{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:13:52Z","timestamp":1782242032989,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T00:00:00Z","timestamp":1190332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioprocess Biosyst Eng"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s00449-007-0159-3","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T13:21:52Z","timestamp":1190294512000},"page":"299-306","source":"Crossref","is-referenced-by-count":15,"title":["Aerobic production of isoamyl acetate by overexpression of the yeast alcohol acetyl-transferases AFT1 and AFT2 in Escherichia coli and using low-cost fermentation ingredients"],"prefix":"10.1007","volume":"31","author":[{"given":"R.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. V.","family":"Vadlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. N.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-Y.","family":"San","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,9,21]]},"reference":[{"key":"159_CR1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/mben.2001.0196","volume":"3","author":"J Bongaerts","year":"2001","unstructured":"Bongaerts J, Kramer M, Muller U, Raeven L, Wubbolts M (2001) Metabolic engineering for microbial production or aromatic amino acids and derived compounds. Metab Eng 3:289\u2013300","journal-title":"Metab Eng"},{"issue":"1","key":"159_CR2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/j.2050-0416.2003.tb00591.x","volume":"109","author":"MG Quilter","year":"2003","unstructured":"Quilter MG, Hurley JC, Lynch FJ, Murphy MG (2003) The production of isoamyl acetate from amyl alcohol by Saccharomyces cerevisiae. J Inst Brew 109(1):34\u201340","journal-title":"J Inst Brew"},{"key":"159_CR3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jctb.722","volume":"77","author":"EJ Vandamme","year":"2002","unstructured":"Vandamme EJ, Soetaert W (2002) Bioflavours and fragrances via fermentation and biocatalysts. J Chem Technol Biotechnol 77:1323\u20131332","journal-title":"J Chem Technol Biotechnol"},{"key":"159_CR4","first-page":"41","volume-title":"Bioprocess production of flavor, fragrance, and color ingredients","author":"DW Armstrong","year":"1994","unstructured":"Armstrong DW, Brown LA (1994) Aliphatic, aromatic and lactone compounds. In: Gabelman A (ed) Bioprocess production of flavor, fragrance, and color ingredients. Wiley, New Jersey, pp 41\u201394"},{"key":"159_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0168-1656(00)00432-6","volume":"87","author":"KS Hari","year":"2001","unstructured":"Hari KS, Divakar S, Prapulla SG, Karanth NG (2001) Enzymatic synthesis of isoamyl acetate using immobilized lipase from Rhizomuco miehei. J Biotechnol 87:193\u2013201","journal-title":"J Biotechnol"},{"key":"159_CR6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-313X.1998.00121.x","volume":"14","author":"N Dudareva","year":"1998","unstructured":"Dudareva N, D\u2019Auria JC, Nam KH, Raguso RA, Pichersky E (1998) Acetyl-CoA: benzyl alcohol acetyltransferase- an enzyme involved in floral scent production in Clarka breweri. Plant J 14:297\u2013304","journal-title":"Plant J"},{"key":"159_CR7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1104\/pp.116.2.599","volume":"116","author":"N Dudareva","year":"1998","unstructured":"Dudareva N, Raguso RA, Wang J, Ross JR, Pichersky E (1998) Floral scent production in Clarkia breweri III. Enzymatic synthesis and emission of benzenoid esters. Plant Physiol 116:599\u2013604","journal-title":"Plant Physiol"},{"key":"159_CR8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1128\/AEM.66.2.744-753.2000","volume":"66","author":"M Lilly","year":"2000","unstructured":"Lilly M, Lambrechts MG, Pretorius IS (2000) Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates. Appl Environ Microbiol 66:744\u2013753","journal-title":"Appl Environ Microbiol"},{"key":"159_CR9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/1097-0061(200010)16:14<1287::AID-YEA613>3.0.CO;2-I","volume":"16","author":"AB Mason","year":"2000","unstructured":"Mason AB, Dufour JP (2000) Alcohol acetyltransferases and the significance of ester synthesis in yeast. Yeast 16:1287\u20131289","journal-title":"Yeast"},{"key":"159_CR10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1021\/jf001075p","volume":"49","author":"M Shalit","year":"2001","unstructured":"Shalit M, Katzir N, Tadmor Y, Larkov O, Burger Y, Shalekhet Y, Lastochkin E, Ravid U, Amar O, Edelstein M, Karchi Z, Lewinsohn E (2001) Acetyl-CoA: alcohol acetyltransferase activity and aroma formation in ripening melon fruits. J Agric Food Chem 49:794\u2013799","journal-title":"J Agric Food Chem"},{"key":"159_CR11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/(SICI)1097-0061(19990330)15:5<409::AID-YEA366>3.0.CO;2-Q","volume":"15","author":"H Yoshimoto","year":"1999","unstructured":"Yoshimoto H, Fujiwara D, Momma T, Tanaka K, Sone H, Nagasawa N, Tamai Y (1999) Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus. Yeast 15:409\u2013417","journal-title":"Yeast"},{"key":"159_CR12","first-page":"1","volume-title":"Bioprocess production of flavor, fragrance, and color ingredients","author":"FW Welsh","year":"1994","unstructured":"Welsh FW (1994) Overview of bioprocess flavor and fragrance production. In: Gabelman A (ed) Bioprocess production of flavor, fragrance, and color ingredients. Wiley, New Jersey pp 1\u20137"},{"key":"159_CR13","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1128\/AEM.60.8.2786-2792.1994","volume":"60","author":"T Fujii","year":"1994","unstructured":"Fujii T, Nagasawa N, Iwamatsu A, Bogaki T, Tamai Y, Hamachi M (1994) Molecular cloning, sequence analysis, and expression of the yeast alcohol acetyltranferase gene. Appl Environ Microbiol 60:2786\u20132792","journal-title":"Appl Environ Microbiol"},{"key":"159_CR14","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1271\/bbb.62.1852","volume":"62","author":"N Nagasawa","year":"1998","unstructured":"Nagasawa N, Bogaki T, Iwamatsu A, Hamachi M, Kumagai C (1998) Cloning and nucleotide sequence of the alcohol acetyltransferase II gene (ATF2) from Saccharomyces cerevisiae Kyokai No. 7. Biosci Biotechnol Biochem 62:1852\u20131857","journal-title":"Biosci Biotechnol Biochem"},{"key":"159_CR15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s002530051662","volume":"53","author":"K Fukuda","year":"2000","unstructured":"Fukuda K, Kiyokawa Y, Yanagiuchi T, Wakai Y, Kitamoto K, Inoue Y, Kimura A (2000) Purification and characterization of isoamyl acetate-hydrolyzing esterase encoded by the IAH1 gene of Saccharomyces cerevisiae from a recombinant Escherichia coli. Appl Microbiol Biotechnol 53:596\u2013600","journal-title":"Appl Microbiol Biotechnol"},{"key":"159_CR16","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1128\/AEM.64.10.4076-4078.1998","volume":"64","author":"K Fukuda","year":"1998","unstructured":"Fukuda K, Yamamoto N, Kiyokawa Y, Yanagiuchi T, Wakai Y, Kitamoto K, Inoue Y, Kimura A (1998) Balance of activities of alcohol acetyltransferase and esterase in Saccharomyces cerevisiae is important for production of isoamyl acetate. Appl Environ Microbiol 64:4076\u20134078","journal-title":"Appl Environ Microbiol"},{"key":"159_CR17","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1271\/bbb.57.2094","volume":"57","author":"T Minetoki","year":"1993","unstructured":"Minetoki T, Bogaki T, Iwamatsu A, Fujii T, Hamachi M (1993) The purification, properties and internal peptide sequences of alcohol acetyltransferase isolated from Saccharomyces cerevisiae Kyokai No. 7. Biosci Biotechnol Biochem 57:2094\u20132098","journal-title":"Biosci Biotechnol Biochem"},{"key":"159_CR18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/mben.2001.0220","volume":"4","author":"KY San","year":"2002","unstructured":"San KY, Bennett GN, Berrios-Rivera SJ, Vadali RV, Yang YT, Horton E, Rudolph FB, Sariyar B, Blackwood K (2002) Metabolic engineering through cofactor manipulation and its effects on metabolic flux redistribution in Escherichia coli. Metab Eng 4:182\u2013192","journal-title":"Metab Eng"},{"key":"159_CR19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ymben.2004.02.006","volume":"6","author":"RV Vadali","year":"2004","unstructured":"Vadali RV, Bennett GN, San KY (2004) Applicability of CoA\/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli. Metab Eng 6:294\u2013299","journal-title":"Metab Eng"},{"key":"159_CR20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/mben.1998.0103","volume":"1","author":"YT Yang","year":"1999","unstructured":"Yang YT, Aristidou AA, San KY, Bennett GN (1999) Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase. Metab Eng 1:26\u201334","journal-title":"Metab Eng"},{"key":"159_CR21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1097-0290(19991105)65:3<291::AID-BIT6>3.0.CO;2-F","volume":"65","author":"YT Yang","year":"1999","unstructured":"Yang YT, Bennett GN, San KY (1999) Effect of inactivation of nuo and ackA-pta on redistribution of metabolic fluxes in Escherichia coli. Biotechnol Bioeng 65:291\u2013297","journal-title":"Biotechnol Bioeng"},{"key":"159_CR22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ymben.2004.02.001","volume":"6","author":"RV Vadali","year":"2004","unstructured":"Vadali RV, Bennett GN, San KY (2004) Cofactor engineering of intracellular CoA\/acetyl-CoA and its effect on metabolic flux redistribution in Escherichia coli. Metab Eng 6:133\u2013139","journal-title":"Metab Eng"},{"key":"159_CR23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00253-003-1452-y","volume":"63","author":"RV Vadali","year":"2004","unstructured":"Vadali RV, Horton CE, Rudolph FB, Bennett GN, San KY (2004) Production of isoamyl acetate in ack-pta and\/or ldh mutants of Escherichia coli with overexpression of yeast ATF2. Appl Microbiol Biotechnol 63:698\u2013704","journal-title":"Appl Microbiol Biotechnol"},{"key":"159_CR24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01023351","volume":"14","author":"GJ Tolentino","year":"1992","unstructured":"Tolentino GJ, Meng SY, Bennett GN, San KY (1992) A pH-regulated promoter for the expression of recombinant proteins in Escherichia coli. Biotechnol Lett 14:157\u2013162","journal-title":"Biotechnol Lett"},{"key":"159_CR25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1021\/bp034326y","volume":"20","author":"RV Vadali","year":"2004","unstructured":"Vadali RV, Bennett GN, San KY (2004) Enhanced isoamyl acetate production upon manipulation of the acetyl-CoA node in Escherichia coli. Biotechnol Prog 20:692\u2013697","journal-title":"Biotechnol Prog"},{"key":"159_CR26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10295-003-0070-0","volume":"30","author":"CE Horton","year":"2003","unstructured":"Horton CE, Huang KX, Bennett GN, Rudolph FB (2003) Heterologous expression of the Saccharomyces cerevisiae alcohol acetyltransferase genes in Clostridium acetobutylicum and Escherichia coli for the production of isoamyl acetate. J Ind Microbiol Biotechnol 30:427\u2013432","journal-title":"J Ind Microbiol Biotechnol"},{"key":"159_CR27","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1128\/AEM.69.5.2831-2841.2003","volume":"69","author":"Y Zhao","year":"2003","unstructured":"Zhao Y, Hindorff LA, Chuang A, Monroe-Augustus M, Lyristis M, Harrison M, Rudolph FB, Bennett GN (2003) Expression of a cloned cyclopropane fatty acid synthase gene reduces solvent formation in Clostridium acetobutylicum ATCC 824 Appl Environ Microbiol 69:2831\u20132841","journal-title":"Appl Environ Microbiol"}],"container-title":["Bioprocess and Biosystems Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-007-0159-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00449-007-0159-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-007-0159-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T17:40:14Z","timestamp":1587922814000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00449-007-0159-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,21]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["159"],"URL":"https:\/\/doi.org\/10.1007\/s00449-007-0159-3","relation":{},"ISSN":["1615-7591","1615-7605"],"issn-type":[{"value":"1615-7591","type":"print"},{"value":"1615-7605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,21]]}}}