{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:54:32Z","timestamp":1794257672760,"version":"4.9.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBA 20020150100104BA"],"award-info":[{"award-number":["UBA 20020150100104BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017642","name":"Spanish National Plan for Scientific and Technical Research and Innovation","doi-asserted-by":"publisher","award":["ANPCyT PICT 0497"],"award-info":[{"award-number":["ANPCyT PICT 0497"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s00441-022-03703-z","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T04:27:42Z","timestamp":1673411262000},"page":"581-604","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Unraveling the effect of the inflammatory microenvironment in spermatogenesis progression"],"prefix":"10.1007","volume":"392","author":[{"given":"Maria Eugenia","family":"Ferreiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia Soledad","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilane","family":"Glienke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Marcelo","family":"Sobarzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-9833","authenticated-orcid":false,"given":"Mar\u00eda Jimena","family":"Ferraris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Alberto","family":"Pisera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Lustig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Ver\u00f3nica","family":"Jacobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Susana","family":"Theas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"3703_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1095\/biolreprod58.2.431","volume":"58","author":"F Bauch\u00e9","year":"1998","unstructured":"Bauch\u00e9 F, St\u00e9phan JP, Touzalin AM, J\u00e9gou B (1998) In vitro regulation of an inducible-type NO synthase in the rat seminiferous tubule cells. Biol Reprod 58:431\u2013438. https:\/\/doi.org\/10.1095\/biolreprod58.2.431","journal-title":"Biol Reprod"},{"key":"3703_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/cyto.990020511","volume":"2","author":"RC Braylan","year":"1982","unstructured":"Braylan RC, Benson NA, Nourse V, Kruth HS (1982) Correlated analysis of cellular DNA, membrane antigens and light scatter of human lymphoid cells. Cytometry 2:337\u2013343. https:\/\/doi.org\/10.1002\/cyto.990020511","journal-title":"Cytometry"},{"key":"3703_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-7-19","author":"BH Caneguim","year":"2009","unstructured":"Caneguim BH, Cerri PS, Spolid\u00f3rio LC, Miraglia SM, Sasso-Cerri E (2009) Structural alterations in the seminiferous tubules of rats treated with immunosuppressor tacrolimus. Reprod Biol Endocrinol. https:\/\/doi.org\/10.1186\/1477-7827-7-19","journal-title":"Reprod Biol Endocrinol"},{"key":"3703_CR4","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1152\/physrev.1972.52.1.198","volume":"52","author":"Y Clermont","year":"1972","unstructured":"Clermont Y (1972) Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol Rev 52:198\u2013236. https:\/\/doi.org\/10.1152\/physrev.1972.52.1.198","journal-title":"Physiol Rev"},{"key":"3703_CR5","doi-asserted-by":"publisher","unstructured":"De SK, Chen HL, Pace JL, Hunt JS, Terranova PF, Enders GC (1993) Expression of tumor necrosis factor-alpha in mouse spermatogenic cells. Endocrinology 133:389\u2013396. https:\/\/doi.org\/10.1210\/endo.133.1.8319585","DOI":"10.1210\/endo.133.1.8319585"},{"key":"3703_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1600-0897.1989.tb00638.x","volume":"20","author":"GF Doncel","year":"1989","unstructured":"Doncel GF, Di Paola JA, Lustig L (1989) Sequential study of the histopathology and cellular and humoral immune response during the development of an autoimmune orchitis in Wistar rats. Am J Reprod Immunol 20:44\u201351. https:\/\/doi.org\/10.1111\/j.1600-0897.1989.tb00638.x","journal-title":"Am J Reprod Immunol"},{"key":"3703_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2010.01137.x","author":"YG Duan","year":"2011","unstructured":"Duan YG, Yu CF, Novak N, Bieber T, Zhu CH, Schuppe HC, Haidl G, Allam JP (2011) Immunodeviation towards a Th17 immune response associated with testicular damage in azoospermic men. Int J Androl. https:\/\/doi.org\/10.1111\/j.1365-2605.2010.01137.x","journal-title":"Int J Androl"},{"key":"3703_CR8","doi-asserted-by":"publisher","unstructured":"Fayomi A, David S, Doungkamchan C, Orwig KE (2018) Spermatogonial stem cells and sspermatogenesis in mice, monkeys and men. Stem Cell Res 29:107\u2013214. https:\/\/doi.org\/10.1016\/j.scr.2018.04.009","DOI":"10.1016\/j.scr.2018.04.009"},{"key":"3703_CR9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.repbio.2019.11.001","volume":"19","author":"ME Ferreiro","year":"2019","unstructured":"Ferreiro ME, Amarilla MS, Glienke L, M\u00e9ndez CS, Gonz\u00e1lez C, Jacobo PV, Sobarzo CM, De Laurentiis A, Ferraris MJ, Theas MS (2019) The inflammatory mediators TNF\u03b1 and nitric oxide arrest spermatogonia GC-1 cell cycle. Reprod Biol 19:329\u2013339. https:\/\/doi.org\/10.1016\/j.repbio.2019.11.001","journal-title":"Reprod Biol"},{"key":"3703_CR10","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/humupd\/dmy009","volume":"24","author":"M Fijak","year":"2018","unstructured":"Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V, Tung KSK, Schuppe HC, Meinhardt A (2018) Infectious, inflammatory and \u201cautoimmune\u201d male factor infertility: how do rodent models inform clinical practice? Hum Reprod Update 24:416\u2013441. https:\/\/doi.org\/10.1093\/humupd\/dmy009","journal-title":"Hum Reprod Update"},{"key":"3703_CR11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0015-0282(02)03206-5","volume":"78","author":"MB Frungieri","year":"2002","unstructured":"Frungieri MB, Calandra RS, Lustig L, Meineke V, K\u00f6hn FM, Vogt HJ, Mayerhofer A (2002) Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril 78:298\u2013306. https:\/\/doi.org\/10.1016\/S0015-0282(02)03206-5","journal-title":"Fertil Steril"},{"key":"3703_CR12","first-page":"245","volume":"78","author":"L G\u00f3nzalez","year":"2018","unstructured":"G\u00f3nzalez L, Amarilla MS, M\u00e9ndez S, Glienke L, Oxilia H, Fulco MF, Jacobo P, Sobarzo CM, TM (2018) Study of spermatogonia population in infertile patients with immune cells infiltrates. Rev Med 78:245\u2013246","journal-title":"Rev Med"},{"key":"3703_CR13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0303-7207(95)03475-M","volume":"108","author":"H Hakovirta","year":"1995","unstructured":"Hakovirta H, Syed V, J\u00e9gou B, Parvinen M (1995) Function of interleukin-6 as an inhibitor of meiotic DNA synthesis in the rat seminiferous epithelium. Mol Cell Endocrinol 108:193\u2013198. https:\/\/doi.org\/10.1016\/0303-7207(95)03475-M","journal-title":"Mol Cell Endocrinol"},{"key":"3703_CR14","doi-asserted-by":"publisher","unstructured":"Hentrich A, Wolter M, Szardening-Kirchner C, L\u00fcers GH, Bergmann M, Kliesch S, Konrad L (2017) Reduced numbers of Sertoli, germ, and spermatogonial stem cells in impaired spermatogenesis. Mod Pathol 30:311. https:\/\/doi.org\/10.1038\/modpathol.2016.194","DOI":"10.1038\/modpathol.2016.194"},{"key":"3703_CR15","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1095\/biolreprod43.3.525","volume":"43","author":"RA Hess","year":"1990","unstructured":"Hess RA (1990) Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol Reprod 43:525\u2013542. https:\/\/doi.org\/10.1095\/biolreprod43.3.525","journal-title":"Biol Reprod"},{"key":"3703_CR16","doi-asserted-by":"publisher","unstructured":"Huckins C (1971a) Cell cycle properties of differentiating spermatogonia in adult Sprague- Dawley rats. Cell Tissue Kinet 4:139\u2013154. https:\/\/doi.org\/10.1111\/j.1365-2184.1971.tb01524.x","DOI":"10.1111\/j.1365-2184.1971.tb01524.x"},{"key":"3703_CR17","doi-asserted-by":"publisher","unstructured":"Huckins C (1971b) The spermatogonial stem cell population. Cell Tissue Kinet 4:313\u2013334. https:\/\/doi.org\/10.1111\/j.1365-2184.1971.tb01543.x","DOI":"10.1111\/j.1365-2184.1971.tb01543.x"},{"key":"3703_CR18","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.imbio.2012.04.007","volume":"217","author":"S Jarazo-Dietrich","year":"2012","unstructured":"Jarazo-Dietrich S, Jacobo P, P\u00e9rez CV, Guazzone VA, Lustig L, Theas MS (2012) Up regulation of nitric oxide synthase-nitric oxide system in the testis of rats undergoing autoimmune orchitis. Immunobiology 217:778\u2013787. https:\/\/doi.org\/10.1016\/j.imbio.2012.04.007","journal-title":"Immunobiology"},{"key":"3703_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128709","author":"SD Dietrich","year":"2015","unstructured":"Jarazo-Dietrich S, Fass MI, Jacobo PV, Sobarzo CMA, Lustig L, Theas MS (2015) Inhibition of NOS-NO system prevents autoimmune orchitis development in rats: Relevance of NO released by testicular macrophages in germ cell apoptosis and testosterone secretion. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0128709","journal-title":"PLoS ONE"},{"key":"3703_CR20","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1095\/biolreprod62.5.1146","volume":"62","author":"H Krishnamurthy","year":"2000","unstructured":"Krishnamurthy H, Danilovich N, Morales CR, Sairam MR (2000) Qualitative and quantitative decline in spermatogenesis of the follicle- stimulating hormone receptor knockout (FORKO) mouse. Biol Reprod 62:1146\u20131159. https:\/\/doi.org\/10.1095\/biolreprod62.5.1146","journal-title":"Biol Reprod"},{"key":"3703_CR21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1749-6632.1952.tb26576.x","volume":"55","author":"CP Leblond","year":"1952","unstructured":"Leblond CP, Clermont Y (1952) Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann N Y Acad Sci 55:548\u2013573. https:\/\/doi.org\/10.1111\/j.1749-6632.1952.tb26576.x","journal-title":"Ann N Y Acad Sci"},{"key":"3703_CR22","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1677\/joe.1.06781","volume":"190","author":"MWM Li","year":"2006","unstructured":"Li MWM, Xia W, Mruk DD, Wang CQF, Yan HHN, Siu MKY, Lui WY, Lee WM, Cheng CY (2006) Tumor necrosis factor \u03b1 reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes. J Endocrinol 190:313\u2013329. https:\/\/doi.org\/10.1677\/joe.1.06781","journal-title":"J Endocrinol"},{"key":"3703_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/BF00427346","volume":"64","author":"JG Linakis","year":"1979","unstructured":"Linakis JG, Cunningham CL (1979) Effects of concentration of ethanol injected intraperitoneally on taste aversion, body temperature, and activity. Psychopharmacology 64:61\u201365. https:\/\/doi.org\/10.1007\/BF00427346","journal-title":"Psychopharmacology"},{"key":"3703_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.583135","volume":"11","author":"L Lustig","year":"2020","unstructured":"Lustig L, Guazzone VA, Theas MS, Pleuger C, Jacobo P, P\u00e9rez CV, Meinhardt A, Fijak M (2020) Pathomechanisms of autoimmune based testicular inflammation. Front Immunol 11:1\u20138. https:\/\/doi.org\/10.3389\/fimmu.2020.583135","journal-title":"Front Immunol"},{"key":"3703_CR25","doi-asserted-by":"publisher","unstructured":"Mayerhofer A, Walenta L, Mayer C, Eubler K, Welter H (2018) Human testicular peritubular cells, mast cells and testicular inflammation. Andrologia 50:e13055.\u00a0https:\/\/doi.org\/10.1111\/and.13055","DOI":"10.1111\/and.13055"},{"key":"3703_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00626-9","author":"V Meineke","year":"2000","unstructured":"Meineke V, Frungieri MB, Jessberger B, Vogt HJ, Mayerhofer A (2000) Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men. Fertil Steril. https:\/\/doi.org\/10.1016\/S0015-0282(00)00626-9","journal-title":"Fertil Steril"},{"key":"3703_CR27","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1369\/0022155413496639","volume":"61","author":"I Mu\u00f1oz-Velasco","year":"2013","unstructured":"Mu\u00f1oz-Velasco I, Ort\u00edz R, Echeverr\u00eda OM, Escobar ML, V\u00e1zquez-Nin GH (2013) Characterization of the pre-meiotic S phase through Incorporation of BrdU during spermatogenesis in the Rat. J Histochem Cytochem 61:680\u2013689. https:\/\/doi.org\/10.1369\/0022155413496639","journal-title":"J Histochem Cytochem"},{"key":"3703_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.112.101709","volume":"87","author":"CV P\u00e9rez","year":"2012","unstructured":"P\u00e9rez CV, Sobarzo CM, Jacobo PV, Pellizzari EH, Cigorraga SB, Denduchis B, Lustig L (2012) Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions. Biol Reprod 87:1\u201312. https:\/\/doi.org\/10.1095\/biolreprod.112.101709","journal-title":"Biol Reprod"},{"key":"3703_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/and.13401","volume":"51","author":"A Pilatz","year":"2019","unstructured":"Pilatz A, Kilb J, Kaplan H, Fietz D, Hossain H, Sch\u00fcttler CG, Diemer T, Bergmann M, Domann E, Weidner W, Wagenlehner F, Schuppe HC (2019) High prevalence of urogenital infection\/inflammation in patients with azoospermia does not impede surgical sperm retrieval. Andrologia 51:1\u201310. https:\/\/doi.org\/10.1111\/and.13401","journal-title":"Andrologia"},{"key":"3703_CR30","doi-asserted-by":"publisher","first-page":"5808","DOI":"10.1073\/pnas.92.13.5808","volume":"92","author":"A Riccioli","year":"1995","unstructured":"Riccioli A, Filippini A, De Cesaris P, Barbacci E, Stefanini M, Starace G, Ziparo E (1995) Inflammatory mediators increase surface expression of integrin ligands, adhesion to lymphocytes, and secretion of interleukin 6 in mouse Sertoli cells. Proc Natl Acad Sci U S A 92:5808\u20135812. https:\/\/doi.org\/10.1073\/pnas.92.13.5808","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3703_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2005.10.006","author":"C Rival","year":"2006","unstructured":"Rival C, Theas MS, Guazzone VA, Lustig L (2006) Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. J Reprod Immunol. https:\/\/doi.org\/10.1016\/j.jri.2005.10.006","journal-title":"J Reprod Immunol"},{"key":"3703_CR32","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/stem.1028","volume":"30","author":"J Savitt","year":"2012","unstructured":"Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW (2012) The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells 30:732\u2013740. https:\/\/doi.org\/10.1002\/stem.1028","journal-title":"Stem Cells"},{"key":"3703_CR33","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/014850190518161","volume":"51","author":"C Sezer","year":"2005","unstructured":"Sezer C, Koksal IT, Usta MF, Gulkesen KH, Erdogru T, Ciftcioglu A, Baykara M (2005) Relationship between mast cell and iNOS expression in testicular tissue associated with infertility. Arch Androl 51:149\u2013158. https:\/\/doi.org\/10.1080\/014850190518161","journal-title":"Arch Androl"},{"key":"3703_CR34","doi-asserted-by":"publisher","unstructured":"Sharma M, Braun RE (2018) Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. Dev. https:\/\/doi.org\/10.1242\/dev.151555","DOI":"10.1242\/dev.151555"},{"key":"3703_CR35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.yexcr.2014.09.002","volume":"329","author":"Y Shiloh","year":"2014","unstructured":"Shiloh Y (2014) ATM: Expanding roles as a chief guardian of genome stability. Exp Cell Res 329:154\u2013161. https:\/\/doi.org\/10.1016\/j.yexcr.2014.09.002","journal-title":"Exp Cell Res"},{"key":"3703_CR36","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrc1011","volume":"3","author":"Y Shiloh","year":"2003","unstructured":"Shiloh Y (2003) ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 3:155\u2013168. https:\/\/doi.org\/10.1038\/nrc1011","journal-title":"Nat Rev Cancer"},{"key":"3703_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/4.3.227","author":"K Steger","year":"1998","unstructured":"Steger K, Aleithe I, Behre H, Bergmann M (1998) The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. Mol Hum Reprod 4:227-233.\u00a0\u00a0https:\/\/doi.org\/10.1093\/molehr\/4.3.227","journal-title":"Mol Hum Reprod"},{"key":"3703_CR38","doi-asserted-by":"publisher","unstructured":"Suescun MO, Rival C, Theas MS, Calandra RS, Lustig L (2003) Involvement of tumor necrosis factor-\u03b1 in the pathogenesis of autoimmune orchitis in rats. Biol Reprod 68:2114-2121. https:\/\/doi.org\/10.1095\/biolreprod.102.011189","DOI":"10.1095\/biolreprod.102.011189"},{"key":"3703_CR39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.stem.2007.10.023","volume":"2","author":"K Takubo","year":"2008","unstructured":"Takubo K, Ohmura M, Azuma M, Nagamatsu G, Yamada W, Arai F, Hirao A, Suda T (2008) Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell Stem Cell 2:170\u2013182. https:\/\/doi.org\/10.1016\/j.stem.2007.10.023","journal-title":"Cell Stem Cell"},{"key":"3703_CR40","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/humrep\/del066","volume":"21","author":"MS Theas","year":"2006","unstructured":"Theas MS, Rival C, Dietrich SJ, Guazzone VA, Lustig L (2006) Death receptor and mitochondrial pathways are involved in germ cell apoptosis in an experimental model of autoimmune orchitis. Hum Reprod 21:1734\u20131742. https:\/\/doi.org\/10.1093\/humrep\/del066","journal-title":"Hum Reprod."},{"key":"3703_CR41","doi-asserted-by":"publisher","unstructured":"Theas MS, Rival C, Jarazo-Dietrich S, Jacobo P, Guazzone VA, Lustig L (2008) Tumour necrosis factor-\u03b1 released by testicular macrophages induces apoptosis of germ cells in autoimmune orchitis. Hum Reprod 23:1865\u20131872. https:\/\/doi.org\/10.1093\/humrep\/den240","DOI":"10.1093\/humrep\/den240"},{"key":"3703_CR42","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/cyto.990060408","volume":"6","author":"MJ van Kroonenburgh","year":"1985","unstructured":"van Kroonenburgh MJ, Beck JL, Scholtz JW, Hacker-Klom U, Herman CJ (1985) DNA analysis and sorting of rat testis cells using two-parameter flow cytometry. Cytometry 6:321\u2013326. https:\/\/doi.org\/10.1002\/cyto.990060408","journal-title":"Cytometry"},{"key":"3703_CR43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/aja.1001650103","volume":"165","author":"T-Y Wing","year":"1982","unstructured":"Wing T-Y, Christensen AK (1982) Morphometric studies on rat seminiferous tubules. Am J Anat 165:13\u201325. https:\/\/doi.org\/10.1002\/aja.1001650103","journal-title":"Am J Anat"},{"key":"3703_CR44","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1210\/endo.132.6.8504748","volume":"132","author":"Y Xiong","year":"1993","unstructured":"Xiong Y, Hales DB (1993) The role of tumor necrosis factor-a in the regulation of mouse leydig cell steroidogenesis. Endocrinology 132:2438\u20132444. https:\/\/doi.org\/10.1210\/endo.132.6.8504748","journal-title":"Endocrinology"},{"key":"3703_CR45","doi-asserted-by":"publisher","unstructured":"Zhang L, Tang J, Haines CJ, Feng H, Lai L, Teng X, Han Y (2011)\u00a0C-Kit and its related genes in spermatogonial differentiation. Spermatogenesis 1, 186\u2013194. https:\/\/doi.org\/10.4161\/spmg.1.3.17760","DOI":"10.4161\/spmg.1.3.17760"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03703-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-022-03703-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-022-03703-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T09:59:25Z","timestamp":1683799165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-022-03703-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["3703"],"URL":"https:\/\/doi.org\/10.1007\/s00441-022-03703-z","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]},"assertion":[{"value":"26 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of rats followed the National Institutes of Health (NIH) guidelines for care and use of experimental animals, and ethical approval was granted by local the committee: CICUAL-Facultad de Medicina, Universidad de Buenos Aires [RES (CD): 2029\/2019].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}