{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:25:22Z","timestamp":1790357122649,"version":"4.1.0"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pannexin (Panx)-1-mediated ATP release has been associated with a broad range of pathological conditions. Conversely, the use of Panx1-inhibitors has shown promising results in the medication of diseases, such as neuroinflammation, melanoma and epilepsy. In addition, Panx1-inhibitors are an indispensable tool for the elucidation of both structure and physiology of Panx1. Over the past years, numerous applications of Panx1-inhibitors have led to new insights into Panx1 influences in health and disease. The major drawback of conventional Panx1-inhibitors, however, is the lack of selectivity resulting in undesired side effects. Nevertheless, these inhibitors are useful resources for drug discovery and lead optimisation approaches have therefore found their way into Panx1 research. Newly developed inhibitors show both high efficacy and selectivity. The combination of drug development and molecular dynamics simulations is a powerful tool to further elucidate both structure and gating mechanisms of Panx1.<\/jats:p>","DOI":"10.1007\/s00441-025-04038-1","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:27:52Z","timestamp":1768537672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Panx1 and drug discovery: from non-specific inhibitors to tailored drug compounds"],"prefix":"10.1007","volume":"403","author":[{"given":"Michael","family":"Kohr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"4038_CR1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41467-025-55936-5","volume":"16","author":"N Abdel Wadood","year":"2025","unstructured":"Abdel Wadood N, Hollenhorst MI, Elhawy MI, Zhao N, Englisch C, Evers SB, Sabachvili M, Maxeiner S, Wyatt A, Herr C, Burkhart A-K, Krause E, Yildiz D, Beckmann A, Kusumakshi S, Riethmacher D, Bischoff M, Iden S, Becker SL, Canning BJ, Flockerzi V, Gudermann T, Chubanov V, Bals R, Meier C, Boehm U, Krasteva-Christ G (2025) Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia. Nat Commun 16:584","journal-title":"Nat Commun"},{"key":"4038_CR2","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1242\/jcs.175968","volume":"128","author":"M Adamczyk","year":"2015","unstructured":"Adamczyk M, Griffiths R, Dewitt S, Kn\u00e4uper V, Aeschlimann D (2015) P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. J Cell Sci 128:4615\u20134628","journal-title":"J Cell Sci"},{"key":"4038_CR3","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15652","volume":"11","author":"SN Arkhipov","year":"2023","unstructured":"Arkhipov SN, Potter DL, Sultanova RF, Ilatovskaya DV, Harris PC, Pavlov TS (2023) Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease. Physiol Rep 11:e15652","journal-title":"Physiol Rep"},{"key":"4038_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2165\/00002018-199921050-00005","volume":"21","author":"P Ball","year":"1999","unstructured":"Ball P, Mandell L, Niki Y, Tillotson G (1999) Comparative tolerability of the newer fluoroquinolone antibacterials. Drug Saf 21:407\u2013421","journal-title":"Drug Saf"},{"key":"4038_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neulet.2007.08.035","volume":"425","author":"S Bang","year":"2007","unstructured":"Bang S, Kim KY, Yoo S, Lee S-H, Hwang SW (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425:120\u2013125","journal-title":"Neurosci Lett"},{"key":"4038_CR6","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ygeno.2003.09.025","volume":"83","author":"A Baranova","year":"2004","unstructured":"Baranova A, Ivanov D, Petrash N, Pestova A, Skoblov M, Kelmanson I, Shagin D, Nazarenko S, Geraymovych E, Litvin O, Tiunova A, Born TL, Usman N, Staroverov D, Lukyanov S, Panchin Y (2004) The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 83:706\u2013716","journal-title":"Genomics"},{"key":"4038_CR7","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1113\/jphysiol.2014.283119","volume":"593","author":"JM Beckel","year":"2015","unstructured":"Beckel JM, Daugherty SL, Tyagi P, Wolf\u2010Johnston AS, Birder LA, Mitchell CH, De Groat WC (2015) Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder. J Physiol 593:1857\u20131871","journal-title":"J Physiol"},{"key":"4038_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00441-015-2281-x","volume":"363","author":"A Beckmann","year":"2016","unstructured":"Beckmann A, Grissmer A, Krause E, Tschernig T, Meier C (2016) Pannexin-1 channels show distinct morphology and no gap junction characteristics in mammalian cells. Cell Tissue Res 363:751\u2013763","journal-title":"Cell Tissue Res"},{"key":"4038_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093058","volume":"9","author":"A Bhaskaracharya","year":"2014","unstructured":"Bhaskaracharya A, Dao-Ung P, Jalilian I, Spildrejorde M, Skarratt KK, Fuller SJ, Sluyter R, Stokes L (2014) Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS ONE 9:e93058","journal-title":"PLoS ONE"},{"key":"4038_CR10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1523\/JNEUROSCI.0257-19.2019","volume":"40","author":"J Bialecki","year":"2020","unstructured":"Bialecki J, Werner A, Weilinger NL, Tucker CM, Vecchiarelli HA, Ega\u00f1a J, Mendizabal-Zubiaga J, Grandes P, Hill MN, Thompson RJ (2020) Suppression of presynaptic glutamate release by postsynaptic metabotropic NMDA receptor signalling to pannexin-1. J Neurosci 40:729\u2013742","journal-title":"J Neurosci"},{"key":"4038_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005824","volume":"8","author":"M Billaud","year":"2015","unstructured":"Billaud M, Chiu Y-H, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE (2015) A molecular signature in the pannexin1 intracellular loop confers channel activation by the a1 adrenoreceptor in smooth muscle cells. Sci Signal 8:ra17","journal-title":"Sci Signal"},{"key":"4038_CR12","doi-asserted-by":"publisher","first-page":"31733","DOI":"10.1074\/jbc.M702422200","volume":"282","author":"D Boassa","year":"2007","unstructured":"Boassa D, Ambrosi C, Qiu F, Dahl G, Gaietta G, Sosinsky G (2007) Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem 282:31733\u201331743","journal-title":"J Biol Chem"},{"key":"4038_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1572418","volume":"12","author":"FJ Bravo","year":"2025","unstructured":"Bravo FJ, Mena J, Mej\u00eda Reyes \u00c1, Sch\u00e4fer C, N\u00fa\u00f1ez-Rojas N, Blamey-Fredes C, Acu\u00f1a-Castillo C, Barrera-Avalos C (2025) The impact of Panx1 on inflammation, immunity, and cancer: a comprehensive review. Front Med 12:1572418","journal-title":"Front Med"},{"key":"4038_CR14","doi-asserted-by":"publisher","first-page":"13644","DOI":"10.1073\/pnas.2233464100","volume":"100","author":"R Bruzzone","year":"2003","unstructured":"Bruzzone R, Hormuzdi SG, Barbe MT, Herb A, Monyer H (2003) Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci 100:13644\u201313649","journal-title":"Proc Natl Acad Sci"},{"key":"4038_CR15","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1471-4159.2004.02947.x","volume":"92","author":"R Bruzzone","year":"2005","unstructured":"Bruzzone R, Barbe MT, Jakob NJ, Monyer H (2005) Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 92:1033\u20131043","journal-title":"J Neurochem"},{"key":"4038_CR16","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1021\/acschemneuro.3c00217","volume":"14","author":"F Bu","year":"2023","unstructured":"Bu F, Li Y, Lan S, Yang T, He B, Dong P, Shen F, Cai H, Lu Y, Fei Y, Xu L, Qin X (2023) Blocking pannexin-1 channels alleviates thalamic hemorrhage-induced pain and inflammatory depolarization of microglia in mice. ACS Chem Neurosci 14:2548\u20132559","journal-title":"ACS Chem Neurosci"},{"key":"4038_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1172\/JCI102482","volume":"30","author":"JM Burnell","year":"1951","unstructured":"Burnell JM, Kirby WMM (1951) Effectiveness of a new compound, benemid, in elevating serum penicillin concentrations. J Clin Invest 30:697\u2013700","journal-title":"J Clin Invest"},{"key":"4038_CR18","doi-asserted-by":"publisher","first-page":"106612","DOI":"10.1016\/j.bioorg.2023.106612","volume":"138","author":"A Caufriez","year":"2023","unstructured":"Caufriez A, Lamouroux A, Martin C, Iaculli D, Ince Erg\u00fc\u00e7 E, Gozalbes R, Mayan MD, Kwak BR, Tabernilla A, Vinken M, Ballet S (2023) Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1. Bioorg Chem 138:106612","journal-title":"Bioorg Chem"},{"key":"4038_CR19","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1038\/s41593-024-01680-w","volume":"27","author":"Y Chen","year":"2024","unstructured":"Chen Y, Luan P, Liu J, Wei Y, Wang C, Wu R, Wu Z, Jing M (2024) Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. Nat Neurosci 27:1522\u20131533","journal-title":"Nat Neurosci"},{"key":"4038_CR20","doi-asserted-by":"publisher","first-page":"113650","DOI":"10.1016\/j.ejmech.2021.113650","volume":"223","author":"L Crocetti","year":"2021","unstructured":"Crocetti L, Guerrini G, Puglioli S, Giovannoni MP, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Wang J, Dahl G (2021) Design and synthesis of the first indole-based blockers of Panx-1 channel. Eur J Med Chem 223:113650","journal-title":"Eur J Med Chem"},{"key":"4038_CR21","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.3390\/ijms23094827","volume":"23","author":"L Crocetti","year":"2022","unstructured":"Crocetti L, Guerrini G, Giovannoni MP, Melani F, Lamanna S, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Wang J, Dahl G (2022) New Panx-1 blockers: synthesis, biological evaluation and molecular dynamic studies. Int J Mol Sci 23:4827","journal-title":"Int J Mol Sci"},{"key":"4038_CR22","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.3390\/ijms24032022","volume":"24","author":"L Crocetti","year":"2023","unstructured":"Crocetti L, Giovannoni MP, Guerrini G, Lamanna S, Melani F, Bartolucci G, Pallecchi M, Paoli P, Lippi M, Wang J, Dahl G (2023) Design, synthesis and pharmacological evaluation of new quinoline-based Panx-1 channel blockers. Int J Mol Sci 24:2022","journal-title":"Int J Mol Sci"},{"key":"4038_CR23","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.3390\/molecules30102171","volume":"30","author":"L Crocetti","year":"2025","unstructured":"Crocetti L, Giovannoni MP, Pavlov TS, Ivanov V, Melani F, Guerrini G (2025) Synthesis of 3-carboxy-6-sulfamoylquinolones and mefloquine-based compounds as Panx1 blockers: molecular docking, electrophysiological and cell culture studies. Molecules 30:2171","journal-title":"Molecules"},{"key":"4038_CR24","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.neuropharm.2013.02.019","volume":"75","author":"G Dahl","year":"2013","unstructured":"Dahl G, Qiu F, Wang J (2013) The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology 75:583\u2013593","journal-title":"Neuropharmacology"},{"key":"4038_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01628-8","volume":"24","author":"A Dehghani","year":"2023","unstructured":"Dehghani A, Schenke M, Van Heiningen SH, Karatas H, Tolner EA, Van Den Maagdenberg AMJM (2023) Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice. J Headache Pain 24:96","journal-title":"J Headache Pain"},{"key":"4038_CR26","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.kint.2020.04.041","volume":"98","author":"LJ DeLalio","year":"2020","unstructured":"DeLalio LJ, Masati E, Mendu S, Ruddiman CA, Yang Y, Johnstone SR, Milstein JA, Keller TCS, Weaver RB, Guagliardo NA, Best AK, Ravichandran KS, Bayliss DA, Sequeira-Lopez MLS, Sonkusare SN, Shu XH, Desai B, Barrett PQ, Le TH, Gomez RA, Isakson BE (2020) Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. Kidney Int 98:630\u2013644","journal-title":"Kidney Int"},{"key":"4038_CR27","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1080\/cac.10.4-6.335.340","volume":"10","author":"R Dermietzel","year":"2003","unstructured":"Dermietzel R, Meier C, Bukauskas F, Spray DC (2003) Following tracks of hemichannels. Cell Commun Adhes 10:335\u2013340","journal-title":"Cell Commun Adhes"},{"key":"4038_CR28","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/nmo.12541","volume":"27","author":"EF Diezmos","year":"2015","unstructured":"Diezmos EF, Sandow SL, Perera DS, King DW, Bertrand PP, Liu L (2015) Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system. Neurogastroenterol Motil 27:672\u2013683","journal-title":"Neurogastroenterol Motil"},{"key":"4038_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28455-w","volume":"13","author":"I Drulyte","year":"2023","unstructured":"Drulyte I, Gutgsell AR, Lloris-Garcer\u00e1 P, Liss M, Geschwindner S, Radjainia M, Frauenfeld J, L\u00f6ving R (2023) Direct cell extraction of membrane proteins for structure\u2013function analysis. Sci Rep 13:1420","journal-title":"Sci Rep"},{"key":"4038_CR30","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1161\/HYPERTENSIONAHA.122.20280","volume":"80","author":"LS Dunaway","year":"2023","unstructured":"Dunaway LS, Billaud M, Macal E, Good ME, Medina CB, Lorenz U, Ravichandran K, Koval M, Isakson BE (2023) Amount of pannexin 1 in smooth muscle cells regulates sympathetic nerve\u2013induced vasoconstriction. Hypertension 80:416\u2013425","journal-title":"Hypertension"},{"key":"4038_CR31","doi-asserted-by":"publisher","first-page":"e0188135","DOI":"10.1371\/journal.pone.0188135","volume":"12","author":"JL Feig","year":"2017","unstructured":"Feig JL, Mediero A, Corciulo C, Liu H, Zhang J, Perez-Aso M, Picard L, Wilder T, Cronstein B (2017) The antiviral drug tenofovir, an inhibitor of pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin. PLoS ONE 12:e0188135","journal-title":"PLoS ONE"},{"key":"4038_CR32","doi-asserted-by":"publisher","first-page":"122851","DOI":"10.1016\/j.lfs.2024.122851","volume":"351","author":"A Fierro-Arenas","year":"2024","unstructured":"Fierro-Arenas A, Landskron G, Camhi-Vainroj I, Basterrechea B, Parada-Venegas D, Lobos-Gonz\u00e1lez L, Dubois-Camacho K, Araneda C, Romero C, Dom\u00ednguez A, V\u00e1squez G, L\u00f3pez-K F, Alvarez K, Gonz\u00e1lez CM, Hager Ribeiro C, Balboa E, Eugenin E, Hermoso MA, De La Fuente L\u00f3pez M (2024) Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival. Life Sci 351:122851","journal-title":"Life Sci"},{"key":"4038_CR33","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.2042-7158.1960.tb12629.x","volume":"12","author":"RSH Finney","year":"1960","unstructured":"Finney RSH, T\u00e1rnoky AL (1960) The pharmacological properties of glycyrrhetinic acid hydrogen succinate (disodium salt). J Pharm Pharmacol 12:49\u201358","journal-title":"J Pharm Pharmacol"},{"key":"4038_CR34","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ncb3194","volume":"17","author":"PW Furlow","year":"2015","unstructured":"Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento O, Tavazoie SF (2015) Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival. Nat Cell Biol 17:943\u2013952","journal-title":"Nat Cell Biol"},{"key":"4038_CR35","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3390\/biom13060887","volume":"13","author":"F Garc\u00eda-Rojas","year":"2023","unstructured":"Garc\u00eda-Rojas F, Flores-Mu\u00f1oz C, Santander O, Solis P, Mart\u00ednez AD, Ardiles \u00c1O, Fuenzalida M (2023) Pannexin-1 modulates inhibitory transmission and hippocampal synaptic plasticity. Biomolecules 13:887","journal-title":"Biomolecules"},{"key":"4038_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12974-018-1069-9","volume":"15","author":"C Garg","year":"2018","unstructured":"Garg C, Seo JH, Ramachandran J, Loh JM, Calderon F, Contreras JE (2018) Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice. J Neuroinflammation 15:42","journal-title":"J Neuroinflammation"},{"key":"4038_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/toxsci\/kfy244","volume":"167","author":"G Giustarini","year":"2019","unstructured":"Giustarini G, Vrisekoop N, Kruijssen L, Wagenaar L, Van Staveren S, Van Roest M, Bleumink R, Bol-Schoenmakers M, Weaver RJ, Koenderman L, Smit J, Pieters R (2019) Trovafloxacin-induced liver injury: lack in regulation of inflammation by inhibition of nucleotide release and neutrophil movement. Toxicol Sci 167:385\u2013396","journal-title":"Toxicol Sci"},{"key":"4038_CR38","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/CIRCRESAHA.117.312380","volume":"122","author":"ME Good","year":"2018","unstructured":"Good ME, Chiu Y-H, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS (2018) Pannexin 1 channels as an unexpected new target of the anti-hypertensive drug spironolactone. Circ Res 122:606\u2013615","journal-title":"Circ Res"},{"key":"4038_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1128\/AAC.37.2.349","volume":"37","author":"BB Gooding","year":"1993","unstructured":"Gooding BB, Jones RN (1993) In vitro antimicrobial activity of CP-99,219, a novel azabicyclo-naphthyridone. Antimicrob Agents Chemother 37:349\u2013353","journal-title":"Antimicrob Agents Chemother"},{"key":"4038_CR40","doi-asserted-by":"publisher","first-page":"123404","DOI":"10.1016\/j.lfs.2025.123404","volume":"364","author":"AL Gouv\u00eaa De Souza","year":"2025","unstructured":"Gouv\u00eaa De Souza AL, Rosa Alves AL, De Sousa JC, Barbosa NC, Rodrigues FC, Santos SACS, De Oliveira TS, Temerozo JR, Bou-Habib DC, Takiya CM, De Azevedo Canetti C, Benjamim CF, Coutinho-Silva R, Kurtenbach E (2025) Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice. Life Sci 364:123404","journal-title":"Life Sci"},{"key":"4038_CR41","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1093\/cvr\/cvab326","volume":"118","author":"B Grimmer","year":"2022","unstructured":"Grimmer B, Krauszman A, Hu X, Kabir G, Connelly KA, Li M, Grune J, Madry C, Isakson BE, Kuebler WM (2022) Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction. Cardiovasc Res 118:2535\u20132547","journal-title":"Cardiovasc Res"},{"key":"4038_CR42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jchemneu.2017.06.003","volume":"85","author":"N Hainz","year":"2017","unstructured":"Hainz N, Becker P, Rapp D, Wagenpfeil S, Wonnenberg B, Beisswenger C, Tschernig T, Meier C (2017) Probenecid-treatment reduces demyelination induced by cuprizone feeding. J Chem Neuroanat 85:21\u201326","journal-title":"J Chem Neuroanat"},{"key":"4038_CR43","doi-asserted-by":"publisher","first-page":"17214","DOI":"10.1038\/s41598-017-17517-5","volume":"7","author":"N Hainz","year":"2017","unstructured":"Hainz N, Wolf S, Beck A, Wagenpfeil S, Tschernig T, Meier C (2017) Probenecid arrests the progression of pronounced clinical symptoms in a mouse model of multiple sclerosis. Sci Rep 7:17214","journal-title":"Sci Rep"},{"key":"4038_CR44","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13104-018-3125-z","volume":"11","author":"N Hainz","year":"2018","unstructured":"Hainz N, Beckmann A, Schubert M, Haase A, Martin U, Tschernig T, Meier C (2018) Human stem cells express pannexins. BMC Res Notes 11:54","journal-title":"BMC Res Notes"},{"key":"4038_CR45","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1111\/acer.15470","volume":"48","author":"R Hornbacher","year":"2024","unstructured":"Hornbacher R, Gully BJ, Brown ZE, Brown JC, Magill M, Cioe PA, Swift RM, Sanna PP, Haass-Koffler CL (2024) Probenecid as a pharmacotherapy for alcohol use disorder: a randomized placebo-controlled alcohol interaction trial. Alcohol Clin Exp Res 48:2391\u20132403","journal-title":"Alcohol Clin Exp Res"},{"key":"4038_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411538","volume":"12","author":"W Hsueh","year":"2025","unstructured":"Hsueh W, Wu Y, Weng M, Liu S, Santavanond JP, Liu Y, Lin C, Lai C, Lu Y, Hsu JY, Gao H, Lee J, Wei S, Lyu P, Poon IKH, Hsieh H, Chiu Y (2025) Novel naphthyridones targeting pannexin 1 for colitis management. Adv Sci 12:2411538","journal-title":"Adv Sci"},{"key":"4038_CR47","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.14336\/AD.2023.0628","volume":"15","author":"Y Huang","year":"2024","unstructured":"Huang Y, Shi Y, Wang M, Liu B, Chang X, Xiao X, Yu H, Cui X, Bai Y (2024) Pannexin1 channel-mediated inflammation in acute ischemic stroke. Aging Dis 15:1296\u20131307","journal-title":"Aging Dis"},{"key":"4038_CR48","doi-asserted-by":"publisher","first-page":"C752","DOI":"10.1152\/ajpcell.00228.2008","volume":"295","author":"R Iglesias","year":"2008","unstructured":"Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E (2008) P2X7 receptor-pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol 295:C752\u2013C760","journal-title":"Am J Physiol Cell Physiol"},{"key":"4038_CR49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3109\/15419061003642618","volume":"16","author":"R Iglesias","year":"2010","unstructured":"Iglesias R, Spray DC, Scemes E (2010) Mefloquine blockade of pannexin1 currents: resolution of a conflict. Cell Commun Adhes 16:131\u2013137","journal-title":"Cell Commun Adhes"},{"key":"4038_CR50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/j.1552-4604.1990.tb03438.x","volume":"30","author":"N Inotsume","year":"1990","unstructured":"Inotsume N, Nishimura M, Nakano M, Fujiyama S, Sato T (1990) The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers. J Clin Pharmacol 30:50\u201356","journal-title":"J Clin Pharmacol"},{"key":"4038_CR51","doi-asserted-by":"publisher","first-page":"13338","DOI":"10.1038\/s41598-023-40004-z","volume":"13","author":"T Kaden","year":"2023","unstructured":"Kaden T, Graf K, Rennert K, Li R, Mosig AS, Raasch M (2023) Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. Sci Rep 13:13338","journal-title":"Sci Rep"},{"key":"4038_CR52","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/03602537808993782","volume":"8","author":"A Karim","year":"1978","unstructured":"Karim A (1978) Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev 8:151\u2013188","journal-title":"Drug Metab Rev"},{"key":"4038_CR53","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1038\/s41467-024-50657-7","volume":"15","author":"CHT Kwok","year":"2024","unstructured":"Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, Van Den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Mor\u00f3n JA, Zamponi GW, Trang T (2024) Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry. Nat Commun 15:6264","journal-title":"Nat Commun"},{"key":"4038_CR54","doi-asserted-by":"publisher","first-page":"1101389","DOI":"10.3389\/fcvm.2023.1101389","volume":"10","author":"Z Ladd","year":"2023","unstructured":"Ladd Z, Su G, Hartman J, Lu G, Hensley S, Upchurch GR, Sharma AK (2023) Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms. Front Cardiovasc Med 10:1101389","journal-title":"Front Cardiovasc Med"},{"key":"4038_CR55","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1158\/0008-5472.CAN-06-1396","volume":"67","author":"CPK Lai","year":"2007","unstructured":"Lai CPK, Bechberger JF, Thompson RJ, MacVicar BA, Bruzzone R, Naus CC (2007) Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res 67:1545\u20131554","journal-title":"Cancer Res"},{"key":"4038_CR56","doi-asserted-by":"publisher","first-page":"H1699","DOI":"10.1152\/ajpheart.00493.2020","volume":"320","author":"IR Lamb","year":"2021","unstructured":"Lamb IR, Novielli-Kuntz NM, Murrant CL (2021) Capillaries communicate with the arteriolar microvascular network by a pannexin\/purinergic-dependent pathway in hamster skeletal muscle. Am J Physiol-Heart Circ Physiol 320:H1699\u2013H1711","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"4038_CR57","doi-asserted-by":"publisher","first-page":"e16113","DOI":"10.14814\/phy2.16113","volume":"12","author":"IR Lamb","year":"2024","unstructured":"Lamb IR, Novielli-Kuntz NM, Murrant CL (2024) The role of pannexin\/purinergic signaling in intervascular communication from capillaries during skeletal muscle contraction in male Golden hamsters. Physiol Rep 12:e16113","journal-title":"Physiol Rep"},{"key":"4038_CR58","doi-asserted-by":"publisher","first-page":"13086","DOI":"10.1021\/acs.jmedchem.3c01116","volume":"66","author":"A Lamouroux","year":"2023","unstructured":"Lamouroux A, Tournier M, Iaculli D, Caufriez A, Rusiecka OM, Martin C, Bes V, Carpio LE, Girardin Y, Loris R, Tabernilla A, Molica F, Gozalbes R, May\u00e1n MD, Vinken M, Kwak BR, Ballet S (2023) Structure-based design and synthesis of stapled10 panx1 analogues for use in cardiovascular inflammatory diseases. J Med Chem 66:13086\u201313102","journal-title":"J Med Chem"},{"key":"4038_CR59","doi-asserted-by":"publisher","first-page":"689","DOI":"10.7150\/jca.79552","volume":"14","author":"S Langlois","year":"2023","unstructured":"Langlois S, St-Pierre M-E, Holland SH, Xiang X, Freeman E, Mohamed H, Dural AC, Hammad A, Karami S, Van De Panne C, Cowan KN (2023) Inhibition of PANX1 channels reduces the malignant properties of human high-risk neuroblastoma. J Cancer 14:689\u2013706","journal-title":"J Cancer"},{"key":"4038_CR60","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3389\/fncel.2014.00392","volume":"8","author":"M Le Vasseur","year":"2014","unstructured":"Le Vasseur M, Lelowski J, Bechberger JF, Sin W-C, Naus CC (2014) Pannexin 2 protein expression is not restricted to the CNS. Front Cell Neurosci 8:392","journal-title":"Front Cell Neurosci"},{"key":"4038_CR61","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1038\/s41388-023-02647-0","volume":"42","author":"H Li","year":"2023","unstructured":"Li H, Jiang W, Zhang S-R, Li P-C, Li T-J, Jin W, Xu H-X, Yu X-J, Liu L (2023) The platelet pannexin 1-IL-1\u03b2 axis orchestrates pancreatic ductal adenocarcinoma invasion and metastasis. Oncogene 42:1453\u20131465","journal-title":"Oncogene"},{"key":"4038_CR62","doi-asserted-by":"publisher","first-page":"e66657","DOI":"10.1371\/journal.pone.0066657","volume":"8","author":"SE Lutz","year":"2013","unstructured":"Lutz SE, Gonz\u00e1lez-Fern\u00e1ndez E, Ventura JCC, P\u00e9rez-Samart\u00edn A, Tarassishin L, Negoro H, Patel NK, Suadicani SO, Lee SC, Matute C, Scemes E (2013) Contribution of pannexin1 to experimental autoimmune encephalomyelitis. PLoS ONE 8:e66657","journal-title":"PLoS ONE"},{"key":"4038_CR63","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1124\/jpet.108.146365","volume":"328","author":"W Ma","year":"2009","unstructured":"Ma W, Hui H, Pelegrin P, Surprenant A (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther 328:409\u2013418","journal-title":"J Pharmacol Exp Ther"},{"key":"4038_CR64","doi-asserted-by":"publisher","first-page":"F69","DOI":"10.1152\/ajprenal.1981.241.1.F69","volume":"241","author":"TD McKinney","year":"1981","unstructured":"McKinney TD, Myers P, Speeg KV (1981) Cimetidine secretion by rabbit renal tubules in vitro. Am J Physiol-Renal Physiol 241:F69\u2013F76","journal-title":"Am J Physiol-Renal Physiol"},{"key":"4038_CR65","doi-asserted-by":"publisher","first-page":"151985","DOI":"10.1016\/j.acthis.2022.151985","volume":"125","author":"CE Mendes","year":"2023","unstructured":"Mendes CE, Palombit K, Alves Pereira TT, Riceti Magalh\u00e3es HI, Ferreira Caetano MA, Castelucci P (2023) Effects of probenecid and brilliant blue G on rat enteric glial cells following intestinal ischemia and reperfusion. Acta Histochem 125:151985","journal-title":"Acta Histochem"},{"key":"4038_CR66","doi-asserted-by":"publisher","first-page":"12013","DOI":"10.1021\/acsami.5c05609","volume":"17","author":"Z Meng","year":"2025","unstructured":"Meng Z, Huang H, Guo J, Wang D, Tao X, Dai Q, Bai Y, Ma C, Huang L, Fu Y, Lu C, Wang H, Wang Q, Li X, Ren H (2025) Promote sepsis recovery through the inhibition of immunothrombosis via a combination of probenecid nanocrystals and cefotaxime sodium. ACS Appl Mater Interfaces 17:12013\u201321032","journal-title":"ACS Appl Mater Interfaces"},{"key":"4038_CR67","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1016\/j.jacep.2023.10.013","volume":"9","author":"L Mezache","year":"2023","unstructured":"Mezache L, Soltisz AM, Johnstone SR, Isakson BE, Veeraraghavan R (2023) Vascular endothelial barrier protection prevents atrial fibrillation by preserving cardiac nanostructure. JACC Clin Electrophysiol 9:2444\u20132458","journal-title":"JACC Clin Electrophysiol"},{"key":"4038_CR68","doi-asserted-by":"publisher","first-page":"7174","DOI":"10.1073\/pnas.95.12.7174","volume":"95","author":"CH Mitchell","year":"1998","unstructured":"Mitchell CH, Carr\u00e9 DA, McGlinn AM, Stone RA, Civan MM (1998) A release mechanism for stored ATP in ocular ciliary epithelial cells. Proc Natl Acad Sci USA 95:7174\u20137178","journal-title":"Proc Natl Acad Sci USA"},{"key":"4038_CR69","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.thromres.2019.09.028","volume":"183","author":"F Molica","year":"2019","unstructured":"Molica F, Meens MJ, Pelli G, Hautefort A, Emre Y, Imhof BA, Fontana P, Scemes E, Morel S, Kwak BR (2019) Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo. Thromb Res 183:56\u201362","journal-title":"Thromb Res"},{"key":"4038_CR70","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1021\/acschemneuro.0c00333","volume":"11","author":"KE Navis","year":"2020","unstructured":"Navis KE, Fan CY, Trang T, Thompson RJ, Derksen DJ (2020) Pannexin 1 channels as a therapeutic target: structure, inhibition, and outlook. ACS Chem Neurosci 11:2163\u20132172","journal-title":"ACS Chem Neurosci"},{"key":"4038_CR71","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1113\/JP278759","volume":"598","author":"BS Nielsen","year":"2020","unstructured":"Nielsen BS, Toft-Bertelsen TL, Lolansen SD, Anderson CL, Nielsen MS, Thompson RJ, MacAulay N (2020) Pannexin 1 activation and inhibition is permeant-selective. J Physiol 598:361\u2013379","journal-title":"J Physiol"},{"key":"4038_CR72","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s11302-021-09805-7","volume":"17","author":"BL O\u2019Donnell","year":"2021","unstructured":"O\u2019Donnell BL, Penuela S (2021) Pannexin 3 channels in health and disease. Purinergic Signal 17:577\u2013589","journal-title":"Purinergic Signal"},{"key":"4038_CR73","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00510.2025","author":"B O\u2019Donnell","year":"2025","unstructured":"O\u2019Donnell B, Williams M, Billaud M, Dunaway LS, Columbus L, Koval M, Isakson BE (2025) Pannexins in the vasculature. Am J Physiol Heart Circ Physiol. https:\/\/doi.org\/10.1152\/ajpheart.00510.2025","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4038_CR74","doi-asserted-by":"publisher","first-page":"891759","DOI":"10.3389\/fphys.2022.891759","volume":"13","author":"S Ohyama","year":"2022","unstructured":"Ohyama S, Ouchi T, Kimura M, Kurashima R, Yasumatsu K, Nishida D, Hitomi S, Ubaidus S, Kuroda H, Ito S, Takano M, Ono K, Mizoguchi T, Katakura A, Shibukawa Y (2022) Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity. Front Physiol 13:891759","journal-title":"Front Physiol"},{"key":"4038_CR75","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1016\/j.celrep.2015.10.042","volume":"13","author":"R Palchaudhuri","year":"2015","unstructured":"Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim S-H, Peterson RT, Fan TM, Hergenrother PJ (2015) A small molecule that induces intrinsic pathway apoptosis with unparalleled speed. Cell Rep 13:2027\u20132036","journal-title":"Cell Rep"},{"key":"4038_CR76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2112870119","volume":"119","author":"CS Patil","year":"2022","unstructured":"Patil CS, Li H, Lavine NE, Shi R, Bodalia A, Siddiqui TJ, Jackson MF (2022) ER-resident STIM1\/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation. Proc Natl Acad Sci 119:e2112870119","journal-title":"Proc Natl Acad Sci"},{"key":"4038_CR77","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1161\/CIRCRESAHA.124.324650","volume":"135","author":"CM Pavelec","year":"2024","unstructured":"Pavelec CM, Young AP, Luviano HL, Orrell EE, Szagdaj A, Poudel N, Wolpe AG, Thomas SH, Yeudall S, Upchurch CM, Okusa MD, Isakson BE, Wolf MJ, Leitinger N (2024) Cardiomyocyte PANX1 controls glycolysis and neutrophil recruitment in hypertrophy. Circ Res 135:503\u2013517","journal-title":"Circ Res"},{"key":"4038_CR78","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","volume":"25","author":"P Pelegrin","year":"2006","unstructured":"Pelegrin P, Surprenant A (2006) Pannexin-1 mediates large pore formation and interleukin-1\u03b2 release by the ATP-gated P2X7 receptor. EMBO J 25:5071\u20135082","journal-title":"EMBO J"},{"key":"4038_CR79","doi-asserted-by":"publisher","first-page":"29184","DOI":"10.1074\/jbc.M112.377176","volume":"287","author":"S Penuela","year":"2012","unstructured":"Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW (2012) Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. J Biol Chem 287:29184\u201329193","journal-title":"J Biol Chem"},{"key":"4038_CR80","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14996","volume":"37","author":"TTA Pereira","year":"2025","unstructured":"Pereira TTA, Mendes CE, Souza RF, Caetano MAF, Magalh\u00e3es HIR, De Paulo CB, Watanabe IS, Castelucci P (2025) Changes in the pannexin channel in ileum myenteric plexus and intestinal motility following ischemia and reperfusion. Neurogastroenterol Motil 37:e14996","journal-title":"Neurogastroenterol Motil"},{"key":"4038_CR81","doi-asserted-by":"publisher","first-page":"e2000097","DOI":"10.1002\/pmic.202000097","volume":"21","author":"TK Phan","year":"2021","unstructured":"Phan TK, Fonseka P, Tixeira R, Pathan M, Ang C, Ozkocak DC, Mathivanan S, Poon IKH (2021) Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size. Proteomics 21:e2000097","journal-title":"Proteomics"},{"key":"4038_CR82","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nature13147","volume":"507","author":"IKH Poon","year":"2014","unstructured":"Poon IKH, Chiu Y-H, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS (2014) Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 507:329\u2013334","journal-title":"Nature"},{"key":"4038_CR83","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1124\/jpet.114.214189","volume":"350","author":"KL Poulsen","year":"2014","unstructured":"Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA (2014) Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-\u03b1 by macrophages: role of the DNA damage response. J Pharmacol Exp Ther 350:164\u2013170","journal-title":"J Pharmacol Exp Ther"},{"key":"4038_CR84","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00441-015-2153-4","volume":"360","author":"Y Qi","year":"2015","unstructured":"Qi Y, Hainz N, Tschernig T, Meier C, Volmer DA (2015) Differential distribution of probenecid as detected by on-tissue mass spectrometry. Cell Tissue Res 360:427\u2013429","journal-title":"Cell Tissue Res"},{"key":"4038_CR85","doi-asserted-by":"publisher","first-page":"C250","DOI":"10.1152\/ajpcell.00433.2008","volume":"296","author":"F Qiu","year":"2009","unstructured":"Qiu F, Dahl G (2009) A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol 296:C250\u2013C255","journal-title":"Am J Physiol Cell Physiol"},{"key":"4038_CR86","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.1016\/j.febslet.2011.09.033","volume":"585","author":"F Qiu","year":"2011","unstructured":"Qiu F, Wang J, Spray DC, Scemes E, Dahl G (2011) Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett 585:3430\u20133435","journal-title":"FEBS Lett"},{"key":"4038_CR87","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00441-015-2294-5","volume":"364","author":"A Raslan","year":"2016","unstructured":"Raslan A, Hainz N, Beckmann A, Tschernig T, Meier C (2016) Pannexin-1 expression in developing mouse nervous system: new evidence for expression in sensory ganglia. Cell Tissue Res 364:29\u201341","journal-title":"Cell Tissue Res"},{"key":"4038_CR88","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/rheumatology\/kep306","volume":"49","author":"TG Rider","year":"2010","unstructured":"Rider TG, Jordan KM (2010) The modern management of gout. Rheumatology 49:5\u201314","journal-title":"Rheumatology"},{"key":"4038_CR89","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/s41586-020-2357-y","volume":"584","author":"Z Ruan","year":"2020","unstructured":"Ruan Z, Orozco IJ, Du J, L\u00fc W (2020) Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature 584:646\u2013651","journal-title":"Nature"},{"key":"4038_CR90","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-025-03994-y","author":"OM Rusiecka","year":"2025","unstructured":"Rusiecka OM, Molica F, Clochard L, Van Campenhout R, De Groof TWM, Bes V, Devoogdt N, Muyldermans S, Vinken M, Kwak BR (2025) Nanobody-based pannexin1 channel inhibitors increase survival after cardiac ischemia\/reperfusion. Cell Tissue Res. https:\/\/doi.org\/10.1007\/s00441-025-03994-y","journal-title":"Cell Tissue Res"},{"key":"4038_CR91","doi-asserted-by":"publisher","first-page":"e2405468121","DOI":"10.1073\/pnas.2405468121","volume":"121","author":"M Salgado","year":"2024","unstructured":"Salgado M, M\u00e1rquez-Miranda V, Ferrada L, Rojas M, Poblete-Flores G, Gonz\u00e1lez-Nilo FD, Ardiles \u00c1O, S\u00e1ez JC (2024) Ca2+ permeation through C-terminal cleaved, but not full-length human pannexin1 hemichannels, mediates cell death. Proc Natl Acad Sci 121:e2405468121","journal-title":"Proc Natl Acad Sci"},{"key":"4038_CR92","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.7150\/thno.100687","volume":"15","author":"M Salgado","year":"2025","unstructured":"Salgado M, Sep\u00falveda-Arriagada V, Konar-Ni\u00e9 M, Garc\u00eda-Robles MA, S\u00e1ez JC (2025) Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3\/Ca2+ \/CaMKII\/pannexin 1-dependent signaling. Theranostics 15:2470\u20132486","journal-title":"Theranostics"},{"key":"4038_CR93","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E21-08-0387","volume":"33","author":"RE Sanchez-Pupo","year":"2022","unstructured":"Sanchez-Pupo RE, O\u2019Donnell BL, Johnston D, Gyenis L, Litchfield DW, Penuela S (2022) Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes. Mol Biol Cell 33:ar24","journal-title":"Mol Biol Cell"},{"key":"4038_CR94","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41419-024-06513-z","volume":"15","author":"JP Santavanond","year":"2024","unstructured":"Santavanond JP, Chiu Y-H, Tixeira R, Liu Z, Yap JKY, Chen KW, Li C-L, Lu Y-R, Roncero-Carol J, Hoijman E, Rutter SF, Shi B, Ryan GF, Hodge AL, Caruso S, Baxter AA, Ozkocak DC, Johnson C, Day ZI, Mayfosh AJ, Hulett MD, Phan TK, Atkin-Smith GK, Poon IKH (2024) The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell Death Dis 15:123","journal-title":"Cell Death Dis"},{"key":"4038_CR95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025178","volume":"6","author":"MF Santiago","year":"2011","unstructured":"Santiago MF, Veliskova J, Patel NK, Lutz SE, Caille D, Charollais A, Meda P, Scemes E (2011) Targeting pannexin1 improves seizure outcome. PLoS ONE 6:e25178","journal-title":"PLoS ONE"},{"key":"4038_CR96","doi-asserted-by":"publisher","first-page":"100478","DOI":"10.1016\/j.jbc.2021.100478","volume":"296","author":"S Sayedyahossein","year":"2021","unstructured":"Sayedyahossein S, Huang K, Li Z, Zhang C, Kozlov AM, Johnston D, Nouri-Nejad D, Dagnino L, Betts DH, Sacks DB, Penuela S (2021) Pannexin 1 binds \u03b2-catenin to modulate melanoma cell growth and metabolism. J Biol Chem 296:100478","journal-title":"J Biol Chem"},{"key":"4038_CR97","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1002\/jps.2600711114","volume":"71","author":"A Selen","year":"1982","unstructured":"Selen A, Amidon GL, Welling PG (1982) Pharmacokinetics of probenecid following oral doses to human volunteers. J Pharm Sci 71:1238\u20131242","journal-title":"J Pharm Sci"},{"key":"4038_CR98","doi-asserted-by":"publisher","first-page":"C761","DOI":"10.1152\/ajpcell.00227.2008","volume":"295","author":"W Silverman","year":"2008","unstructured":"Silverman W, Locovei S, Dahl G (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol-Cell Physiol 295:C761\u2013C767","journal-title":"Am J Physiol-Cell Physiol"},{"key":"4038_CR99","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s10194-024-01938-5","volume":"26","author":"KO Soylu","year":"2025","unstructured":"Soylu KO, Yemisci M, Karatas H (2025) The link between spreading depolarization and innate immunity in the central nervous system. J Headache Pain 26:25","journal-title":"J Headache Pain"},{"key":"4038_CR100","doi-asserted-by":"publisher","first-page":"9071","DOI":"10.3390\/ijms22169071","volume":"22","author":"Y Srisomboon","year":"2021","unstructured":"Srisomboon Y, Ohkura N, Iijima K, Kobayashi T, Maniak PJ, Kita H, O\u2019Grady SM (2021) Airway exposure to polyethyleneimine nanoparticles induces type 2 immunity by a mechanism involving oxidative stress and ATP release. Int J Mol Sci 22:9071","journal-title":"Int J Mol Sci"},{"key":"4038_CR101","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1021\/tx7003085","volume":"21","author":"Q Sun","year":"2008","unstructured":"Sun Q, Zhu R, Foss FW, Macdonald TL (2008) In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity. Chem Res Toxicol 21:711\u2013719","journal-title":"Chem Res Toxicol"},{"key":"4038_CR102","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02137-1","volume":"21","author":"R Van Campenhout","year":"2023","unstructured":"Van Campenhout R, De Groof TWM, Kadam P, Kwak BR, Muyldermans S, Devoogdt N, Vinken M (2023) Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury. J Nanobiotechnology 21:371","journal-title":"J Nanobiotechnology"},{"key":"4038_CR103","doi-asserted-by":"publisher","first-page":"110290","DOI":"10.1016\/j.isci.2024.110290","volume":"27","author":"T Vardam-Kaur","year":"2024","unstructured":"Vardam-Kaur T, Banuelos A, Gabaldon-Parish M, Macedo BG, Salgado CL, Wanhainen KM, Zhou MH, Van Dijk S, Santiago-Carvalho I, Beniwal AS, Leff CL, Peng C, Tran NL, Jameson SC, Borges Da Silva H (2024) The ATP-exporting channel pannexin 1 promotes CD8+ T cell effector and memory responses. iScience 27:110290","journal-title":"iScience"},{"key":"4038_CR104","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1096\/fj.201902901R","volume":"34","author":"EHJ Verschuren","year":"2020","unstructured":"Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ (2020) Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB J 34:6382\u20136398","journal-title":"FASEB J"},{"key":"4038_CR105","doi-asserted-by":"publisher","first-page":"C1112","DOI":"10.1152\/ajpcell.00097.2007","volume":"293","author":"J Wang","year":"2007","unstructured":"Wang J, Ma M, Locovei S, Keane RW, Dahl G (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol 293:C1112\u2013C1119","journal-title":"Am J Physiol Cell Physiol"},{"key":"4038_CR106","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1085\/jgp.201310966","volume":"141","author":"J Wang","year":"2013","unstructured":"Wang J, Jackson DG, Dahl G (2013) The food dye FD&C blue no. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol 141:649\u2013656","journal-title":"J Gen Physiol"},{"key":"4038_CR107","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1113\/jphysiol.1995.sp021003","volume":"488","author":"A Warner","year":"1995","unstructured":"Warner A, Clements DK, Parikh S, Evans WH, DeHaan RL (1995) Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes. J Physiol 488:721\u2013728","journal-title":"J Physiol"},{"key":"4038_CR108","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","volume":"32","author":"NL Weilinger","year":"2012","unstructured":"Weilinger NL, Tang PL, Thompson RJ (2012) Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases. J Neurosci 32:12579\u201312588","journal-title":"J Neurosci"},{"key":"4038_CR109","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nn.4236","volume":"19","author":"NL Weilinger","year":"2016","unstructured":"Weilinger NL, Lohman AW, Rakai BD, Ma EMM, Bialecki J, Maslieieva V, Rilea T, Bandet MV, Ikuta NT, Scott L, Colicos MA, Teskey GC, Winship IR, Thompson RJ (2016) Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci 19:432\u2013442","journal-title":"Nat Neurosci"},{"key":"4038_CR110","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pharmthera.2017.07.001","volume":"180","author":"J Willebrords","year":"2017","unstructured":"Willebrords J, Maes M, Crespo Yanguas S, Vinken M (2017) Inhibitors of connexin and pannexin channels as potential therapeutics. Pharmacol Ther 180:144\u2013160","journal-title":"Pharmacol Ther"},{"key":"4038_CR111","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.ijmm.2014.05.002","volume":"304","author":"B Wonnenberg","year":"2014","unstructured":"Wonnenberg B, Tschernig T, Voss M, Bischoff M, Meier C, Schirmer SH, Langer F, Bals R, Beisswenger C (2014) Probenecid reduces infection and inflammation in acute Pseudomonas aeruginosa pneumonia. Int J Med Microbiol 304:725\u2013729","journal-title":"Int J Med Microbiol"},{"key":"4038_CR112","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.4049\/jimmunol.1901089","volume":"204","author":"Y Yang","year":"2020","unstructured":"Yang Y, Delalio LJ, Best AK, Macal E, Milstein J, Donnelly I, Miller AM, McBride M, Shu X, Koval M, Isakson BE, Johnstone SR (2020) Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium. J Immunol 204:2995\u20133007","journal-title":"J Immunol"},{"key":"4038_CR113","doi-asserted-by":"publisher","first-page":"115316","DOI":"10.1016\/j.intimp.2025.115316","volume":"164","author":"B Y\u0131ld\u0131z","year":"2025","unstructured":"Y\u0131ld\u0131z B, Erg\u00fc\u00e7 E\u0130, Carpio LE, Gozalbes R, Ortiz-Gonz\u00e1lez C, Orhan H, Demeyer K, Vinken M, Tabernilla A (2025) Silybin, silychristin and silydianin are potential novel plant-based pannexin1 channel inhibitors. Int Immunopharmacol 164:115316","journal-title":"Int Immunopharmacol"},{"key":"4038_CR114","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41401-021-00619-2","volume":"43","author":"F Yin","year":"2022","unstructured":"Yin F, Zheng P, Zhao L, Wang Y, Miao N, Zhou Z, Cheng Q, Chen P, Xie H, Li J, Ni J, Zhou L, Zhang W, Wang X, Liu J, Lu L (2022) Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease. Acta Pharmacol Sin 43:86\u201395","journal-title":"Acta Pharmacol Sin"},{"key":"4038_CR115","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1097\/j.pain.0000000000003476","volume":"166","author":"K Zepeda-Morales","year":"2025","unstructured":"Zepeda-Morales K, Bravo D, Ar\u00e1nguiz-Barrera J, Ampuero E, Renard GM, Pelissier T, Hern\u00e1ndez A, Retamal JS, Constandil L (2025) N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats. Pain 166:1369\u20131381","journal-title":"Pain"},{"key":"4038_CR116","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1113\/jphysiol.2012.236265","volume":"590","author":"M Zhang","year":"2012","unstructured":"Zhang M, Piskuric NA, Vollmer C, Nurse CA (2012) P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP. J Physiol 590:4335\u20134350","journal-title":"J Physiol"},{"key":"4038_CR117","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/15419060802014081","volume":"15","author":"G Zoidl","year":"2008","unstructured":"Zoidl G, Kremer M, Zoidl C, Bunse S, Dermietzel R (2008) Molecular diversity of connexin and pannexin genes in the retina of the zebrafish Danio rerio. Cell Commun Adhes 15:169\u2013183","journal-title":"Cell Commun Adhes"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-025-04038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-025-04038-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-025-04038-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:04:55Z","timestamp":1778749495000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-025-04038-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":117,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4038"],"URL":"https:\/\/doi.org\/10.1007\/s00441-025-04038-1","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article was originally published under the subscription model but it is now published under an Open Access license.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6"}}