{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:14:08Z","timestamp":1737695648130,"version":"3.33.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bioprocess Biosyst Eng"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00449-024-03095-0","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T04:01:29Z","timestamp":1728273689000},"page":"85-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative investigation of the effect of mechanical and geometrical factors of a laboratory-scale bioreactor using a vibrating agitator on mammalian cell culture indices"],"prefix":"10.1007","volume":"48","author":[{"given":"Sepehr","family":"Govara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Hosseinalipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"3095_CR1","volume-title":"Cell and tissue reaction engineering","author":"R Eibl","year":"2008","unstructured":"Eibl R, Eibl D, P\u00f6rtner R, Catapano G, Czermak P (2008) Cell and tissue reaction engineering. Springer, Berlin"},{"key":"3095_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2022.102828","author":"C Matanguihan","year":"2022","unstructured":"Matanguihan C, Wu P (2022) Upstream continuous processing: recent advances in production of biopharmaceuticals and challenges in manufacturing. Curr Opin Biotechnol. https:\/\/doi.org\/10.1016\/j.copbio.2022.102828","journal-title":"Curr Opin Biotechnol"},{"key":"3095_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/cben.202100022","author":"R Sharma","year":"2022","unstructured":"Sharma R, Harrison STL, Tai SL (2022) Advances in bioreactor systems for the production of biologicals in mammalian cells. ChemBioEng Rev. https:\/\/doi.org\/10.1002\/cben.202100022","journal-title":"ChemBioEng Rev"},{"key":"3095_CR4","unstructured":"Popovi\u0107 MK, P\u00f6rtner R (2012) Bioreactors and cultivation systems for cell and tissue culture. Encyclopedia of Life Support Systems (EOLSS), Paris"},{"key":"3095_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.522","author":"R Bareither","year":"2011","unstructured":"Bareither R, Pollard D (2011) A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need. Biotechnol Prog. https:\/\/doi.org\/10.1002\/btpr.522","journal-title":"Biotechnol Prog"},{"key":"3095_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/elsc.201900162","author":"K Paul","year":"2020","unstructured":"Paul K, Herwig C (2020) Scale-down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large-scale bioreactors. Eng Life Sci. https:\/\/doi.org\/10.1002\/elsc.201900162","journal-title":"Eng Life Sci"},{"key":"3095_CR7","doi-asserted-by":"publisher","DOI":"10.2174\/187220811797579105","author":"P Fernandes","year":"2011","unstructured":"Fernandes P, Carvalho F, Marques MPC (2011) Miniaturization in biotechnology: speeding up the development of bioprocesses. Recent Pat Biotechnol. https:\/\/doi.org\/10.2174\/187220811797579105","journal-title":"Recent Pat Biotechnol"},{"key":"3095_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2006.10.006","author":"M Micheletti","year":"2006","unstructured":"Micheletti M, Lye GJ (2006) Microscale bioprocess optimisation. Curr Opin Biotechnol. https:\/\/doi.org\/10.1016\/j.copbio.2006.10.006","journal-title":"Curr Opin Biotechnol"},{"key":"3095_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27795","author":"H Morschett","year":"2021","unstructured":"Morschett H, Tenhaef N, Hemmerich J, Herbst L, Spiertz M, Dogan D, Wiechert W, Noack S, Oldiges M (2021) Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model-driven process analysis. Biotechnol Bioeng. https:\/\/doi.org\/10.1002\/bit.27795","journal-title":"Biotechnol Bioeng"},{"key":"3095_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0051951","author":"A Prokop","year":"2006","unstructured":"Prokop A, Rosenberg MZ (2006) Bioreactor for mammalian cell culture. Vertebr Cell Cult II Enzym Technol. https:\/\/doi.org\/10.1007\/BFb0051951","journal-title":"Vertebr Cell Cult II Enzym Technol"},{"key":"3095_CR11","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2018.1489778","author":"A Valdiani","year":"2019","unstructured":"Valdiani A, Hansen OK, Nielsen UB, Johannsen VK, Shariat M, Georgiev MI, Omidvar V, Ebrahimi M, Tavakoli Dinanai E, Abiri R (2019) Bioreactor-based advances in plant tissue and cell culture: challenges and prospects. Crit Rev Biotechnol. https:\/\/doi.org\/10.1080\/07388551.2018.1489778","journal-title":"Crit Rev Biotechnol"},{"key":"3095_CR12","unstructured":"Spier MR, Vandenberghe L, Medeiros ABP, Soccol CR (2011) In: Antolli PG, Liu Z (eds) Bioreactors: design, properties and applications. Nova Science Publishers, New York"},{"key":"3095_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-018-1902-7","author":"A Kazemzadeh","year":"2018","unstructured":"Kazemzadeh A, Elias C, Tamer M, Ein-Mozaffari F (2018) Hydrodynamic performance of a single-use aerated stirred bioreactor in animal cell culture: applications of tomography, dynamic gas disengagement (DGD), and CFD. Bioprocess Biosyst Eng. https:\/\/doi.org\/10.1007\/s00449-018-1902-7","journal-title":"Bioprocess Biosyst Eng"},{"key":"3095_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24780","author":"D Bulnes-Abundis","year":"2013","unstructured":"Bulnes-Abundis D, Carrillo-Cocom LM, Ar\u00e1iz-Hern\u00e1ndez D, Garc\u00eda-Ulloa A, Granados-Pastor M, S\u00e1nchez-Arreola PB, Murugappan G, Alvarez MM (2013) A simple eccentric stirred tank mini-bioreactor: mixing characterization and mammalian cell culture experiments. Biotechnol Bioeng. https:\/\/doi.org\/10.1002\/bit.24780","journal-title":"Biotechnol Bioeng"},{"key":"3095_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-021-00154-3","author":"D Lim","year":"2022","unstructured":"Lim D, Renteria ES, Sime DS, Ju YM, Kim JH, Criswell T, Shupe TD, Atala A, Marini FC, Gurcan MN, Soker S, Hunsberger J, Yoo JJ (2022) Bioreactor design and validation for manufacturing strategies in tissue engineering. Bio-design Manuf. https:\/\/doi.org\/10.1007\/s42242-021-00154-3","journal-title":"Bio-design Manuf"},{"key":"3095_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.expthermflusci.2018.04.006","author":"F Qiu","year":"2018","unstructured":"Qiu F, Liu Z, Liu R, Quan X, Tao C, Wang Y (2018) Gas-liquid mixing performance, power consumption, and local void fraction distribution in stirred tank reactors with a rigid-flexile impeller. Exp Therm Fluid Sci. https:\/\/doi.org\/10.1016\/j.expthermflusci.2018.04.006","journal-title":"Exp Therm Fluid Sci"},{"key":"3095_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00369462","author":"RS Cherry","year":"1986","unstructured":"Cherry RS, Papoutsakis ET (1986) Hydrodynamic effects on cells in agitated tissue culture reactors. Bioprocess Eng. https:\/\/doi.org\/10.1007\/BF00369462","journal-title":"Bioprocess Eng"},{"key":"3095_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/pr2040753","author":"MZ Ismadi","year":"2014","unstructured":"Ismadi MZ, Hourigan K, Fouras A (2014) Experimental characterisation of fluid mechanics in a spinner flask bioreactor. Processes. https:\/\/doi.org\/10.3390\/pr2040753","journal-title":"Processes"},{"key":"3095_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106493","author":"MZ Ismadi","year":"2014","unstructured":"Ismadi MZ, Gupta P, Fouras A, Verma P, Jadhav S, Bellare J, Hourigan K (2014) Flow characterization of a spinner flask for induced pluripotent stem cell culture application. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0106493","journal-title":"PLoS ONE"},{"key":"3095_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2023.118545","author":"JN Delbridge","year":"2023","unstructured":"Delbridge JN, Barrett TA, Ducci A, Micheletti M (2023) Power, mixing and flow dynamics of the novel Allegro\u2122 stirred tank reactor. Chem Eng Sci. https:\/\/doi.org\/10.1016\/j.ces.2023.118545","journal-title":"Chem Eng Sci"},{"key":"3095_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20667","author":"B Bilgen","year":"2005","unstructured":"Bilgen B, Chang-Mateu IM, Barabino GA (2005) Characterization of mixing in a novel wavy-walled bioreactor for tissue engineering. Biotechnol Bioeng. https:\/\/doi.org\/10.1002\/bit.20667","journal-title":"Biotechnol Bioeng"},{"key":"3095_CR22","doi-asserted-by":"publisher","unstructured":"Ozturk SS (2013) In: Zhou W, Kantardjieff A (eds) Equipment for large-scale mammalian cell culture. Springer, Berlin. https:\/\/doi.org\/10.1007\/10_2013_259","DOI":"10.1007\/10_2013_259"},{"key":"3095_CR23","doi-asserted-by":"publisher","unstructured":"Bl\u00fcml G (2007) In: P\u00f6rtner R (ed) Animal cell biotechnology. Methods and protocols, 2nd edn. Humana Press, Totowa. https:\/\/doi.org\/10.1007\/978-1-59745-399-8_5","DOI":"10.1007\/978-1-59745-399-8_5"},{"key":"3095_CR24","unstructured":"Eichermueller MC (2014) A performance study and characterization of a single use pharmaceutical vibrational mixer using computational fluid dynamics. ProQuest Dissertations, Ann Arbor"},{"key":"3095_CR25","unstructured":"FUNDAMIX\u00ae VibromixerCharacterization (2014) DiVA portal. http:\/\/kth.diva-portal.org"},{"key":"3095_CR26","volume-title":"Fermentation and biochemical engineering handbook","author":"CM Todaro","year":"2014","unstructured":"Todaro CM, Vogel HC (2014) Fermentation and biochemical engineering handbook. Elsevier, Amsterdam"},{"key":"3095_CR27","doi-asserted-by":"publisher","DOI":"10.1252\/jcej.33.879","author":"Y Komoda","year":"2000","unstructured":"Komoda Y, Inoue Y, Hirata Y (2000) Mixing performance by reciprocating disk in cylindrical vessel. J Chem Eng Japan. https:\/\/doi.org\/10.1252\/jcej.33.879","journal-title":"J Chem Eng Japan"},{"key":"3095_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/S0255-2701(02)00214-3","author":"J Kamie\u0144ski","year":"2003","unstructured":"Kamie\u0144ski J, W\u00f3jtowicz R (2003) Dispersion of liquid\u2013liquid systems in a mixer with a reciprocating agitator. Chem Eng Process Process Intensif. https:\/\/doi.org\/10.1016\/S0255-2701(02)00214-3","journal-title":"Chem Eng Process Process Intensif"},{"key":"3095_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cep.2006.05.002","author":"S Masiuk","year":"2007","unstructured":"Masiuk S, Rakoczy R (2007) Power consumption, mixing time, heat and mass transfer measurements for liquid vessels that are mixed using reciprocating multiplates agitators. Chem Eng Process Process Intensif. https:\/\/doi.org\/10.1016\/j.cep.2006.05.002","journal-title":"Chem Eng Process Process Intensif"},{"key":"3095_CR30","doi-asserted-by":"publisher","DOI":"10.1021\/ie303086r","author":"M Kordas","year":"2013","unstructured":"Kordas M, Story G, Konopacki M, Rakoczy R (2013) Study of mixing time in a liquid vessel with rotating and reciprocating agitator. Ind Eng Chem Res. https:\/\/doi.org\/10.1021\/ie303086r","journal-title":"Ind Eng Chem Res"},{"key":"3095_CR31","doi-asserted-by":"publisher","DOI":"10.1021\/ie500604q","author":"R W\u00f3jtowicz","year":"2014","unstructured":"W\u00f3jtowicz R (2014) Choice of an optimal agitated vessel for the drawdown of floating solids. Ind Eng Chem Res. https:\/\/doi.org\/10.1021\/ie500604q","journal-title":"Ind Eng Chem Res"},{"key":"3095_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2017.07.010","author":"R W\u00f3jtowicz","year":"2017","unstructured":"W\u00f3jtowicz R (2017) Flow pattern and power consumption in a vibromixer. Chem Eng Sci. https:\/\/doi.org\/10.1016\/j.ces.2017.07.010","journal-title":"Chem Eng Sci"},{"key":"3095_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cherd.2018.08.003","author":"PM Orlewski","year":"2018","unstructured":"Orlewski PM, Wang Y, Hosseinalipour MS, Kryscio D, Iggland M, Mazzotti M (2018) Characterization of a vibromixer: experimental and modelling study of mixing in a batch reactor. Chem Eng Res Des. https:\/\/doi.org\/10.1016\/j.cherd.2018.08.003","journal-title":"Chem Eng Res Des"},{"key":"3095_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260070406","author":"K Ulrich","year":"1965","unstructured":"Ulrich K, Moore GE (1965) A vibrating mixer for agitation of suspension cultures of mammalian cells. Biotechnol Bioeng. https:\/\/doi.org\/10.1002\/bit.260070406","journal-title":"Biotechnol Bioeng"},{"key":"3095_CR35","doi-asserted-by":"publisher","unstructured":"Malik P, Mukherjee TK (2023) In: Mukherjee TK, Malik P, Mukherjee S (eds) Practical approach to mammalian cell and organ culture. Springer, Singapore. https:\/\/doi.org\/10.1007\/978-981-19-1731-8_15-2","DOI":"10.1007\/978-981-19-1731-8_15-2"},{"key":"3095_CR36","doi-asserted-by":"publisher","unstructured":"Birch JR, Arathoon R (2018) In: Lubiniecki AS (ed) Large-scale mammalian cell culture technology, 1st edn. Taylor & Francis, London. https:\/\/doi.org\/10.1201\/9780203749166","DOI":"10.1201\/9780203749166"},{"key":"3095_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0048442","author":"RT Acton","year":"2006","unstructured":"Acton RT, Lynn JD (2006) Description and operation of a large-scale, mammalian cell, suspension culture facility. Adv Biochem Eng. https:\/\/doi.org\/10.1007\/BFb0048442","journal-title":"Adv Biochem Eng"},{"key":"3095_CR38","doi-asserted-by":"publisher","unstructured":"Gupta SK, Dangi AK, Smita M, Dwivedi S, Shukla P (2019) In: Shukla P (ed) Effectual bioprocess development for protein production. Elsevier, Amsterdam. https:\/\/doi.org\/10.1016\/B978-0-12-815407-6.00011-3","DOI":"10.1016\/B978-0-12-815407-6.00011-3"},{"key":"3095_CR39","volume-title":"Principles of fermentation technology","author":"PF Stanbury","year":"2013","unstructured":"Stanbury PF, Whitaker A, Hall SJ (2013) Principles of fermentation technology. Elsevier, Amsterdam"},{"key":"3095_CR40","doi-asserted-by":"publisher","unstructured":"Engineering Statistics Handbook (2012) NIST, Gaithersburg. http:\/\/www.itl.nist.gov\/div898\/handbook. https:\/\/doi.org\/10.18434\/M32189","DOI":"10.18434\/M32189"},{"key":"3095_CR41","doi-asserted-by":"publisher","unstructured":"Ward OP (1991) In: Ward OP (ed) Bioprocessing, 1st edn. Springer, Boston. https:\/\/doi.org\/10.1007\/978-1-4615-3914-8_3","DOI":"10.1007\/978-1-4615-3914-8_3"},{"key":"3095_CR42","doi-asserted-by":"publisher","unstructured":"Tolbert WR, Feder J (1983) In: Tsao GT (ed) Annual reports on fermentation processes. Elsevier, Amsterdam. https:\/\/doi.org\/10.1016\/B978-0-12-040306-6.50008-0","DOI":"10.1016\/B978-0-12-040306-6.50008-0"},{"key":"3095_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(72)90025-4","author":"U Iversen","year":"1972","unstructured":"Iversen U, Iversen OH, Bluming AZ, Ziegler JL, Kyalwasi S (1972) Cell kinetics of African cases of Burkitt lymphoma: a preliminary report. Eur J Cancer. https:\/\/doi.org\/10.1016\/0014-2964(72)90025-4","journal-title":"Eur J Cancer"}],"container-title":["Bioprocess and Biosystems Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-024-03095-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00449-024-03095-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-024-03095-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T08:21:55Z","timestamp":1737620515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00449-024-03095-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3095"],"URL":"https:\/\/doi.org\/10.1007\/s00449-024-03095-0","relation":{},"ISSN":["1615-7591","1615-7605"],"issn-type":[{"type":"print","value":"1615-7591"},{"type":"electronic","value":"1615-7605"}],"subject":[],"published":{"date-parts":[[2024,10,7]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This declaration is \u201cnot applicable\u201d.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}