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While the benefit of trismus rehabilitation after surgery and radiotherapy is well established, the evidence during radiotherapy is less clear. This may be due to poor adherence to trismus exercises secondary to acute mucositis. This study assessed the feasibility of using a novel trismus device during adjuvant radiotherapy for HNC in patients with acute postoperative trismus. Prospective single-arm cohort feasibility study. Eligible patients had undergone surgery with curative intent for HNC, planned for adjuvant radiotherapy, and were suitable for trismus rehabilitation. Participants completed a 10-week exercise program using a novel jaw stretching device. Study outcomes were adherence, maximal incisal opening (MIO), and trismus-related function and quality of life scores, assessed at baseline, 10\u00a0weeks, and 6\u00a0months after commencing exercises. Nine patients diagnosed with trismus after primary surgery were recruited. The mean increase in MIO at 10\u00a0weeks was 7.8\u00a0mm (range \u22124 to 15\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), and at 6\u00a0months was 10.6\u00a0mm (range 1\u201326\u00a0mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Significant improvements were observed in trismus-related quality of life (Gothenburg Trismus Questionnaire; <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Adherence to the exercises was 100% in week 1\u20132, 67% in weeks 3\u20136, and 100% at 10\u00a0weeks (1\u00a0month post radiation). This study demonstrates the feasibility of using a novel jaw stretching device during adjuvant radiotherapy. Further evaluation is warranted to assess the effectiveness of early intervention and prevention of trismus during HNC radiotherapy.<\/jats:p><jats:p><jats:bold>Level of Evidence: IV<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00455-024-10668-4","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T20:02:38Z","timestamp":1708113758000},"page":"864-871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pilot Study of Intensive Trismus Intervention Using Restorabite\u2122 During Unilateral Adjuvant Radiation for Head and Neck Cancer"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-210X","authenticated-orcid":false,"given":"Emma","family":"Charters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Loy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"10668_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ijom.2005.08.001","volume":"35","author":"PU Dijkstra","year":"2006","unstructured":"Dijkstra PU, Huisman PM, Roodenburg JL. Criteria for trismus in head and neck oncology. Int J Oral Maxillofac Surg. 2006;35:337\u201342.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"6","key":"10668_CR2","first-page":"278","volume":"16","author":"J Johnson","year":"2010","unstructured":"Johnson J, van As-Brooks CJ, Fagerberg-Mohlin B, Finizia C. Trismus in head and neck cancer patients in Sweden: incidence and risk factors. Med Sci Monit. 2010;16(6):278\u201382.","journal-title":"Med Sci Monit"},{"issue":"6","key":"10668_CR3","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3109\/0284186X.2012.744466","volume":"52","author":"N Pauli","year":"2013","unstructured":"Pauli N, Johnson J, Finizia C, Andrell P. The incidence of trismus and long-term impact on health-related quality of life in patients with head and neck cancer. Acta Oncol. 2013;52(6):1137\u201345.","journal-title":"Acta Oncol"},{"issue":"9","key":"10668_CR4","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.oraloncology.2013.05.009","volume":"49","author":"AJ Lyons","year":"2013","unstructured":"Lyons AJ, Crichton S, Pezier T. Trismus following radiotherapy to the head and neck is likely to have distinct genotype dependent cause. Oral Oncol. 2013;49(9):932\u20136.","journal-title":"Oral Oncol"},{"key":"10668_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cden.2007.09.004","volume":"52","author":"DJ Fischer","year":"2009","unstructured":"Fischer DJ, Epstein JB. Management of patients who have undergone head and neck cancer therapy. 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