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Evidence is lacking about their use in acute stroke care. This systematic review evaluated the literature about barriers and facilitators to FWP implementation in acute stroke unit settings. Electronic databases and grey literature sources were systematically searched, eligible studies were critically appraised, and data extracted and mapped onto the Consolidated Framework for Implementation Research (CFIR). The results are presented in a narrative synthesis. Five studies were identified for inclusion: Two qualitative studies, 1 mixed method study, 1 randomised controlled trial and 1 pilot cohort study. Barriers and facilitators to implementation were identified across the 5 CFIR domains. Key barriers were a lack of evidence base and a standard protocol, trying to adapt and deliver a protocol designed for a different setting, complexity of patient selection and FWP design, culture of risk aversion, nursing staff availability and skills to deliver the FWP, and a greater use of agency nurses and transient workforce. Key facilitators were the existence of national guidance for research into its use, implementation of oral care protocols prior to FWP implementation, the unique characteristics of the acute stroke setting, leadership and modelling by senior clinicians, interdisciplinary working and accountability for roles and responsibilities for each discipline, regular communication and ongoing education, and involving patients in decision making and implementation. The findings of this review will guide the data collection of a feasibility study of the FWP in acute stroke.<\/jats:p>","DOI":"10.1007\/s00455-025-10805-7","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T07:10:03Z","timestamp":1738739403000},"page":"1023-1034","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Barriers and Facilitators to implementation of the Free Water Protocol in the Acute Stroke Unit Setting: A Mixed Methods Systematic Review"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-2456","authenticated-orcid":false,"given":"Sabrina A.","family":"Eltringham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Martindale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lightbody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Pownall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"10805_CR1","doi-asserted-by":"publisher","unstructured":"Dziewas R, Michou E, Trapl-Grundschober M et al. 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