:465\u2013473","journal-title":"Diabetes Res Clin Pract"},{"key":"3046_CR57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11626-010-9356-5","volume":"47","author":"PV Phuc","year":"2011","unstructured":"Phuc PV, Nhung TH, Loan DTT, Chung DC, Ngoc PK (2011) Differentiating of banked human umbilical cord blood-derived mesenchymal stem cells into insulin-secreting cells. In Vitro Cell Dev Biol Anim 47:54\u201363","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"3046_CR58","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3727\/096368911X612530","volume":"21","author":"KR Prabakar","year":"2012","unstructured":"Prabakar KR, Dom\u00ednguez-Bendala J, Molano RD, Pileggi A, Villate S, Ricordi C, Inverardi L (2012) Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant 21:1321\u20131339","journal-title":"Cell Transplant"},{"key":"3046_CR59","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/157488810793351668","volume":"5","author":"AS Reddi","year":"2010","unstructured":"Reddi AS, Kuppasani K, Ende N (2010) Human umbilical cord blood as an emerging stem cell therapy for diabetes mellitus. Curr Stem Cell Res Ther 5:356\u2013361","journal-title":"Curr Stem Cell Res Ther"},{"key":"3046_CR60","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/1574888X10666141212122421","volume":"10","author":"AS Reddi","year":"2015","unstructured":"Reddi AS, Kothari N, Kuppasani K, Ende N (2015) Human umbilical cord blood cells and diabetes mellitus: recent advances. Curr Stem Cell Res Ther 10:266\u2013270","journal-title":"Curr Stem Cell Res Ther"},{"key":"3046_CR61","first-page":"211","volume":"17","author":"F Sahraneshin Samani","year":"2015","unstructured":"Sahraneshin Samani F, Ebrahimi M, Zandieh T, Khoshchehreh R, Baghaban Eslaminejad M, Aghdami N, Baharvand H (2015) In vitro differentiation of human umbilical cord blood CD133(+)cells into insulin producing cells in co-culture with rat pancreatic mesenchymal stem cells. Cell J 17:211\u2013220","journal-title":"Cell J"},{"key":"3046_CR62","doi-asserted-by":"crossref","first-page":"L1002","DOI":"10.1152\/ajplung.90347.2008","volume":"297","author":"KD Salazar","year":"2009","unstructured":"Salazar KD, Lankford SM, Brody AR (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297:L1002\u2013L1011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3046_CR63","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1182\/blood-2006-02-002246","volume":"109","author":"K Sato","year":"2007","unstructured":"Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, Muroi K, Ozawa K (2007) Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109:228\u2013234","journal-title":"Blood"},{"key":"3046_CR64","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12015-009-9098-5","volume":"5","author":"M Secco","year":"2009","unstructured":"Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri AR, Okamoto OK, Verjovski-Almeida S, Zatz M (2009) Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Stem Cell Rev 5:387\u2013401","journal-title":"Stem Cell Rev"},{"key":"3046_CR65","doi-asserted-by":"crossref","first-page":"e2524","DOI":"10.1038\/cddis.2016.442","volume":"7","author":"T-H Shin","year":"2016","unstructured":"Shin T-H, Kim H-S, Kang T-W, Lee B-C, Lee H-Y, Kim Y-J, Shin J-H, Seo Y, Won Choi S, Lee S, Shin K, Seo K-W, Kang K-S (2016) Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis. Cell Death Dis 7:e2524","journal-title":"Cell Death Dis"},{"key":"3046_CR66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.numecd.2017.02.004","volume":"27","author":"V Sordi","year":"2017","unstructured":"Sordi V, Pellegrini S, Krampera M, Marchetti P, Pessina A, Ciardelli G, Fadini G, Pintus C, Pant\u00e8 G, Piemonti L (2017) Stem cells to restore insulin production and cure diabetes. Nutr Metab Cardiovasc Dis 27:583\u2013600","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"3046_CR67","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1002\/art.27548","volume":"62","author":"L Sun","year":"2010","unstructured":"Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S (2010) Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 62:2467\u20132475","journal-title":"Arthritis Rheum"},{"key":"3046_CR68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/dgd.12214","volume":"57","author":"B Sun","year":"2015","unstructured":"Sun B, Liu R, Xiao Z-D (2015) Induction of insulin-producing cells from umbilical cord blood-derived stromal cells by activation of the c-met\/HGF axis. Develop Growth Differ 57:353\u2013361","journal-title":"Develop Growth Differ"},{"key":"3046_CR69","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.diff.2014.08.001","volume":"87","author":"P Van Pham","year":"2014","unstructured":"Van Pham P, Thi-My Nguyen P, Thai-Quynh Nguyen A, Minh Pham V, Nguyen-Tu Bui A, Thi-Tung Dang L, Gia Nguyen K, Kim Phan N (2014) Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection. Differentiation 87:200\u2013208","journal-title":"Differentiation"},{"key":"3046_CR70","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/bmt.2008.316","volume":"43","author":"M von Bonin","year":"2009","unstructured":"von Bonin M, St\u00f6lzel F, Goedecke A, Richter K, Wuschek N, H\u00f6lig K, Platzbecker U, Illmer T, Schaich M, Schetelig J, Kiani A, Ordemann R, Ehninger G, Schmitz M, Bornh\u00e4user M (2009) Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium. Bone Marrow Transplant 43:245\u2013251","journal-title":"Bone Marrow Transplant"},{"key":"3046_CR71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2567.2008.02891.x","volume":"126","author":"M Wang","year":"2009","unstructured":"Wang M, Yang Y, Yang D, Luo F, Liang W, Guo S, Xu J (2009) The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro. Immunology 126:220\u2013232","journal-title":"Immunology"},{"key":"3046_CR72","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1089\/scd.2013.0023","volume":"22","author":"L Wang","year":"2013","unstructured":"Wang L, Wang L, Cong X, Liu G, Zhou J, Bai B, Li Y, Bai W, Li M, Ji H, Zhu D, Wu M, Liu Y (2013) Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy. Stem Cells Dev 22:3192\u20133202","journal-title":"Stem Cells Dev"},{"key":"3046_CR73","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/ar4520","volume":"16","author":"D Wang","year":"2014","unstructured":"Wang D, Li J, Zhang Y, Zhang M, Chen J, Li X, Hu X, Jiang S, Shi S, Sun L (2014) Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther 16:R79","journal-title":"Arthritis Res Ther"},{"key":"3046_CR74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/7651_2015_287","volume":"1433","author":"A Willcox","year":"2016","unstructured":"Willcox A, Gillespie KM (2016) Histology of type 1 diabetes pancreas. Methods Mol Biol 1433:105\u2013117","journal-title":"Methods Mol Biol"},{"key":"3046_CR75","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1097\/TP.0b013e31821aba18","volume":"91","author":"K-H Wu","year":"2011","unstructured":"Wu K-H, Chan C-K, Tsai C, Chang Y-H, Sieber M, Chiu T-H, Ho M, Peng C-T, Wu H-P, Huang J-L (2011) Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells. Transplantation 91:1412\u20131416","journal-title":"Transplantation"},{"key":"3046_CR76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00441-016-2499-2","volume":"368","author":"J Xv","year":"2017","unstructured":"Xv J, Ming Q, Wang X, Zhang W, Li Z, Wang S, Li Y, Li L (2017) Mesenchymal stem cells moderate immune response of type 1 diabetes. Cell Tissue Res 368:239\u2013248","journal-title":"Cell Tissue Res"},{"key":"3046_CR77","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1634\/stemcells.2005-0079","volume":"23","author":"S Yoshida","year":"2005","unstructured":"Yoshida S, Ishikawa F, Kawano N, Shimoda K, Nagafuchi S, Shimoda S, Yasukawa M, Kanemaru T, Ishibashi H, Shultz LD, Harada M (2005) Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 23:1409\u20131416","journal-title":"Stem Cells"},{"key":"3046_CR78","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11892-012-0308-1","volume":"12","author":"Y Zhao","year":"2012","unstructured":"Zhao Y (2012) Stem cell educator therapy and induction of immune balance. Curr Diab Rep 12:517\u2013523","journal-title":"Curr Diab Rep"},{"key":"3046_CR79","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.autrev.2010.08.011","volume":"10","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, Mazzone T (2010) Human cord blood stem cells and the journey to a cure for type 1 diabetes. Autoimmun Rev 10:103\u2013107","journal-title":"Autoimmun Rev"},{"key":"3046_CR80","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.yexcr.2006.04.008","volume":"312","author":"Y Zhao","year":"2006","unstructured":"Zhao Y, Wang H, Mazzone T (2006) Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res 312:2454\u20132464","journal-title":"Exp Cell Res"},{"key":"3046_CR81","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.imlet.2006.10.007","volume":"108","author":"Y Zhao","year":"2007","unstructured":"Zhao Y, Huang Z, Qi M, Lazzarini P, Mazzone T (2007) Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett 108:78\u201387","journal-title":"Immunol Lett"},{"key":"3046_CR82","volume":"4","author":"Y Zhao","year":"2009","unstructured":"Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA (2009) Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One 4:e4226","journal-title":"PLoS One"},{"key":"3046_CR83","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.trsl.2010.01.003","volume":"155","author":"Y Zhao","year":"2010","unstructured":"Zhao Y, Lin B, Dingeldein M, Guo C, Hwang D, Holterman MJ (2010) New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes. Transl Res 155:211\u2013216","journal-title":"Transl Res"},{"key":"3046_CR84","doi-asserted-by":"crossref","unstructured":"Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, Li H, Zhang Y, Diao Y, Li Y, Chen Y, Sun X, Fisk MB, Skidgel R, Holterman M, Prabhakar B, Mazzone T (2012) Reversal of type 1 diabetes via islet \u03b2 cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med 10(3)","DOI":"10.1186\/1741-7015-10-3"},{"key":"3046_CR85","doi-asserted-by":"crossref","first-page":"80","DOI":"10.7150\/ijbs.7237","volume":"10","author":"Q-S Zhao","year":"2013","unstructured":"Zhao Q-S, Xia N, Zhao N, Li M, Bi C-L, Zhu Q, Qiao G-F, Cheng Z-F (2013a) Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. Int J Biol Sci 10:80\u201389","journal-title":"Int J Biol Sci"},{"key":"3046_CR86","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1741-7015-11-160","volume":"11","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Zhou H, Yin Z, Chen Y, Zhang Y, Wang S, Shen J, Thaker H, Jain S, Li Y, Diao Y, Chen Y, Sun X, Fisk MB, Li H (2013b) Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I\/II clinical trial. BMC Med 11:160","journal-title":"BMC Med"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-019-03046-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00441-019-03046-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-019-03046-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T23:08:41Z","timestamp":1592262521000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00441-019-03046-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["3046"],"URL":"https:\/\/doi.org\/10.1007\/s00441-019-03046-2","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"26 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}