{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:46:47Z","timestamp":1770972407434,"version":"3.50.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["447251\/2014-7"],"award-info":[{"award-number":["447251\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["16\/2551-0000223-1"],"award-info":[{"award-number":["16\/2551-0000223-1"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o Vale do Taquari de Educa\u00e7\u00e3o e Desenvolvimento Social","award":["08\/Reitoria\/Univates\/2016"],"award-info":[{"award-number":["08\/Reitoria\/Univates\/2016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00441-019-03080-0","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T07:03:06Z","timestamp":1566543786000},"page":"389-405","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ready for the journey: a comparative proteome profiling of porcine cauda epididymal fluid and spermatozoa"],"prefix":"10.1007","volume":"379","author":[{"given":"Augusto","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Esp\u00edndola","family":"Argenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Binato","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00e9lia","family":"Santi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Orlando","family":"Beys-da-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"3rd","given":"John R.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-8443","authenticated-orcid":false,"given":"Ivan Cunha","family":"Bustamante-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"3080_CR1","first-page":"25","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G (2000) Gene ontology: tool for the unification of biology. Gene Ontol Consortium Nat Genet 25:25\u201329","journal-title":"Gene Ontol Consortium Nat Genet"},{"key":"3080_CR2","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/jcp.21349","volume":"215","author":"KM Baska","year":"2008","unstructured":"Baska KM, Manandhar G, Feng D, Agca Y, Tengowski MW, Sutovsky M, Yi YJ, Sutovsky P (2008) Mechanism of extracellular ubiquitination in the mammalian epididymis. J Cell Physiol 215:684\u2013696","journal-title":"J Cell Physiol"},{"key":"3080_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1439-0272.1996.tb02773.x","volume":"28","author":"JP Binette","year":"1996","unstructured":"Binette JP, Ohishi H, Burgi W, Kimura A, Suyemitsu T, Seno N, Schmid K (1996) The content and distribution of glycosaminoglycans in the ejaculates of normal and vasectomized men. Andrologia 28:145\u2013149","journal-title":"Andrologia"},{"key":"3080_CR4","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.2527\/jas.2009-2583","volume":"88","author":"E Chabory","year":"2010","unstructured":"Chabory E, Damon C, Lenoir A, Henry-Berger J, Vernet P, Cadet R, Saez F, Drevet JR (2010) Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity. J Anim Sci 88:1321\u20131331","journal-title":"J Anim Sci"},{"key":"3080_CR5","first-page":"2074","volume":"119","author":"E Chabory","year":"2009","unstructured":"Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, Garrel C, Saez F, Cadet R, Henry-Berger J, Schoor M, Gottwald U, Habenicht U, Drevet JR, Vernet P (2009) Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest 119:2074\u20132085","journal-title":"J Clin Invest"},{"key":"3080_CR6","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","volume":"21","author":"A Conesa","year":"2005","unstructured":"Conesa A, Gotz S, Garcia-Gomez JM, Terol J, Talon M, Robles M (2005) Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21:3674\u20133676","journal-title":"Bioinformatics"},{"key":"3080_CR7","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.bbagen.2014.10.020","volume":"1850","author":"M Conrad","year":"2015","unstructured":"Conrad M, Ingold I, Buday K, Kobayashi S, Angeli JP (2015) ROS, thiols and thiol-regulating systems in male gametogenesis. Biochim Biophys Acta 1850:1566\u20131574","journal-title":"Biochim Biophys Acta"},{"key":"3080_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1006\/dbio.1993.1012","volume":"155","author":"AE Cowan","year":"1993","unstructured":"Cowan AE, Myles DG (1993) Biogenesis of surface domains during spermiogenesis in the guinea pig. Dev Biol 155:124\u2013133","journal-title":"Dev Biol"},{"key":"3080_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.mce.2005.12.022","volume":"250","author":"JL Dacheux","year":"2006","unstructured":"Dacheux JL, Belghazi M, Lanson Y, Dacheux F (2006) Human epididymal secretome and proteome. Mol Cell Endocrinol 250:36\u201342","journal-title":"Mol Cell Endocrinol"},{"key":"3080_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mce.2009.03.007","volume":"306","author":"JL Dacheux","year":"2009","unstructured":"Dacheux JL, Belleannee C, Jones R, Labas V, Belghazi M, Guyonnet B, Druart X, Gatti JL, Dacheux F (2009) Mammalian epididymal proteome. Mol Cell Endocrinol 306:45\u201350","journal-title":"Mol Cell Endocrinol"},{"key":"3080_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.theriogenology.2004.09.015","volume":"63","author":"JL Dacheux","year":"2005","unstructured":"Dacheux JL, Castella S, Gatti JL, Dacheux F (2005) Epididymal cell secretory activities and the role of proteins in boar sperm maturation. Theriogenology 63:319\u2013341","journal-title":"Theriogenology"},{"key":"3080_CR12","doi-asserted-by":"publisher","first-page":"R27","DOI":"10.1530\/REP-13-0420","volume":"147","author":"JL Dacheux","year":"2014","unstructured":"Dacheux JL, Dacheux F (2014) New insights into epididymal function in relation to sperm maturation. Reproduction 147:R27\u2013R42","journal-title":"Reproduction"},{"key":"3080_CR13","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1051\/rnd:19800617","volume":"20","author":"JL Dacheux","year":"1980","unstructured":"Dacheux JL, Paquignon M (1980) Relations between the fertilizing ability, motility and metabolism of epididymal spermatozoa. Reprod Nutr Dev 20:1085\u20131099","journal-title":"Reprod Nutr Dev"},{"key":"3080_CR14","doi-asserted-by":"publisher","first-page":"631","DOI":"10.4067\/S0716-97602006000500006","volume":"39","author":"DG Dapino","year":"2006","unstructured":"Dapino DG, Marini PE, Cabada MO (2006) Effect of heparin on in vitro capacitation of boar sperm. Biol Res 39:631\u2013639","journal-title":"Biol Res"},{"issue":"Suppl 1","key":"3080_CR15","doi-asserted-by":"publisher","first-page":"S199","DOI":"10.1016\/j.ejogrb.2009.02.018","volume":"144","author":"MA El-Taieb","year":"2009","unstructured":"El-Taieb MA, Herwig R, Nada EA, Greilberger J, Marberger M (2009) Oxidative stress and epididymal sperm transport, motility and morphological defects. Eur J Obstet Gynecol Reprod Biol 144(Suppl 1):S199\u2013S203","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3080_CR16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nprot.2007.131","volume":"2","author":"O Emanuelsson","year":"2007","unstructured":"Emanuelsson O, Brunak S, von Heijne G, Nielsen H (2007) Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc 2:953\u2013971","journal-title":"Nat Protoc"},{"key":"3080_CR17","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1002\/pmic.201100056","volume":"11","author":"B Fr\u00e4nzel","year":"2011","unstructured":"Fr\u00e4nzel B, Wolters DA (2011) Advanced MudPIT as a next step toward high proteome coverage. Proteomics 11:3651\u20133656","journal-title":"Proteomics"},{"key":"3080_CR18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1152\/physrev.00027.2001","volume":"82","author":"MH Glickman","year":"2002","unstructured":"Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373\u2013428","journal-title":"Physiol Rev"},{"key":"3080_CR19","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00441-012-1452-2","volume":"349","author":"A Govindaraju","year":"2012","unstructured":"Govindaraju A, Dogan S, Rodriguez-Osorio N, Grant K, Kaya A, Memili E (2012) Delivering value from sperm proteomics for fertility. Cell Tissue Res 349:783\u2013793","journal-title":"Cell Tissue Res"},{"key":"3080_CR20","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1186\/1471-2164-10-369","volume":"10","author":"B Guyonnet","year":"2009","unstructured":"Guyonnet B, Marot G, Dacheux JL, Mercat MJ, Schwob S, Jaffrezic F, Gatti JL (2009) The adult boar testicular and epididymal transcriptomes. BMC Genomics 10:369","journal-title":"BMC Genomics"},{"key":"3080_CR21","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/S0006-291X(82)80143-5","volume":"107","author":"RR Handrow","year":"1982","unstructured":"Handrow RR, Lenz RW, Ax RL (1982) Structural comparisons among glycosaminoglycans to promote an acrosome reaction in bovine spermatozoa. Biochem Biophys Res Commun 107:1326\u20131332","journal-title":"Biochem Biophys Res Commun"},{"key":"3080_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","volume":"16","author":"H Heberle","year":"2015","unstructured":"Heberle H, Meirelles GV, da Silva FR, Telles GP, Minghim R (2015) InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinformatics 16:169","journal-title":"BMC Bioinformatics"},{"key":"3080_CR23","volume-title":"The epididymis: from molecules to clinical practice","author":"L Hermo","year":"2002","unstructured":"Hermo L, Robaire B (2002) Epididymal cell types and their functions. In: Robaire B, Hinton BT (eds) The epididymis: from molecules to clinical practice. Springer, New York"},{"key":"3080_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jemt.1070300106","volume":"30","author":"BT Hinton","year":"1995","unstructured":"Hinton BT, Palladino MA (1995) Epididymal epithelium: its contribution to the formation of a luminal fluid microenvironment. Microsc Res Tech 30:67\u201381","journal-title":"Microsc Res Tech"},{"key":"3080_CR25","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1439-0531.2010.01701.x","volume":"46","author":"M Koziorowska-Gilun","year":"2011","unstructured":"Koziorowska-Gilun M, Koziorowski M, Fraser L, Strzezek J (2011) Antioxidant defence system of boar cauda epididymidal spermatozoa and reproductive tract fluids. Reproduction in domestic animals =. Zuchthygiene 46:527\u2013533","journal-title":"Zuchthygiene"},{"key":"3080_CR26","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","volume":"305","author":"A Krogh","year":"2001","unstructured":"Krogh A, Larsson B, von Heijne G, Sonnhammer EL (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305:567\u2013580","journal-title":"J Mol Biol"},{"key":"3080_CR27","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jprot.2014.09.031","volume":"113","author":"V Labas","year":"2015","unstructured":"Labas V, Spina L, Belleannee C, Teixeira-Gomes AP, Gargaros A, Dacheux F, Dacheux JL (2015) Analysis of epididymal sperm maturation by MALDI profiling and top-down mass spectrometry. J Proteome 113:226\u2013243","journal-title":"J Proteome"},{"key":"3080_CR28","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/0006-291X(82)91224-4","volume":"106","author":"RW Lenz","year":"1982","unstructured":"Lenz RW, Ax RL, Grimek HJ, First NL (1982) Proteoglycan from bovine follicular fluid enhances an acrosome reaction in bovine spermatozoa. Biochem Biophys Res Commun 106:1092\u20131098","journal-title":"Biochem Biophys Res Commun"},{"key":"3080_CR29","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jri.2006.01.008","volume":"71","author":"J Liberda","year":"2006","unstructured":"Liberda J, Manaskova P, Prelovska L, Ticha M, Jonakova V (2006) Saccharide-mediated interactions of boar sperm surface proteins with components of the porcine oviduct. J Reprod Immunol 71:112\u2013125","journal-title":"J Reprod Immunol"},{"key":"3080_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P (2015) The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst 1:417\u2013425","journal-title":"Cell Syst"},{"key":"3080_CR31","doi-asserted-by":"publisher","first-page":"720","DOI":"10.4103\/1008-682X.143247","volume":"17","author":"PA Martin-DeLeon","year":"2015","unstructured":"Martin-DeLeon PA (2015) Epididymosomes: transfer of fertility-modulating proteins to the sperm surface. Asian J Androl 17:720\u2013725","journal-title":"Asian J Androl"},{"key":"3080_CR32","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1002\/rcm.1603","volume":"18","author":"WH McDonald","year":"2004","unstructured":"McDonald WH, Tabb DL, Sadygov RG, MacCoss MJ, Venable J, Graumann J, Johnson JR, Cociorva D, Yates JR 3rd (2004) MS1, MS2, and SQT-three unified, compact, and easily parsed file formats for the storage of shotgun proteomic spectra and identifications. Rapid Commun Mass Spectrom 18:2162\u20132168","journal-title":"Rapid Commun Mass Spectrom"},{"key":"3080_CR33","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/j.jprot.2010.06.005","volume":"73","author":"AA Moura","year":"2010","unstructured":"Moura AA, Souza CE, Stanley BA, Chapman DA, Killian GJ (2010) Proteomics of cauda epididymal fluid from mature Holstein bulls. J Proteome 73:2006\u20132020","journal-title":"J Proteome"},{"key":"3080_CR34","volume-title":"Nutrient requirements of swine","author":"NRC","year":"2012","unstructured":"NRC (2012) Nutrient requirements of swine. The National Academies Press, Washington, DC"},{"key":"3080_CR35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.anireprosci.2012.08.027","volume":"135","author":"K Park","year":"2012","unstructured":"Park K, Jeon S, Song Y-J, Yi LSH (2012) Proteomic analysis of boar spermatozoa and quantity changes of superoxide dismutase 1, glutathione peroxidase, and peroxiredoxin 5 during epididymal maturation. Anim Reprod Sci 135:53\u201361","journal-title":"Anim Reprod Sci"},{"key":"3080_CR36","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.theriogenology.2015.01.033","volume":"83","author":"S Pena Jr","year":"2015","unstructured":"Pena S Jr, Summers P, Gummow B, Paris DB (2015) Oviduct binding ability of porcine spermatozoa develops in the epididymis and can be advanced by incubation with caudal fluid. Theriogenology 83:1502\u20131513","journal-title":"Theriogenology"},{"key":"3080_CR37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jprot.2016.04.026","volume":"142","author":"C Perez-Patino","year":"2016","unstructured":"Perez-Patino C, Barranco I, Parrilla I, Valero ML, Martinez EA, Rodriguez-Martinez H, Roca J (2016) Characterization of the porcine seminal plasma proteome comparing ejaculate portions. J Proteome 142:15\u201323","journal-title":"J Proteome"},{"key":"3080_CR38","volume-title":"The proteome of pig spermatozoa is remodeled during ejaculation","author":"C Perez-Patino","year":"2018","unstructured":"Perez-Patino C, Parrilla I, Li J, Barranco I, Martinez EA, Rodriguez-Martinez H, Roca J (2018) The proteome of pig spermatozoa is remodeled during ejaculation. Molecular & cellular proteomics, MCP"},{"key":"3080_CR39","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/nmeth.1701","volume":"8","author":"TN Petersen","year":"2011","unstructured":"Petersen TN, Brunak S, von Heijne G, Nielsen H (2011) SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 8:785\u2013786","journal-title":"Nat Methods"},{"key":"3080_CR40","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"3080_CR41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","volume":"339","author":"C Ramakers","year":"2003","unstructured":"Ramakers C, Ruijter JM, Deprez RH, Moorman AF (2003) Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett 339:62\u201366","journal-title":"Neurosci Lett"},{"issue":"2","key":"3080_CR42","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1095\/biolreprod.103.020487","volume":"70","author":"J Rivlin","year":"2003","unstructured":"Rivlin J, Mendel J, Rubinstein S, Etkovitz N, Breitbart H (2003) Role of hydrogen peroxide in sperm capacitation and acrosome reaction. Biol Reprod 70(2):518\u2013522","journal-title":"Biol Reprod"},{"key":"3080_CR43","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1095\/biolreprod.102.013771","volume":"69","author":"KP Roberts","year":"2003","unstructured":"Roberts KP, Wamstad JA, Ensrud KM, Hamilton DW (2003) Inhibition of capacitation-associated tyrosine phosphorylation signaling in rat sperm by epididymal protein Crisp-1. Biol Reprod 69:572\u2013581","journal-title":"Biol Reprod"},{"issue":"Suppl 1","key":"3080_CR44","doi-asserted-by":"publisher","first-page":"S138","DOI":"10.1016\/j.theriogenology.2007.03.018","volume":"68","author":"H Rodriguez-Martinez","year":"2007","unstructured":"Rodriguez-Martinez H (2007) Role of the oviduct in sperm capacitation. Theriogenology 68(Suppl 1):S138\u2013S146","journal-title":"Theriogenology"},{"key":"3080_CR45","first-page":"129","volume":"58","author":"H Rodriguez-Martinez","year":"2001","unstructured":"Rodriguez-Martinez H, Tienthai P, Suzuki K, Funahashi H, Ekwall H, Johannisson A (2001) Involvement of oviduct in sperm capacitation and oocyte development in pigs. Reprod (Cambridge, England) Suppl 58:129\u2013145","journal-title":"Reprod (Cambridge, England) Suppl"},{"key":"3080_CR46","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/gkp045","volume":"37","author":"JM Ruijter","year":"2009","unstructured":"Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ, Moorman AF (2009) Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 37:e45","journal-title":"Nucleic Acids Res"},{"key":"3080_CR47","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1021\/pr401075f","volume":"13","author":"L Santi","year":"2014","unstructured":"Santi L, Beys-da-Silva WO, Berger M, Calzolari D, Guimaraes JA, Moresco JJ, Yates JR 3rd (2014) Proteomic profile of Cryptococcus neoformans biofilm reveals changes in metabolic processes. J Proteome Res 13:1545\u20131559","journal-title":"J Proteome Res"},{"key":"3080_CR48","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1095\/biolreprod.104.029330","volume":"72","author":"E Sostaric","year":"2005","unstructured":"Sostaric E, van de Lest CH, Colenbrander B, Gadella BM (2005) Dynamics of carbohydrate affinities at the cell surface of capacitating bovine sperm cells. Biol Reprod 72:346\u2013357","journal-title":"Biol Reprod"},{"key":"3080_CR49","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1745-7262.2007.00281.x","volume":"9","author":"R Sullivan","year":"2007","unstructured":"Sullivan R, Frenette G, Girouard J (2007) Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit. Asian J Androl 9:483\u2013491","journal-title":"Asian J Androl"},{"key":"3080_CR50","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1530\/REP-13-0058","volume":"146","author":"R Sullivan","year":"2013","unstructured":"Sullivan R, Saez F (2013) Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology. Reproduction 146:R21\u2013R35","journal-title":"Reproduction"},{"key":"3080_CR51","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/jemt.10319","volume":"61","author":"P Sutovsky","year":"2003","unstructured":"Sutovsky P (2003) Ubiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: killing three birds with one stone. Microsc Res Tech 61:88\u2013102","journal-title":"Microsc Res Tech"},{"key":"3080_CR52","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1242\/jcs.114.9.1665","volume":"114","author":"P Sutovsky","year":"2001","unstructured":"Sutovsky P, Moreno R, Ramalho-Santos J, Dominko T, Thompson WE, Schatten G (2001) A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis. J Cell Sci 114:1665\u20131675","journal-title":"J Cell Sci"},{"key":"3080_CR53","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1095\/biolreprod55.5.956","volume":"55","author":"P Syntin","year":"1996","unstructured":"Syntin P, Dacheux F, Druart X, Gatti JL, Okamura N, Dacheux JL (1996) Characterization and identification of proteins secreted in the various regions of the adult boar epididymis. Biol Reprod 55:956\u2013974","journal-title":"Biol Reprod"},{"key":"3080_CR54","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1095\/biolreprod61.6.1622","volume":"61","author":"P Syntin","year":"1999","unstructured":"Syntin P, Dacheux J-L, Dacheux F (1999) Postnatal development and regulation of proteins secreted in the boar epididymis. Biol Reprod 61:1622\u20131635","journal-title":"Biol Reprod"},{"key":"3080_CR55","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1021\/pr015504q","volume":"1","author":"DL Tabb","year":"2002","unstructured":"Tabb DL, McDonald WH, Yates JR 3rd (2002) DTASelect and contrast: tools for assembling and comparing protein identifications from shotgun proteomics. J Proteome Res 1:21\u201326","journal-title":"J Proteome Res"},{"key":"3080_CR56","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1095\/biolreprod64.2.491","volume":"64","author":"R Talevi","year":"2001","unstructured":"Talevi R, Gualtieri R (2001) Sulfated glycoconjugates are powerful modulators of bovine sperm adhesion and release from the oviductal epithelium in vitro. Biol Reprod 64:491\u2013498","journal-title":"Biol Reprod"},{"key":"3080_CR57","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1017\/S143192760505021X","volume":"11","author":"MW Tengowski","year":"2005","unstructured":"Tengowski MW, Sutovsky P, Hedlund LW, Guyot DJ, Burkhardt JE, Thompson WE, Sutovsky M, Johnson GA (2005) Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. Microsc Microanal 11:300\u2013312","journal-title":"Microsc Microanal"},{"key":"3080_CR58","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/mrd.20287","volume":"71","author":"I Therien","year":"2005","unstructured":"Therien I, Bergeron A, Bousquet D, Manjunath P (2005) Isolation and characterization of glycosaminoglycans from bovine follicular fluid and their effect on sperm capacitation. Mol Reprod Dev 71:97\u2013106","journal-title":"Mol Reprod Dev"},{"key":"3080_CR59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mce.2003.10.069","volume":"216","author":"P Vernet","year":"2004","unstructured":"Vernet P, Aitken RJ, Drevet JR (2004) Antioxidant strategies in the epididymis. Mol Cell Endocrinol 216:31\u201339","journal-title":"Mol Cell Endocrinol"},{"key":"3080_CR60","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe K, Taskesen E, van Bochoven A, Posthuma D (2017) Functional mapping and annotation of genetic associations with FUMA. Nat Commun 8:1826","journal-title":"Nat Commun"},{"key":"3080_CR61","doi-asserted-by":"publisher","first-page":"5683","DOI":"10.1021\/ac010617e","volume":"73","author":"DA Wolters","year":"2001","unstructured":"Wolters DA, Washburn MP, Yates JR 3rd (2001) An automated multidimensional protein identification technology for shotgun proteomics. Anal Chem 73:5683\u20135690","journal-title":"Anal Chem"},{"key":"3080_CR62","first-page":"S174","volume":"5","author":"T Xu","year":"2006","unstructured":"Xu T, Venable JD, Park SK, Lu B, Liao L, Wohlschlegel J, Hewel J, Yates JR (2006) ProLuCID, a fast and sensitive tandem mass spectra-based protein identification program. Mol Cell Proteomics 5:S174","journal-title":"Mol Cell Proteomics"},{"key":"3080_CR63","first-page":"189","volume-title":"The physiology of reproduction","author":"R Yanagimachi","year":"1994","unstructured":"Yanagimachi R (1994) Mammalian fertilization. In: Knobil E, Neill JD (eds) The physiology of reproduction. Raven Press, New York, pp 189\u2013317"},{"key":"3080_CR64","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.theriogenology.2016.07.008","volume":"86","author":"IZ Zaja","year":"2016","unstructured":"Zaja IZ, Samardzija M, Vince S, Sluganovic A, Strelec S, Suran J, DelVechio I, Duricic D, Ostovic M, Valpotic H, Milinkovic-Tur S (2016) Antioxidant protection and lipid peroxidation in testes and different parts of epididymis in boars. Theriogenology 86:2194\u20132201","journal-title":"Theriogenology"},{"key":"3080_CR65","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fendo.2018.00059","volume":"9","author":"W Zhou","year":"2018","unstructured":"Zhou W, De Iuliis GN, Dun MD, Nixon B (2018) Characteristics of the epididymal luminal environment responsible for sperm maturation and storage. Front Endocrinol (Lausanne) 9:59","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3080_CR66","doi-asserted-by":"crossref","unstructured":"Zigo M, Jonakova V, Manaskova-Postlerova P, Kerns K, Sutovsky P (2019) Ubiquitin-proteasome system participates in the de-aggregation of spermadhesin and DQH protein during boar sperm capacitation. Reproduction","DOI":"10.1530\/REP-18-0413"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-019-03080-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-019-03080-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-019-03080-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T14:08:51Z","timestamp":1650463731000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-019-03080-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["3080"],"URL":"https:\/\/doi.org\/10.1007\/s00441-019-03080-0","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"assertion":[{"value":"14 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures with animals described in this article were previously approved by the Local Animal Experimentation Ethics Committee (protocol 001\/2015) and according to the Brazilian Animal Welfare legislation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}