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The expression and location of AQP1 and other AQPs in the placenta and foetal membranes of <jats:italic>AQP1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, AQP1-siRNA transfected WISH cells and oligohydramnios patients were also detected. Compared to control mice, <jats:italic>AQP1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice exhibited reduced copulation plug and successful pregnancy rates, but these effects were accompanied by a larger AF volume and lower AF osmolality at late gestation. AQP9 expression was significantly decreased in the placenta and foetal membranes of <jats:italic>AQP1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice, while AQP8 level was elevated in the foetal membranes of <jats:italic>AQP1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. Moreover, AQP9 expression was suppressed in WISH cells after AQP1 downregulation. Furthermore, AQP9 expression was associated with AQP1 level in the placenta and foetal membranes in oligohydramnios. AQP1 may play a critical role in regulating pregnancy outcome and maternal-foetal fluid homeostasis. Changes in AQP1 expression may lead to compensatory alterations in AQP8 and AQP9 expression in the placenta.<\/jats:p>","DOI":"10.1007\/s00441-020-03221-w","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T12:02:51Z","timestamp":1592222571000},"page":"543-554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aquaporin 1 affects pregnancy outcome and regulates aquaporin 8 and 9 expressions in the placenta"],"prefix":"10.1007","volume":"381","author":[{"given":"Hui","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizuo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8389-928X","authenticated-orcid":false,"given":"Xueqiong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"3221_CR1","doi-asserted-by":"crossref","first-page":"R506","DOI":"10.1152\/ajpregu.00175.2013","volume":"305","author":"DF Anderson","year":"2013","unstructured":"Anderson DF, Jonker SS, Louey S, Cheung CY, Brace RA (2013) Regulation of intramembranous absorption and volume by constituents in fetal sheep urine. 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