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All animal studies were performed in compliance with the regulations and guidelines of the Peking University institutional animal care committee (LA 2018016) and conducted according to AAALAC and IACUC guidelines.All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}