{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:37:54Z","timestamp":1792096674349,"version":"4.4.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Natural Science Foundation of Shandong of China","award":["ZR2012CM030"],"award-info":[{"award-number":["ZR2012CM030"]}]},{"DOI":"10.13039\/501100013385","name":"National Science and Technology Program during the Twelfth Five-year Plan Period","doi-asserted-by":"crossref","award":["2017ASTP01"],"award-info":[{"award-number":["2017ASTP01"]}],"id":[{"id":"10.13039\/501100013385","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011529","name":"Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province","doi-asserted-by":"crossref","award":["201822018"],"award-info":[{"award-number":["201822018"]}],"id":[{"id":"10.13039\/501100011529","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00441-021-03434-7","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T09:02:43Z","timestamp":1617094963000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Essential roles of matrix metalloproteinases in axolotl digit regeneration"],"prefix":"10.1007","volume":"385","author":[{"given":"Tianyue","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna S.","family":"Walczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-8364","authenticated-orcid":false,"given":"Yujun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"3434_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.matbio.2005.03.007","volume":"24","author":"S Bai","year":"2005","unstructured":"Bai S, Thummel R, Godwin AR, Nagase H, Itoh Y, Li L, Evans R, McDermott J, Seiki M, Sarras MP Jr (2005) Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol 24:247\u2013260","journal-title":"Matrix Biol"},{"key":"3434_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1126\/science.276.5309.81","volume":"276","author":"JP Brockes","year":"1997","unstructured":"Brockes JP (1997) Amphibian limb regeneration: rebuilding a complex structure. Science 276:81\u201387","journal-title":"Science"},{"key":"3434_CR3","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrm881","volume":"3","author":"JP Brockes","year":"2002","unstructured":"Brockes JP, Kumar A (2002) Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nat Rev Mol Cell Biol 3:566\u2013574","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3434_CR4","first-page":"887","volume":"46","author":"SV Bryant","year":"2002","unstructured":"Bryant SV, Endo T, Gardiner DM (2002) Vertebrate limb regeneration and the origin of limb stem cells. Int J Dev Biol 46:887\u2013896","journal-title":"Int J Dev Biol"},{"key":"3434_CR5","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1002\/dvdy.22669","volume":"240","author":"LJ Campbell","year":"2011","unstructured":"Campbell LJ, Su\u00e1rez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM (2011) Gene expression profile of the regeneration epithelium during axolotl limb regeneration. Dev Dyn 240:1826\u20131840","journal-title":"Dev Dyn"},{"key":"3434_CR6","first-page":"6037","volume":"8","author":"F Cao","year":"2015","unstructured":"Cao F, Liu T, Xu Y, Xu D, Feng S (2015) Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-\u03baB and JNK signaling pathways. Int J Clin Exp Pathol 8:6037\u20136045","journal-title":"Int J Clin Exp Pathol"},{"key":"3434_CR7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.devcel.2016.10.013","volume":"39","author":"JD Currie","year":"2016","unstructured":"Currie JD, Kawaguchi A, Traspas RM, Schuez M, Chara O, Tanaka EM (2016) Live imaging of axolotl digit regeneration reveals spatiotemporal choreography of diverse connective tissue progenitor pools. Dev Cell 39:411\u2013423","journal-title":"Dev Cell"},{"key":"3434_CR8","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bone.2010.12.017","volume":"48","author":"E de Vrieze","year":"2011","unstructured":"de Vrieze E, Sharif F, Metz JR, Flik G, Richardson MK (2011) Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. Bone 48:704\u2013712","journal-title":"Bone"},{"key":"3434_CR9","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1126\/science.1077804","volume":"298","author":"K Echeverri","year":"2002","unstructured":"Echeverri K, Tanaka EM (2002) Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science 298:1993\u20131996","journal-title":"Science"},{"key":"3434_CR10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/ncomms1389","volume":"2","author":"G Eguchi","year":"2011","unstructured":"Eguchi G, Eguchi Y, Nakamura K, Yadav MC, Mill\u00e1n JL, Tsonis PA (2011) Regenerative capacity in newts is not altered by repeated regeneration and ageing. Nat Commun 2:384","journal-title":"Nat Commun"},{"key":"3434_CR11","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.biocel.2006.09.013","volume":"39","author":"C Fan","year":"2007","unstructured":"Fan C, Zhang S, Liu Z, Li L, Luan J, Saren G (2007) Identification and expression of a novel class of glutathione-S-transferase from amphioxus Branchiostoma belcheri with implications to the origin of vertebrate liver. Int J Biochem Cell Biol 39:450\u2013461","journal-title":"Int J Biochem Cell Biol"},{"key":"3434_CR12","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1242\/dev.121.6.1731","volume":"121","author":"DM Gardiner","year":"1995","unstructured":"Gardiner DM, Blumberg B, Komine Y, Bryant SV (1995) Regulation of HoxA expression in developing and regenerating axolotl limbs. Development 121:1731\u20131741","journal-title":"Development"},{"key":"3434_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/dvdy.10243","volume":"226","author":"D Gourevitch","year":"2003","unstructured":"Gourevitch D, Clark L, Chen P, Seitz A, Samulewicz SJ, Heber-Katz E (2003) Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model. Dev Dyn 226:377\u2013387","journal-title":"Dev Dyn"},{"key":"3434_CR14","doi-asserted-by":"publisher","first-page":"25964","DOI":"10.1074\/jbc.M113.459784","volume":"288","author":"I Herrera","year":"2013","unstructured":"Herrera I, Cisneros J, Maldonado M, Ram\u00edrez R, Ortiz-Quintero B, Anso E, Chandel NS, Selman M, Pardo A (2013) Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption. J Biol Chem 288:25964\u201325975","journal-title":"J Biol Chem"},{"key":"3434_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0092-8674(00)80064-1","volume":"99","author":"K Holmbeck","year":"1999","unstructured":"Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Robey PG, Poole AR, Pidoux I, Ward JM, Birkedal-Hansen H (1999) MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99:81\u201392","journal-title":"Cell"},{"key":"3434_CR16","doi-asserted-by":"publisher","first-page":"e55649","DOI":"10.1371\/journal.pone.0055649","volume":"8","author":"ME Isolani","year":"2013","unstructured":"Isolani ME, Abril JF, Sal\u00f3 E, Deri P, Bianucci AM, Batistoni R (2013) Planarians as a model to assess in vivo the role of matrix metalloproteinase genes during homeostasis and regeneration. PLoS One 8:e55649","journal-title":"PLoS One"},{"key":"3434_CR17","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/dvdy.10247","volume":"226","author":"T Kato","year":"2003","unstructured":"Kato T, Miyazaki K, Shimizu-Nishikawa K, Koshiba K, Obara M, Mishima HK, Yoshizato K (2003) Unique expression patterns of matrix metalloproteinases in regenerating newt limbs. Dev Dyn 226:366\u2013376","journal-title":"Dev Dyn"},{"key":"3434_CR18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/nature08152","volume":"460","author":"M Kragl","year":"2009","unstructured":"Kragl M, Knapp D, Nacu E, Khattak S, Maden M, Epperlein HH, Tanaka EM (2009) Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460:60\u201365","journal-title":"Nature"},{"key":"3434_CR19","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1242\/dev.121160","volume":"142","author":"DC LeBert","year":"2015","unstructured":"LeBert DC, Squirrell JM, Rindy J, Broadbridge E, Lui Y, Zakrzewska A, Eliceiri KW, Meijer AH, Huttenlocher A (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development 142:2136\u20132146","journal-title":"Development"},{"key":"3434_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"3434_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ydbio.2008.04.004","volume":"319","author":"KD McClure","year":"2008","unstructured":"McClure KD, Sustar A, Schubiger G (2008) Three genes control the timing, the site and the size of blastema formation in Drosophila. Dev Biol 319:68\u201377","journal-title":"Dev Biol"},{"key":"3434_CR22","doi-asserted-by":"publisher","first-page":"6819","DOI":"10.1073\/pnas.93.13.6819","volume":"93","author":"K Miyazaki","year":"1996","unstructured":"Miyazaki K, Uchiyama K, Imokawa Y, Yoshizato K (1996) Cloning and characterization of cDNAs for matrix metalloproteinases of regenerating newt limbs. Proc Natl Acad Sci U S A 93:6819\u20136824","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3434_CR23","doi-asserted-by":"publisher","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","volume":"274","author":"H Nagase","year":"1999","unstructured":"Nagase H, Woessner JF (1999) Matrix metalloproteinases. J Biol Chem 274:21491\u201321494","journal-title":"J Biol Chem"},{"key":"3434_CR24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1016-8478(23)13518-7","volume":"9","author":"IS Park","year":"1999","unstructured":"Park IS, Kim WS (1999) Modulation of gelatinase activity correlates with the dedifferentiation profile of regenerating salamander limbs. Mol Cells 9:119\u2013126","journal-title":"Mol Cells"},{"key":"3434_CR25","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1046\/j.1524-475X.1999.00423.x","volume":"7","author":"WC Parks","year":"1999","unstructured":"Parks WC (1999) Matrix metalloproteinases in repair. Wound Repair Regen 7:423\u2013432","journal-title":"Wound Repair Regen"},{"key":"3434_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1432-0436.1984.tb01403.x","volume":"27","author":"DL Stocum","year":"1984","unstructured":"Stocum DL (1984) The urodele limb regeneration blastema: determination and organization of the morphogenetic field. Differentiation 27:13\u201328","journal-title":"Differentiation"},{"key":"3434_CR27","first-page":"205","volume":"7","author":"CS Thornton","year":"1968","unstructured":"Thornton CS (1968) Amphibian limb regeneration Adv Morphog 7:205\u2013249","journal-title":"Amphibian limb regeneration Adv Morphog"},{"key":"3434_CR28","series-title":"Methods in molecular biology (methods and protocols)","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-1-61779-854-2_8","volume-title":"Metastasis research protocols","author":"M Toth","year":"2012","unstructured":"Toth M, Sohail A, Fridman R (2012) Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography. In: Dwek M, Brooks S, Schumacher U (eds) Metastasis research protocols, vol 878. Methods in molecular biology (methods and protocols). Humana Press, Totowa, NJ, pp 121\u2013135"},{"key":"3434_CR29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ydbio.2004.12.003","volume":"279","author":"V Vinarsky","year":"2005","unstructured":"Vinarsky V, Atkinson DL, Stevenson TJ, Keating MT, Odelberg SJ (2005) Normal newt limb regeneration requires matrix metalloproteinase function. Dev Biol 279:86\u201398","journal-title":"Dev Biol"},{"key":"3434_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10142-010-0199-7","volume":"11","author":"Y Wang","year":"2011","unstructured":"Wang Y, Zhang S (2011) Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and \u201cpre-hepatic\u201d acute phase response. Funct Integr Genomics 11:111\u2013118","journal-title":"Funct Integr Genomics"},{"key":"3434_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/(SICI)1097-0177(199909)216:1<2::AID-DVDY2>3.0.CO;2-P","volume":"216","author":"EV Yang","year":"1999","unstructured":"Yang EV, Gardiner DM, Carlson MR, Nugas CA, Bryant SV (1999) Expression of Mmp-9 and related matrix metalloproteinase genes during axolotl limb regeneration. Dev Dyn 216:2\u20139","journal-title":"Dev Dyn"}],"updated-by":[{"DOI":"10.1007\/s00441-021-03476-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000}}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03434-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-021-03434-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03434-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T03:22:56Z","timestamp":1724728976000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-021-03434-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["3434"],"URL":"https:\/\/doi.org\/10.1007\/s00441-021-03434-7","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00441-021-03476-x","asserted-by":"object"}]},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,30]]},"assertion":[{"value":"5 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00441-021-03476-x","URL":"https:\/\/doi.org\/10.1007\/s00441-021-03476-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animals used in this study were maintained and handled according to the protocols approved by Ethics Committee on Animal Experimentation of College of Marine Life Science of Ocean University of China (20-04-07). All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human and animal participants"}},{"value":"The authors declare that there is no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}