{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:14:28Z","timestamp":1793142868818,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00441-022-03663-4","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T10:02:53Z","timestamp":1657015373000},"page":"71-92","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effectiveness of exosome mediated miR-126 and miR-146a delivery on cardiac tissue regeneration"],"prefix":"10.1007","volume":"390","author":[{"given":"Shilan","family":"Shafei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-6365","authenticated-orcid":false,"given":"Mehdi","family":"Khanmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ghanbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajihe Taghdiri","family":"Nooshabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein Ahmadi","family":"Tafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharam","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maniya","family":"Kasaiyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Basiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Tavoosidana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"3663_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms8321","volume":"6","author":"M Alexander","year":"2015","unstructured":"Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O\u2019Connell RM (2015) Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun 6:1\u201316","journal-title":"Nat Commun"},{"key":"3663_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/adma.201303233","volume":"26","author":"N Annabi","year":"2014","unstructured":"Annabi N, Tamayol A, Uquillas JA, Akbari M, Bertassoni LE, Cha C, Camci-Unal G, Dokmeci MR, Peppas NA, Khademhosseini A (2014) 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv Mater 26:85\u2013124","journal-title":"Adv Mater"},{"key":"3663_CR3","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/pharmaceutics10040218","volume":"10","author":"SG Antimisiaris","year":"2018","unstructured":"Antimisiaris SG, Mourtas S, Marazioti A (2018) Exosomes and exosome-inspired vesicles for targeted drug delivery. Pharmaceutics 10:218","journal-title":"Pharmaceutics"},{"key":"3663_CR4","first-page":"62","volume":"106","author":"PS Azevedo","year":"2015","unstructured":"Azevedo PS, Polegato BF, Minicucci MF, Paiva SA, Zornoff LA (2015) Cardiac remodeling: concepts, clinical impact, pathophysiological mechanisms and pharmacologic treatment. Arq Bras Cardiol 106:62\u201369","journal-title":"Arq Bras Cardiol"},{"key":"3663_CR5","doi-asserted-by":"crossref","unstructured":"Badali E, Mohajer M, Hassanzadeh S, Saghati S, Khanmohammadi M (2021) Enzymatic crosslinked hydrogels for biomedical application","DOI":"10.20944\/preprints202104.0652.v1"},{"key":"3663_CR6","doi-asserted-by":"crossref","unstructured":"Bahrami N, Bayat M, Farzin A, Sadredin Hajseyedjavadi M, Goodarzi A, Salehi M, Karimi R, Mohamadnia A, Ahmadi A, Khanmohammadi M (2019) The ability of 3D alginate\/polyvinyl alcohol cross-linked hybrid hydrogel to differentiate periodontal ligament stem cells into osteoblasts. Arch Neurosci 6","DOI":"10.5812\/ans.85118"},{"key":"3663_CR7","doi-asserted-by":"publisher","first-page":"8306","DOI":"10.1096\/fj.201801768RR","volume":"33","author":"H Cai","year":"2019","unstructured":"Cai H, Wu F-Y, Wang Q-L, Xu P, Mou F-F, Shao S-J, Luo Z-R, Zhu J, Xuan S-S, Lu R (2019) Self-assembling peptide modified with QHREDGS as a novel delivery system for mesenchymal stem cell transplantation after myocardial infarction. FASEB J 33:8306\u20138320","journal-title":"FASEB J"},{"key":"3663_CR8","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1093\/cvr\/cvy067","volume":"114","author":"CW Chen","year":"2018","unstructured":"Chen CW, Wang LL, Zaman S, Gordon J, Arisi MF, Venkataraman CM, Chung JJ, Hung G, Gaffey AC, Spruce LA (2018) Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction. Cardiovasc Res 114:1029\u20131040","journal-title":"Cardiovasc Res"},{"key":"3663_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s13238-018-0529-4","volume":"10","author":"Y Cheng","year":"2019","unstructured":"Cheng Y, Zeng Q, Han Q, Xia W (2019) Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes. Protein Cell 10:295\u2013299","journal-title":"Protein Cell"},{"key":"3663_CR10","doi-asserted-by":"crossref","unstructured":"Davachi SM, Haramshahi SMA, Akhavirad SA, Bahrami N, Hassanzadeh S, Ezzatpour S, Hassanzadeh N, Kebria MM, Khanmohammadi M, Bagher Z (2022) Development of chitosan\/hyaluronic acid hydrogel scaffolds via enzymatic reaction for cartilage tissue engineering. Mater Today Commun 30","DOI":"10.1016\/j.mtcomm.2022.103230"},{"key":"3663_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.2174\/22115528113020020001","volume":"2","author":"M Fernandes Ribeiro","year":"2013","unstructured":"Fernandes Ribeiro M, Zhu H, Millard RW, Fan G-C (2013) Exosomes function in pro-and anti-angiogenesis. Curr Angiogenesis 2:54\u201359","journal-title":"Curr Angiogenesis"},{"key":"3663_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","volume":"15","author":"JE Fish","year":"2008","unstructured":"Fish JE, Santoro MM, Morton SU, Yu S, Yeh R-F, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15:272\u2013284","journal-title":"Dev Cell"},{"key":"3663_CR13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/cvr\/cvs109","volume":"94","author":"D Fraccarollo","year":"2012","unstructured":"Fraccarollo D, Galuppo P, Bauersachs J (2012) Novel therapeutic approaches to post-infarction remodelling. Cardiovasc Res 94:293\u2013303","journal-title":"Cardiovasc Res"},{"key":"3663_CR14","doi-asserted-by":"publisher","first-page":"672","DOI":"10.4049\/jimmunol.1403155","volume":"195","author":"M Gao","year":"2015","unstructured":"Gao M, Wang X, Zhang X, Ha T, Ma H, Liu L, Kalbfleisch JH, Gao X, Kao RL, Williams DL (2015) Attenuation of cardiac dysfunction in polymicrobial sepsis by microRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression. J Immunol 195:672\u2013682","journal-title":"J Immunol"},{"key":"3663_CR15","doi-asserted-by":"publisher","first-page":"13878","DOI":"10.1002\/jcp.28070","volume":"234","author":"XH Gong","year":"2019","unstructured":"Gong XH, Liu H, Wang SJ, Liang SW, Wang GG (2019) Exosomes derived from SDF1-overexpressing mesenchymal stem cells inhibit ischemic myocardial cell apoptosis and promote cardiac endothelial microvascular regeneration in mice with myocardial infarction. J Cell Physiol 234:13878\u201313893","journal-title":"J Cell Physiol"},{"key":"3663_CR16","doi-asserted-by":"crossref","unstructured":"Goodarzi A, Khanmohammadi M, Ebrahimi-Barough S, Azami M, Amani A, Baradaran-Rafii A, Ai A, Farzin A, Ai J (2019) Alginate-based hydrogel containing taurine-loaded chitosan nanoparticles in biomedical application. Arch Neurosci 6","DOI":"10.5812\/ans.86349"},{"key":"3663_CR17","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1039\/C9BM00101H","volume":"7","author":"C Han","year":"2019","unstructured":"Han C, Zhou J, Liang C, Liu B, Pan X, Zhang Y, Wang Y, Yan B, Xie W, Liu F (2019) Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair. Biomater Sci 7:2920\u20132933","journal-title":"Biomater Sci"},{"key":"3663_CR18","doi-asserted-by":"publisher","first-page":"1500122","DOI":"10.1002\/advs.201500122","volume":"2","author":"A Hasan","year":"2015","unstructured":"Hasan A, Khattab A, Islam MA, Hweij KA, Zeitouny J, Waters R, Sayegh M, Hossain MM, Paul A (2015) Injectable hydrogels for cardiac tissue repair after myocardial infarction. Adv Sci 2:1500122","journal-title":"Adv Sci"},{"key":"3663_CR19","doi-asserted-by":"crossref","unstructured":"Hassani A, Khoshfetrat AB, Rahbarghazi R, Sakai S (2021) Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation. Carbohydr Polym 118807","DOI":"10.1016\/j.carbpol.2021.118807"},{"key":"3663_CR20","doi-asserted-by":"crossref","unstructured":"Huang W, Tian S-S, Hang P-Z, Sun C, Guo J, Du Z-M (2016) Combination of microRNA-21 and microRNA-146a attenuates cardiac dysfunction and apoptosis during acute myocardial infarction in mice. Mol Ther-Nucleic Acids 5","DOI":"10.1038\/mtna.2016.12"},{"key":"3663_CR21","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","volume":"2","author":"AG-E Ibrahim","year":"2014","unstructured":"Ibrahim AG-E, Cheng K, Marb\u00e1n E (2014) Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Rep 2:606\u2013619","journal-title":"Stem Cell Rep"},{"key":"3663_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","volume":"4","author":"J Karar","year":"2011","unstructured":"Karar J, Maity A (2011) PI3K\/AKT\/mTOR pathway in angiogenesis. Front Mol Neurosci 4:51","journal-title":"Front Mol Neurosci"},{"key":"3663_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109808","volume":"103","author":"M Khanmohammadi","year":"2019","unstructured":"Khanmohammadi M, Nemati S, Ai J, Khademi F (2019) Multipotency expression of human adipose stem cells in filament-like alginate and gelatin derivative hydrogel fabricated through visible light-initiated crosslinking. Mater Sci Eng, C 103:109808","journal-title":"Mater Sci Eng, C"},{"key":"3663_CR24","first-page":"215","volume":"2","author":"Y Koga","year":"2011","unstructured":"Koga Y, Yasunaga M, Moriya Y, Akasu T, Fujita S, Yamamoto S, Matsumura Y (2011) Exosome can prevent RNase from degrading microRNA in feces. J Gastrointest Oncol 2:215","journal-title":"J Gastrointest Oncol"},{"key":"3663_CR25","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2217\/rme.11.35","volume":"6","author":"RC Lai","year":"2011","unstructured":"Lai RC, Chen TS, Lim SK (2011) Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med 6:481\u2013492","journal-title":"Regen Med"},{"key":"3663_CR26","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.7150\/thno.32637","volume":"9","author":"K Lv","year":"2019","unstructured":"Lv K, Li Q, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C (2019) Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics 9:7403","journal-title":"Theranostics"},{"key":"3663_CR27","doi-asserted-by":"crossref","unstructured":"Ma T, Chen Y, Chen Y, Meng Q, Sun J, Shao L, Yu Y, Huang H, Hu Y, Yang Z (2018) MicroRNA-132, delivered by mesenchymal stem cell-derived exosomes, promote angiogenesis in myocardial infarction. Stem Cells Int\u00a02018","DOI":"10.1155\/2018\/3290372"},{"key":"3663_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/bioengineering5020028","volume":"5","author":"M Madigan","year":"2018","unstructured":"Madigan M, Atoui R (2018) Therapeutic use of stem cells for myocardial infarction. Bioengineering 5:28","journal-title":"Bioengineering"},{"key":"3663_CR29","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1021\/acsbiomaterials.6b00176","volume":"3","author":"MR Melhem","year":"2017","unstructured":"Melhem MR, Park J, Knapp L, Reinkensmeyer L, Cvetkovic C, Flewellyn J, Lee MK, Jensen TW, Bashir R, Kong H (2017) 3D printed stem-cell-laden, microchanneled hydrogel patch for the enhanced release of cell-secreting factors and treatment of myocardial infarctions. ACS Biomater Sci Eng 3:1980\u20131987","journal-title":"ACS Biomater Sci Eng"},{"key":"3663_CR30","first-page":"1321","volume":"17","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P (2016) Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur J Echocardiogr 17:1321\u20131360","journal-title":"Eur J Echocardiogr"},{"key":"3663_CR31","unstructured":"Nooshabadi V (2019) Endometrial mesenchymal stem cell-derived exosome promote endothelial cell angiogenesis in a dose dependent manner: a new perspective on regenerative medicine and cell-free therapy. Arch Neurosci"},{"key":"3663_CR32","doi-asserted-by":"crossref","unstructured":"Nooshabadi VT, Khanmohamadi M, Valipour E, Mahdipour S, Salati A, Malekshahi ZV, Shafei S, Amini E, Farzamfar S, Ai J (2020a) Impact of exosome loaded chitosan hydrogel in wound repair and layered dermal reconstitution in mice animal model. J Biomed Mater Res A","DOI":"10.1002\/jbm.a.36959"},{"key":"3663_CR33","doi-asserted-by":"crossref","unstructured":"Nooshabadi VT, Khanmohammadi M, Shafei S, Banafshe HR, Malekshahi ZV, Ebrahimi-Barough S, Ai J (2020) Impact of atorvastatin loaded exosome as an anti-glioblastoma carrier to induce apoptosis of U87 cancer cells in 3D culture model. Biochem Biophys Rep 23","DOI":"10.1016\/j.bbrep.2020.100792"},{"key":"3663_CR34","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1089\/ten.tea.2013.0620","volume":"20","author":"S Pok","year":"2014","unstructured":"Pok S, Benavides OM, Hallal P, Jacot JG (2014) Use of myocardial matrix in a chitosan-based full-thickness heart patch. Tissue Eng Part A 20:1877\u20131887","journal-title":"Tissue Eng Part A"},{"key":"3663_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40591-015-0041-7","volume":"3","author":"F Pourrajab","year":"2015","unstructured":"Pourrajab F, Yazdi MB, Zarch MB, Zarch MB, Hekmatimoghaddam S (2015) Cross talk of the first-line defense TLRs with PI3K\/Akt pathway, in preconditioning therapeutic approach. Mol Cell Ther 3:1\u201310","journal-title":"Mol Cell Ther"},{"key":"3663_CR36","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1172\/JCI123135","volume":"129","author":"L Qiao","year":"2019","unstructured":"Qiao L, Hu S, Liu S, Zhang H, Ma H, Huang K, Li Z, Su T, Vandergriff A, Tang J (2019) microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. J Clin Investig 129:2237\u20132250","journal-title":"J Clin Investig"},{"key":"3663_CR37","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.biotechadv.2013.12.010","volume":"32","author":"J Radhakrishnan","year":"2014","unstructured":"Radhakrishnan J, Krishnan UM, Sethuraman S (2014) Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnol Adv 32:449\u2013461","journal-title":"Biotechnol Adv"},{"key":"3663_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.matbio.2017.10.003","volume":"75","author":"K Rilla","year":"2019","unstructured":"Rilla K, Mustonen A-M, Arasu UT, H\u00e4rk\u00f6nen K, Matilainen J, Nieminen P (2019) Extracellular vesicles are integral and functional components of the extracellular matrix. Matrix Biol 75:201\u2013219","journal-title":"Matrix Biol"},{"key":"3663_CR39","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1161\/CIRCRESAHA.114.300639","volume":"114","author":"S Sahoo","year":"2014","unstructured":"Sahoo S, Losordo DW (2014) Exosomes and cardiac repair after myocardial infarction. Circ Res 114:333\u2013344","journal-title":"Circ Res"},{"key":"3663_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1159\/000461596","volume":"54","author":"H-H Seo","year":"2017","unstructured":"Seo H-H, Lee S-Y, Lee CY, Kim R, Kim P, Oh S, Lee H, Lee MY, Kim J, Kim LK (2017) Exogenous miRNA-146a enhances the therapeutic efficacy of human mesenchymal stem cells by increasing vascular endothelial growth factor secretion in the ischemia\/reperfusion-injured heart. J Vasc Res 54:100\u2013108","journal-title":"J Vasc Res"},{"key":"3663_CR41","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.biotechadv.2016.03.003","volume":"34","author":"M Sepantafar","year":"2016","unstructured":"Sepantafar M, Maheronnaghsh R, Mohammadi H, Rajabi-Zeleti S, Annabi N, Aghdami N, Baharvand H (2016) Stem cells and injectable hydrogels: synergistic therapeutics in myocardial repair. Biotechnol Adv 34:362\u2013379","journal-title":"Biotechnol Adv"},{"key":"3663_CR42","doi-asserted-by":"crossref","unstructured":"Shafei S, Khanmohammadi M, Heidari R, Ghanbari H, Taghdiri Nooshabadi V, Farzamfar S, Akbariqomi M, Sanikhani NS, Absalan M, Tavoosidana G (2019) Exosome loaded alginate hydrogel promotes tissue regeneration in full\u2010thickness skin wounds: an in vivo study. J Biomed Mater Res A","DOI":"10.1002\/jbm.a.36835"},{"key":"3663_CR43","doi-asserted-by":"crossref","unstructured":"Shafei S, Khanmohammadi M, Heidari R, Ghanbari H, Taghdiri Nooshabadi V, Farzamfar S, Akbariqomi M, Sanikhani NS, Absalan M, Tavoosidana G (2020) Exosome loaded alginate hydrogel promotes tissue regeneration in full\u2010thickness skin wounds: an in vivo study. J Biomed Mater Res A 108:545\u2013556","DOI":"10.1002\/jbm.a.36835"},{"key":"3663_CR44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/01.ccx.0000224869.86205.1a","volume":"12","author":"M Slama","year":"2006","unstructured":"Slama M, Maizel J (2006) Echocardiographic measurement of ventricular function. Curr Opin Crit Care 12:241\u2013248","journal-title":"Curr Opin Crit Care"},{"key":"3663_CR45","first-page":"217","volume":"67","author":"D Suvakanta","year":"2010","unstructured":"Suvakanta D, Padala NM, Lilakanta N, Prasanta C (2010) Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm Drug Res 67:217\u2013223","journal-title":"Acta Pol Pharm Drug Res"},{"key":"3663_CR46","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCRESAHA.114.300584","volume":"114","author":"A Waldenstr\u00f6m","year":"2014","unstructured":"Waldenstr\u00f6m A, Ronquist G (2014) Role of exosomes in myocardial remodeling. Circ Res 114:315\u2013324","journal-title":"Circ Res"},{"key":"3663_CR47","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/s41551-017-0157-y","volume":"1","author":"LL Wang","year":"2017","unstructured":"Wang LL, Liu Y, Chung JJ, Wang T, Gaffey AC, Lu M, Cavanaugh CA, Zhou S, Kanade R, Atluri P (2017) Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury. Nat Biomed Eng 1:983\u2013992","journal-title":"Nat Biomed Eng"},{"key":"3663_CR48","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1016\/j.actbio.2009.04.040","volume":"5","author":"T Wang","year":"2009","unstructured":"Wang T, Jiang X-J, Tang Q-Z, Li X-Y, Lin T, Wu D-Q, Zhang X-Z, Okello E (2009) Bone marrow stem cells implantation with \u03b1-cyclodextrin\/MPEG\u2013PCL\u2013MPEG hydrogel improves cardiac function after myocardial infarction. Acta Biomater 5:2939\u20132944","journal-title":"Acta Biomater"},{"key":"3663_CR49","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvu044","volume":"102","author":"X Wang","year":"2014","unstructured":"Wang X, Ha T, Zou J, Ren D, Liu L, Zhang X, Kalbfleisch J, Gao X, Williams D, Li C (2014) MicroRNA-125b protects against myocardial ischaemia\/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6. Cardiovasc Res 102:385\u2013395","journal-title":"Cardiovasc Res"},{"key":"3663_CR50","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1126\/science.1114519","volume":"309","author":"E Wienholds","year":"2005","unstructured":"Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, De Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH (2005) MicroRNA expression in zebrafish embryonic development. Science 309:310\u2013311","journal-title":"Science"},{"key":"3663_CR51","first-page":"619","volume":"14","author":"X Xue","year":"2018","unstructured":"Xue X, Shi X, Dong H, You S, Cao H, Wang K, Wen Y, Shi D, He B, Li Y (2018) Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice. Nanomedicine: Nanotechnology. Biol Med 14:619\u2013631","journal-title":"Biol Med"},{"key":"3663_CR52","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1159\/000477597","volume":"42","author":"H-H Yang","year":"2017","unstructured":"Yang H-H, Chen Y, Gao C-Y, Cui Z-T, Yao J-M (2017) Protective effects of MicroRNA-126 on human cardiac microvascular endothelial cells against hypoxia\/reoxygenation-induced injury and inflammatory response by activating PI3K\/Akt\/eNOS signaling pathway. Cell Physiol Biochem 42:506\u2013518","journal-title":"Cell Physiol Biochem"},{"key":"3663_CR53","doi-asserted-by":"crossref","unstructured":"Zahiri M, Khanmohammadi M, Goodarzi A, Ababzadeh S, Farahani MS, Mohandesnezhad S, Bahrami N, Nabipour I, Ai J (2019) Encapsulation of curcumin loaded chitosan nanoparticle within poly (\u03b5-caprolactone) and gelatin fiber mat for wound healing and layered dermal reconstitution. Int J Biol Macromol","DOI":"10.1016\/j.ijbiomac.2019.10.255"},{"key":"3663_CR54","doi-asserted-by":"publisher","first-page":"L110","DOI":"10.1152\/ajplung.00423.2016","volume":"312","author":"D Zhang","year":"2017","unstructured":"Zhang D, Lee H, Zhu Z, Minhas JK, Jin Y (2017) Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 312:L110\u2013L121","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3663_CR55","doi-asserted-by":"publisher","first-page":"30081","DOI":"10.1021\/acsami.8b08449","volume":"10","author":"K Zhang","year":"2018","unstructured":"Zhang K, Zhao X, Chen X, Wei Y, Du W, Wang Y, Liu L, Zhao W, Han Z, Kong D (2018) Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces 10:30081\u201330091","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03663-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-022-03663-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03663-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T04:03:21Z","timestamp":1664597001000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-022-03663-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["3663"],"URL":"https:\/\/doi.org\/10.1007\/s00441-022-03663-4","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,5]]},"assertion":[{"value":"4 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments comply with the National Institutes of Health guide for the care and use of laboratory animals (NIH Publications No. 8023, revised 1978). Experiments were approved by the national ethics committee of Tehran University of Medical Sciences (ethical code: IR.TUMS.REC.1394.1594) and were performed according to the university\u2019s guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This manuscript contains no details or videos relating to a person, so this section is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}