{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:11:28Z","timestamp":1792782688741,"version":"4.5.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/15087-8"],"award-info":[{"award-number":["2020\/15087-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["22\/04367-5"],"award-info":[{"award-number":["22\/04367-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/22532-0"],"award-info":[{"award-number":["2019\/22532-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/15087-8"],"award-info":[{"award-number":["2020\/15087-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Financial Code 001"],"award-info":[{"award-number":["Financial Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU and the State Research Agency","award":["PCI2022-121990"],"award-info":[{"award-number":["PCI2022-121990"]}]},{"name":"EU and the State Research Agency","award":["PCI2022-121990"],"award-info":[{"award-number":["PCI2022-121990"]}]},{"name":"ERA-NET AquaticPollutants Joint Transnational Call","award":["869178"],"award-info":[{"award-number":["869178"]}]},{"name":"ERA-NET AquaticPollutants Joint Transnational Call","award":["869178"],"award-info":[{"award-number":["869178"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bioprocess Biosyst Eng"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00449-025-03281-8","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:22:25Z","timestamp":1767860545000},"page":"691-710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Understanding the kinetics of antibiotic mixture biotransformation and microbial interactions in an anaerobic fixed-bed reactor for wastewater treatment"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-0092","authenticated-orcid":false,"given":"Mateus","family":"Cottorello-Fons\u00eaca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5721-3072","authenticated-orcid":false,"given":"Elias G. F.","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-8287","authenticated-orcid":false,"given":"Francisco R. S.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-4133","authenticated-orcid":false,"given":"Rodrigo B.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-1116","authenticated-orcid":false,"given":"Isabel K.","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-561X","authenticated-orcid":false,"given":"Rogers","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-9093","authenticated-orcid":false,"given":"Marcelo","family":"Zaiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"3281_CR1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.anaerobe.2017.06.007","volume":"48","author":"J Ker\u010dmar","year":"2017","unstructured":"Ker\u010dmar J, Pintar A (2017) Support material dictates the attached biomass characteristics during the immobilization process in anaerobic continuous-flow packed-bed bioreactor. Anaerobe 48:194\u2013202. https:\/\/doi.org\/10.1016\/j.anaerobe.2017.06.007","journal-title":"Anaerobe"},{"key":"3281_CR2","doi-asserted-by":"publisher","unstructured":"Cayetano RDA, Kim GB, Park J, Yang YH, Jeon BH, Jang M, Kim SH (2022) Biofilm formation as a method of improved treatment during anaerobic digestion of organic matter for biogas recovery. Bioresour Technol 344. https:\/\/doi.org\/10.1016\/j.biortech.2021.126309","DOI":"10.1016\/j.biortech.2021.126309"},{"key":"3281_CR3","doi-asserted-by":"publisher","unstructured":"Carneiro RB, Mukaeda CM, Sabatini CA, Santos-Neto \u00c1J, Zaiat M (2020) Influence of organic loading rate on Ciprofloxacin and sulfamethoxazole biodegradation in anaerobic fixed bed biofilm reactors. J Environ Manage 273. https:\/\/doi.org\/10.1016\/j.jenvman.2020.111170","DOI":"10.1016\/j.jenvman.2020.111170"},{"key":"3281_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.watres.2015.06.042","volume":"83","author":"ME Casas","year":"2015","unstructured":"Casas ME, Chhetri RK, Ooi G, Hansen KMS, Litty K, Christensson M, Kragelund C, Andersen HR, Bester K (2015) Biodegradation of pharmaceuticals in hospital wastewater by staged moving bed biofilm reactors (MBBR). Water Res 83:293\u2013302. https:\/\/doi.org\/10.1016\/j.watres.2015.06.042","journal-title":"Water Res"},{"key":"3281_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.scitotenv.2019.04.437","volume":"678","author":"RB Carneiro","year":"2019","unstructured":"Carneiro RB, Sabatini CA, Santos-Neto \u00c1J, Zaiat M (2019) Feasibility of anaerobic packed and structured-bed reactors for sulfamethoxazole and Ciprofloxacin removal from domestic sewage. Sci Total Environ 678:419\u2013429. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.437","journal-title":"Sci Total Environ"},{"key":"3281_CR6","doi-asserted-by":"publisher","unstructured":"Rusu A, Munteanu AC, Arb\u0103na\u0219i EM, Uivarosi V (2023) Overview of Side-Effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics 15. https:\/\/doi.org\/10.3390\/pharmaceutics15030804","DOI":"10.3390\/pharmaceutics15030804"},{"key":"3281_CR7","doi-asserted-by":"publisher","unstructured":"Cottorello-Fons\u00eaca M, Castro GB, Corbi JJ, Zaiat M (2025) Anaerobic reactors for hospital wastewater treatment: a critical review of microbial communities in the antibiotic biodegradation and ecotoxicological impacts. Biodegradation 36. https:\/\/doi.org\/10.1007\/s10532-025-10207-4","DOI":"10.1007\/s10532-025-10207-4"},{"key":"3281_CR8","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.2134\/jeq2011.0459","volume":"41","author":"I Rosendahl","year":"2012","unstructured":"Rosendahl I, Siemens J, Kindler R, Groeneweg J, Zimmermann J, Czerwinski S, Lamsh\u00f6ft M, Laabs V, Wilke B-M, Vereecken H, Amelung W (2012) Persistence of the fluoroquinolone antibiotic Difloxacin in soil and lacking effects on nitrogen turnover. J Environ Qual 41:1275\u20131283. https:\/\/doi.org\/10.2134\/jeq2011.0459","journal-title":"J Environ Qual"},{"key":"3281_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jenvman.2013.02.007","volume":"120","author":"N Dorival-Garc\u00eda","year":"2013","unstructured":"Dorival-Garc\u00eda N, Zafra-G\u00f3mez A, Naval\u00f3n A, Gonz\u00e1lez-L\u00f3pez J, Hontoria E, V\u00edlchez JL (2013) Removal and degradation characteristics of quinolone antibiotics in laboratory-scale activated sludge reactors under aerobic, nitrifying and anoxic conditions. J Environ Manage 120:75\u201383. https:\/\/doi.org\/10.1016\/j.jenvman.2013.02.007","journal-title":"J Environ Manage"},{"key":"3281_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pr8111479","volume":"8","author":"M Conde-Cid","year":"2020","unstructured":"Conde-Cid M, N\u00fa\u00f1ez-Delgado A, Fern\u00e1ndez-Sanjurjo MJ, \u00c1lvarez-Rodr\u00edguez E, Fern\u00e1ndez-Calvi\u00f1o D (2020) Arias-Est\u00e9vez, Tetracycline and sulfonamide antibiotics in soils: Presence, fate and environmental risks. Processes 8:1\u201340. https:\/\/doi.org\/10.3390\/pr8111479","journal-title":"Processes"},{"key":"3281_CR11","doi-asserted-by":"publisher","unstructured":"Tian S, Zhang C, Huang D, Wang R, Zeng G, Yan M, Xiong W, Zhou C, Cheng M, Xue W, Yang Y, Wang W (2020) Recent progress in sustainable technologies for adsorptive and reactive removal of sulfonamides. Chem Eng J 389. https:\/\/doi.org\/10.1016\/j.cej.2019.123423","DOI":"10.1016\/j.cej.2019.123423"},{"key":"3281_CR12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jhazmat.2012.04.044","volume":"221\u2013222","author":"A Bia\u0142k-Bieli\u0144ska","year":"2012","unstructured":"Bia\u0142k-Bieli\u0144ska A, Stolte S, Matzke M, Fabia\u0144ska A, Maszkowska J, Ko\u0142odziejska M, Liberek B, Stepnowski P, Kumirska J (2012) Hydrolysis of sulphonamides in aqueous solutions. J Hazard Mater 221\u2013222:264\u2013274. https:\/\/doi.org\/10.1016\/j.jhazmat.2012.04.044","journal-title":"J Hazard Mater"},{"key":"3281_CR13","doi-asserted-by":"publisher","unstructured":"Carneiro RB, Gil-Solsona R, Subirats J, Restrepo-Montes E, Zaiat M, Santos-Neto \u00c1J, Gago-Ferrero P (2024) Biotransformation pathways of pharmaceuticals and personal care products (PPCPs) during acidogenesis and methanogenesis of anaerobic digestion. J Hazard Mater 478. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.135444","DOI":"10.1016\/j.jhazmat.2024.135444"},{"key":"3281_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jhazmat.2016.04.067","volume":"315","author":"X Bai","year":"2016","unstructured":"Bai X, Acharya K (2016) Removal of trimethoprim, sulfamethoxazole, and triclosan by the green Alga nannochloris Sp. J Hazard Mater 315:70\u201375. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.04.067","journal-title":"J Hazard Mater"},{"key":"3281_CR15","doi-asserted-by":"publisher","unstructured":"Mpatani FM, Aryee AA, Kani AN, Han R, Li Z, Dovi E, Qu L (2021) A review of treatment techniques applied for selective removal of emerging pollutant-trimethoprim from aqueous systems. J Clean Prod 308. https:\/\/doi.org\/10.1016\/j.jclepro.2021.127359","DOI":"10.1016\/j.jclepro.2021.127359"},{"key":"3281_CR16","doi-asserted-by":"publisher","unstructured":"Kraupner N, Ebmeyer S, Hutinel M, Fick J, Flach CF, Larsson DGJ (2020) Selective concentrations for Trimethoprim resistance in aquatic environments. Environ Int 144. https:\/\/doi.org\/10.1016\/j.envint.2020.106083","DOI":"10.1016\/j.envint.2020.106083"},{"key":"3281_CR17","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1080\/09593330.2015.1088072","volume":"37","author":"S Chatila","year":"2016","unstructured":"Chatila S, Amparo MR, Carvalho LS, Penteado ED, Tomita IN, Santos-Neto \u00c1J, Lima Gomes PCF, Zaiat M (2016) Sulfamethoxazole and Ciprofloxacin removal using a horizontal-flow anaerobic immobilized biomass reactor. Environ Technol (United Kingdom) 37:847\u2013853. https:\/\/doi.org\/10.1080\/09593330.2015.1088072","journal-title":"Environ Technol (United Kingdom)"},{"key":"3281_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.jenvman.2017.09.048","volume":"204","author":"GHD Oliveira","year":"2017","unstructured":"Oliveira GHD, Santos-Neto AJ, Zaiat M (2017) Removal of the veterinary antimicrobial sulfamethazine in a horizontal-flow anaerobic immobilized biomass (HAIB) reactor subjected to step changes in the applied organic loading rate. J Environ Manage 204:674\u2013683. https:\/\/doi.org\/10.1016\/j.jenvman.2017.09.048","journal-title":"J Environ Manage"},{"key":"3281_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.anaerobe.2005.12.003","volume":"12","author":"AJ Silva","year":"2006","unstructured":"Silva AJ, Hirasawa JS, Varesche MB, Foresti E, Zaiat M (2006) Evaluation of support materials for the immobilization of sulfate-reducing bacteria and methanogenic archaea. Anaerobe 12:93\u201398. https:\/\/doi.org\/10.1016\/j.anaerobe.2005.12.003","journal-title":"Anaerobe"},{"key":"3281_CR20","doi-asserted-by":"crossref","unstructured":"Octave (1999) Levenspiel, chemical reaction engineering. Wiley","DOI":"10.1021\/ie990488g"},{"key":"3281_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s43393-021-00034-y","volume":"1","author":"B Tiwari","year":"2021","unstructured":"Tiwari B, Sellamuthu B, Pich\u00e9-Choquette S, Drogui P, Tyagi RD, Vaudreuil MA, Sauv\u00e9 S, Buelna G, Dub\u00e9 R (2021) Dynamics of bacterial community at varying sludge retention time within membrane bioreactor treating synthetic hospital wastewater. Syst Microbiol Biomanufacturing 1:471\u2013482. https:\/\/doi.org\/10.1007\/s43393-021-00034-y","journal-title":"Syst Microbiol Biomanufacturing"},{"key":"3281_CR22","first-page":"33","volume":"11","author":"M Zaiat","year":"1994","unstructured":"Zaiat M, Cabral AKA, Foresti E (1994) Horizontal-flow anaerobic immobilized sludge reactor for wastewater treatment: conception and performance evaluation. Revista Brasileira De Engenharia \u2013 Caderno De Engenharia Qu\u00edmica 11:33\u201342","journal-title":"Revista Brasileira De Engenharia \u2013 Caderno De Engenharia Qu\u00edmica"},{"key":"3281_CR23","volume-title":"Standard methods for the examination of water and wastewater","author":"American Public Health Association (APHA)","year":"2005","unstructured":"American Public Health Association (APHA) (2005) Standard methods for the examination of water and wastewater, 21st edn. American Water Works Association\/American Public Works Association\/Water Environment Federation, Washington, DC, USA.","edition":"21"},{"key":"3281_CR24","first-page":"406","volume":"58","author":"LE Ripley","year":"1986","unstructured":"Ripley LE, Boyle WC, Converse JC (1986) Improved alkalimetric monitoring for anaerobic digestion of high-strenght wastes. Water Pollut Control Fed 58:406\u2013411. http:\/\/www.jstor.org\/stable\/25042933 accessed December 10, 2025","journal-title":"Water Pollut Control Fed"},{"key":"3281_CR25","doi-asserted-by":"publisher","unstructured":"Adorno MAT, Hirasawa JS, Varesche MBA (2014) Development and validation of two methods to quantify volatile acids (C2-C6) by GC\/FID: headspace (Automatic and Manual) and Liquid-Liquid extraction (LLE). Am J Anal Chem 406\u2013414. https:\/\/doi.org\/10.4236\/AJAC.2014.57049","DOI":"10.4236\/AJAC.2014.57049"},{"key":"3281_CR26","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.1007\/s00216-015-9038-y","volume":"407","author":"PCF Lima Gomes","year":"2015","unstructured":"Lima Gomes PCF, Tomita IN, Santos-Neto \u00c1J, Zaiat M (2015) Rapid determination of 12 antibiotics and caffeine in sewage and bioreactor effluent by online column-switching liquid chromatography\/tandem mass spectrometry. Anal Bioanal Chem 407:8787\u20138801. https:\/\/doi.org\/10.1007\/s00216-015-9038-y","journal-title":"Anal Bioanal Chem"},{"key":"3281_CR27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1590\/S0104-66322002000300001","volume":"19","author":"EFM Camargo","year":"2002","unstructured":"Camargo EFM, Ratusznei SM, Rodrigues JAD, Zaiat M, Borzani W (2002) Treatment of low-strength wastewater using immobilized biomass in a sequencing batch external loop reactor: influence of the medium superficial velocity on the stability and performance. Braz J Chem Eng 19:267\u2013275. https:\/\/doi.org\/10.1590\/S0104-66322002000300001","journal-title":"Braz J Chem Eng"},{"key":"3281_CR28","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.scitotenv.2017.12.004","volume":"622\u2013623","author":"L Gonzalez-Gil","year":"2018","unstructured":"Gonzalez-Gil L, Mauricio-Iglesias M, Serrano D, Lema JM, Carballa M (2018) Role of methanogenesis on the biotransformation of organic micropollutants during anaerobic digestion. Sci Total Environ 622\u2013623:459\u2013466. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.12.004","journal-title":"Sci Total Environ"},{"key":"3281_CR29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.watres.2018.05.032","volume":"142","author":"L Gonzalez-Gil","year":"2018","unstructured":"Gonzalez-Gil L, Mauricio-Iglesias M, Carballa M, Lema JM (2018) Why are organic micropollutants not fully biotransformed? A mechanistic modelling approach to anaerobic systems. Water Res 142:115\u2013128. https:\/\/doi.org\/10.1016\/j.watres.2018.05.032","journal-title":"Water Res"},{"key":"3281_CR30","doi-asserted-by":"publisher","first-page":"103740","DOI":"10.1016\/j.jwpe.2023.103740","volume":"53","author":"EGF Rezende","year":"2023","unstructured":"Rezende EGF, Oliveira GHD, Couto PT, Zaiat M, Ribeiro R (2023) Modeling polyhydroxyalkanoates production from sugarcane Vinasse by mixed microbial cultures. J Water Process Eng 53:103740. https:\/\/doi.org\/10.1016\/j.jwpe.2023.103740","journal-title":"J Water Process Eng"},{"key":"3281_CR31","unstructured":"Sahlin K Estimating convergence of Markov chain Monte Carlo simulations, n.d. www.math.su.se"},{"key":"3281_CR32","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1128\/AEM.66.12.5488-5491.2000","volume":"66","author":"RI Griffiths","year":"2000","unstructured":"Griffiths RI, Whiteley AS, O\u2019donnell AG, Bailey MJ (2000) Rapid method for coextraction of DNA and RNA from natural environments for analysis of ribosomal DNA-and rRNA-Based microbial community composition. Appl Environ Microbiol 66:5488\u20135491. https:\/\/doi.org\/10.1128\/AEM.66.12.5488-5491.2000","journal-title":"Appl Environ Microbiol"},{"key":"3281_CR33","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/bit.20347","volume":"89","author":"Y Yu","year":"2005","unstructured":"Yu Y, Lee C, Kim J, Hwang S (2005) Group-specific primer and probe sets to detect methanogenic communities using quantitative real-time polymerase chain reaction. Biotechnol Bioeng 89:670\u2013679. https:\/\/doi.org\/10.1002\/bit.20347","journal-title":"Biotechnol Bioeng"},{"key":"3281_CR34","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.1000080107","volume":"108","author":"JG Caporaso","year":"2011","unstructured":"Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh PJ, Fierer N, Knight R (2011) Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci U S A 108:4516\u20134522. https:\/\/doi.org\/10.1073\/pnas.1000080107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3281_CR35","doi-asserted-by":"publisher","unstructured":"Patel BB, Gundaliya DPJ, Patel DUD, Khare DU (2021) Hydrodynamics of hybrid upflow anaerobic sludge blanket reactors using tracer studies. Environ Challenges 5. https:\/\/doi.org\/10.1016\/j.envc.2021.100358","DOI":"10.1016\/j.envc.2021.100358"},{"key":"3281_CR36","doi-asserted-by":"publisher","unstructured":"Delforno TP, Lacerda J\u00fanior GV, Noronha MF, Sakamoto IK, Varesche MBA, Oliveira VM (2017) Microbial diversity of a full-scale UASB reactor applied to poultry slaughterhouse wastewater treatment: integration of 16S rRNA gene amplicon and shotgun metagenomic sequencing. Microbiologyopen 6. https:\/\/doi.org\/10.1002\/mbo3.443","DOI":"10.1002\/mbo3.443"},{"key":"3281_CR37","doi-asserted-by":"publisher","unstructured":"Carneiro RB, Takeda PY, Dias MES, Nogueira EW, Zaiat M, Santos-Neto \u00c1J (2025) Biosorption assessment of emerging contaminants onto acidogenic and methanogenic biofilm reactors: influence of lipophilic and electrostatic interactions. J Environ Chem Eng 13. https:\/\/doi.org\/10.1016\/j.jece.2025.115654","DOI":"10.1016\/j.jece.2025.115654"},{"key":"3281_CR38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.watres.2017.02.001","volume":"116","author":"AK Ghattas","year":"2017","unstructured":"Ghattas AK, Fischer F, Wick A, Ternes TA (2017) Anaerobic biodegradation of (emerging) organic contaminants in the aquatic environment. Water Res 116:268\u2013295. https:\/\/doi.org\/10.1016\/j.watres.2017.02.001","journal-title":"Water Res"},{"key":"3281_CR39","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jhazmat.2014.06.031","volume":"278","author":"T Alvarino","year":"2014","unstructured":"Alvarino T, Suarez S, Lema JM, Omil F (2014) Understanding the removal mechanisms of PPCPs and the influence of main technological parameters in anaerobic UASB and aerobic CAS reactors. J Hazard Mater 278:506\u2013513. https:\/\/doi.org\/10.1016\/j.jhazmat.2014.06.031","journal-title":"J Hazard Mater"},{"key":"3281_CR40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.chemosphere.2015.09.016","volume":"144","author":"T Alvarino","year":"2016","unstructured":"Alvarino T, Su\u00e1rez S, Garrido M, Lema JM, Omil F (2016) A UASB reactor coupled to a hybrid aerobic MBR as innovative plant configuration to enhance the removal of organic micropollutants. Chemosphere 144:452\u2013458. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.09.016","journal-title":"Chemosphere"},{"key":"3281_CR41","doi-asserted-by":"publisher","unstructured":"Mortensen AT, Goonesekera EM, Dechesne A, Elad T, Tang K, Andersen HR, Smets BF, Valverde-P\u00e9rez B (2023) Methanotrophic oxidation of organic micropollutants and nitrogen upcycling in a hybrid membrane biofilm reactor (hMBfR) for simultaneous O2 and CH4 supply. Water Res 242. https:\/\/doi.org\/10.1016\/j.watres.2023.120104","DOI":"10.1016\/j.watres.2023.120104"},{"key":"3281_CR42","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.1021\/acs.est.6b02007","volume":"50","author":"E Torresi","year":"2016","unstructured":"Torresi E, Fowler SJ, Polesel F, Bester K, Andersen HR, Smets BF, Pl\u00f3sz BG, Christensson M (2016) Biofilm thickness influences biodiversity in nitrifying MBBRs - Implications on micropollutant removal. Environ Sci Technol 50:9279\u20139288. https:\/\/doi.org\/10.1021\/acs.est.6b02007","journal-title":"Environ Sci Technol"},{"key":"3281_CR43","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.biortech.2017.03.159","volume":"236","author":"K Tang","year":"2017","unstructured":"Tang K, Ooi GTH, Litty K, Sundmark K, Kaarsholm KMS, Sund C, Kragelund C, Christensson M, Bester K, Andersen HR (2017) Removal of pharmaceuticals in conventionally treated wastewater by a Polishing moving bed biofilm reactor (MBBR) with intermittent feeding. Bioresour Technol 236:77\u201386. https:\/\/doi.org\/10.1016\/j.biortech.2017.03.159","journal-title":"Bioresour Technol"},{"key":"3281_CR44","doi-asserted-by":"publisher","unstructured":"Li H, Song HL, Xu H, Lu Y, Zhang S, Yang YL, Yang XL, Lu YX (2020) Effect of the coexposure of sulfadiazine, Ciprofloxacin and zinc on the fate of antibiotic resistance genes, bacterial communities and functions in three-dimensional biofilm-electrode reactors. Bioresour Technol 296. https:\/\/doi.org\/10.1016\/j.biortech.2019.122290","DOI":"10.1016\/j.biortech.2019.122290"},{"key":"3281_CR45","doi-asserted-by":"publisher","unstructured":"Zhou M, Li C, Zhao L, Ning J, Pan X, Cai G, Zhu G (2021) Synergetic effect of nano zero-valent iron and activated carbon on high-level Ciprofloxacin removal in hydrolysis-acidogenesis of anaerobic digestion. Sci Total Environ 752. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.142261","DOI":"10.1016\/j.scitotenv.2020.142261"},{"key":"3281_CR46","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.scitotenv.2018.07.267","volume":"646","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, He Y, Xiang Y, Meng S, Liu X, Yu J, Yang J, Zhang J, Qin P, Luo L (2019) Single and simultaneous adsorption of Pefloxacin and Cu(II) ions from aqueous solutions by oxidized multiwalled carbon nanotube. Sci Total Environ 646:29\u201336. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.07.267","journal-title":"Sci Total Environ"},{"key":"3281_CR47","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.biortech.2018.05.022","volume":"263","author":"J Luo","year":"2018","unstructured":"Luo J, Li X, Ge C, M\u00fcller K, Yu H, Huang P, Li J, Tsang DCW, Bolan NS, Rinklebe J, Wang H (2018) Sorption of norfloxacin, sulfamerazine and Oxytetracycline by KOH-modified Biochar under single and ternary systems. Bioresour Technol 263:385\u2013392. https:\/\/doi.org\/10.1016\/j.biortech.2018.05.022","journal-title":"Bioresour Technol"},{"key":"3281_CR48","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/J.APCATB.2017.11.071","volume":"225","author":"X Chen","year":"2018","unstructured":"Chen X, Oh WD, Hu ZT, Sun YM, Webster RD, Li SZ, Lim TT (2018) Enhancing Sulfacetamide degradation by peroxymonosulfate activation with N-doped graphene produced through delicately-controlled nitrogen functionalization via tweaking thermal annealing processes. Appl Catal B 225:243\u2013257. https:\/\/doi.org\/10.1016\/J.APCATB.2017.11.071","journal-title":"Appl Catal B"},{"key":"3281_CR49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/J.AQUAENG.2018.12.004","volume":"84","author":"C Chokejaroenrat","year":"2019","unstructured":"Chokejaroenrat C, Sakulthaew C, Angkaew A, Satapanajaru T, Poapolathep A, Chirasatienpon T (2019) Remediating sulfadimethoxine-contaminated aquaculture wastewater using ZVI-activated persulfate in a flow-through system. Aquac Eng 84:99\u2013105. https:\/\/doi.org\/10.1016\/J.AQUAENG.2018.12.004","journal-title":"Aquac Eng"},{"key":"3281_CR50","doi-asserted-by":"publisher","first-page":"7234","DOI":"10.1021\/acs.est.9b01131","volume":"53","author":"AS Oberoi","year":"2019","unstructured":"Oberoi AS, Jia Y, Zhang H, Khanal SK, Lu H (2019) Insights into the fate and removal of antibiotics in engineered biological treatment systems: A critical review. Environ Sci Technol 53:7234\u20137264. https:\/\/doi.org\/10.1021\/acs.est.9b01131","journal-title":"Environ Sci Technol"},{"key":"3281_CR51","doi-asserted-by":"publisher","unstructured":"Gaballah MS, Chand H, Guo J, Zhang C (2024) Mixed veterinary antibiotics removal and effects on anaerobic digestion of animal wastes: current practices and future perspectives. Chem Eng J 483. https:\/\/doi.org\/10.1016\/j.cej.2024.149131","DOI":"10.1016\/j.cej.2024.149131"},{"key":"3281_CR52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0923-0467(94)87028-4","volume":"56","author":"Y Arcand","year":"1994","unstructured":"Arcand Y, Guiof SR, Desrochersa M, Chavarieb C (1994) Impact of the reactor hydrodynamics and organic loading on the size and activity of anaerobic granules. Chem Eng J 56:23\u201335. https:\/\/doi.org\/10.1016\/0923-0467(94)87028-4","journal-title":"Chem Eng J"},{"key":"3281_CR53","volume-title":"Fundamentals of ecology","author":"EP Odum","year":"1971","unstructured":"Odum EP (1971) Fundamentals of ecology, 3rd edn. Oxford University Press, New York","edition":"3"},{"key":"3281_CR54","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ibiod.2018.12.010","volume":"138","author":"CF Granatto","year":"2019","unstructured":"Granatto CF, Macedo TZ, Gerosa LE, Sakamoto IK, Silva EL, Varesche MBA (2019) Scale-up evaluation of anaerobic degradation of linear alkylbenzene sulfonate from sanitary sewage in expanded granular sludge bed reactor. Int Biodeterior Biodegradation 138:23\u201332. https:\/\/doi.org\/10.1016\/j.ibiod.2018.12.010","journal-title":"Int Biodeterior Biodegradation"},{"key":"3281_CR55","doi-asserted-by":"publisher","unstructured":"Oberoi AS, Surendra KC, Wu D, Lu H, Wong JWC, Kumar S, Khanal (2022) Anaerobic membrane bioreactors for pharmaceutical-laden wastewater treatment: A critical review. Bioresour Technol 361. https:\/\/doi.org\/10.1016\/j.biortech.2022.127667","DOI":"10.1016\/j.biortech.2022.127667"},{"key":"3281_CR56","doi-asserted-by":"publisher","unstructured":"Su Y, Qian J, Wang J, Mi X, Huang Q, Zhang Y, Jiang Q, Wang Q (2024) Unraveling the mechanism of Norfloxacin removal and fate of antibiotics resistance genes (ARGs) in the sulfur-mediated autotrophic denitrification via metagenomic and metatranscriptomic analyses. Sci Total Environ 922. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171328","DOI":"10.1016\/j.scitotenv.2024.171328"},{"key":"3281_CR57","doi-asserted-by":"publisher","unstructured":"Guo B, Yu N, Weissbrodt DG, Liu Y (2021) Effects of micro-aeration on microbial niches and antimicrobial resistances in Blackwater anaerobic digesters. Water Res 196. https:\/\/doi.org\/10.1016\/j.watres.2021.117035","DOI":"10.1016\/j.watres.2021.117035"},{"key":"3281_CR58","doi-asserted-by":"publisher","unstructured":"Guo M, Wei S, Guo MX, Li M, Qi X, Wang Y, Jia X (2024) Potential mechanisms of propionate degradation and methanogenesis in anaerobic digestion coupled with microbial electrolysis cell system: importance of Biocathode. Bioresour Technol 400. https:\/\/doi.org\/10.1016\/j.biortech.2024.130695","DOI":"10.1016\/j.biortech.2024.130695"},{"key":"3281_CR59","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.ijhydene.2024.09.213","volume":"88","author":"RR Mikheeva","year":"2024","unstructured":"Mikheeva RR, Katraeva IV, Kovalev AA, Shekhurdina SV, Zhuravleva EA, Laikova AA, Kovalev DA, Litti YV (2024) Optimization of two-stage thermophilic anaerobic digestion of dairy wastewater: effect of carrier material on process performance and microbial community. Int J Hydrogen Energy 88:1108\u20131122. https:\/\/doi.org\/10.1016\/j.ijhydene.2024.09.213","journal-title":"Int J Hydrogen Energy"},{"key":"3281_CR60","doi-asserted-by":"publisher","unstructured":"Wu J, Zhuang X, Zhang W, Wang Y (2025) Collaborative or competitive interactions between bacteria and methanogens on the Biocorrosion of Q235A steel. Environ Res 268. https:\/\/doi.org\/10.1016\/j.envres.2025.120826","DOI":"10.1016\/j.envres.2025.120826"},{"key":"3281_CR61","doi-asserted-by":"publisher","unstructured":"Kang J, Hong B, Ma S, Wu J, Yang Z, Fan X, Shao L, Sun K, Zhao J, Fang H, Wu T (2025) Ecological factors affecting toluene biosynthesis from bacterial communities. Sci Total Environ 959. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.178186","DOI":"10.1016\/j.scitotenv.2024.178186"},{"key":"3281_CR62","doi-asserted-by":"publisher","unstructured":"Granatto CF, Grosseli GM, Sakamoto IK, Fadini PS, Varesche MBA (2021) Influence of cosubstrate and hydraulic retention time on the removal of drugs and hygiene products in sanitary sewage in an anaerobic expanded granular sludge bed reactor. J Environ Manage 299. https:\/\/doi.org\/10.1016\/j.jenvman.2021.113532","DOI":"10.1016\/j.jenvman.2021.113532"},{"key":"3281_CR63","doi-asserted-by":"publisher","unstructured":"Buakaew T, Ratanatamskul C (2025) Enhanced pharmaceutical removal from Building wastewater by the novel integrated system of anaerobic baffled biofilm-membrane bioreactor and UV\/O3: microbial community, occurrence of bio-intermediates and post-treatment. J Environ Manage 377. https:\/\/doi.org\/10.1016\/j.jenvman.2025.124657","DOI":"10.1016\/j.jenvman.2025.124657"},{"key":"3281_CR64","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.biortech.2015.05.050","volume":"192","author":"TP Delforno","year":"2015","unstructured":"Delforno TP, Moura AGL, Okada DY, Sakamoto IK, Varesche MBA (2015) Microbial diversity and the implications of sulfide levels in an anaerobic reactor used to remove an anionic surfactant from laundry wastewater. Bioresour Technol 192:37\u201345. https:\/\/doi.org\/10.1016\/j.biortech.2015.05.050","journal-title":"Bioresour Technol"},{"key":"3281_CR65","doi-asserted-by":"publisher","unstructured":"Carneiro RB, Gomes GM, Camargo FP, Zaiat M, Santos-Neto \u00c1J (2024) Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation. Chemosphere 357. https:\/\/doi.org\/10.1016\/j.chemosphere.2024.142006","DOI":"10.1016\/j.chemosphere.2024.142006"},{"key":"3281_CR66","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1099\/00207713-40-1-79","volume":"40","author":"G Patel","year":"1990","unstructured":"Patel G, Sprott G (1990) Methanosaeta 1051 concilii gen. Nov. sp. Nov. (Methanothrix 1052 concilii) and Methanosaeta Thermoacetophila nom. rev., comb. Nov. Int J Syst Bacteriol 40:79\u201382. https:\/\/doi.org\/10.1099\/00207713-40-1-79","journal-title":"Int J Syst Bacteriol"},{"key":"3281_CR67","doi-asserted-by":"publisher","unstructured":"Xian Y, Cao L, Lu Y, Li Q, Su C, He Y, Zhou G, Chen S, Gao S (2025) Metagenomics and metaproteomics reveal the effects of sludge types and inoculation modes on N,N-dimethylformamide degradation pathways and the microbial community involved. J Hazard Mater 481. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.136548","DOI":"10.1016\/j.jhazmat.2024.136548"},{"key":"3281_CR68","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.renene.2021.07.049","volume":"179","author":"B Tonanzi","year":"2021","unstructured":"Tonanzi B, Gallipoli A, Gianico A, Montecchio D, Pagliaccia P, Rossetti S, Braguglia CM (2021) Elucidating the key factors in semicontinuous anaerobic digestion of urban biowaste: the crucial role of sludge addition in process stability, microbial community enrichment and methane production. Renew Energy 179:272\u2013284. https:\/\/doi.org\/10.1016\/j.renene.2021.07.049","journal-title":"Renew Energy"},{"key":"3281_CR69","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jhazmat.2018.05.059","volume":"357","author":"TH Hu","year":"2018","unstructured":"Hu TH, Whang LM, Huang CY (2018) Methanogenic degradation of tetramethylammonium hydroxide by methanomethylovorans and methanosarcina. J Hazard Mater 357:180\u2013186. https:\/\/doi.org\/10.1016\/j.jhazmat.2018.05.059","journal-title":"J Hazard Mater"},{"key":"3281_CR70","doi-asserted-by":"publisher","unstructured":"Yun H, Liang B, He Z, Li M, Zong S, Wang Z, Ge B, Zhang P, Li X, Wang A (2023) Insights into methanogenesis of mesophilic-psychrophilic varied anaerobic digestion of municipal sludge with antibiotic stress. J Environ Manage 331. https:\/\/doi.org\/10.1016\/j.jenvman.2023.117278","DOI":"10.1016\/j.jenvman.2023.117278"},{"key":"3281_CR71","doi-asserted-by":"publisher","unstructured":"Guo J, Peng Y, Ni BJ, Han X, Fan L, Yuan Z (2015) Dissecting microbial community structure and methane-producing pathways of a full-scale anaerobic reactor digesting activated sludge from wastewater treatment by metagenomic sequencing. Microb Cell Fact 14. https:\/\/doi.org\/10.1186\/s12934-015-0218-4","DOI":"10.1186\/s12934-015-0218-4"},{"key":"3281_CR72","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.copbio.2015.01.008","volume":"33","author":"M Carballa","year":"2015","unstructured":"Carballa M, Regueiro L, Lema JM (2015) Microbial management of anaerobic digestion: exploiting the microbiome-functionality nexus. Curr Opin Biotechnol 33:103\u2013111. https:\/\/doi.org\/10.1016\/j.copbio.2015.01.008","journal-title":"Curr Opin Biotechnol"},{"key":"3281_CR73","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.cej.2019.04.033","volume":"371","author":"K Zhu","year":"2019","unstructured":"Zhu K, Zhang L, Mu L, Ma J, Li C, Li A (2019) Anaerobic digestion of surfactant and lipid co-existing organic waste: focusing on the antagonistic enhancement. Chem Eng J 371:96\u2013106. https:\/\/doi.org\/10.1016\/j.cej.2019.04.033","journal-title":"Chem Eng J"},{"key":"3281_CR74","doi-asserted-by":"publisher","unstructured":"Zhu K, Zhang L, Wang X, Mu L, Li C, Li A (2021) Inhibition of Norfloxacin on anaerobic digestion: focusing on the recoverability and shifted microbial communities. Sci Total Environ 752. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.141733","DOI":"10.1016\/j.scitotenv.2020.141733"},{"key":"3281_CR75","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.scitotenv.2018.08.328","volume":"649","author":"TP Delforno","year":"2019","unstructured":"Delforno TP, Macedo TZ, Midoux C, Lacerda GV, Ru\u00e9 O, Mariadassou M, Loux V, Varesche MBA, Bouchez T, Bize A, Oliveira VM (2019) Comparative metatranscriptomic analysis of anaerobic digesters treating anionic surfactant contaminated wastewater. Sci Total Environ 649:482\u2013494. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.08.328","journal-title":"Sci Total Environ"},{"key":"3281_CR76","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1128\/AEM.02378-07","volume":"74","author":"YL Qiu","year":"2008","unstructured":"Qiu YL, Hanada S, Ohashi A, Harada H, Kamagata Y, Sekiguchi Y (2008) Syntrophorhabdus aromaticivorans gen. nov., sp. nov., the first cultured anaerobe capable of degrading phenol to acetate in obligate syntrophic associations with a hydrogenotrophic methanogen. Appl Environ Microbiol 74:2051\u20132058. https:\/\/doi.org\/10.1128\/AEM.02378-07","journal-title":"Appl Environ Microbiol"},{"key":"3281_CR77","doi-asserted-by":"publisher","unstructured":"Liu W, Xia R, Ding X, Cui W, Li T, Li G, Luo W (2022) Impacts of nano-zero-valent iron on antibiotic removal by anaerobic membrane bioreactor for swine wastewater treatment. J Memb Sci 659. https:\/\/doi.org\/10.1016\/j.memsci.2022.120762","DOI":"10.1016\/j.memsci.2022.120762"},{"key":"3281_CR78","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.watres.2018.02.057","volume":"136","author":"Y Jia","year":"2018","unstructured":"Jia Y, Khanal SK, Shu H, Zhang H, Chen GH, Lu H (2018) Ciprofloxacin degradation in anaerobic sulfate-reducing bacteria (SRB) sludge system: mechanism and pathways. Water Res 136:64\u201374. https:\/\/doi.org\/10.1016\/j.watres.2018.02.057","journal-title":"Water Res"},{"key":"3281_CR79","doi-asserted-by":"publisher","unstructured":"Tang T, Liu M, Du Y, Chen Y (2022) Deciphering the internal mechanisms of Ciprofloxacin affected anaerobic digestion, its degradation and detoxification mechanism. Sci Total Environ 842. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156718","DOI":"10.1016\/j.scitotenv.2022.156718"},{"key":"3281_CR80","doi-asserted-by":"publisher","unstructured":"Wang X, Wei Y, Zhang Z, Cao M, Liang B, Yue X, Zhou A (2025) Efficient anaerobic biodegradation of Trimethoprim driven by electrogenic respiration: optimizing bioelectro-characterization, elucidating biodegradation mechanism and fate of antibiotic resistance genes systematically. J Hazard Mater 492. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.138070","DOI":"10.1016\/j.jhazmat.2025.138070"},{"key":"3281_CR81","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2134\/jeq2016.04.0152","volume":"46","author":"A Spielmeyer","year":"2017","unstructured":"Spielmeyer A, Stahl F, Petri MS, Zerr W, Brunn H, Hamscher G (2017) Transformation of sulfonamides and tetracyclines during anaerobic fermentation of liquid manure. J Environ Qual 46:160\u2013168. https:\/\/doi.org\/10.2134\/jeq2016.04.0152","journal-title":"J Environ Qual"},{"key":"3281_CR82","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1021\/acs.est.6b05549","volume":"51","author":"L Gonzalez-Gil","year":"2017","unstructured":"Gonzalez-Gil L, Carballa M, Lema JM (2017) Cometabolic enzymatic transformation of organic micropollutants under methanogenic conditions. Environ Sci Technol 51:2963\u20132971. https:\/\/doi.org\/10.1021\/acs.est.6b05549","journal-title":"Environ Sci Technol"}],"container-title":["Bioprocess and Biosystems Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-025-03281-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00449-025-03281-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00449-025-03281-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:41:40Z","timestamp":1774582900000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00449-025-03281-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["3281"],"URL":"https:\/\/doi.org\/10.1007\/s00449-025-03281-8","relation":{},"ISSN":["1615-7591","1615-7605"],"issn-type":[{"value":"1615-7591","type":"print"},{"value":"1615-7605","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"4 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}