{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:34Z","timestamp":1791837514774,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"research fund project of zhejiang province traditional chinese medicine science and technology plan"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s00441-022-03652-7","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T12:56:34Z","timestamp":1659012994000},"page":"281-292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HDAC5 inactivates CYR61-regulated CD31\/mTOR axis to prevent the occurrence of preeclampsia"],"prefix":"10.1007","volume":"390","author":[{"given":"Peiyue","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-470X","authenticated-orcid":false,"given":"Xiaofu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"3652_CR1","doi-asserted-by":"publisher","unstructured":"Azar C, Valentine MC, Trausch-Azar J et al (2021) RNA-Seq identifies genes whose proteins are upregulated during syncytia development in murine C2C12 myoblasts and human BeWo trophoblasts. Physiol Rep 9:e14671. https:\/\/doi.org\/10.14814\/phy2.14671","DOI":"10.14814\/phy2.14671"},{"key":"3652_CR2","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/molehr\/gat050","volume":"19","author":"CW Chang","year":"2013","unstructured":"Chang CW, Cheong ML, Chang GD, Tsai MS, Chen H (2013) Involvement of Epac1\/Rap1\/CaMKI\/HDAC5 signaling cascade in the regulation of placental cell fusion. Mol Hum Reprod 19:745\u2013755. https:\/\/doi.org\/10.1093\/molehr\/gat050","journal-title":"Mol Hum Reprod"},{"key":"3652_CR3","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1007\/s13277-014-2915-8","volume":"36","author":"G Cheng","year":"2015","unstructured":"Cheng G, Zhang H, Zhang L, Zhang J (2015) Cyr61 promotes growth of glioblastoma in vitro and in vivo. Tumour Biol 36:2869\u20132873. https:\/\/doi.org\/10.1007\/s13277-014-2915-8","journal-title":"Tumour Biol"},{"key":"3652_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.545852","volume":"8","author":"Y Chu","year":"2020","unstructured":"Chu Y, Chen W, Peng W et al (2020) Amnion-derived mesenchymal stem cell exosomes-mediated autophagy promotes the survival of trophoblasts under hypoxia through mTOR pathway by the downregulation of EZH2. Front Cell Dev Biol 8:545852. https:\/\/doi.org\/10.3389\/fcell.2020.545852","journal-title":"Front Cell Dev Biol"},{"key":"3652_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118358","volume":"261","author":"Y Fan","year":"2020","unstructured":"Fan Y, Dong Z, Zhou G et al (2020) Elevated miR-23a impairs trophoblast migration and invasiveness through HDAC2 inhibition and NF-kappaB activation. Life Sci 261:118358. https:\/\/doi.org\/10.1016\/j.lfs.2020.118358","journal-title":"Life Sci"},{"key":"3652_CR6","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3892\/ijmm.2018.3887","volume":"42","author":"J Feng","year":"2018","unstructured":"Feng J, Wang X, Li H, Wang L, Tang Z (2018) Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts. Int J Mol Med 42:3125\u20133134. https:\/\/doi.org\/10.3892\/ijmm.2018.3887","journal-title":"Int J Mol Med"},{"key":"3652_CR7","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/mnfr.201500466","volume":"60","author":"W Gan","year":"2016","unstructured":"Gan W, Dang Y, Han X et al (2016) ERK5\/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells. Mol Nutr Food Res 60:266\u2013277. https:\/\/doi.org\/10.1002\/mnfr.201500466","journal-title":"Mol Nutr Food Res"},{"issue":"Suppl 1","key":"3652_CR8","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1111\/nure.12055","volume":"71","author":"A Jeyabalan","year":"2013","unstructured":"Jeyabalan A (2013) Epidemiology of preeclampsia: impact of obesity. Nutr Rev 71(Suppl 1):S18-25. https:\/\/doi.org\/10.1111\/nure.12055","journal-title":"Nutr Rev"},{"key":"3652_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101062","volume":"42","author":"O Klymenko","year":"2020","unstructured":"Klymenko O, Brecklinghaus T, Dille M et al (2020) Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle. Mol Metab 42:101062. https:\/\/doi.org\/10.1016\/j.molmet.2020.101062","journal-title":"Mol Metab"},{"key":"3652_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s004670050033","volume":"14","author":"NB Kuemmerle","year":"2000","unstructured":"Kuemmerle NB, Lin PS, Krieg RJ Jr, Lin KC, Ward KP, Chan JC (2000) Gene expression after intrarenal injection of plasmid DNA in the rat. Pediatr Nephrol 14:152\u2013157. https:\/\/doi.org\/10.1007\/s004670050033","journal-title":"Pediatr Nephrol"},{"key":"3652_CR11","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1007\/s00018-011-0778-3","volume":"68","author":"LF Lau","year":"2011","unstructured":"Lau LF (2011) CCN1\/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68:3149\u20133163. https:\/\/doi.org\/10.1007\/s00018-011-0778-3","journal-title":"Cell Mol Life Sci"},{"key":"3652_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.canlet.2011.10.016","volume":"315","author":"KB Lee","year":"2012","unstructured":"Lee KB, Byun HJ, Park SH, Park CY, Lee SH, Rho SB (2012) CYR61 controls p53 and NF-kappaB expression through PI3K\/Akt\/mTOR pathways in carboplatin-induced ovarian cancer cells. Cancer Lett 315:86\u201395. https:\/\/doi.org\/10.1016\/j.canlet.2011.10.016","journal-title":"Cancer Lett"},{"key":"3652_CR13","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.7150\/thno.31868","volume":"9","author":"XC Li","year":"2019","unstructured":"Li XC, Jin F, Wang BY, Yin XJ, Hong W, Tian FJ (2019) The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA. Theranostics 9:3853\u20133865. https:\/\/doi.org\/10.7150\/thno.31868","journal-title":"Theranostics"},{"key":"3652_CR14","doi-asserted-by":"publisher","first-page":"15807","DOI":"10.1074\/jbc.M708933200","volume":"283","author":"MT Lin","year":"2008","unstructured":"Lin MT, Kuo IH, Chang CC et al (2008) Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61\/CCN1-induced gastric cancer cell invasion. J Biol Chem 283:15807\u201315815. https:\/\/doi.org\/10.1074\/jbc.M708933200","journal-title":"J Biol Chem"},{"key":"3652_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.semnephrol.2010.10.004","volume":"31","author":"SE Maynard","year":"2011","unstructured":"Maynard SE, Karumanchi SA (2011) Angiogenic factors and preeclampsia. Semin Nephrol 31:33\u201346. https:\/\/doi.org\/10.1016\/j.semnephrol.2010.10.004","journal-title":"Semin Nephrol"},{"key":"3652_CR16","first-page":"92","volume":"48","author":"JM Niu","year":"2013","unstructured":"Niu JM, Lei Q, Lu LJ et al (2013) Evaluation of the diagnostic criteria of gestational metabolic syndrome and analysis of the risk factors. Zhonghua Fu Chan Ke Za Zhi 48:92\u201397","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"140","key":"3652_CR17","doi-asserted-by":"publisher","first-page":"e120","DOI":"10.1016\/j.ajog.2012.06.011","volume":"207","author":"L Petrozella","year":"2012","unstructured":"Petrozella L, Mahendroo M, Timmons B, Roberts S, McIntire D, Alexander JM (2012) Endothelial microparticles and the antiangiogenic state in preeclampsia and the postpartum period. Am J Obstet Gynecol 207(140):e120-146. https:\/\/doi.org\/10.1016\/j.ajog.2012.06.011","journal-title":"Am J Obstet Gynecol"},{"key":"3652_CR18","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1179\/1607845414Y.0000000178","volume":"20","author":"M Salem","year":"2015","unstructured":"Salem M, Kamal S, El Sherbiny W, Abdel Aal AA (2015) Flow cytometric assessment of endothelial and platelet microparticles in preeclampsia and their relation to disease severity and Doppler parameters. Hematology 20:154\u2013159. https:\/\/doi.org\/10.1179\/1607845414Y.0000000178","journal-title":"Hematology"},{"key":"3652_CR19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/MNH.0000000000000105","volume":"24","author":"M Sircar","year":"2015","unstructured":"Sircar M, Thadhani R, Karumanchi SA (2015) Pathogenesis of preeclampsia. Curr Opin Nephrol Hypertens 24:131\u2013138. https:\/\/doi.org\/10.1097\/MNH.0000000000000105","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"3652_CR20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001559RR","volume":"35","author":"M Sun","year":"2021","unstructured":"Sun M, Gao J, Meng T et al (2021) Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123\/Dvl2\/JNK signaling in the trophoblast cell line HTR8\/SVneo, a possible role in preeclampsia. FASEB J 35:e21169. https:\/\/doi.org\/10.1096\/fj.202001559RR","journal-title":"FASEB J"},{"key":"3652_CR21","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1002\/art.40890","volume":"71","author":"PS Tsou","year":"2019","unstructured":"Tsou PS, Khanna D, Sawalha AH (2019) Identification of cysteine-rich angiogenic inducer 61 as a potential antifibrotic and proangiogenic mediator in scleroderma. Arthritis Rheumatol 71:1350\u20131359. https:\/\/doi.org\/10.1002\/art.40890","journal-title":"Arthritis Rheumatol"},{"key":"3652_CR22","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1002\/art.39828","volume":"68","author":"PS Tsou","year":"2016","unstructured":"Tsou PS, Wren JD, Amin MA et al (2016) Histone deacetylase 5 is overexpressed in scleroderma endothelial cells and impairs angiogenesis via repression of proangiogenic factors. Arthritis Rheumatol 68:2975\u20132985. https:\/\/doi.org\/10.1002\/art.39828","journal-title":"Arthritis Rheumatol"},{"key":"3652_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bbrc.2010.12.120","volume":"405","author":"T Usui","year":"2011","unstructured":"Usui T, Okada M, Hara Y, Yamawaki H (2011) Exploring calmodulin-related proteins, which mediate development of hypertension, in vascular tissues of spontaneous hypertensive rats. Biochem Biophys Res Commun 405:47\u201351. https:\/\/doi.org\/10.1016\/j.bbrc.2010.12.120","journal-title":"Biochem Biophys Res Commun"},{"key":"3652_CR24","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1159\/000088461","volume":"25","author":"HV Vu","year":"2005","unstructured":"Vu HV, Ianosi-Irimie MR, Pridjian CA et al (2005) Involvement of marinobufagenin in a rat model of human preeclampsia. Am J Nephrol 25:520\u2013528. https:\/\/doi.org\/10.1159\/000088461","journal-title":"Am J Nephrol"},{"key":"3652_CR25","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.placenta.2019.08.077","volume":"87","author":"L Wang","year":"2019","unstructured":"Wang L, Zhang Y, Qu H et al (2019a) Reduced ELABELA expression attenuates trophoblast invasion through the PI3K\/AKT\/mTOR pathway in early onset preeclampsia. Placenta 87:38\u201345. https:\/\/doi.org\/10.1016\/j.placenta.2019.08.077","journal-title":"Placenta"},{"key":"3652_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41440-018-0150-1","volume":"42","author":"Y Wang","year":"2019","unstructured":"Wang Y, Gu Y, Alexander JS, Lewis DF (2019b) Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia. Hypertens Res 42:155\u2013164. https:\/\/doi.org\/10.1038\/s41440-018-0150-1","journal-title":"Hypertens Res"},{"key":"3652_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3109\/09513590903184100","volume":"26","author":"Z Wang","year":"2010","unstructured":"Wang Z, Lu S, Liu C et al (2010) Expressional and epigenetic alterations of placental matrix metalloproteinase 9 in preeclampsia. Gynecol Endocrinol 26:96\u2013102. https:\/\/doi.org\/10.3109\/09513590903184100","journal-title":"Gynecol Endocrinol"},{"key":"3652_CR28","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1210\/en.2009-1195","volume":"151","author":"N Wolf","year":"2010","unstructured":"Wolf N, Yang W, Dunk CE et al (2010) Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology 151:2835\u20132845. https:\/\/doi.org\/10.1210\/en.2009-1195","journal-title":"Endocrinology"},{"key":"3652_CR29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1600-0897.2011.01080.x","volume":"67","author":"X Zhang","year":"2012","unstructured":"Zhang X, Ding L, Diao Z, Yan G, Sun H, Hu Y (2012) CYR61 modulates the vascular endothelial growth factor C expression of decidual NK cells via PI3K\/AKT pathway. Am J Reprod Immunol 67:216\u2013223. https:\/\/doi.org\/10.1111\/j.1600-0897.2011.01080.x","journal-title":"Am J Reprod Immunol"},{"key":"3652_CR30","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1128\/MCB.01500-09","volume":"30","author":"G Zupkovitz","year":"2010","unstructured":"Zupkovitz G, Grausenburger R, Brunmeir R et al (2010) The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol 30:1171\u20131181. https:\/\/doi.org\/10.1128\/MCB.01500-09","journal-title":"Mol Cell Biol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03652-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-022-03652-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03652-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T07:04:05Z","timestamp":1667372645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-022-03652-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["3652"],"URL":"https:\/\/doi.org\/10.1007\/s00441-022-03652-7","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,28]]},"assertion":[{"value":"26 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}