{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:52:39Z","timestamp":1782337959003,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SERB\/LS-962\/2012"],"award-info":[{"award-number":["SERB\/LS-962\/2012"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bioprocess Biosyst Eng"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00449-016-1719-1","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T06:54:48Z","timestamp":1482130488000},"page":"537-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Graphene nanoflakes on transparent glass electrode sensor for electrochemical sensing of anti-diabetic drug"],"prefix":"10.1007","volume":"40","author":[{"given":"Jagriti","family":"Narang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitali","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kathuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manan","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"1719_CR1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7326\/0003-4819-137-1-200207020-00009","volume":"137","author":"D Kirpichnikov","year":"2002","unstructured":"Kirpichnikov D, McFarlane SI, Sowers JR (2002) Metformin: an update. Ann Intern Med 137:25\u201333","journal-title":"Ann Intern Med"},{"key":"1719_CR2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.clinbiochem.2010.11.004","volume":"44","author":"J Lu","year":"2011","unstructured":"Lu J, Randell E, Han Y, Adeli K, Krahn J, Meng QH (2011) Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy. Clin Biochem 44:307\u2013311","journal-title":"Clin Biochem"},{"key":"1719_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","volume":"346","author":"WC Knowler","year":"2002","unstructured":"Knowler WC, Barrett-Connor E, Fowle SE (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393\u2013403","journal-title":"N Engl J Med"},{"key":"1719_CR4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4158\/EP.12.S1.20","volume":"12","author":"RE Ratner","year":"2006","unstructured":"Ratner RE (2006) An update on the diabetes prevention program. Endocr Pract 12:20\u201324","journal-title":"Endocr Pract"},{"key":"1719_CR5","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/diabetes.51.7.2074","volume":"51","author":"N Musi","year":"2002","unstructured":"Musi N et al (2002) Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51:2074\u20132081","journal-title":"Diabetes"},{"key":"1719_CR6","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jpba.2007.04.014","volume":"44","author":"XJ Tian","year":"2007","unstructured":"Tian XJ, Song JF (2007) Catalytic action of copper (II) ion on electrochemical oxidation of metformine 1200 and voltammetric determination of metformin in pharmaceuticals. J Pharm Biomed Anal 44:1192\u20131196","journal-title":"J Pharm Biomed Anal"},{"key":"1719_CR7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0378-4347(97)00568-9","volume":"706","author":"B Chiavarino","year":"1998","unstructured":"Chiavarino B, Crestoni ME, Marzio AD, Fornarini S (1998) Determination of sulfonamide antibiotics by gas\u00a0chromatography\u00a0coupled with atomic emission detection. J Chromatogr B Biomed Sci Appl 706:269\u2013277","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"1719_CR8","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jpba.2010.03.017","volume":"53","author":"II Hamdan","year":"2010","unstructured":"Hamdan II, Bani Jaber AK, Abushoffa AM (2010) Development and validation of a stability indicating capillary electrophoresis method for the determination of metformin hydrochloride in tablets. J Pharm Biomed Anal 53:1254\u20131257","journal-title":"J Pharm Biomed Anal"},{"key":"1719_CR9","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1080\/00032718508066218","volume":"18","author":"JM Calatayud","year":"1985","unstructured":"Calatayud JM, Falco PC, Marti MCP (1985) Metformin and moroxidine determination with Cu (II). Anal Lett 18:1381\u20131390","journal-title":"Anal Lett"},{"key":"1719_CR10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4314\/tjpr.v11i1.14","volume":"11","author":"P Umapathi","year":"2012","unstructured":"Umapathi P, Ayyappan J, Quine SD (2012) Quantitative determination of metformin hydrochloride in tablet formulation containing croscarmellose sodium as disintegrant by HPLC and UV spectrophotometry. Trop J Pharm Res 11:107\u2013116","journal-title":"Trop J Pharm Res"},{"key":"1719_CR11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.chroma.2003.11.042","volume":"1027","author":"SY Feng","year":"2004","unstructured":"Feng SY, Lai EPC, Zlotorzynska ED, Sadeghi S (2004) Molecularly imprinted solid-phase extraction for the screening of antihyperglycemic biguanide. J Chromatogr A 1027:155\u2013160","journal-title":"J Chromatogr A"},{"key":"1719_CR12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0039-9140(03)00123-1","volume":"60","author":"IHI Habib","year":"2003","unstructured":"Habib IHI, Kamel MS (2003) Near infra-red reflectance spectroscopic determination of metformin in tablets. Talanta 60:185\u2013190","journal-title":"Talanta"},{"key":"1719_CR13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.2116\/analsci.27.1037","volume":"27","author":"MR Sohrabi","year":"2011","unstructured":"Sohrabi MR, Kamali N, Khakpour M (2011) Simultaneous spectrophotometric determination of metformin hydrochloride and glibenclamide in binary mixtures using combined discrete and continuous wavelet transforms. Anal Sci 27:1037\u20131041","journal-title":"Anal Sci"},{"key":"1719_CR14","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.msec.2016.02.006","volume":"62","author":"C Singhal","year":"2016","unstructured":"Singhal C, Malhotra N, Chauhan N, Narang S, Pundir CS, Narang J (2016) Hierarchical electrodeposition of methylene blue on ZnO nanocrystals thin films layered on SnO2\/F electrode for in vitro sensing of anti-thalassemic drug. Mater Sci Eng C 62:596\u2013604","journal-title":"Mater Sci Eng C"},{"key":"1719_CR15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bios.2016.07.013","volume":"86","author":"J Narang","year":"2016","unstructured":"Narang J, Singhal C, Malhotra N, Narang S, Pn AK, Gupta R, Kansal R, Pundir CS (2016) Impedimetric genosensor for ultratrace detection of hepatitis B virus DNA in patient samples assisted by zeolites and MWCNT nano-composites. Biosens Bioelectron 86:566\u2013574","journal-title":"Biosens Bioelectron"},{"key":"1719_CR16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.msec.2016.07.012","volume":"69","author":"C Singhal","year":"2016","unstructured":"Singhal C, Malhotra N, Pundir CS, Gaud D, Narang J (2016) An enzyme free vitamin C augmented sensing with different ZnO morphologies on SnO2\/F transparent glass electrode: a comparative study. Mater Sci Eng C 69:769\u2013779","journal-title":"Mater Sci Eng C"},{"issue":"3","key":"1719_CR17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/adma.201303075","volume":"26","author":"O Parlak","year":"2014","unstructured":"Parlak O, Turner APF, Tiwari A (2014) On\/off switchable zipper-like bioelectronics on a graphene interface. Adv Mater 26(3):482\u2013486","journal-title":"Adv Mater"},{"key":"1719_CR18","doi-asserted-by":"crossref","unstructured":"Tiwari A (2012). Intelligent nanomaterials, 2nd edn. Wiley, New York","DOI":"10.1002\/9781118311974"},{"key":"1719_CR19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1103\/RevModPhys.81.109","volume":"81","author":"AHC Neto","year":"2009","unstructured":"Neto AHC, Guinea F, Peres N, Novoselov K, Geim A (2009) The electronic properties of graphene. Rev Mod Phys 81:109","journal-title":"Rev Mod Phys"},{"key":"1719_CR20","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1039\/C5TB01355K","volume":"3","author":"O Parlak","year":"2015","unstructured":"Parlak O, Turner APF, Tiwari A (2015) pH-induced on\/off-switchable graphene bioelectronics. J Mater Chem B 3:7434\u20137439","journal-title":"J Mater Chem B"},{"key":"1719_CR21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1039\/C2TC00010E","volume":"1","author":"YC Lai","year":"2013","unstructured":"Lai YC et al (2013) Low operation voltage macromolecular composite memory assisted by graphene nanoflakes. J Mater Chem C 1:552","journal-title":"J Mater Chem C"},{"key":"1719_CR22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/00018732.2010.487978","volume":"59","author":"DSL Abergel","year":"2010","unstructured":"Abergel DSL, Apalkov V, Berashevich J, Zieler K, Chakraborty T (2010) Properties of graphene: a theoretical perspective. Adv Phys 59:261\u2013482","journal-title":"Adv Phys"},{"issue":"9","key":"1719_CR23","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1149\/1.2100851","volume":"134","author":"TB Hunter","year":"1987","unstructured":"Hunter TB, Tyler PS, Smyrl WH, White HS (1987) Impedance analysis of poly (vinylferrocene) films. J Electrochem Soc 134(9):2198\u20132240","journal-title":"J Electrochem Soc"},{"key":"1719_CR24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF01009134","volume":"17","author":"C Gabrielli","year":"1987","unstructured":"Gabrielli C, Haas O, Takenouti H (1987) Impedance analysis of electrodes modified with a reversible redox polymer film. J Appl Electrochem 17:82\u201390","journal-title":"J Appl Electrochem"},{"key":"1719_CR25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0003-2670(96)00437-0","volume":"338","author":"Y Wang","year":"1997","unstructured":"Wang Y, Zhu G, Wang E (1997) Electrochemical behavior of FAD at a gold electrode studied by electrochemical quartz crystal microbalance. Anal Chim Acta 338:97\u2013101","journal-title":"Anal Chim Acta"},{"key":"1719_CR26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.snb.2015.01.033","volume":"210","author":"S Mutyala","year":"2015","unstructured":"Mutyala S, Mathiyarasu J (2015) Preparation of graphene nanoflakes and its application for detection of hydrazine. Sens Act B 210:692\u2013699","journal-title":"Sens Act B"},{"issue":"2","key":"1719_CR27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jpba.2007.07.010","volume":"45","author":"S Skrzypek","year":"2007","unstructured":"Skrzypek S, Mirceski V, Ciesielski W, Soko\u0142owski A, Zakrzewski R (2007) Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry. J Pharm Biomed Anal 45(2):275\u2013281","journal-title":"J Pharm Biomed Anal"},{"issue":"1","key":"1719_CR28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jelechem.2011.08.008","volume":"661","author":"E Khaled","year":"2011","unstructured":"Khaled E, Kamel SM, Hassan HM, Aboul-Enein HY (2011) Cyclodextrin-based dextromethorphan potentiometric sensors. J Electroanal Chem 661(1):239\u2013244","journal-title":"J Electroanal Chem"},{"key":"1719_CR29","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1016\/S1452-3981(23)08121-X","volume":"9","author":"LM Blanco Jerez","year":"2014","unstructured":"Blanco Jerez LM, Garc\u00eda-P\u00e9rez UM, Zambrano-Robledo P, Hern\u00e1ndez-Moreira J (2014) Carbon Paste electrode modified with BiVO4 to sense metformin. Int J Electrochem Sci 9:4643\u20134652","journal-title":"Int J Electrochem Sci"}],"container-title":["Bioprocess and Biosystems Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-016-1719-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00449-016-1719-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-016-1719-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:20:45Z","timestamp":1692613245000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00449-016-1719-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["1719"],"URL":"https:\/\/doi.org\/10.1007\/s00449-016-1719-1","relation":{},"ISSN":["1615-7591","1615-7605"],"issn-type":[{"value":"1615-7591","type":"print"},{"value":"1615-7605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}