{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:51:13Z","timestamp":1758819073423,"version":"3.37.3"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00441-020-03354-y","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T03:31:16Z","timestamp":1611891076000},"page":"771-788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptomic profile of VEGF-regulated genes in human cervical epithelia"],"prefix":"10.1007","volume":"384","author":[{"given":"MacKinsey","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-8108","authenticated-orcid":false,"given":"Chishimba Nathan","family":"Mowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"3354_CR1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ygyno.2003.11.031","volume":"93","author":"WS Ahn","year":"2004","unstructured":"Ahn WS, Bae SM, Lee JM, Namkoong SE, Han S-J, Cho YL, Nam GH, Seo JS, Kim CK, Kim YW et al (2004) Searching for pathogenic gene functions to cervical cancer. Gynecol Oncol 93:41\u201348","journal-title":"Gynecol Oncol"},{"key":"3354_CR2","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1210\/jc.2007-2813","volume":"93","author":"S Andersson","year":"2008","unstructured":"Andersson S, Minjarez D, Yost NP, Ann Word R et al (2008) Estrogen and progesterone metabolism in the cervix during pregnancy and parturition. J Clin Endocrinol and Metab 93:2366\u20132374","journal-title":"J Clin Endocrinol and Metab"},{"key":"3354_CR3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20150437","volume":"469","author":"E Babu","year":"2015","unstructured":"Babu E, Bhutia YD, Ramachandran S, Gnanaprakasam JP, Prasad PD, Thangaraju M, Ganapathy V et al (2015) Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Biochem J 469:17\u201323","journal-title":"Biochem J"},{"key":"3354_CR4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0002-9378(93)90634-U","volume":"169","author":"CG Barclay","year":"1993","unstructured":"Barclay CG, Brennand JE, Kelly RW, Calder AA et al (1993) Interleukin-8 production by the human cervix. Am J Obstet Gynecol 169:625\u2013632","journal-title":"Am J Obstet Gynecol"},{"key":"3354_CR5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1009292506879","volume":"2","author":"P Bausero","year":"1998","unstructured":"Bausero P, Freitas S, Meduri G, Perrot-Applanat M et al (1998) Paracrine action of VEGF in the human endometrium: Regulation by ovarian steroids. Angiogenesis 2:167\u2013182","journal-title":"Angiogenesis"},{"key":"3354_CR6","doi-asserted-by":"crossref","first-page":"11650","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29:11650\u201321188","journal-title":"Ann Stat"},{"key":"3354_CR7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.tem.2015.06.004","volume":"26","author":"SH Chung","year":"2015","unstructured":"Chung SH (2015) Targeting female hormone receptors as cervical cancer therapy. Trends Endocrinol Metab 26:399\u2013401","journal-title":"Trends Endocrinol Metab"},{"key":"3354_CR8","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1073\/pnas.87.7.2628","volume":"87","author":"G Conn","year":"1990","unstructured":"Conn G, Bayne ML, Sodermann DD, Kwok PW, Sullivan KA, Palisi TM, Hope DA, Thomas KA et al (1990) Amino acid sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci USA 87:2628\u20132632","journal-title":"Proc Natl Acad Sci USA"},{"key":"3354_CR9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1210\/endo.133.2.8344219","volume":"133","author":"K Cullinan-Bove","year":"1993","unstructured":"Cullinan-Bove K, Koos RD (1993) Vascular endothelial growth factor\/vascular permeability expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology 133:829\u2013837","journal-title":"Endocrinology"},{"key":"3354_CR10","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1312256","volume":"255","author":"C de Vries","year":"1992","unstructured":"de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT et al (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Sci 255:989\u2013991","journal-title":"Sci"},{"key":"3354_CR11","unstructured":"Deshais R [Video]. Deshais (Amgen): 2 Cullin-RING ubiquitin ligases: Structure, mechanism, and regulation. YouTube. https:\/\/www.youtube.com\/watch?v=-5WbCdbNMKo. Published 23 May 2017. Accessed 1 June 2019"},{"key":"3354_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1530\/JOE-12-0469","volume":"217","author":"SM Donnelly","year":"2013","unstructured":"Donnelly SM, Nguyen BT, Rhyne S, Estes J, Jesmin S, Mowa CN et al (2013) Vascular endothelial growth factor induces growth of uterine cervix and immune cell recruitment in mice. J Endocrinol 217:83\u201394","journal-title":"J Endocrinol"},{"key":"3354_CR13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cell.2008.07.022","volume":"134","author":"DM Duda","year":"2008","unstructured":"Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, Schulman BA et al (2008) Structural insights into NEDD8 activation of cullin-RING ligases: Conformational control of conjugation. Cell 134:995\u20131006","journal-title":"Cell"},{"key":"3354_CR14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/01.ATV.20.3.659","volume":"20","author":"J Dulak","year":"2000","unstructured":"Dulak J, J\u00f3zkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, W\u00f3jtowicz A, Szuba A, Cooke JP et al (2000) Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20:659\u2013666","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3354_CR15","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/humrep\/12.5.1080","volume":"12","author":"E El Maradny","year":"1997","unstructured":"El Maradny E, Kanayama N, Kobayashi H, Hossain B, Khatun S, Liping S, Kobayashi T, Terao T et al (1997) The role of hyaluronic acid as a mediator and regulator of cervical ripening. Hum Reprod 12:1080\u20131088","journal-title":"Hum Reprod"},{"key":"3354_CR16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","volume":"18","author":"N Ferrara","year":"1997","unstructured":"Ferrara N, Davis-Smyth T (1997) The biology of vascular endothelial growth factor. Endocr Rev 18:4\u20135","journal-title":"Endocr Rev"},{"key":"3354_CR17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N Ferrara","year":"2003","unstructured":"Ferrara N, Gerber HP, LeCouter J et al (2003) The biology of VEGF and its receptors. Nat Med 9:669\u2013676","journal-title":"Nat Med"},{"key":"3354_CR18","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0002-9440(10)65067-5","volume":"156","author":"MJ Frederick","year":"2000","unstructured":"Frederick MJ, Henderson Y, Xu X, Deavers MT, Sahin AA, Wu H, Lewis DE, El-Naggar AK, Clayman GL et al (2000) In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am J Pathol 156:1937\u20131950","journal-title":"Am J Pathol"},{"key":"3354_CR19","unstructured":"GeneCards: MT-CO2 Gene (Protein Coding) Mitochondrially Encoded Cytochrome C Oxidase II. https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=MT-CO2. Accessed 1 June 2019"},{"key":"3354_CR20","unstructured":"GeneCards. MT-CO3 Gene (Protein Coding) Mitochondrially Encoded Cytochrome C Oxidase III. https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=MT-CO3. Accessed 1 June 2019"},{"key":"3354_CR21","unstructured":"Genetics Home Reference MT-CO2 gene. In Genetics Home Reference"},{"key":"3354_CR22","unstructured":"Genetics Home Reference MT-CO3 gene. In Genetics Home Reference"},{"key":"3354_CR23","unstructured":"Genetics Home Reference MTATP6 gene. In Genetics Home Reference"},{"key":"3354_CR24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0889-8529(18)30058-6","volume":"24","author":"LT Goldsmith","year":"1995","unstructured":"Goldsmith LT, Weiss G, Steinetz BG et al (1995) Relaxin and its role in pregnancy. Endocrinol Metab Clin North Am 24:171\u2013186","journal-title":"Endocrinol Metab Clin North Am"},{"key":"3354_CR25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00441-018-02983-8","volume":"376","author":"J Gordon","year":"2019","unstructured":"Gordon J, Mowa CN (2019) Mechanobiology of mice cervix: Expression profile of mechano-related molecules during pregnancy. Cell Tissue Res 376:443\u2013456","journal-title":"Cell Tissue Res"},{"key":"3354_CR26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-012-2206-2","volume":"135","author":"XL Gu","year":"2012","unstructured":"Gu XL, Ou ZL, Lin FJ, Yang XL, Luo JM, Shen ZZ, Shao ZM et al (2012) Expression of CXCL14 and its anticancer role in breast cancer. Breast Cancer Res and Treat 135:725\u2013735","journal-title":"Breast Cancer Res and Treat"},{"key":"3354_CR27","doi-asserted-by":"crossref","first-page":"77020","DOI":"10.18632\/oncotarget.20331","volume":"8","author":"D Guo","year":"2017","unstructured":"Guo D, Wang Q, Li C, Wang Y, Chen X et al (2017) VEGF stimulated the angiogenesis by promoting the mitochondrial functions. Oncotarget 8:77020\u201377027","journal-title":"Oncotarget"},{"key":"3354_CR28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2005.08.016","volume":"100","author":"N Gupta","year":"2006","unstructured":"Gupta N, Prasad PD, Ghamande S, Moore-Martin P, Herdman AV, Martindale RG, Podolsky R, Mager S, Ganapathy ME, Ganapathy V et al (2006) Up-regulation of the amino acid transporter ATB (0,+) (SLC6A14) in carcinoma of the cervix. Gynecol Oncol 100:8\u201313","journal-title":"Gynecol Oncol"},{"key":"3354_CR29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10555-017-9718-5","volume":"37","author":"T Gutschner","year":"2018","unstructured":"Gutschner T, Richtig G, Haemmerle M, Pichler M et al (2018) From biomarkers to therapeutic targets-the promises and perils of long non-coding RNAs in cancer. Cancer Metastasis Rev 37:83\u2013105","journal-title":"Cancer Metastasis Rev"},{"key":"3354_CR30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1095\/biolreprod.104.032979","volume":"72","author":"JC Havelock","year":"2005","unstructured":"Havelock JC, Keller P, Muleba N, Mayhew BA, Casey BM, Rainey WE, Word RA et al (2005) Human myometrial gene expression before and during parturition. Biol Reprod 72:707\u2013719","journal-title":"Biol Reprod"},{"key":"3354_CR31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1089\/jir.2016.0076","volume":"37","author":"M Hern\u00e1ndez-Ruiz","year":"2017","unstructured":"Hern\u00e1ndez-Ruiz M, Zlotnik A (2017) Mucosal chemokines. J Interferon Cytokine Res 37:62\u201370","journal-title":"J Interferon Cytokine Res"},{"key":"3354_CR32","first-page":"3183","volume":"60","author":"S Hyder","year":"2000","unstructured":"Hyder S, Nawaz Z, Chiappetta C, Stancel G et al (2000) Identification of functional estrogen response elements in the gene coding for the potent vascular endothelial growth factor. Cancer Res 60:3183\u20133190","journal-title":"Cancer Res"},{"key":"3354_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/JME-13-0051","volume":"51","author":"MM Ivanova","year":"2013","unstructured":"Ivanova MM, Radde BN, Son J, Mehta FF, Chung SH, Klinge CM et al (2013) Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus. J Mol Endocrinol 51:233\u2013246","journal-title":"J Mol Endocrinol"},{"key":"3354_CR34","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1158\/1078-0432.CCR-18-2434","volume":"25","author":"X Jia","year":"2019","unstructured":"Jia X, Li C, Li L, Liu X, Zhou L, Zhang W, Ni S, Lu Y, Chen L, Jeong LS, Yu J, Zhang Y, Zhang J, He S, Hu X, Sun H, Yu K, Liu G, Zhao H, Zhang Y, Jia L, Shao ZM et al (2019) Neddylation inactivation facilitates FOXO3a nuclear export to suppress estrogen receptor transcription and improve fulvestrant sensitivity. Clin Cancer Res 25:3658\u20133672","journal-title":"Clin Cancer Res"},{"key":"3354_CR35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.str.2015.02.003","volume":"23","author":"NJ Kershaw","year":"2015","unstructured":"Kershaw NJ, Babon JJ (2015) VHL: Culling the hypoxic response. Structure 23:435\u2013436","journal-title":"Structure"},{"key":"3354_CR36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.18388\/abp.2003_3713","volume":"50","author":"H Kimura","year":"2003","unstructured":"Kimura H, Esumi H (2003) Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochim Pol 50:49\u201359","journal-title":"Acta Biochim Pol"},{"key":"3354_CR37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/ncrna4040040","volume":"4","author":"CM Klinge","year":"2018","unstructured":"Klinge CM (2018) Non-coding RNAs in breast cancer: Intracellular and intercellular communication. Noncoding RNA 4:40\u201374","journal-title":"Noncoding RNA"},{"key":"3354_CR38","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1096\/fasebj.6.7.1563592","volume":"6","author":"TC Laurent","year":"1992","unstructured":"Laurent TC, Fraser JR (1992) Hyaluronan. FASEB J 6:2397\u20132404","journal-title":"FASEB J"},{"key":"3354_CR39","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1210\/endo.142.9.8387","volume":"142","author":"JA Lenhart","year":"2001","unstructured":"Lenhart JA, Ryan PL, Ohleth KM, Palmer SS, Bagnell CA et al (2001) Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig. Endocrinol 142:3941\u20133949","journal-title":"Endocrinol"},{"key":"3354_CR40","doi-asserted-by":"crossref","first-page":"106648","DOI":"10.18632\/oncotarget.20678","volume":"8","author":"Q Li","year":"2017","unstructured":"Li Q, Pan X, Wang X, Jiao X, Zheng J, Li Z, Huo Y (2017) Long noncoding RNA MALAT1 promotes cell proliferation through suppressing miR-205 and promoting SMAD4 expression in osteosarcoma. Oncotarget 8:106648\u2013106660","journal-title":"Oncotarget"},{"key":"3354_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12950-015-0109-9","volume":"13","author":"J Lu","year":"2016","unstructured":"Lu J, Chatterjee M, Schmid H, Beck S, Gawaz M et al (2016) CXCL14 as an emerging immune and inflammatory modulator. J Inflamm (Lond) 13:1","journal-title":"J Inflamm (Lond)"},{"key":"3354_CR42","first-page":"24","volume":"78","author":"M Mahendroo","year":"2017","unstructured":"Mahendroo M (2017) Cervical hyaluronan biology in pregnancy, parturition and preterm birth. Matrix Biol 78:24\u201331","journal-title":"Matrix Biol"},{"key":"3354_CR43","first-page":"981","volume":"13","author":"MS Mahendroo","year":"1999","unstructured":"Mahendroo MS, Porter A, Russell DW, Word RA et al (1999) The parturition defect in steroid 5alpha- reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol 13:981\u2013992","journal-title":"Mol Endocrinol"},{"key":"3354_CR44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/jid.2012.264","volume":"133","author":"M Markiewicz","year":"2013","unstructured":"Markiewicz M, Znoyko S, Stawski L, Ghatnekar A, Gilkeson G, Trojanowska M et al (2013) A role for estrogen receptor-\u03b1 and estrogen receptor-\u03b2 in collagen biosynthesis in mouse skin. J Invest Dermatol 133:120\u2013127","journal-title":"J Invest Dermatol"},{"key":"3354_CR45","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1042\/BJ20150721","volume":"470","author":"AN McCracken","year":"2015","unstructured":"McCracken AN, Edinger AL (2015) Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14. Biochem J 470:e17\u2013e19","journal-title":"Biochem J"},{"key":"3354_CR46","doi-asserted-by":"crossref","first-page":"17455","DOI":"10.18632\/oncotarget.8159","volume":"7","author":"FF Mehta","year":"2016","unstructured":"Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH et al (2016) Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus. Oncotarget 7:17455\u201317467","journal-title":"Oncotarget"},{"key":"3354_CR47","first-page":"124A","volume":"7","author":"DA Minjarez","year":"2000","unstructured":"Minjarez DA, Miller RT, Lindquist A, Anderson S, Word RA et al (2000) Regulation of steroid hormone metabolism by 17-hydroxysteroid dehydrogenase type 2 in the human cervix. J Soc Gynecol Invest 7:124A","journal-title":"J Soc Gynecol Invest"},{"key":"3354_CR48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2990.2004.00603.x","volume":"31","author":"F Mori","year":"2005","unstructured":"Mori F, Nishie M, Piao Y-S, Kito K, Kamitani T, Takahashi H, Wakabayashi K et al (2005) Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders. Neuropathol Appl Neurobiol 31:53\u201361","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3354_CR49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","volume":"5","author":"A Mortazavi","year":"2008","unstructured":"Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B et al (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5:621\u2013628","journal-title":"Nat Methods"},{"key":"3354_CR50","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1369\/jhc.4A6455.2004","volume":"52","author":"CN Mowa","year":"2004","unstructured":"Mowa CN, Jesmin S, Sakuma I, Usip S, Togashi H, Yoshioka M, Hattori Y, Papka R et al (2004) Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: Effects of denervation and implications for cervical ripening. J Histochem Cytochem 52:1665\u20131674","journal-title":"J Histochem Cytochem"},{"key":"3354_CR51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-6-1","volume":"6","author":"CN Mowa","year":"2008","unstructured":"Mowa CN, Li T, Jesmin S, Folkesson HG, Usip SE, Papka RE, Hou G et al (2008) Delineation of VEGF-regulated genes and function in the cervix of pregnant rodents by DNA microarray analysis. Reprod Biol Endocrinol 6:1\u201310","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"3354_CR52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1677\/joe.0.1670363","volume":"167","author":"CN Mowa","year":"2000","unstructured":"Mowa CN, Iwanaga T (2000a) Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat\u2013an analysis by in situ hybridization. J Endocrinol 167(3):363\u2013369","journal-title":"J Endocrinol"},{"issue":"1","key":"3354_CR53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1677\/joe.0.1650059","volume":"165","author":"CN Mowa","year":"2000","unstructured":"Mowa CN, Iwanaga T (2000b) Differential distribution of oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of rats as revealed by in situ hybridization. J Endocrinol 165(1):59\u201366","journal-title":"J Endocrinol"},{"key":"3354_CR54","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1073\/pnas.200377097","volume":"97","author":"MD Mueller","year":"2000","unstructured":"Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN et al (2000) Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc Natl Acad Sci USA 97:10972\u201310977","journal-title":"Proc Natl Acad Sci USA"},{"key":"3354_CR55","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.129.4.895","volume":"129","author":"T Mustonen","year":"1995","unstructured":"Mustonen T, Alitalo K (1995) Endothelial receptor tyrosine involved in angiogenesis. J Cell Biol 129:895\u2013898","journal-title":"J Cell Biol"},{"key":"3354_CR56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2220\/biomedres.33.363","volume":"33","author":"B-TA Nguyen","year":"2012","unstructured":"Nguyen B-TA, Minkiewicz V, McCabe E, Cecile J, Mowa CN et al (2012) Vascular endothelial growth factor induces mRNA expression of pro-inflammatory factors in the uterine cervix of mice. Biomed Res 33:363\u2013372","journal-title":"Biomed Res"},{"key":"3354_CR57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10555-007-9108-5","volume":"27","author":"DM Noonan","year":"2008","unstructured":"Noonan DM, De Lerma BA, Vannini N, AlbiniA ML et al (2008) Inflammation, inflammatory cells and angiogenesis: Decisions and indecisions. Cancer Metastasis Rev 27:31\u201340","journal-title":"Cancer Metastasis Rev"},{"key":"3354_CR58","first-page":"1","volume":"1","author":"T Ohashi","year":"2014","unstructured":"Ohashi T, Anumba D, Mowa CN et al (2014) VEGF and its receptors in uterine cervix: Dose-dependent modulation by hypoxia and estrogen and cellular localization in human. J Cytol Tissue Biology 1:1\u20138","journal-title":"J Cytol Tissue Biology"},{"key":"3354_CR59","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","volume":"269","author":"JE Park","year":"1994","unstructured":"Park JE, Chen HH, Winer J, Houck KA, Ferrara N et al (1994) Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR. J Biol Chem 269:25646\u201325654","journal-title":"J Biol Chem"},{"key":"3354_CR60","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI118926","volume":"98","author":"R Pfundt","year":"1996","unstructured":"Pfundt R, van Ruissen F, van Vlijmen-Willems IM, Alkemade HA, Zeeuwen PL, Jap PH, Dijkman H, Fransen J, Croes H, van Erp PE, Schalkwijk J et al (1996) Constitutive and inducible expression of SKALP\/elafin provides anti-elastase defense in human epithelia. J Clin Invest 98:1389\u20131399","journal-title":"J Clin Invest"},{"key":"3354_CR61","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4267\/2042\/47260","volume":"16","author":"M Pickard","year":"2012","unstructured":"Pickard M (2012) FAU (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed. Atlas Genet Cytogenet Oncol Haematol 16:12\u201317. https:\/\/doi.org\/10.4267\/2042\/47260","journal-title":"Atlas Genet Cytogenet Oncol Haematol"},{"key":"3354_CR62","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.3390\/ijms16035864","volume":"16","author":"CE Ren","year":"2015","unstructured":"Ren CE, Zhu X, Li J, Lyle C, Dowdy S, Podratz KC, Byck D, Chen HB, Jiang SW et al (2015) Microarray analysis on gene regulation by estrogen, progesterone and tamoxifen in human endometrial stromal cells. Int J Mol Sci 16:5864\u20135885","journal-title":"Int J Mol Sci"},{"key":"3354_CR63","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1074\/jbc.M110.188706","volume":"286","author":"JH Ryu","year":"2011","unstructured":"Ryu JH, Li SH, Park HS, Park JW, Lee B, Chun YS et al (2011) Hypoxia-inducible factor \u03b1 subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent. J Biol Chem 286:6963\u20136970","journal-title":"J Biol Chem"},{"key":"3354_CR64","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrm1366","volume":"5","author":"CJ Schofield","year":"2004","unstructured":"Schofield CJ, Ratcliffe PJ (2004) Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 5:343\u2013354","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3354_CR65","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2016.07.027","volume":"166","author":"DC Scott","year":"2016","unstructured":"Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA et al (2016) Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. Cell 166:1198-1214.e24","journal-title":"Cell"},{"key":"3354_CR66","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1158\/0008-5472.CAN-04-2056","volume":"64","author":"TD Shellenberger","year":"2004","unstructured":"Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, Burdick MD, Ioannides CG, Efferson CL, El-Naggar AK, Roberts D, Clayman GL, Frederick MJ et al (2004) BRAK\/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res 64:8262\u20138270","journal-title":"Cancer Res"},{"key":"3354_CR67","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0065-230X(08)60716-2","volume":"67","author":"M Shibuya","year":"1995","unstructured":"Shibuya M (1995) Role of VEGF-Flt-1 receptor system in normal and tumor angiogenesis. Adv Cancer Res 67:281\u2013316","journal-title":"Adv Cancer Res"},{"key":"3354_CR68","first-page":"59","volume":"237","author":"M Shibuya","year":"1999","unstructured":"Shibuya M, Ito N, Claesson-Welsh L et al (1999) Structure and function of VEGF receptor-1 and -2. Curr Top Microbiol Immunol 237:59\u201383","journal-title":"Curr Top Microbiol Immunol"},{"key":"3354_CR69","first-page":"3112","volume":"81","author":"JL Shifren","year":"1996","unstructured":"Shifren JL, Tsen JF, Zaloudek CJ, Ryan LP, Meng YG, Ferrara N, Jaffe RB, Taylor RN et al (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81:3112\u20133118","journal-title":"J Clin Endocrinol Metab"},{"key":"3354_CR70","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1074\/jbc.271.7.3877","volume":"271","author":"DT Shima","year":"1996","unstructured":"Shima DT, Kuroki M, Deutsch U, Ng YS, Adamis AP, D\u2019Amore PA et al (1996) The mouse gene for vascular endothelial growth factor. Genomic structure, definition of transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J Biol Chem 271:3877\u20133883","journal-title":"J Biol Chem"},{"key":"3354_CR71","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/bjc.2016.104","volume":"114","author":"E Sj\u00f6berg","year":"2016","unstructured":"Sj\u00f6berg E, Augsten M, Bergh J, Jirstr\u00f6m K, \u00d6stman A et al (2016) Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer. Br J Cancer 114:1117\u20131124","journal-title":"Br J Cancer"},{"key":"3354_CR72","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1210\/me.2003-0362","volume":"18","author":"R Soares","year":"2004","unstructured":"Soares R, Balogh G, Guo S, G\u00e4rtner F, Russo J, Schmitt F et al (2004) Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol 18:2333\u20132343","journal-title":"Mol Endocrinol"},{"key":"3354_CR73","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0002-9440(10)64381-7","volume":"160","author":"R Soares","year":"2002","unstructured":"Soares R, Reis-Filho JS, Gartner F, Schmitt FC et al (2002) Vascular endothelial growth factor, transforming growth factor-alpha, and estrogen receptors: Possible cross-talks and interactions. Am J Pathol 160:381\u2013383","journal-title":"Am J Pathol"},{"issue":"1","key":"3354_CR74","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00441-015-2184-x","volume":"362","author":"R Stanley","year":"2015","unstructured":"Stanley R, Ohashi T, Mowa C (2015) Postpartum cervical repair in mice: a morphological characterization and potential role for angiogenic factors. Cell Tissue Res 362(1):253\u201363","journal-title":"Cell Tissue Res"},{"key":"3354_CR75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1530\/JME-17-0179","volume":"60","author":"RL Stanley","year":"2018","unstructured":"Stanley RL, Ohashi T, Gordon J, Mowa CN et al (2018) A proteomic profile of postpartum cervical repair in mice. J Mol Endocrinol 60:17\u201328","journal-title":"J Mol Endocrinol"},{"key":"3354_CR76","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1210\/en.2006-0851","volume":"148","author":"BC Timmons","year":"2007","unstructured":"Timmons BC, Mitchell SM, Gilpin C, Mahendroo MS et al (2007) Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition. Endocrinol 148:1278\u20131287","journal-title":"Endocrinol"},{"key":"3354_CR77","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1016\/S0021-9258(18)99049-6","volume":"266","author":"E Tischer","year":"1991","unstructured":"Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA et al (1991) The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266:11947\u201311954","journal-title":"J Biol Chem"},{"key":"3354_CR78","doi-asserted-by":"crossref","first-page":"424526","DOI":"10.1155\/2012\/424526","volume":"2012","author":"Y Tutar","year":"2012","unstructured":"Tutar Y (2012) Pseudogenes. Comp funct Genomics 2012:424526","journal-title":"Comp funct Genomics"},{"key":"3354_CR79","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.siny.2015.12.009","volume":"21","author":"J Vink","year":"2016","unstructured":"Vink J, Feltovich H (2016) Cervical etiology of spontaneous preterm birth. Semin Fetal Neonatal Med 21:106\u2013112","journal-title":"Semin Fetal Neonatal Med"},{"key":"3354_CR80","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ygyno.2007.05.009","volume":"106","author":"G Walker","year":"2007","unstructured":"Walker G, MacLeod K, Williams ARW, Cameron DA, Smyth JF, Langdon SP et al (2007) Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Gynecol Oncol 106:461\u2013468","journal-title":"Gynecol Oncol"},{"key":"3354_CR81","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0076-6879(04)80006-5","volume":"380","author":"J Weber","year":"2004","unstructured":"Weber J, Senior AE (2004) Fluorescent probes applied to catalytic cooperativity in ATP synthase. Methods Enzymol 380:132\u2013152","journal-title":"Methods Enzymol"},{"key":"3354_CR82","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-2006-956777","volume":"25","author":"RA Word","year":"2007","unstructured":"Word RA, Li XH, Hnat M, Carrick K et al (2007) Dynamics of cervical remodeling during pregnancy and parturition: Mechanisms and current concepts. Semin Reprod Med 25:69\u201379","journal-title":"Semin Reprod Med"},{"key":"3354_CR83","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.08-106468","volume":"22","author":"GL Wright","year":"2008","unstructured":"Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC et al (2008) VEGF stimulation of mitochondrial biogenesis: Requirement of AKT3 kinase. FASEB J 22:3264\u20133275","journal-title":"FASEB J"},{"key":"3354_CR84","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ajpath.2013.07.016","volume":"183","author":"J Yang","year":"2013","unstructured":"Yang J, Wheeler SE, Velikoff M, Kleavland KRK, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK et al (2013) Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. American J Path 183:1559\u20131570","journal-title":"American J Path"},{"key":"3354_CR85","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0008-6363(00)00268-6","volume":"49","author":"I Zachary","year":"2001","unstructured":"Zachary I, Gliki G (2001) Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49:568\u2013581","journal-title":"Cardiovasc Res"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-020-03354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-020-03354-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-020-03354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T21:17:48Z","timestamp":1670966268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-020-03354-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["3354"],"URL":"https:\/\/doi.org\/10.1007\/s00441-020-03354-y","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"type":"print","value":"0302-766X"},{"type":"electronic","value":"1432-0878"}],"subject":[],"published":{"date-parts":[[2021,1,29]]},"assertion":[{"value":"4 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical statements"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}