{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:31:34Z","timestamp":1782973894794,"version":"3.54.5"},"reference-count":126,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s00441-023-03821-2","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T04:01:50Z","timestamp":1691812910000},"page":"75-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting"],"prefix":"10.1007","volume":"394","author":[{"given":"Prajakta","family":"Teli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaijayanti","family":"Kale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-7414","authenticated-orcid":false,"given":"Anuradha","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"3821_CR1","doi-asserted-by":"publisher","unstructured":"Abuirmeileh AN, Alzoubi KH, Rababa\u2019h AM (2020) The effect of levosimendan on two distinct rodent models of Parkinson\u2019s disease. Curr Alzheimer Res 17(11):1043\u20131051. https:\/\/doi.org\/10.2174\/1567205017666201218102724","DOI":"10.2174\/1567205017666201218102724"},{"key":"3821_CR2","doi-asserted-by":"publisher","unstructured":"Aguilar MA, Rodriguez-Arias M, Mar\u00ed-Sanmill\u00e1n MI, Mi\u00f1arro J (1997) Effects of risperidone on conditioned avoidance responding in male mice. Behav Pharmacol 8(8):669\u2013676. https:\/\/doi.org\/10.1097\/00008877-199712000-00001","DOI":"10.1097\/00008877-199712000-00001"},{"key":"3821_CR3","doi-asserted-by":"publisher","first-page":"612078","DOI":"10.3389\/FPHAR.2021.612078","volume":"12","author":"S Ahmad","year":"2021","unstructured":"Ahmad S, Khan A, Ali W, Jo MH, Park J, Ikram M, Kim MO (2021) Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment. Front Pharmacol 12:612078\u2013612078. https:\/\/doi.org\/10.3389\/FPHAR.2021.612078","journal-title":"Front Pharmacol"},{"issue":"Pt A","key":"3821_CR4","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/J.NEUBIOREV.2017.01.004","volume":"74","author":"RM Ahmed","year":"2017","unstructured":"Ahmed RM, Irish M, van Eersel J, Ittner A, Ke YD, Volkerling A, van der Hoven J, Tanaka K, Karl T, Kassiou M, Kril JJ, Piguet O, G\u00f6tz J, Kiernan MC, Halliday GM, Hodges JR, Ittner LM (2017) Mouse models of frontotemporal dementia: a comparison of phenotypes with clinical symptomatology. Neurosci Biobehav Rev 74(Pt A):126\u2013138. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2017.01.004","journal-title":"Neurosci Biobehav Rev"},{"key":"3821_CR5","doi-asserted-by":"publisher","unstructured":"Akamatsu M, Yamashita T, Hirose N, Teramoto S, Kwak S (2016) The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice OPEN. https:\/\/doi.org\/10.1038\/srep28649","DOI":"10.1038\/srep28649"},{"issue":"1","key":"3821_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/S13311-013-0233-2","volume":"11","author":"PJ Allen","year":"2014","unstructured":"Allen PJ, Feigin A (2014) Gene-based therapies in Parkinson\u2019s disease. Neurother\u202f: J Am Soc Exp NeuroTher 11(1):60\u201367. https:\/\/doi.org\/10.1007\/S13311-013-0233-2","journal-title":"Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics"},{"issue":"10110","key":"3821_CR7","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1016\/S0140-6736(17)32399-1","volume":"390","author":"RM Anderson","year":"2017","unstructured":"Anderson RM, Hadjichrysanthou C, Evans S, Wong MM (2017) Why do so many clinical trials of therapies for Alzheimer\u2019s disease fail? Lancet (london, England) 390(10110):2327\u20132329. https:\/\/doi.org\/10.1016\/S0140-6736(17)32399-1","journal-title":"Lancet (london, England)"},{"issue":"6","key":"3821_CR8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/JAMA.2019.22360","volume":"323","author":"MJ Armstrong","year":"2020","unstructured":"Armstrong MJ, Okun MS (2020) Diagnosis and treatment of Parkinson disease: a review. JAMA 323(6):548\u2013560. https:\/\/doi.org\/10.1001\/JAMA.2019.22360","journal-title":"JAMA"},{"key":"3821_CR9","doi-asserted-by":"publisher","unstructured":"Ayalon G, Lee SH, Adolfsson O, Foo-Atkins C, Atwal JK, Blendstrup M, Booler H, Bravo J, Brendza R, Brunstein F, Chan R, Chandra P, Couch JA, Datwani A, Demeule B, DiCara D, Erickson R, Ernst JA, Foreman O, \u2026 Kerchner GA (2021) Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer\u2019s disease. Sci Transl Med 13(593). https:\/\/doi.org\/10.1126\/SCITRANSLMED.ABB2639","DOI":"10.1126\/SCITRANSLMED.ABB2639"},{"key":"3821_CR10","doi-asserted-by":"publisher","unstructured":"Balon K, and Wiatrak B (2021) PC12 and THP-1 cell lines as neuronal and microglia model in neurobiological research. Appl Sci 11(9):3729.\u00a0https:\/\/doi.org\/10.3390\/APP11093729","DOI":"10.3390\/APP11093729"},{"key":"3821_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/frym.2018.00070","author":"T Berman","year":"2018","unstructured":"Berman T, Bayati A (2018) What are neurodegenerative diseases and how do they affect the brain? Frontiers for Young Minds. https:\/\/doi.org\/10.3389\/frym.2018.00070","journal-title":"Frontiers for Young Minds"},{"issue":"2","key":"3821_CR12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/AR.A.10059","volume":"272A","author":"T Boland","year":"2003","unstructured":"Boland T, Mironov V, Gutowska A, Roth EA, Markwald RR (2003) Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. Anat Rec A Discov Mol Cell Evol Biol 272A(2):497\u2013502. https:\/\/doi.org\/10.1002\/AR.A.10059","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"3821_CR13","doi-asserted-by":"publisher","unstructured":"Bourque M, Morissette M, Conquet F, Charvin D, Di Paolo T (2023) Foliglurax a positive allosteric modulator of the metabotrophic glutamate receptor 4 protects dopaminergic neurons in MPTP-lesioned male mice. Brain Res 148349. https:\/\/doi.org\/10.1016\/J.BRAINRES.2023.148349","DOI":"10.1016\/J.BRAINRES.2023.148349"},{"key":"3821_CR14","doi-asserted-by":"publisher","unstructured":"Brassard JA, Nikolaev M, H\u00fcbscher T, Hofer M, and Lutolf MP (2020) Recapitulating macro-scale tissue self-organization through organoid bioprinting. Nature Mater 20(1):22\u201329. https:\/\/doi.org\/10.1038\/s41563-020-00803-5","DOI":"10.1038\/s41563-020-00803-5"},{"issue":"9","key":"3821_CR15","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1289\/EHP.7567","volume":"113","author":"RC Brown","year":"2005","unstructured":"Brown RC, Lockwood AH, Sonawane BR (2005) Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect 113(9):1250\u20131256. https:\/\/doi.org\/10.1289\/EHP.7567","journal-title":"Environ Health Perspect"},{"key":"3821_CR16","doi-asserted-by":"publisher","unstructured":"Burkhardt MF, Martinez FJ, Wright S, Ramos C, Volfson D, Mason M, Garnes J, Dang V, Lievers J, Shoukat-Mumtaz U, Martinez R, Gai H, Blake R, Vaisberg E, Grskovic M, Johnson C, Irion S, Bright J, Cooper B, Javaherian A (2013) A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol Cell Neurosci 56:355\u2013364. https:\/\/doi.org\/10.1016\/J.MCN.2013.07.007","DOI":"10.1016\/J.MCN.2013.07.007"},{"key":"3821_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/J.EXPNEUROL.2014.06.022","volume":"261","author":"SS Chen","year":"2014","unstructured":"Chen SS, Yang C, Hao F, Li C, Lu T, Zhao LR, Duan WM (2014) Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism. Exp Neurol 261:87\u201396. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2014.06.022","journal-title":"Exp Neurol"},{"key":"3821_CR18","doi-asserted-by":"publisher","unstructured":"Cope MB, Li X, Jumbo-Lucioni P, DiCostanzo CA, Jamison WG, Kesterson RA, Allison DB, Nagy TR (2009) Risperidone alters food intake core body temperature and locomotor activity in mice. Physiol Behav 96(3):457\u2013463. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2008.11.011","DOI":"10.1016\/J.PHYSBEH.2008.11.011"},{"issue":"2","key":"3821_CR19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/MT.2014.206","volume":"23","author":"\u00d3 Cordero-Llana","year":"2015","unstructured":"Cordero-Llana \u00d3, Houghton BC, Rinaldi F, Taylor H, Y\u00e1\u00f1ez-Mu\u00f1oz RJ, Uney JB, Wong LF, Caldwell MA (2015) Enhanced efficacy of the CDNF\/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson\u2019s disease. Mol Ther\u202f: J Am Soc Gene Ther 23(2):244\u2013254. https:\/\/doi.org\/10.1038\/MT.2014.206","journal-title":"Molecular Therapy : the Journal of the American Society of Gene Therapy"},{"key":"3821_CR20","doi-asserted-by":"publisher","unstructured":"Crouch B, Yeap JM, Pais B, Riedel G, Platt B (2019) Of mice and motion: Behavioural-EEG phenotyping of Alzheimer\u2019s disease mouse models. J Neurosci Methods 319:89\u201398. https:\/\/doi.org\/10.1016\/J.JNEUMETH.2018.06.028","DOI":"10.1016\/J.JNEUMETH.2018.06.028"},{"issue":"7","key":"3821_CR21","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1139\/CJPP-2015-0459","volume":"94","author":"M Cs\u00f6b\u00f6nyeiov\u00e1","year":"2016","unstructured":"Cs\u00f6b\u00f6nyeiov\u00e1 M, Pol\u00e1k \u0160, Dani\u0161ovi\u010d L (2016) Toxicity testing and drug screening using iPSC-derived hepatocytes, cardiomyocytes, and neural cells. Can J Physiol Pharmacol 94(7):687\u2013694. https:\/\/doi.org\/10.1139\/CJPP-2015-0459","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"3821_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/JNR.20899","volume":"84","author":"X Cui","year":"2006","unstructured":"Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 84(3):647\u2013654. https:\/\/doi.org\/10.1002\/JNR.20899","journal-title":"J Neurosci Res"},{"key":"3821_CR23","doi-asserted-by":"publisher","unstructured":"Cummings JL, Morstorf T, and Zhong K (2014. Alzheimer\u2019s disease drug-development pipeline: few candidates, frequent failures. Alzheimer\u2019s Res and Ther 6(4).\u00a0https:\/\/doi.org\/10.1186\/ALZRT269","DOI":"10.1186\/ALZRT269"},{"issue":"2","key":"3821_CR24","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/S11948-015-9659-8","volume":"22","author":"HJ Curzer","year":"2016","unstructured":"Curzer HJ, Perry G, Wallace MC, Perry D (2016) The three Rs of animal research: what they mean for the institutional animal care and use committee and why. Sci Eng Ethics 22(2):549\u2013565. https:\/\/doi.org\/10.1007\/S11948-015-9659-8","journal-title":"Sci Eng Ethics"},{"issue":"10","key":"3821_CR25","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/S41593-018-0236-8","volume":"21","author":"TM Dawson","year":"2018","unstructured":"Dawson TM, Golde TE, Lagier-Tourenne C (2018) Animal models of neurodegenerative diseases. Nat Neurosci 21(10):1370\u20131379. https:\/\/doi.org\/10.1038\/S41593-018-0236-8","journal-title":"Nat Neurosci"},{"issue":"1","key":"3821_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/J.NBD.2012.09.007","volume":"50","author":"D Devos","year":"2013","unstructured":"Devos D, Lebouvier T, Lardeux B, Biraud M, Rouaud T, Pouclet H, Coron E, Bruley des Varannes S, Naveilhan P, Nguyen JM, Neunlist M, and Derkinderen P (2013) Colonic inflammation in Parkinson\u2019s disease. Neurobiol Dis 50(1):42\u201348. https:\/\/doi.org\/10.1016\/J.NBD.2012.09.007","journal-title":"Neurobiol Dis"},{"key":"3821_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ph11020044","author":"F Dur\u00e3es","year":"2018","unstructured":"Dur\u00e3es F, Pinto M, Sousa E (2018) Old drugs as new treatments for neurodegenerative diseases. In Pharmaceuticals. https:\/\/doi.org\/10.3390\/ph11020044","journal-title":"In Pharmaceuticals"},{"key":"3821_CR28","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/J.LFS.2015.10.025","volume":"152","author":"S Dutta","year":"2016","unstructured":"Dutta S, Sengupta P (2016) Men and mice: relating their ages. Life Sci 152:244\u2013248. https:\/\/doi.org\/10.1016\/J.LFS.2015.10.025","journal-title":"Life Sci"},{"key":"3821_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/J.JCONREL.2015.07.020","volume":"215","author":"KA Fitzgerald","year":"2015","unstructured":"Fitzgerald KA, Malhotra M, Curtin CM, O\u2019Brien FJ, O\u2019Driscoll CM (2015) Life in 3D is never flat: 3D models to optimise drug delivery. JCR\u202f: Official J Controlled Release Soc 215:39\u201354.\u00a0https:\/\/doi.org\/10.1016\/J.JCONREL.2015.07.020","journal-title":"Journal of Controlled Release : Official Journal of the Controlled Release Society"},{"issue":"9","key":"3821_CR30","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1016\/J.DRUDIS.2019.06.003","volume":"24","author":"N Franzen","year":"2019","unstructured":"Franzen N, van Harten WH, Ret\u00e8l VP, Loskill P, van den Eijnden-van Raaij J, IJzerman, M. (2019) Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug Discov Today 24(9):1720\u20131724. https:\/\/doi.org\/10.1016\/J.DRUDIS.2019.06.003","journal-title":"Drug Discovery Today"},{"issue":"5","key":"3821_CR31","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/DMM.030205","volume":"10","author":"AD Gitler","year":"2017","unstructured":"Gitler AD, Dhillon P, Shorter J (2017) Neurodegenerative disease: models, mechanisms, and a new hope. Dis Model Mech 10(5):499\u2013502. https:\/\/doi.org\/10.1242\/DMM.030205","journal-title":"Dis Model Mech"},{"issue":"6","key":"3821_CR32","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/J.YMTHE.2006.09.001","volume":"14","author":"JA Gonzalez-Barrios","year":"2006","unstructured":"Gonzalez-Barrios JA, Lindahl M, Bannon MJ, Anaya-Mart\u00ednez V, Flores G, Navarro-Quiroga I, Trudeau LE, Aceves J, Martinez-Arguelles DB, Garcia-Villegas R, Jim\u00e9nez I, Segovia J, Martinez-Fong D (2006) Neurotensin polyplex as an efficient carrier for delivering the human GDNF gene into nigral dopamine neurons of hemiparkinsonian rats. Mol Ther\u202f: J Am Soc Gene Ther 14(6):857\u2013865. https:\/\/doi.org\/10.1016\/J.YMTHE.2006.09.001","journal-title":"Molecular Therapy : the Journal of the American Society of Gene Therapy"},{"issue":"6","key":"3821_CR33","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1093\/NAR\/GKT1351","volume":"42","author":"K Gordon","year":"2014","unstructured":"Gordon K, Clouaire T, Bao XX, Kemp SE, Xenophontos M, de Las Heras JI, Stancheva I (2014) Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression. Nucleic Acids Res 42(6):3529. https:\/\/doi.org\/10.1093\/NAR\/GKT1351","journal-title":"Nucleic Acids Res"},{"key":"3821_CR34","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN-428-18","author":"M Gourie-Devi","year":"2018","unstructured":"Gourie-Devi M (2018) Relevance of neuroepidemiology: burden of neurological disorders and public health issues. Annal Ind Acad Neurol. https:\/\/doi.org\/10.4103\/aian.AIAN-428-18","journal-title":"In Annals of Indian Academy of Neurology"},{"issue":"11","key":"3821_CR35","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1002\/JNR.23625","volume":"93","author":"LM Grant","year":"2015","unstructured":"Grant LM, Kelm-Nelson CA, Hilby BL, Blue KV, Paul Rajamanickam ES, Pultorak JD, Fleming SM, Ciucci MR (2015) Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson\u2019s disease. J Neurosci Res 93(11):1713\u20131727. https:\/\/doi.org\/10.1002\/JNR.23625","journal-title":"J Neurosci Res"},{"key":"3821_CR36","doi-asserted-by":"publisher","unstructured":"Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LPW, Rothstein JD (2017) Mutant Huntingtin disrupts the nuclear pore complex. Neuron 94(1):93\u2013107.e6.\u00a0https:\/\/doi.org\/10.1016\/J.NEURON.2017.03.023","DOI":"10.1016\/J.NEURON.2017.03.023"},{"key":"3821_CR37","doi-asserted-by":"publisher","unstructured":"Gross SK, Shim BS, Bartus RT, Deaver D, McEachin Z, B\u00e9tourn\u00e9 A, Boulis NM, and Maragakis NJ (2020) Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery. Exp Neurol 323.\u00a0https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2019.113091","DOI":"10.1016\/J.EXPNEUROL.2019.113091"},{"issue":"10","key":"3821_CR38","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1002\/2211-5463.13285","volume":"11","author":"M Hashimoto","year":"2021","unstructured":"Hashimoto M, Watanabe K, Miyoshi K, Koyanagi Y, Tadano J, Miyawaki I (2021) Multiplatform metabolomic analysis of the R6\/2 mouse model of Huntington\u2019s disease. FEBS Open Bio 11(10):2807\u20132818. https:\/\/doi.org\/10.1002\/2211-5463.13285","journal-title":"FEBS Open Bio"},{"key":"3821_CR39","doi-asserted-by":"publisher","unstructured":"Hebb ALO, Robertson HA, Denovan-Wright EM (2004) Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington\u2019s disease transgenic mice prior to the onset of motor symptoms. Neuroscience 123(4):967\u2013981. https:\/\/doi.org\/10.1016\/j.neuroscience.2003.11.009","DOI":"10.1016\/j.neuroscience.2003.11.009"},{"issue":"1","key":"3821_CR40","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.2147\/IJN.S61940","volume":"9","author":"E Herr\u00e1n","year":"2014","unstructured":"Herr\u00e1n E, Requejo C, Ruiz-Ortega JA, Aristieta A, Igartua M, Bengoetxea H, Ugedo L, Pedraz JL, Lafuente JV, Hern\u00e1ndez RM (2014) Increased antiparkinson efficacy of the combined administration of VEGF- and GDNF-loaded nanospheres in a partial lesion model of Parkinson\u2019s disease. Int J Nanomed 9(1):2677\u20132687. https:\/\/doi.org\/10.2147\/IJN.S61940","journal-title":"Int J Nanomed"},{"issue":"7384","key":"3821_CR41","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/NATURE10821","volume":"482","author":"MA Israel","year":"2012","unstructured":"Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LSB (2012) Probing sporadic and familial Alzheimer\u2019s disease using induced pluripotent stem cells. Nature 482(7384):216\u2013220. https:\/\/doi.org\/10.1038\/NATURE10821","journal-title":"Nature"},{"key":"3821_CR42","doi-asserted-by":"publisher","unstructured":"Jankowsky JL, and Zheng H (2017) Practical considerations for choosing a mouse model of Alzheimer\u2019s disease. Mol Neurodegener 12(1).\u00a0https:\/\/doi.org\/10.1186\/S13024-017-0231-7","DOI":"10.1186\/S13024-017-0231-7"},{"issue":"3","key":"3821_CR43","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1042\/EBC20200128","volume":"65","author":"S Jeon","year":"2021","unstructured":"Jeon S, Lee SH, Ahmed SB, Han J, Heo SJ, Kang HW (2021) 3D cell aggregate printing technology and its applications. Essays Biochem 65(3):467\u2013480. https:\/\/doi.org\/10.1042\/EBC20200128","journal-title":"Essays Biochem"},{"key":"3821_CR44","doi-asserted-by":"publisher","unstructured":"Jucker M (2010) The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nature Med 16(11):1210\u20131214. https:\/\/doi.org\/10.1038\/nm.2224","DOI":"10.1038\/nm.2224"},{"key":"3821_CR45","doi-asserted-by":"publisher","unstructured":"Van Kampen JM, Baranowski DC, Robertson HA, Shaw CA, Kay DG, and Lewis P (2015) The progressive BSSG rat model of Parkinson\u2019s: recapitulating multiple key features of the human disease. PloS One 10(10).\u00a0https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0139694","DOI":"10.1371\/JOURNAL.PONE.0139694"},{"key":"3821_CR46","doi-asserted-by":"publisher","unstructured":"Kasper C, Egger D, Senatov F, Raghunath M, Chariyev-Prinz F, Louit A, Galbraith T, and Berthod F (2023) In vitro 3D modeling of neurodegenerative diseases. Bioeng 10(1):93. https:\/\/doi.org\/10.3390\/BIOENGINEERING10010093","DOI":"10.3390\/BIOENGINEERING10010093"},{"issue":"1","key":"3821_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4161\/SPMG.19885","volume":"2","author":"G Kaur","year":"2012","unstructured":"Kaur G, Dufour JM (2012) Cell lines: valuable tools or useless artifacts. Spermatogenesis 2(1):1\u20135. https:\/\/doi.org\/10.4161\/SPMG.19885","journal-title":"Spermatogenesis"},{"key":"3821_CR48","doi-asserted-by":"publisher","unstructured":"Kehoe EG, McNulty JP, Mullins PG, Bokde ALW (2014) Advances in MRI biomarkers for the diagnosis of Alzheimer\u2019s disease. Biomark Med 8(9):1151\u20131169. https:\/\/doi.org\/10.2217\/BMM.14.42","DOI":"10.2217\/BMM.14.42"},{"issue":"6","key":"3821_CR49","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1016\/J.NEUROBIOLAGING.2015.03.002","volume":"36","author":"Y Komuro","year":"2015","unstructured":"Komuro Y, Xu G, Bhaskar K, Lamb BT (2015) Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiol Aging 36(6):2034\u20132042. https:\/\/doi.org\/10.1016\/J.NEUROBIOLAGING.2015.03.002","journal-title":"Neurobiol Aging"},{"issue":"1","key":"3821_CR50","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/JNR.24578","volume":"99","author":"F Kosel","year":"2021","unstructured":"Kosel F, Hamilton JS, Harrison SL, Godin V, Franklin TB (2021) Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice. J Neurosci Res 99(1):209\u2013222. https:\/\/doi.org\/10.1002\/JNR.24578","journal-title":"J Neurosci Res"},{"issue":"9","key":"3821_CR51","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3109\/1061186X.2015.1020809","volume":"23","author":"AD Kulkarni","year":"2015","unstructured":"Kulkarni AD, Vanjari YH, Sancheti KH, Belgamwar VS, Surana SJ, Pardeshi CV (2015) Nanotechnology-mediated nose to brain drug delivery for Parkinson\u2019s disease: a mini review. J Drug Target 23(9):775\u2013788. https:\/\/doi.org\/10.3109\/1061186X.2015.1020809","journal-title":"J Drug Target"},{"key":"3821_CR52","doi-asserted-by":"publisher","unstructured":"Kuttner-Hirshler Y, Venkatasubramanian PN, Apolinario J, Bonds J, Wyrwicz AM, Lazarov O (2017) Brain biomarkers in familial Alzheimer\u2019s disease mouse models. J Alzheimer\u2019s Dis: JAD 60(3):949\u2013958. https:\/\/doi.org\/10.3233\/JAD-170269","DOI":"10.3233\/JAD-170269"},{"issue":"7912","key":"3821_CR53","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/D41586-022-01502-8","volume":"606","author":"D Kwon","year":"2022","unstructured":"Kwon D (2022) Guardians of the brain: how a special immune system protects our grey matter. Nature 606(7912):22\u201324. https:\/\/doi.org\/10.1038\/D41586-022-01502-8","journal-title":"Nature"},{"issue":"15","key":"3821_CR54","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3390\/NU14153125\/S1","volume":"14","author":"D Lee","year":"2022","unstructured":"Lee D, Kim N, Jeon SH, Gee MS, Ju YJ, Jung MJ, Cho JS, Lee Y, Lee S, Lee JK (2022) Hesperidin improves memory function by enhancing neurogenesis in a mouse model of Alzheimer\u2019s disease. Nutrients 14(15):3125. https:\/\/doi.org\/10.3390\/NU14153125\/S1","journal-title":"Nutrients"},{"key":"3821_CR55","doi-asserted-by":"publisher","unstructured":"Lee DJ, Milosevic L, Gramer R, Sasikumar S, Al-Ozzi TM, De Vloo P, Dallapiazza RF, Elias GJB, Cohn M, Kalia SK, Hutchison WD, Fasano A, Lozano AM (2019) Nucleus basalis of Meynert neuronal activity in Parkinson\u2019s disease. J Neurosurg 132(2):574\u2013582. https:\/\/doi.org\/10.3171\/2018.11.JNS182386","DOI":"10.3171\/2018.11.JNS182386"},{"key":"3821_CR56","doi-asserted-by":"publisher","unstructured":"Lee KH, Lee DW, and Kang BC (2020) The \u201cR\u201d principles in laboratory animal experiments. Lab Animal Res 36(1). https:\/\/doi.org\/10.1186\/S42826-020-00078-6","DOI":"10.1186\/S42826-020-00078-6"},{"issue":"8","key":"3821_CR57","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1097\/WNR.0B013E32832B8BE4","volume":"20","author":"W Lee","year":"2009","unstructured":"Lee W, Pinckney J, Lee V, Lee JH, Fischer K, Polio S, Park JK, Yoo SS (2009) Three-dimensional bioprinting of rat embryonic neural cells. NeuroReport 20(8):798\u2013803. https:\/\/doi.org\/10.1097\/WNR.0B013E32832B8BE4","journal-title":"NeuroReport"},{"issue":"2","key":"3821_CR58","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/J.EXPNEUROL.2010.02.014","volume":"223","author":"YB Lee","year":"2010","unstructured":"Lee YB, Polio S, Lee W, Dai G, Menon L, Carroll RS, Yoo SS (2010) Bio-printing of collagen and VEGF-releasing fibrin gel scaffolds for neural stem cell culture. Exp Neurol 223(2):645\u2013652. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2010.02.014","journal-title":"Exp Neurol"},{"issue":"27","key":"3821_CR59","doi-asserted-by":"publisher","first-page":"9248","DOI":"10.1523\/JNEUROSCI.1731-12.2012","volume":"32","author":"X Lin","year":"2012","unstructured":"Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, Cai H (2012) Conditional expression of Parkinson\u2019s disease-related mutant \u03b1-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1. J Neurosci 32(27):9248\u20139264. https:\/\/doi.org\/10.1523\/JNEUROSCI.1731-12.2012","journal-title":"J Neurosci"},{"key":"3821_CR60","doi-asserted-by":"publisher","unstructured":"Low LA, and Tagle DA (2017) Organs-on-chips: progress, challenges, and future directions. Exp Biol Med 242(16):1573\u20131578.\u00a0\u00a0https:\/\/doi.org\/10.1177\/1535370217700523","DOI":"10.1177\/1535370217700523"},{"key":"3821_CR61","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/J.BIOMATERIALS.2015.07.022","volume":"67","author":"R Lozano","year":"2015","unstructured":"Lozano R, Stevens L, Thompson BC, Gilmore KJ, Gorkin R, Stewart EM, in het Panhuis, M., Romero-Ortega, M., & Wallace, G. G. (2015) 3D printing of layered brain-like structures using peptide modified gellan gum substrates. Biomaterials 67:264\u2013273. https:\/\/doi.org\/10.1016\/J.BIOMATERIALS.2015.07.022","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"3821_CR62","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0166-4328(01)00261-3","volume":"126","author":"HG L\u00fcesse","year":"2001","unstructured":"L\u00fcesse HG, Schiefer J, Spruenken A, Puls C, Block F, Kosinski CM (2001) Evaluation of R6\/2 HD transgenic mice for therapeutic studies in Huntington\u2019s disease: behavioral testing and impact of diabetes mellitus. Behav Brain Res 126(1\u20132):185\u2013195. https:\/\/doi.org\/10.1016\/S0166-4328(01)00261-3","journal-title":"Behav Brain Res"},{"issue":"Pt A","key":"3821_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.BRAINRES.2018.03.024","volume":"1693","author":"C Lutz","year":"2018","unstructured":"Lutz C (2018) Mouse models of ALS: past, present and future. Brain Res 1693(Pt A):1\u201310. https:\/\/doi.org\/10.1016\/J.BRAINRES.2018.03.024","journal-title":"Brain Res"},{"issue":"7","key":"3821_CR64","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/J.NANO.2012.02.009","volume":"8","author":"D Martinez-Fong","year":"2012","unstructured":"Martinez-Fong D, Bannon MJ, Trudeau LE, Gonzalez-Barrios JA, Arango-Rodriguez ML, Hernandez-Chan NG, Reyes-Corona D, Armend\u00e1riz-Borunda J, Navarro-Quiroga I (2012) NTS-polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson\u2019s disease. Nanomed Nanotechnol Biol Med 8(7):1052\u20131069. https:\/\/doi.org\/10.1016\/J.NANO.2012.02.009","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"8","key":"3821_CR65","doi-asserted-by":"publisher","first-page":"e1043","DOI":"10.1016\/S2214-109X(21)00214-X","volume":"9","author":"MM Mehndiratta","year":"2021","unstructured":"Mehndiratta MM, Aggarwal V (2021) Neurological disorders in India: past, present, and next steps. Lancet Glob Health 9(8):e1043\u2013e1044. https:\/\/doi.org\/10.1016\/S2214-109X(21)00214-X","journal-title":"Lancet Glob Health"},{"key":"3821_CR66","doi-asserted-by":"publisher","unstructured":"Menalled LB, Patry M, Ragland N, Lowden PAS, Goodman J, Minnich J, Zahasky B, Park L, Leeds J, Howland D, Signer E, Tobin AJ, Brunner D (2010) Comprehensive behavioral testing in the R6\/2 mouse model of Huntington\u2019s disease shows no benefit from CoQ10 or minocycline. PLOS ONE 5(3):e9793. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0009793","DOI":"10.1371\/JOURNAL.PONE.0009793"},{"issue":"1","key":"3821_CR67","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/CNE.10776","volume":"465","author":"LB Menalled","year":"2003","unstructured":"Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF (2003) Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington\u2019s disease with 140 CAG repeats. J Comp Neurol 465(1):11\u201326. https:\/\/doi.org\/10.1002\/CNE.10776","journal-title":"J Comp Neurol"},{"key":"3821_CR68","doi-asserted-by":"publisher","unstructured":"Mustapha M, and Taib CNM (2021) MPTP-induced mouse model of Parkinson\u2019s disease: a promising direction of therapeutic strategies. Bosnian J Basic Med Sci 21(4):422\u2013433. https:\/\/doi.org\/10.17305\/BJBMS.2020.5181","DOI":"10.17305\/BJBMS.2020.5181"},{"key":"3821_CR69","doi-asserted-by":"publisher","unstructured":"Nadella R, Voutilainen MH, Saarma M, Gonzalez-Barrios JA, Leon-Chavez BA, Jimnez, J DM, Jimnez SDH, Escobedo L, and Martinez-Fong D (2014) Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. J Neuroinflammation 11(1). https:\/\/doi.org\/10.1186\/S12974-014-0209-0","DOI":"10.1186\/S12974-014-0209-0"},{"issue":"4","key":"3821_CR70","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/J.JBIOSC.2012.05.009","volume":"114","author":"K Nagai","year":"2012","unstructured":"Nagai K (2012) Bovine milk phospholipid fraction protects Neuro2a cells from endoplasmic reticulum stress via PKC activation and autophagy. J Biosci Bioeng 114(4):466\u2013471. https:\/\/doi.org\/10.1016\/J.JBIOSC.2012.05.009","journal-title":"J Biosci Bioeng"},{"issue":"2","key":"3821_CR71","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1254\/JPHS.13019FP","volume":"122","author":"QA Nazari","year":"2013","unstructured":"Nazari QA, Kume T, Takada-Takatori Y, Izumi Y, Akaike A (2013) Protective effect of luteolin on an oxidative-stress model induced by microinjection of sodium nitroprusside in mice. J Pharmacol Sci 122(2):109\u2013117. https:\/\/doi.org\/10.1254\/JPHS.13019FP","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"3821_CR72","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1254\/JPHS.12143FP","volume":"120","author":"QA Nazari","year":"2012","unstructured":"Nazari QA, Mizuno K, Kume T, Takada-Takatori Y, Izumi Y, Akaike A (2012) In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice. J Pharmacol Sci 120(2):105\u2013111. https:\/\/doi.org\/10.1254\/JPHS.12143FP","journal-title":"J Pharmacol Sci"},{"issue":"8","key":"3821_CR73","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/0024-3205(87)90299-2","volume":"40","author":"WJ Nicklas","year":"1987","unstructured":"Nicklas WJ, Youngster SK, Kindt MV, Heikkila RE (1987) MPTP, MPP+ and mitochondrial function. Life Sci 40(8):721\u2013729. https:\/\/doi.org\/10.1016\/0024-3205(87)90299-2","journal-title":"Life Sci"},{"key":"3821_CR74","doi-asserted-by":"publisher","unstructured":"Niu M, Zhao F, Bondelid K, Siedlak S L, Torres S, Fujioka H, Wang W, Liu J, and Zhu X (2021) VPS35 D620N knockin mice recapitulate cardinal features of Parkinson\u2019s disease. Aging Cell 20(5):e13347. https:\/\/doi.org\/10.1111\/ACEL.13347","DOI":"10.1111\/ACEL.13347"},{"issue":"3","key":"3821_CR75","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular A\u03b2 and synaptic dysfunction. Neuron 39(3):409\u2013421. https:\/\/doi.org\/10.1016\/S0896-6273(03)00434-3","journal-title":"Neuron"},{"key":"3821_CR76","doi-asserted-by":"publisher","unstructured":"Olanow C W, Kieburtz K, and Schapira AHV (2008) Why have we failed to achieve neuroprotection in Parkinson\u2019s disease? Annals Neurol 64(SUPPL. 2).\u00a0https:\/\/doi.org\/10.1002\/ANA.21461","DOI":"10.1002\/ANA.21461"},{"key":"3821_CR77","doi-asserted-by":"publisher","unstructured":"Osaki T, Uzel SGM, and Kamm RD (2018) Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons. Sci Adv 4(10). https:\/\/doi.org\/10.1126\/SCIADV.AAT5847","DOI":"10.1126\/SCIADV.AAT5847"},{"issue":"4","key":"3821_CR78","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/S12035-019-01847-8","volume":"57","author":"E Paldino","year":"2020","unstructured":"Paldino E, Balducci C, La Vitola P, Artioli L, D\u2019Angelo V, Giamp\u00e0 C, Artuso V, Forloni G, Fusco FR (2020) Neuroprotective effects of doxycycline in the R6\/2 mouse model of Huntington\u2019s disease. Mol Neurobiol 57(4):1889\u20131903. https:\/\/doi.org\/10.1007\/S12035-019-01847-8","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3821_CR79","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/1566523214666140120121733","volume":"14","author":"J Pardo","year":"2014","unstructured":"Pardo J, Morel G, Astiz M, Schwerdt J, Leon M, Rodriguez S, Herenu C, Goya R (2014) Gene therapy and cell reprogramming for the aging brain: achievements and promise. Curr Gene Ther 14(1):24\u201334. https:\/\/doi.org\/10.2174\/1566523214666140120121733","journal-title":"Curr Gene Ther"},{"issue":"5","key":"3821_CR80","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/J.CELL.2008.07.041","volume":"134","author":"IH Park","year":"2008","unstructured":"Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ (2008a) Disease-specific induced pluripotent stem cells. Cell 134(5):877\u2013886. https:\/\/doi.org\/10.1016\/J.CELL.2008.07.041","journal-title":"Cell"},{"issue":"7175","key":"3821_CR81","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nature06534","volume":"451","author":"IH Park","year":"2008","unstructured":"Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ (2008b) Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451(7175):141\u2013146. https:\/\/doi.org\/10.1038\/nature06534","journal-title":"Nature"},{"key":"3821_CR82","doi-asserted-by":"publisher","unstructured":"Park J, Wetzel I, Marriott I, Dr\u00e9au D, D\u2019Avanzo C, Kim DY, Tanzi RE, and Cho H (2018) A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer\u2019s disease. Nature Neurosci 21(7):941\u2013951.\u00a0https:\/\/doi.org\/10.1038\/s41593-018-0175-4","DOI":"10.1038\/s41593-018-0175-4"},{"issue":"1","key":"3821_CR83","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/EMPH\/EOW014","volume":"2016","author":"RL Perlman","year":"2016","unstructured":"Perlman RL (2016) Mouse models of human disease: an evolutionary perspective. Evolution, Medicine, and Public Health 2016(1):170. https:\/\/doi.org\/10.1093\/EMPH\/EOW014","journal-title":"Evolution, Medicine, and Public Health"},{"issue":"6","key":"3821_CR84","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/14737175.2016.1176531","volume":"16","author":"S Pfeuffer","year":"2016","unstructured":"Pfeuffer S, Ruck T, Kleinschnitz C, Wiendl H, Meuth SG (2016) Failed, interrupted and inconclusive trials on relapsing multiple sclerosis treatment: update 2010\u20132015. Expert Rev Neurother 16(6):689\u2013700. https:\/\/doi.org\/10.1080\/14737175.2016.1176531","journal-title":"Expert Rev Neurother"},{"key":"3821_CR85","doi-asserted-by":"publisher","unstructured":"Razgado-Hernandez LF, Espadas-Alvarez AJ, Reyna-Velazquez P, Sierra-Sanchez A, Anaya-Martinez V, Jimenez-Estrada I, Bannon MJ, Martinez-Fong D, and Aceves-Ruiz J (2015) The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson\u2019s disease. PloS One 10(2).\u00a0https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0117391","DOI":"10.1371\/JOURNAL.PONE.0117391"},{"key":"3821_CR86","doi-asserted-by":"publisher","unstructured":"Renner M, Lancaster MA, Bian S, Choi H, Ku T, Peer A, Chung K, and Knoblich JA (2017) Self-organized developmental patterning and differentiation in cerebral organoids. The EMBO J 36(10):1316\u20131329. https:\/\/doi.org\/10.15252\/EMBJ.201694700","DOI":"10.15252\/EMBJ.201694700"},{"key":"3821_CR87","doi-asserted-by":"publisher","unstructured":"Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, Bezprozvanny I (2017) The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol Dis 97(Pt A):46\u201359. https:\/\/doi.org\/10.1016\/J.NBD.2016.10.006","DOI":"10.1016\/J.NBD.2016.10.006"},{"key":"3821_CR88","doi-asserted-by":"publisher","unstructured":"Sampson TR, Challis C, Jain N, Moiseyenko A, Ladinsky MS, Shastri GG, Thron T, Needham BD, Horvath I, Debelius JW, Janssen S, Knight R, Wittung-Stafshede P, Gradinaru V, Chapman M, Mazmanian SK (2020) A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice. ELife 9. https:\/\/doi.org\/10.7554\/ELIFE.53111","DOI":"10.7554\/ELIFE.53111"},{"issue":"3","key":"3821_CR89","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/JOIM.12191","volume":"275","author":"LS Schneider","year":"2014","unstructured":"Schneider LS, Mangialasche F, Andreasen N, Feldman H, Giacobini E, Jones R, Mantua V, Mecocci P, Pani L, Winblad B, Kivipelto M (2014) Clinical trials and late-stage drug development for Alzheimer\u2019s disease: an appraisal from 1984 to 2014. J Intern Med 275(3):251\u2013283. https:\/\/doi.org\/10.1111\/JOIM.12191","journal-title":"J Intern Med"},{"key":"3821_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.PNEUROBIO.2013.04.001","volume":"106\u2013107","author":"BD Semple","year":"2013","unstructured":"Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ (2013) Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol 106\u2013107:1\u201316. https:\/\/doi.org\/10.1016\/J.PNEUROBIO.2013.04.001","journal-title":"Prog Neurobiol"},{"key":"3821_CR91","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/J.ACTBIO.2016.12.048","volume":"54","author":"MA Sheikh","year":"2017","unstructured":"Sheikh MA, Malik YS, Xing Z, Guo Z, Tian H, Zhu X, Chen X (2017) Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinson\u2019s disease (PD). Acta Biomater 54:58\u201368. https:\/\/doi.org\/10.1016\/J.ACTBIO.2016.12.048","journal-title":"Acta Biomater"},{"key":"3821_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/563481","volume":"2013","author":"S Sheikh","year":"2013","unstructured":"Sheikh S, Ejazul H, Mir SS (2013) Neurodegenerative diseases: multifactorial conformational diseases and their therapeutic interventions. J Neurodegener Dis 2013:1\u20138. https:\/\/doi.org\/10.1155\/2013\/563481","journal-title":"Journal of Neurodegenerative Diseases"},{"key":"3821_CR93","doi-asserted-by":"publisher","unstructured":"Shimoke K, Sasaya H, and Ikeuchi T (2011) Analysis of the role of nerve growth factor in promoting cell survival during endoplasmic reticulum stress in PC12 cells. Meth Enzymol 490(C)53\u201370. https:\/\/doi.org\/10.1016\/B978-0-12-385114-7.00003-9","DOI":"10.1016\/B978-0-12-385114-7.00003-9"},{"issue":"20","key":"3821_CR94","doi-asserted-by":"publisher","first-page":"1900962","DOI":"10.1002\/ADVS.201900962","volume":"6","author":"Y Shin","year":"2019","unstructured":"Shin Y, Choi SH, Kim E, Bylykbashi E, Kim JA, Chung S, Kim DY, Kamm RD, Tanzi RE (2019) Blood\u2013brain barrier dysfunction in a 3d in vitro model of Alzheimer\u2019s disease. Adv Sci 6(20):1900962. https:\/\/doi.org\/10.1002\/ADVS.201900962","journal-title":"Advanced Science"},{"issue":"3","key":"3821_CR95","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/S10439-014-1207-1","volume":"43","author":"A Skardal","year":"2015","unstructured":"Skardal A, Atala A (2015) Biomaterials for integration with 3-D bioprinting. Ann Biomed Eng 43(3):730\u2013746. https:\/\/doi.org\/10.1007\/S10439-014-1207-1","journal-title":"Ann Biomed Eng"},{"key":"3821_CR96","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/FCELL.2020.00328\/BIBTEX","volume":"8","author":"A Slanzi","year":"2020","unstructured":"Slanzi A, Iannoto G, Rossi B, Zenaro E, Constantin G (2020) In vitro models of neurodegenerative diseases. Front Cell Dev Biol 8:328.\u00a0https:\/\/doi.org\/10.3389\/FCELL.2020.00328\/BIBTEX","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"7","key":"3821_CR97","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/NAN.12396","volume":"43","author":"MY Son","year":"2017","unstructured":"Son MY, Sim H, Son YS, Jung KB, Lee MO, Oh JH, Chung SK, Jung CR, Kim J (2017) Distinctive genomic signature of neural and intestinal organoids from familial Parkinson\u2019s disease patient-derived induced pluripotent stem cells. Neuropathol Appl Neurobiol 43(7):584\u2013603. https:\/\/doi.org\/10.1111\/NAN.12396","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3821_CR98","doi-asserted-by":"publisher","unstructured":"Song L, Yuan X, Jones Z, Griffin K, Zhou Y, Ma T, and Li Y (2019) Assembly of human stem cell-derived cortical spheroids and vascular spheroids to model 3-D brain-like tissues. Sci Rep 9(1). https:\/\/doi.org\/10.1038\/S41598-019-42439-9","DOI":"10.1038\/S41598-019-42439-9"},{"key":"3821_CR99","doi-asserted-by":"publisher","unstructured":"Sullivan MA, Lane SD, Volkerling A, Engel M, Werry EL, Kassiou M, and Werry E (2022) 3D bioprinting of stem cell-derived central nervous system cells enables astrocyte growth, vasculogenesis and enhances neural differentiation\/function. BioRxiv 11(13):516338. https:\/\/doi.org\/10.1101\/2022.11.13.516338","DOI":"10.1101\/2022.11.13.516338"},{"issue":"Pt 9","key":"3821_CR100","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1093\/BRAIN\/AWR159","volume":"134","author":"V Swarup","year":"2011","unstructured":"Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP (2011) Pathological hallmarks of amyotrophic lateral sclerosis\/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain\u202fJ Neurol 134(Pt 9):2610\u20132626. https:\/\/doi.org\/10.1093\/BRAIN\/AWR159","journal-title":"Brain : A Journal of Neurology"},{"issue":"5","key":"3821_CR101","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/J.CELL.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861\u2013872. https:\/\/doi.org\/10.1016\/J.CELL.2007.11.019","journal-title":"Cell"},{"key":"3821_CR102","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/272630","author":"EK Tan","year":"2015","unstructured":"Tan EK, Srivastava AK, Arnold WD, Singh MP, Zhang Y (2015) Neurodegeneration: etiologies and new therapies. BioMed Res Int. https:\/\/doi.org\/10.1155\/2015\/272630","journal-title":"In BioMed Research International"},{"key":"3821_CR103","doi-asserted-by":"publisher","unstructured":"Tang M, Rich JN, and Chen S (2021) Biomaterials and 3D bioprinting strategies to model glioblastoma and the blood-brain barrier. Adv Mater 33(5).\u00a0https:\/\/doi.org\/10.1002\/ADMA.202004776","DOI":"10.1002\/ADMA.202004776"},{"key":"3821_CR104","doi-asserted-by":"publisher","unstructured":"Tankersley CG, Haenggeli C, Rothstein JD (2007) Respiratory impairment in a mouse model of amyotrophic lateral sclerosis. J Appl Physiol (Bethesda Md.: 1985) 102(3):926\u2013932. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00193.2006","DOI":"10.1152\/JAPPLPHYSIOL.00193.2006"},{"issue":"4","key":"3821_CR105","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1089\/BRAIN.2011.0055","volume":"1","author":"QK Telesford","year":"2011","unstructured":"Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ (2011) The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect 1(4):295\u2013308. https:\/\/doi.org\/10.1089\/BRAIN.2011.0055","journal-title":"Brain Connectivity"},{"key":"3821_CR106","doi-asserted-by":"publisher","unstructured":"Teli, P., Kale, V., & Vaidya, A. (2022). Mesenchymal stromal cells-derived secretome protects Neuro-2a cells from oxidative stress-induced loss of neurogenesis. Exp Neurol 354:114107.\u00a0https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2022.114107","DOI":"10.1016\/J.EXPNEUROL.2022.114107"},{"issue":"4","key":"3821_CR107","doi-asserted-by":"publisher","first-page":"329","DOI":"10.2217\/RME-2022-0201","volume":"18","author":"P Teli","year":"2023","unstructured":"Teli P, Nachanekar A, Kale V, Vaidya A (2023) Priming mesenchymal stromal cells with neurotrophic factors boosts the neuro-regenerative potential of their secretome. Regen Med 18(4):329\u2013346. https:\/\/doi.org\/10.2217\/RME-2022-0201","journal-title":"Regen Med"},{"key":"3821_CR108","doi-asserted-by":"publisher","unstructured":"Thomas, M., & Willerth, S. M. (2017). 3-D bioprinting of neural tissue for applications in cell therapy and drug screening. Front Bioeng Biotechnol 5(NOV):69. https:\/\/doi.org\/10.3389\/FBIOE.2017.00069\/BIBTEX","DOI":"10.3389\/FBIOE.2017.00069\/BIBTEX"},{"issue":"7","key":"3821_CR109","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1073\/PNAS.93.7.3155","volume":"93","author":"PH Tu","year":"1996","unstructured":"Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VMY (1996) Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci USA 93(7):3155\u20133160. https:\/\/doi.org\/10.1073\/PNAS.93.7.3155","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"3821_CR110","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/S40139-015-0086-Y","volume":"3","author":"EW Uhl","year":"2015","unstructured":"Uhl EW, Warner NJ (2015) Mouse models as predictors of human responses: evolutionary medicine. Curr Pathobiol Rep 3(3):219\u2013223.\u00a0https:\/\/doi.org\/10.1007\/S40139-015-0086-Y","journal-title":"Current Pathobiology Reports"},{"key":"3821_CR111","doi-asserted-by":"publisher","unstructured":"Wareham LK, Liddelow SA, Temple S, Benowitz LI, di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre, A la, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Calkins DJ (2022) Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener 17(1). https:\/\/doi.org\/10.1186\/S13024-022-00524-0","DOI":"10.1186\/S13024-022-00524-0"},{"key":"3821_CR112","doi-asserted-by":"publisher","unstructured":"Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Lander ES (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915):520\u2013562. https:\/\/doi.org\/10.1038\/NATURE01262","DOI":"10.1038\/NATURE01262"},{"key":"3821_CR113","doi-asserted-by":"publisher","unstructured":"West T, Hu Y, Verghese PB, Bateman RJ, Braunstein JB, Fogelman I, Budur K, Florian H, Mendonca N, Holtzman DM (2017) Preclinical and clinical development of ABBV-8E12 a humanized anti-tau antibody for treatment of Alzheimer\u2019s disease and other tauopathies. J Prev Alzheimer\u2019s Dis 4(4):236\u2013241. https:\/\/doi.org\/10.14283\/JPAD.2017.36","DOI":"10.14283\/JPAD.2017.36"},{"key":"3821_CR114","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.19","volume-title":"Global burden of neurological disorders estimates and projections","author":"Who.","year":"2008","unstructured":"Who. (2008) Global burden of neurological disorders estimates and projections. Public Health Challenges, Neurol Disord\u00a0https:\/\/doi.org\/10.1001\/archneurol.2007.19"},{"issue":"7","key":"3821_CR115","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1136\/JNNP-2015-312036","volume":"87","author":"B Xiao","year":"2016","unstructured":"Xiao B, Hui Ng H, Takahashi R, Tan EK (2016) Induced pluripotent stem cells in Parkinson\u2019s disease: scientific and clinical challenges. J Neurol Neurosurg Psychiatry 87(7):697\u2013702. https:\/\/doi.org\/10.1136\/JNNP-2015-312036","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"3821_CR116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13024-017-0149-0\/TABLES\/4","volume":"12","author":"H Xicoy","year":"2017","unstructured":"Xicoy H, Wieringa B, Martens GJM (2017) The SH-SY5Y cell line in Parkinson\u2019s disease research: a systematic review. Mol Neurodegener 12(1):1\u201311. https:\/\/doi.org\/10.1186\/S13024-017-0149-0\/TABLES\/4","journal-title":"Mol Neurodegener"},{"issue":"23","key":"3821_CR117","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1093\/HMG\/DDR394","volume":"20","author":"T Yagi","year":"2011","unstructured":"Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N (2011) Modeling familial Alzheimer\u2019s disease with induced pluripotent stem cells. Hum Mol Genet 20(23):4530\u20134539. https:\/\/doi.org\/10.1093\/HMG\/DDR394","journal-title":"Hum Mol Genet"},{"key":"3821_CR118","doi-asserted-by":"publisher","unstructured":"Yanamandra K, Jiang H, Mahan TE, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM (2015) Anti-tau antibody reduces insoluble tau and decreases brain atrophy. Ann Clin Transl Neurol 2(3):278\u2013288. https:\/\/doi.org\/10.1002\/ACN3.176","DOI":"10.1002\/ACN3.176"},{"key":"3821_CR119","doi-asserted-by":"crossref","unstructured":"Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM (2013) Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 80(2):402\u2013414. https:\/\/doi.org\/10.1016\/J.NEURON.2013.07.046","DOI":"10.1016\/j.neuron.2013.07.046"},{"key":"3821_CR120","doi-asserted-by":"publisher","unstructured":"Yang Q, Jiao B, Shen L (2020) The development of C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia disorders. Front Genet 11:1045. https:\/\/doi.org\/10.3389\/FGENE.2020.562758\/BIBTEX","DOI":"10.3389\/FGENE.2020.562758\/BIBTEX"},{"issue":"9","key":"3821_CR121","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/NRN.2017.85","volume":"18","author":"H Zeng","year":"2017","unstructured":"Zeng H, Sanes JR (2017) Neuronal cell-type classification: challenges, opportunities and the path forward. Nat Rev Neurosci 18(9):530\u2013546. https:\/\/doi.org\/10.1038\/NRN.2017.85","journal-title":"Nat Rev Neurosci"},{"key":"3821_CR122","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/J.EXGER.2017.01.010","volume":"89","author":"J Zhang","year":"2017","unstructured":"Zhang J, Cai Q, Jiang M, Liu Y, Gu H, Guo J, Sun H, Fang J, Jin L (2017) Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK\/mTOR mediated autophagic inhibition. Exp Gerontol 89:45\u201356. https:\/\/doi.org\/10.1016\/J.EXGER.2017.01.010","journal-title":"Exp Gerontol"},{"key":"3821_CR123","doi-asserted-by":"publisher","unstructured":"Zhang X, Feng ZJ, Chergui K (2014) Allosteric modulation of GluN2C\/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson\u2019s disease. Br J Pharmacol 171(16):3938\u20133945. https:\/\/doi.org\/10.1111\/BPH.12758","DOI":"10.1111\/BPH.12758"},{"key":"3821_CR124","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bioactmat.2021.09.023","volume":"11","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Chen H, Long X, Xu T (2022) Three-dimensional-engineered bioprinted in vitro human neural stem cell self-assembling culture model constructs of Alzheimer\u2019s disease. Bioactive Materials 11:192\u2013205. https:\/\/doi.org\/10.1016\/j.bioactmat.2021.09.023","journal-title":"Bioactive Materials"},{"issue":"5","key":"3821_CR125","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","volume":"163","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of the blood-brain barrier. Cell 163(5):1064\u20131078. https:\/\/doi.org\/10.1016\/j.cell.2015.10.067","journal-title":"Cell"},{"key":"3821_CR126","doi-asserted-by":"publisher","unstructured":"Zhu F, Nair RR, Fisher EMC, and Cunningham TJ (2019) Humanising the mouse genome piece by piece. Nature Commun 10(1). https:\/\/doi.org\/10.1038\/S41467-019-09716-7","DOI":"10.1038\/S41467-019-09716-7"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-023-03821-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-023-03821-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-023-03821-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:06:26Z","timestamp":1696590386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-023-03821-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,12]]},"references-count":126,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["3821"],"URL":"https:\/\/doi.org\/10.1007\/s00441-023-03821-2","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,12]]},"assertion":[{"value":"15 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}