{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:03:16Z","timestamp":1761562996016,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["HL141345"],"award-info":[{"award-number":["HL141345"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20TPA35490215","952237"],"award-info":[{"award-number":["20TPA35490215","952237"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s00441-023-03813-2","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T11:02:07Z","timestamp":1691838127000},"page":"189-207","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hutchinson-Gilford progeria patient-derived cardiomyocyte model of carrying LMNA gene variant c.1824 C\u2009&gt;\u2009T"],"prefix":"10.1007","volume":"394","author":[{"given":"Selene","family":"Perales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoth","family":"Sigamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheeja","family":"Rajasingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras","family":"Czirok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-4083","authenticated-orcid":false,"given":"Johnson","family":"Rajasingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"issue":"6","key":"3813_CR1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/cvr\/cvz217","volume":"116","author":"P Benzoni","year":"2019","unstructured":"Benzoni P, Campostrini G, Landi S, Bertini V, Marchina E, Iascone M, Ahlberg G, Olesen MS, Crescini E, Mora C, Bisleri G, Muneretto C, Ronca R, Presta M, Poliani PL, Piovani G, Verardi R, Di Pasquale E, Consiglio A, Dell\u2019Era P (2019) Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes. Cardiovasc Res 116(6):1147\u20131160. https:\/\/doi.org\/10.1093\/cvr\/cvz217","journal-title":"Cardiovasc Res"},{"key":"3813_CR2","first-page":"275","volume-title":"The Enzymes","author":"WR Bishop","year":"2011","unstructured":"Bishop WR, Doll R, Kirschmeier P (2011) 15 - Farnesyl Transferase inhibitors: from targeted cancer therapeutic to a potential treatment for progeria. In: Tamanoi F, Hrycyna CA, Bergo MO (eds) The Enzymes, vol 29. Academic Press, pp 275\u2013303"},{"issue":"1","key":"3813_CR3","doi-asserted-by":"publisher","first-page":"5501","DOI":"10.1038\/s41467-019-13167-5","volume":"10","author":"E Bolderson","year":"2019","unstructured":"Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O\u2019Byrne KJ, Richard DJ (2019) Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nat Commun 10(1):5501. https:\/\/doi.org\/10.1038\/s41467-019-13167-5","journal-title":"Nat Commun"},{"issue":"3","key":"3813_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/6799","volume":"21","author":"G Bonne","year":"1999","unstructured":"Bonne G, Barletta MRD, Varnous S, B\u00e9cane H-M, Hammouda E-H, Merlini L, Muntoni F, Greenberg CR, Gary F, Urtizberea J-A (1999) Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nat Genet 21(3):285\u2013288","journal-title":"Nat Genet"},{"issue":"5","key":"3813_CR5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1161\/01.CIR.101.5.473","volume":"101","author":"GL Brodsky","year":"2000","unstructured":"Brodsky GL, Muntoni F, Miocic S, Sinagra G, Sewry C, Mestroni L (2000) Lamin A\/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement. Circulation 101(5):473\u2013476","journal-title":"Circulation"},{"issue":"6","key":"3813_CR6","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1093\/nar\/gkab110","volume":"49","author":"JT Burgess","year":"2021","unstructured":"Burgess JT, Cheong CM, Suraweera A, Sobanski T, Beard S, Dave K, Rose M, Boucher D, Croft LV, Adams MN, O\u2019Byrne K, Richard DJ, Bolderson E (2021) Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity. Nucleic Acids Res 49(6):3294\u20133307. https:\/\/doi.org\/10.1093\/nar\/gkab110","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"3813_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/HCO.0b013e32835f0c79","volume":"28","author":"M-E Cattin","year":"2013","unstructured":"Cattin M-E, Muchir A, Bonne G (2013) \u2018State-of-the-heart\u2019 of cardiac laminopathies. Curr Opin Cardiol 28(3):297\u2013304. https:\/\/doi.org\/10.1097\/HCO.0b013e32835f0c79","journal-title":"Curr Opin Cardiol"},{"issue":"3","key":"3813_CR8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2012.01.059","volume":"149","author":"CY Chen","year":"2012","unstructured":"Chen CY, Chi YH, Mutalif RA, Starost MF, Myers TG, Anderson SA, Stewart CL, Jeang KT (2012) Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell 149(3):565\u2013577. https:\/\/doi.org\/10.1016\/j.cell.2012.01.059","journal-title":"Cell"},{"issue":"Pt 8","key":"3813_CR9","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1242\/jcs.139683","volume":"127","author":"ZJ Chen","year":"2014","unstructured":"Chen ZJ, Wang WP, Chen YC, Wang JY, Lin WH, Tai LA, Liou GG, Yang CS, Chi YH (2014) Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies. J Cell Sci 127(Pt 8):1792\u20131804. https:\/\/doi.org\/10.1242\/jcs.139683","journal-title":"J Cell Sci"},{"issue":"6","key":"3813_CR10","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s11373-007-9198-7","volume":"14","author":"CJ Cheng","year":"2007","unstructured":"Cheng CJ, Wu YC, Shu JA, Ling TY, Kuo HC, Wu JY, Chang EE, Chang SC, Huang YH (2007) Aberrant expression and distribution of the OCT-4 transcription factor in seminomas. J Biomed Sci 14(6):797\u2013807. https:\/\/doi.org\/10.1007\/s11373-007-9198-7","journal-title":"J Biomed Sci"},{"issue":"1","key":"3813_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-10094-7","volume":"7","author":"A Czirok","year":"2017","unstructured":"Czirok A, Isai DG, Kosa E, Rajasingh S, Kinsey W, Neufeld Z, Rajasingh J (2017) Optical-flow based non-invasive analysis of cardiomyocyte contractility. Sci Rep 7(1):1\u201311","journal-title":"Sci Rep"},{"key":"3813_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fcell.2019.00048","volume":"7","author":"T Dharmaraj","year":"2019","unstructured":"Dharmaraj T, Guan Y, Liu J, Badens C, Gaborit B, Wilson KL (2019) Rare BANF1 alleles and relatively frequent EMD alleles including&nbsp;\u2018healthy lipid\u2019 emerin p.D149H in the ExAC cohort. Front Cell Dev Biol 7:48. https:\/\/doi.org\/10.3389\/fcell.2019.00048","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"3813_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s40265-020-01464-z","volume":"81","author":"S Dhillon","year":"2021","unstructured":"Dhillon S (2021) Lonafarnib: first approval. Drugs 81(2):283\u2013289","journal-title":"Drugs"},{"issue":"6937","key":"3813_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nature01629","volume":"423","author":"M Eriksson","year":"2003","unstructured":"Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423(6937):293\u2013298","journal-title":"Nature"},{"issue":"23","key":"3813_CR15","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","volume":"341","author":"D Fatkin","year":"1999","unstructured":"Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ Jr, Spudich S, De Girolami U (1999) Missense mutations in the rod domain of the lamin A\/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med 341(23):1715\u20131724","journal-title":"N Engl J Med"},{"key":"3813_CR16","first-page":"188","volume":"73","author":"H Gilford","year":"1904","unstructured":"Gilford H (1904) Progeria: a form of senilism. Practitioner 73:188\u2013217","journal-title":"Practitioner"},{"key":"3813_CR17","doi-asserted-by":"crossref","unstructured":"Gonzalez JM, Pla D, Perez-Sala D, Andres V (2011) A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy","DOI":"10.2741\/216"},{"key":"3813_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/B978-1-4160-6231-8.10011-X","volume-title":"In Brocklehurst's Textbook of Geriatric Medicine and Gerontology","author":"LB Gordon","year":"2010","unstructured":"Gordon LB (2010) The premature aging syndrome Hutchinson-Gilford progeria: insights into normal aging. In Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Elsevier, pp 66\u201372"},{"issue":"3","key":"3813_CR19","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.cell.2013.12.028","volume":"156","author":"LB Gordon","year":"2014","unstructured":"Gordon LB, Rothman FG, L\u00f3pez-Ot\u00edn C, Misteli T (2014) Progeria: a paradigm for translational medicine. Cell 156(3):400\u2013407","journal-title":"Cell"},{"issue":"16","key":"3813_CR20","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1001\/jama.2018.3264","volume":"319","author":"LB Gordon","year":"2018","unstructured":"Gordon LB, Shappell H, Massaro J, D\u2019Agostino RB, Brazier J, Campbell SE, Kleinman ME, Kieran MW (2018) Association of lonafarnib treatment vs no treatment with mortality rate in patients with Hutchinson-Gilford progeria syndrome. JAMA 319(16):1687\u20131695","journal-title":"JAMA"},{"issue":"1","key":"3813_CR21","doi-asserted-by":"publisher","first-page":"112508","DOI":"10.1016\/j.yexcr.2021.112508","volume":"400","author":"N Gurusamy","year":"2021","unstructured":"Gurusamy N, Rajasingh S, Sigamani V, Rajasingh R, Isai DG, Czirok A, Bittel D, Rajasingh J (2021) Noonan syndrome patient-specific induced cardiomyocyte model carrying SOS1 gene variant c.1654A>G. Exp Cell Res 400(1):112508. https:\/\/doi.org\/10.1016\/j.yexcr.2021.112508","journal-title":"Exp Cell Res"},{"issue":"10","key":"3813_CR22","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1128\/mcb.26.10.3738-3751.2006","volume":"26","author":"F Haque","year":"2006","unstructured":"Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, Fry AM, Trembath RC, Shackleton S (2006) SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol 26(10):3738\u20133751. https:\/\/doi.org\/10.1128\/mcb.26.10.3738-3751.2006","journal-title":"Mol Cell Biol"},{"issue":"5","key":"3813_CR23","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1074\/jbc.M109.071910","volume":"285","author":"F Haque","year":"2010","unstructured":"Haque F, Mazzeo D, Patel JT, Smallwood DT, Ellis JA, Shanahan CM, Shackleton S (2010) Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem 285(5):3487\u20133498. https:\/\/doi.org\/10.1074\/jbc.M109.071910","journal-title":"J Biol Chem"},{"issue":"10","key":"3813_CR24","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/eurheartj\/ehx596","volume":"39","author":"NE Hasselberg","year":"2017","unstructured":"Hasselberg NE, Haland TF, Saberniak J, Brekke PH, Berge KE, Leren TP, Edvardsen T, Haugaa KH (2017) Lamin A\/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation. Eur Heart J 39(10):853\u2013860. https:\/\/doi.org\/10.1093\/eurheartj\/ehx596","journal-title":"Eur Heart J"},{"issue":"23","key":"3813_CR25","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1002\/ajmg.a.31346","volume":"140","author":"RC Hennekam","year":"2006","unstructured":"Hennekam RC (2006) Hutchinson-Gilford progeria syndrome: review of the phenotype. Am J Med Genet A 140(23):2603\u20132624. https:\/\/doi.org\/10.1002\/ajmg.a.31346","journal-title":"Am J Med Genet A"},{"key":"3813_CR26","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/095952878606900127","volume":"69","author":"J Hutchinson","year":"1886","unstructured":"Hutchinson J (1886a) Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages, in a boy whose mother had been almost wholly bald from alopecia areata from the age of six. Med Chir Trans 69:473\u2013477. https:\/\/doi.org\/10.1177\/095952878606900127","journal-title":"Med Chir Trans"},{"key":"3813_CR27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/095952878606900127","volume":"69","author":"J Hutchinson","year":"1886","unstructured":"Hutchinson J (1886b) Congenital absence of hair and mammary glands with atrophic condition of the skin and its appendages, in a boy whose mother had been almost wholly bald from alopecia areata from the age of six. Med Chir Trans 69:473","journal-title":"Med Chir Trans"},{"issue":"1","key":"3813_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-92631-z","volume":"11","author":"A Kychygina","year":"2021","unstructured":"Kychygina A, Dall\u2019Osto, M., Allen, J. A., Cadoret, J.-C., Piras, V., Pickett, H. A., & Crabbe, L. (2021) Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools. Sci Rep 11(1):1\u201320","journal-title":"Sci Rep"},{"key":"3813_CR29","doi-asserted-by":"publisher","unstructured":"Loo TH, Ye X, Chai RJ, Ito M, Bonne G, Ferguson-Smith AC, Stewart CL (2019) The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity. Elife 8. https:\/\/doi.org\/10.7554\/eLife.49485","DOI":"10.7554\/eLife.49485"},{"issue":"8","key":"3813_CR30","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/cdd.2010.183","volume":"18","author":"E Mattioli","year":"2011","unstructured":"Mattioli E, Columbaro M, Capanni C, Maraldi NM, Cenni V, Scotlandi K, Marino MT, Merlini L, Squarzoni S, Lattanzi G (2011) Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle. Cell Death Differ 18(8):1305\u20131315. https:\/\/doi.org\/10.1038\/cdd.2010.183","journal-title":"Cell Death Differ"},{"issue":"10","key":"3813_CR31","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.molmed.2006.08.006","volume":"12","author":"M Meta","year":"2006","unstructured":"Meta M, Yang SH, Bergo MO, Fong LG, Young SG (2006) Protein farnesyltransferase inhibitors and progeria. Trends Mol Med 12(10):480\u2013487. https:\/\/doi.org\/10.1016\/j.molmed.2006.08.006","journal-title":"Trends Mol Med"},{"issue":"9","key":"3813_CR32","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","volume":"9","author":"A Muchir","year":"2000","unstructured":"Muchir A, Bonne G, van der Kooi AJ, van Meegen M, Baas F, Bolhuis PA, de Visser M, Schwartz K (2000) Identification of mutations in the gene encoding lamins A\/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum Mol Genet 9(9):1453\u20131459","journal-title":"Hum Mol Genet"},{"issue":"5","key":"3813_CR33","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1172\/JCI29042","volume":"117","author":"A Muchir","year":"2007","unstructured":"Muchir A, Pavlidis P, Decostre V, Herron AJ, Arimura T, Bonne G, Worman HJ (2007) Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. J Clin Investig 117(5):1282\u20131293","journal-title":"J Clin Investig"},{"issue":"15","key":"3813_CR34","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1177\/1535370219862243","volume":"244","author":"C \u00d6stlund","year":"2019","unstructured":"\u00d6stlund C, Chang W, Gundersen GG, Worman HJ (2019) Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections. Exp Biol Med (maywood) 244(15):1333\u20131344. https:\/\/doi.org\/10.1177\/1535370219862243","journal-title":"Exp Biol Med (maywood)"},{"key":"3813_CR35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12867-014-0027-z","volume":"15","author":"N Paquet","year":"2014","unstructured":"Paquet N, Box JK, Ashton NW, Suraweera A, Croft LV, Urquhart AJ, Bolderson E, Zhang SD, O\u2019Byrne KJ, Richard DJ (2014) N\u00e9stor-Guillermo progeria syndrome: a biochemical insight into barrier-to-autointegration factor 1, alanine 12 threonine mutation. BMC Mol Biol 15:27. https:\/\/doi.org\/10.1186\/s12867-014-0027-z","journal-title":"BMC Mol Biol"},{"key":"3813_CR36","doi-asserted-by":"publisher","first-page":"932956","DOI":"10.3389\/fcvm.2022.932956","volume":"9","author":"K Perepelina","year":"2022","unstructured":"Perepelina K, Zaytseva A, Khudiakov A, Neganova I, Vasichkina E, Malashicheva A, Kostareva A (2022) LMNA mutation leads to cardiac sodium channel dysfunction in the Emery-Dreifuss muscular dystrophy patient. Front Cardiovasc Med 9:932956. https:\/\/doi.org\/10.3389\/fcvm.2022.932956","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"3813_CR37","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1399-0004.2004.00315.x","volume":"66","author":"R Pollex","year":"2004","unstructured":"Pollex R, Hegele RA (2004) Hutchinson-Gilford progeria syndrome. Clin Genet 66(5):375\u2013381","journal-title":"Clin Genet"},{"issue":"4","key":"3813_CR38","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1001\/jamacardio.2017.5235","volume":"3","author":"A Prakash","year":"2018","unstructured":"Prakash A, Gordon LB, Kleinman ME, Gurary EB, Massaro J, D\u2019Agostino R, Kieran MW, Gerhard-Herman M, Smoot L (2018) Cardiac abnormalities in patients with Hutchinson-Gilford progeria syndrome. JAMA Cardiol 3(4):326\u2013334","journal-title":"JAMA Cardiol"},{"issue":"5","key":"3813_CR39","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ajhg.2011.04.010","volume":"88","author":"XS Puente","year":"2011","unstructured":"Puente XS, Quesada V, Osorio FG, Cabanillas R, Cadi\u00f1anos J, Fraile JM, Ord\u00f3\u00f1ez GR, Puente DA, Guti\u00e9rrez-Fern\u00e1ndez A, Fanjul-Fern\u00e1ndez M, L\u00e9vy N, Freije JM, L\u00f3pez-Ot\u00edn C (2011) Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet 88(5):650\u2013656. https:\/\/doi.org\/10.1016\/j.ajhg.2011.04.010","journal-title":"Am J Hum Genet"},{"issue":"8","key":"3813_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134093","volume":"10","author":"S Rajasingh","year":"2015","unstructured":"Rajasingh S, Thangavel J, Czirok A, Samanta S, Roby KF, Dawn B, Rajasingh J (2015) Generation of functional cardiomyocytes from efficiently generated human iPSCs and a novel method of measuring contractility. PLoS ONE 10(8)","journal-title":"PLoS ONE"},{"issue":"22","key":"3813_CR41","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/CIRCULATIONAHA.121.055313","volume":"144","author":"A S\u00e1nchez-L\u00f3pez","year":"2021","unstructured":"S\u00e1nchez-L\u00f3pez A, Espin\u00f3s-Est\u00e9vez C, Gonz\u00e1lez-G\u00f3mez C, Gonzalo P, Andr\u00e9s-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR, Mac\u00edas \u00c1, Del Campo L (2021) Cardiovascular progerin suppression and lamin A restoration rescue Hutchinson-Gilford progeria syndrome. Circulation 144(22):1777\u20131794","journal-title":"Circulation"},{"key":"3813_CR42","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/B978-0-444-62702-5.00018-4","volume":"132","author":"NJ Ullrich","year":"2015","unstructured":"Ullrich NJ, Gordon LB (2015) Hutchinson-Gilford progeria syndrome. Handb Clin Neurol 132:249\u2013264","journal-title":"Handb Clin Neurol"},{"issue":"7","key":"3813_CR43","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1634\/stemcells.2006-0611","volume":"25","author":"S Zangrossi","year":"2007","unstructured":"Zangrossi S, Marabese M, Broggini M, Giordano R, D\u2019Erasmo M, Montelatici E, Intini D, Neri A, Pesce M, Rebulla P, Lazzari L (2007) Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells 25(7):1675\u20131680. https:\/\/doi.org\/10.1634\/stemcells.2006-0611","journal-title":"Stem Cells"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-023-03813-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-023-03813-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-023-03813-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:06:32Z","timestamp":1696590392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-023-03813-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,12]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["3813"],"URL":"https:\/\/doi.org\/10.1007\/s00441-023-03813-2","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"type":"print","value":"0302-766X"},{"type":"electronic","value":"1432-0878"}],"subject":[],"published":{"date-parts":[[2023,8,12]]},"assertion":[{"value":"14 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}