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Endogenous neural stem\/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair process. However, molecular mechanisms underlying CNS disease-induced SVZ NSPC-redirected migration to the lesion area are poorly understood. Here, we show that genetic depletion of the p75 neurotrophin receptor (<jats:italic>p75<\/jats:italic><jats:sup><jats:italic>NTR\u2212\/\u2212<\/jats:italic><\/jats:sup>) in mice reduced SVZ NSPC migration towards the lesion area after cortical injury and that <jats:italic>p75<\/jats:italic><jats:sup><jats:italic>NTR\u2212\/\u2212<\/jats:italic><\/jats:sup> NSPCs failed to migrate upon BDNF stimulation in vitro. Cortical injury rapidly increased p75<jats:sup>NTR<\/jats:sup> abundance in SVZ NSPCs via bone morphogenetic protein (BMP) receptor signaling. SVZ-derived <jats:italic>p75<\/jats:italic><jats:sup><jats:italic>NTR\u2212\/\u2212<\/jats:italic><\/jats:sup> NSPCs revealed an altered cytoskeletal network- and small GTPase family-related gene and protein expression. In accordance, BMP-treated non-migrating <jats:italic>p75<\/jats:italic><jats:sup><jats:italic>NTR\u2212\/\u2212<\/jats:italic><\/jats:sup> NSPCs revealed an altered morphology and \u03b1-tubulin expression compared to BMP-treated migrating wild-type NSPCs. We propose that BMP-induced p75<jats:sup>NTR<\/jats:sup> abundance in NSPCs is a regulator of SVZ NSPC migration to the lesion area via regulation of the cytoskeleton following cortical injury.<\/jats:p>","DOI":"10.1007\/s00441-021-03539-z","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T04:02:42Z","timestamp":1635220962000},"page":"415-431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke"],"prefix":"10.1007","volume":"387","author":[{"given":"Sachin S.","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash C.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Conforti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-di","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Greulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike-Ast","family":"Dumbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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