{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:23:37Z","timestamp":1786980217650,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00441-021-03478-9","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:03:16Z","timestamp":1626307396000},"page":"571-583","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Human umbilical cord mesenchymal stem cells reconstruct the vaginal wall of ovariectomized Sprague\u2013Dawley rats: implications for pelvic floor reconstruction"],"prefix":"10.1007","volume":"386","author":[{"given":"Meng","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-5426","authenticated-orcid":false,"given":"Lan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"3478_CR1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00192-011-1384-5","volume":"22","author":"H Abed","year":"2011","unstructured":"Abed H, Rahn DD, Lowenstein L, Balk EM, Clemons JL, Rogers RG (2011) Incidence and management of graft erosion, wound granulation, and dyspareunia following vaginal prolapse repair with graft materials: a systematic review. Int Urogynecol J 22:789\u2013798","journal-title":"Int Urogynecol J"},{"key":"3478_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ucl.2018.08.008","volume":"46","author":"K Amin","year":"2019","unstructured":"Amin K, Lee U (2019) Surgery for anterior compartment vaginal prolapse: suture-based repair. Urol Clin North Am 46:61\u201370","journal-title":"Urol Clin North Am"},{"key":"3478_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.fertnstert.2012.05.038","volume":"98","author":"A Atala","year":"2012","unstructured":"Atala A (2012) Tissue engineering of reproductive tissues and organs. Fertil Steril 98:21\u201329","journal-title":"Fertil Steril"},{"key":"3478_CR4","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s00192-013-2169-9","volume":"24","author":"MD Barber","year":"2013","unstructured":"Barber MD, Maher C (2013) Epidemiology and outcome assessment of pelvic organ prolapse. Int Urogynecol J 24:1783\u20131790","journal-title":"Int Urogynecol J"},{"key":"3478_CR5","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00192-012-1927-4","volume":"24","author":"M Boennelycke","year":"2013","unstructured":"Boennelycke M, Gras S, Lose G (2013) Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse. Int Urogynecol J 24:741\u2013747","journal-title":"Int Urogynecol J"},{"key":"3478_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1067\/mob.2002.124843","volume":"187","author":"MK Boreham","year":"2002","unstructured":"Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA (2002a) Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 187:56\u201363","journal-title":"Am J Obstet Gynecol"},{"key":"3478_CR7","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1067\/mob.2002.130005","volume":"187","author":"MK Boreham","year":"2002","unstructured":"Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA (2002b) Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol 187:1501\u20131508","journal-title":"Am J Obstet Gynecol"},{"key":"3478_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11934-014-0425-2","volume":"15","author":"B Chen","year":"2014","unstructured":"Chen B, Dave B (2014) Challenges and future prospects for tissue engineering in female pelvic medicine and reconstructive surgery. Curr Urol Rep 15:425","journal-title":"Curr Urol Rep"},{"key":"3478_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jep.2011.02.011","volume":"135","author":"G Chen","year":"2011","unstructured":"Chen G, Wu L, Deng CQ (2011) The effects of BuYang HuanWu decoction and its effective components on proliferation-related factors and ERK1\/2 signal transduction pathway in cultured vascular smooth muscle cells. J Ethnopharmacol 135:7\u201314","journal-title":"J Ethnopharmacol"},{"key":"3478_CR10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.actbio.2016.05.010","volume":"39","author":"S Darzi","year":"2016","unstructured":"Darzi S, Urbankova I, Su K, White J, Lo C, Alexander D, Werkmeister JA, Gargett CE, Deprest J (2016) Tissue response to collagen containing polypropylene meshes in an ovine vaginal repair model. Acta Biomater 39:114\u2013123","journal-title":"Acta Biomater"},{"key":"3478_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1097\/00003081-199312000-00014","volume":"36","author":"JO DeLancey","year":"1993","unstructured":"DeLancey JO (1993) Pelvic organ prolapse: clinical management and scientific foundations. Clin Obstet Gynecol 36:895\u2013896","journal-title":"Clin Obstet Gynecol"},{"key":"3478_CR12","doi-asserted-by":"publisher","first-page":"45709","DOI":"10.1038\/srep45709","volume":"7","author":"S Emmerson","year":"2017","unstructured":"Emmerson S, Young N, Rosamilia A, Parkinson L, Edwards SL, Vashi AV, Davies-Tuck M, White J, Elgass K, Lo C, Arkwright J, Werkmeister JA, Gargett CE (2017) Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse. Sci Rep 7:45709","journal-title":"Sci Rep"},{"key":"3478_CR13","doi-asserted-by":"publisher","first-page":"165.e1","DOI":"10.1016\/j.ajog.2007.03.040","volume":"197","author":"LB Epstein","year":"2007","unstructured":"Epstein LB, Graham CA, Heit MH (2007) Systemic and vaginal biomechanical properties of women with normal vaginal support and pelvic organ prolapse. Am J Obstet Gynecol 197:165.e1-e6","journal-title":"Am J Obstet Gynecol"},{"key":"3478_CR14","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00192-007-0459-9","volume":"19","author":"MF Fialkow","year":"2008","unstructured":"Fialkow MF, Newton KM, Lentz GM, Weiss NS (2008) Lifetime risk of surgical management for pelvic organ prolapse or urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 19:437\u2013440","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"3478_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/nau.20798","volume":"29","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN (2010) International Urogyneco-logical Association; International Continence Society. An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29:4\u201320","journal-title":"Neurourol Urodyn"},{"key":"3478_CR16","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1089\/scd.2011.0674","volume":"21","author":"ST Hsiao","year":"2012","unstructured":"Hsiao ST, Asgari A, Lokmic Z, Sinclair R, Dusting GJ, Lim SY, Dilley RJ (2012) Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev 21:2189\u20132203","journal-title":"Stem Cells Dev"},{"key":"3478_CR17","doi-asserted-by":"publisher","first-page":"e44791","DOI":"10.1371\/journal.pone.0044791","volume":"7","author":"PI Imoukhuede","year":"2012","unstructured":"Imoukhuede PI, Popel AS (2012) Expression of VEGF receptors on endothelial cells in mouse skeletal muscle. PLoS One 7:e44791","journal-title":"PLoS ONE"},{"key":"3478_CR18","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.bbrc.2007.01.045","volume":"354","author":"Y Iso","year":"2007","unstructured":"Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine P, Prockop DJ (2007) Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun 354:700\u2013706","journal-title":"Biochem Biophys Res Commun"},{"key":"3478_CR19","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0140-6736(07)60462-0","volume":"369","author":"JE Jelovsek","year":"2007","unstructured":"Jelovsek JE, Maher C, Barber MD (2007) Pelvic organ prolapse. Lancet 369:1027\u20131038","journal-title":"Lancet"},{"key":"3478_CR20","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1111\/j.1471-0528.2008.01845.x","volume":"115","author":"X Jia","year":"2008","unstructured":"Jia X, Glazener C, Mowatt G, MacLennan G, Bain C, Fraser C, Burr J (2008) Efficacy and safety of using mesh or grafts in surgery for anterior and\/or posterior vaginal wall prolapse: systematic review and meta-analysis. BJOG 115:1350\u20131361","journal-title":"BJOG"},{"key":"3478_CR21","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1089\/ten.tea.2010.0010","volume":"16","author":"SK Kang","year":"2010","unstructured":"Kang SK, Kang KS, Jee MK, Kim BS (2010) Vascular endothelial growth factor\/kinase insult domain receptor (KDR)\/fetal liver kinase 1 (FLK1)-mediated skin- epithelial progenitor cells reprogramming. Tissue Eng Part A 16:2687\u20132697","journal-title":"Tissue Eng Part A"},{"key":"3478_CR22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00192-008-0737-1","volume":"20","author":"MH Kerkhof","year":"2009","unstructured":"Kerkhof MH, Hendriks L, Brolmann HA (2009) Changes in connective tissue in patients with pelvic organ prolapse\u2014a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 20:461\u2013474","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"3478_CR23","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s00404-010-1518-x","volume":"283","author":"E Knuuti","year":"2011","unstructured":"Knuuti E, Kauppila S, Kotila V, Risteli J, Nissi R (2011) Genitourinary prolapse and joint hypermobility are associated with altered type I and III collagen metabolism. Arch Gynecol Obstet 283:1081\u20131085","journal-title":"Arch Gynecol Obstet"},{"key":"3478_CR24","doi-asserted-by":"publisher","first-page":"936","DOI":"10.5966\/sctm.2013-0197","volume":"3","author":"K Kuismanen","year":"2014","unstructured":"Kuismanen K, Sartoneva R, Haimi S, Mannerstr\u00f6m B, Tom\u00e1s E, Miettinen S, Nieminen K (2014) Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study. Stem Cells Transl Med 3:936\u2013941","journal-title":"Stem Cells Transl Med"},{"key":"3478_CR25","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s12195-009-0090-6","volume":"2","author":"K Kurpinski","year":"2009","unstructured":"Kurpinski K, Chu J, Wang D, Li S (2009) Proteomic profiling of mesenchymal stem cell responses to mechanical strain and TGF-beta1. Cell Mol Bioeng 2:606\u2013614","journal-title":"Cell Mol Bioeng"},{"key":"3478_CR26","first-page":"627","volume-title":"The biomedical engineering handbook","author":"ST Li","year":"1995","unstructured":"Li ST (1995) Biologic biomaterials: tissue derived biomaterials (collagen). In: Bronzino JD (ed) The biomedical engineering handbook. CRS Press, Boca Raton, FL, pp 627\u2013647"},{"key":"3478_CR27","first-page":"8921284","volume":"2019","author":"M Mao","year":"2019","unstructured":"Mao M, Li Y, Zhang Y, Kang J, Zhu L (2019) Tissue composition and biomechanical property changes in the vaginal wall of ovariectomized young rats. Biomed Res Int 2019:8921284","journal-title":"Biomed Res Int"},{"key":"3478_CR28","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ajog.2004.07.008","volume":"192","author":"PA Moalli","year":"2005","unstructured":"Moalli PA, Howden NS, Lowder JL, Navarro J, Debes KM, Abramowitch SD, Woo SL (2005) A rat model to study the structural properties of the vagina and its supportive tissues. Am J Obstet Gynecol 192:80\u201388","journal-title":"Am J Obstet Gynecol"},{"key":"3478_CR29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/GCO.0b013e32830fe3c1","volume":"20","author":"JN Nguyen","year":"2008","unstructured":"Nguyen JN (2008) The use of grafts for anterior vaginal prolapse repair: pros and cons. Curr Opin Obstet Gynecol 20:501\u2013505","journal-title":"Curr Opin Obstet Gynecol"},{"key":"3478_CR30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/AOG.0b013e3182397009","volume":"119","author":"SD Pathi","year":"2012","unstructured":"Pathi SD, Acevedo JF, Keller PW, Kishore AH, Miller RT, Wai CY, Word RA (2012) Recovery of the injured external anal sphincter after injection of local or intravenous mesenchymal stem cells. Obstet Gynecol 119:134\u2013144","journal-title":"Obstet Gynecol"},{"key":"3478_CR31","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1177\/0963689717722787","volume":"26","author":"M Pokrywczynska","year":"2017","unstructured":"Pokrywczynska M, Jundzill A, Warda K, Buchholz L, Rasmus M, Adamowicz J, Bodnar M, Marszalek A, Helmin-Basa A, Michalkiewicz J, Gagat M, Grzanka A, Frontczak-Baniewicz M, Gastecka AM, Kloskowski T, Nowacki M, Ricordi C, Drewa T (2017) Does the mesenchymal stem cell source influence smooth muscle regeneration in tissue-engineered urinary bladders? Cell Transplant 26:1780\u20131791","journal-title":"Cell Transplant"},{"key":"3478_CR32","doi-asserted-by":"publisher","first-page":"590.e1","DOI":"10.1016\/j.ajog.2008.02.022","volume":"198","author":"DD Rahn","year":"2008","unstructured":"Rahn DD, Ruff MD, Brown SA, Tibbals HF, Word RA (2008) Biomechanical properties of the vaginal wall: effect of pregnancy, elastic fiber deficiency, and pelvic organ prolapse. Am J Obstet Gynecol 198:590.e1\u2013e6","journal-title":"Am J Obstet Gynecol"},{"key":"3478_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.stem.2012.02.005","volume":"10","author":"SH Ranganath","year":"2012","unstructured":"Ranganath SH, Levy O, Inamdar MS, Karp JM (2012) Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 10:244\u2013258","journal-title":"Cell Stem Cell"},{"key":"3478_CR34","doi-asserted-by":"publisher","first-page":"12167","DOI":"10.1073\/pnas.0604850103","volume":"103","author":"LV Rodr\u00edguez","year":"2006","unstructured":"Rodr\u00edguez LV, Alfonso Z, Zhang R, Leung J, Wu B, Ignarro LJ (2006) Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. Proc Natl Acad Sci U S A 103:12167\u201312172","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3478_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00192-015-2831-5","volume":"27","author":"Z Sadeghi","year":"2016","unstructured":"Sadeghi Z, Isariyawongse J, Kavran M, Izgi K, Marini G, Molter J, Daneshgari F, Flask CA, Caplan A, Hijaz A (2016) Mesenchymal stem cell therapy in a rat model of birth-trauma injury: functional improvements and biodistribution. Int Urogynecol J 27:291\u2013300","journal-title":"Int Urogynecol J"},{"key":"3478_CR36","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1097\/AOG.0b013e3181f73729","volume":"116","author":"FJ Smith","year":"2010","unstructured":"Smith FJ, Holman CAJ, Moorin RE, Tsokos N (2010) Lifetime risk of undergoing surgery for pelvic organ prolapse. Obstet Gynecol 116:1096\u20131100","journal-title":"Obstet Gynecol"},{"key":"3478_CR37","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.juro.2006.03.070","volume":"176","author":"S Takahashi","year":"2006","unstructured":"Takahashi S, Chen Q, Ogushi T, Fujimura T, Kumagai J, Matsumoto S, Hijikata S, Tabata Y, Kitamura T (2006) Periurethral injection of sustained release basic fibroblast growth factor improves sphincteric contractility of the rat urethra denervated by botulinum-a toxin. J Urol 176:819\u2013823","journal-title":"J Urol"},{"key":"3478_CR38","first-page":"785","volume":"20","author":"D Ulrich","year":"2014","unstructured":"Ulrich D, Edwards SL, Su K, Tan KS, White JF, Ramshaw JAM, Lo C, Rosamilia A, Werkmeister JA, Gargett CE (2014) Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair. Tissue Eng Part A 20:785\u2013798","journal-title":"Tissue Eng Part A"},{"key":"3478_CR39","doi-asserted-by":"publisher","first-page":"F1089","DOI":"10.1152\/ajprenal.00230.2017","volume":"313","author":"S Yoshikawa","year":"2017","unstructured":"Yoshikawa S, Sumino Y, Kwon J, Suzuki T, Kitta T, Miyazato M, Yoshimura N (2017) Effects of multiple simulated birth traumas on urethral continence function in rats. Am J Physiol Renal Physiol 313:F1089\u2013F1096","journal-title":"Am J Physiol Renal Physiol"},{"key":"3478_CR40","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.juro.2012.05.017","volume":"188","author":"L Zhou","year":"2012","unstructured":"Zhou L, Lee JH, Wen Y, Constantinou C, Yoshinobu M, Omata S, Chen B (2012) Biomechanical properties and associated collagen composition in vaginal tissue of women with pelvic organ prolapse. J Urol 188:875\u2013880","journal-title":"J Urol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03478-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-021-03478-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03478-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T04:10:04Z","timestamp":1637035804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-021-03478-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3478"],"URL":"https:\/\/doi.org\/10.1007\/s00441-021-03478-9","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"6 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}