{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:08:06Z","timestamp":1774926486321,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR058175"],"award-info":[{"award-number":["RS-2021-NR058175"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00459728"],"award-info":[{"award-number":["RS-2024-00459728"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00441-026-04060-x","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:32:39Z","timestamp":1772771559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lgr5 positive stem cells sustain homeostasis and drive regeneration of the nasal septum olfactory epithelium"],"prefix":"10.1007","volume":"403","author":[{"given":"Suyeon","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Yi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Sung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"4060_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07544-9","author":"DF Albeanu","year":"2018","unstructured":"Albeanu DF, Provost AC, Agarwal P, Soucy ER, Zak JD, Murthy VN (2018) Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-018-07544-9","journal-title":"Nat Commun"},{"key":"4060_CR2","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H (2007) Identification of stem cells in small intestine and colon by marker gene. Nature 449:1003-U1001","journal-title":"Nature"},{"key":"4060_CR3","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1073\/pnas.0711027105","volume":"105","author":"NF Berbari","year":"2008","unstructured":"Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K (2008) Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc Natl Acad Sci U S A 105:4242\u20134246","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4060_CR4","doi-asserted-by":"crossref","unstructured":"Hao K, Chen YW, Yan XM, Zhu XL (2021) Cilia locally synthesize proteins to sustain their ultrastructure and functions. Nat Commun 12(1):6971","DOI":"10.1038\/s41467-021-27298-1"},{"key":"4060_CR5","doi-asserted-by":"publisher","first-page":"E5589","DOI":"10.1073\/pnas.1701333114","volume":"114","author":"DB Herrick","year":"2017","unstructured":"Herrick DB, Lin B, Peterson J, Schnittke N, Schwob JE (2017) Notch1 maintains dormancy of olfactory horizontal basal cells, a reserve neural stem cell. Proc Natl Acad Sci U S A 114:E5589\u2013E5598","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4060_CR6","doi-asserted-by":"crossref","unstructured":"Kostic L, Leung C, Murad KA, Kancheva S, Perna S, Lee BR, Barker N (2024) Lgr5 marks stem\/progenitor cells contributing to epithelial and muscle development in the mouse esophagus. Nat Commun 15(1):7145","DOI":"10.1038\/s41467-024-51559-4"},{"key":"4060_CR7","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/ng1418","volume":"36","author":"HM Kulaga","year":"2004","unstructured":"Kulaga HM, Leitch CC, Eichers ER, Badano JL, Lesemann A, Hoskins BE, Lupski JR, Beales PL, Reed RR, Katsanis N (2004) Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet 36:994\u2013998","journal-title":"Nat Genet"},{"key":"4060_CR8","doi-asserted-by":"crossref","unstructured":"Lim HYG, Yada S, Barker N (2022) Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models. Star Protoc 3(2):101411","DOI":"10.1016\/j.xpro.2022.101411"},{"key":"4060_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.stem.2013.11.008","volume":"14","author":"C Metcalfe","year":"2014","unstructured":"Metcalfe C, Kljavin NM, Ybarra R, de Sauvage FJ (2014) Stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 14:149\u2013159","journal-title":"Cell Stem Cell"},{"key":"4060_CR10","doi-asserted-by":"crossref","unstructured":"Qi Z, Li YH, Zhao B, Xu C, Liu Y, Li HN, Zhang BJ, Wang XQ, Yang X, Xie W, Li BJ, Han JDJ, Chen YG (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nat Commun 8:13824","DOI":"10.1038\/ncomms13824"},{"key":"4060_CR11","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.7150\/thno.60636","volume":"12","author":"WW Ren","year":"2022","unstructured":"Ren WW, Ma ZJ, Wang L, Feng XY, Yu HM, Yu YQ (2022) Lgr5+ cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages. Theranostics 12:5631\u20135644","journal-title":"Theranostics"},{"key":"4060_CR12","doi-asserted-by":"publisher","first-page":"E5068","DOI":"10.1073\/pnas.1512272112","volume":"112","author":"N Schnittke","year":"2015","unstructured":"Schnittke N, Herrick DB, Lin B, Peterson J, Coleman JH, Packard AI, Jang W, Schwob JE (2015) Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium. Proc Natl Acad Sci U S A 112:E5068-5077","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4060_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nature10408","volume":"478","author":"H Tian","year":"2011","unstructured":"Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ (2011) A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478:255-U148","journal-title":"Nature"},{"key":"4060_CR14","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abq4341","author":"S Ualiyeva","year":"2024","unstructured":"Ualiyeva S, Lemire E, Wong C, Perniss A, Boyd AA, Avil\u00e9s EC, Minichetti DG, Maxfield AZ, Roditi RE, Matsumoto I, Wang X, Deng WJ, Barrett NA, Buchheit KM, Laidlaw TM, Boyce JA, Bankova LG, Haber AL (2024) A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation. Sci Immunol. https:\/\/doi.org\/10.1126\/sciimmunol.abq4341","journal-title":"Sci Immunol"},{"key":"4060_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","volume":"14","author":"F Wang","year":"2012","unstructured":"Wang F, Flanagan J, Su N, Wang LC, Bui S, Nielson A, Wu XY, Vo HT, Ma XJ, Luo YL (2012) RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. J Mol Diagn 14:22\u201329","journal-title":"J Mol Diagn"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-026-04060-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-026-04060-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-026-04060-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:14:21Z","timestamp":1774923261000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-026-04060-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["4060"],"URL":"https:\/\/doi.org\/10.1007\/s00441-026-04060-x","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31"}}