{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:27Z","timestamp":1760953827496},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00464-011-2114-2","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:53:16Z","timestamp":1326934396000},"page":"1856-1864","source":"Crossref","is-referenced-by-count":7,"title":["Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models"],"prefix":"10.1007","volume":"26","author":[{"given":"Xiaohong","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali A. C.","family":"Herath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Ho","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kirchoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Njoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M. C.","family":"Shantha Kumara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Naffouje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"2114_CR1","unstructured":"DeVita H, Rosenberg (2005) DeVita, Hellman, and Rosenberg\u2019s cancer. In: Principles and practice of oncology, 8th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1061\u20131125"},{"issue":"2","key":"2114_CR2","first-page":"273","volume":"100","author":"JL Weese","year":"1986","unstructured":"Weese JL, Ottery FD, Emoto SE (1986) Do operations facilitate tumor growth? An experimental model in rats. Surgery 100(2):273\u2013277","journal-title":"Surgery"},{"issue":"6","key":"2114_CR3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archsurg.1995.01430060087016","volume":"130","author":"JD Allendorf","year":"1995","unstructured":"Allendorf JD, Bessler M, Kayton ML, Oesterling SD, Treat MR, Nowygrod R, Whelan RL (1995) Increased tumor establishment and growth after laparotomy vs. laparoscopy in a murine model. Arch Surg 130(6):649\u2013653","journal-title":"Arch Surg"},{"issue":"3","key":"2114_CR4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004649900952","volume":"13","author":"JD Allendorf","year":"1999","unstructured":"Allendorf JD, Bessler M, Horvath KD, Marvin MR, Laird DA, Whelan RL (1999) Increased tumor establishment and growth after open vs. laparoscopic surgery in mice may be related to differences in postoperative T-cell function. Surg Endosc 13(3):233\u2013235","journal-title":"Surg Endosc"},{"issue":"8","key":"2114_CR5","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1007\/s00464-001-8158-y","volume":"16","author":"P Wildbrett","year":"2002","unstructured":"Wildbrett P, Oh A, Carter JJ, Schuster H, Bessler, Jaboci CA, Whelan RL (2002) Increased rates of pulmonary metastases following sham laparotomy compared to CO2 pneumoperitoneum and the inhibition of metastases utilizing perioperative immunomodulation and a tumor vaccine. Surg Endosc 16(8):1162\u20131169","journal-title":"Surg Endosc"},{"issue":"6","key":"2114_CR6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/SLA.0b013e3181a6cd72","volume":"249","author":"HM Kumara","year":"2009","unstructured":"Kumara HM, Feingold D, Kalady M, Dujovny N, Senagore A, Hyman A, Cekic V, Whelan RL (2009) Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion. Ann Surg 249(6):973\u2013977","journal-title":"Ann Surg"},{"issue":"2","key":"2114_CR7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1445-2197.1978.tb07311.x","volume":"48","author":"T Morris","year":"1978","unstructured":"Morris T, Lincoln F, Lee A (1978) The effect of 5-fluorouracil on abdominal wound healing in rats. Aust N Z J Surg 48(2):219\u2013221","journal-title":"Aust N Z J Surg"},{"issue":"3","key":"2114_CR8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000129333","volume":"26","author":"S Weiber","year":"1994","unstructured":"Weiber S, Graf W, Glimelius B, Jiborn H, Pahlman L, Zederfeldt B (1994) The effect of 5-fluorouracil on wound healing and collagen synthesis in left colon anastomoses. An experimental study in the rat. Eur Surg Res 26(3):173\u2013178","journal-title":"Eur Surg Res"},{"issue":"4","key":"2114_CR9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000104472","volume":"53","author":"VK Shukla","year":"2007","unstructured":"Shukla VK, Pandey M, Das PC, Tiwary SK, Chansouria JP, Kumar M, Singh G, Pandey SK, Singh G (2007) Effect of 5-fluorouracil and mitomycin on the healing of intestinal anastomosis. Chemotherapy 53(4):275\u2013281","journal-title":"Chemotherapy"},{"issue":"33","key":"2114_CR10","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.3748\/wjg.15.4156","volume":"15","author":"L Ozel","year":"2009","unstructured":"Ozel L, Ozel MS, Toros AB, Kara M, Ozkan KS, Tellioglu G, Krand O, Koyuturk M, Berber I (2009) Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats. World J Gastroenterol 15(33):4156\u20134162","journal-title":"World J Gastroenterol"},{"issue":"6","key":"2114_CR11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1158\/1940-6207.CAPR-09-0083","volume":"2","author":"AM Bode","year":"2009","unstructured":"Bode AM, Dong Z (2009) Epigallocatechin 3-gallate and green tea catechins: united they work, divided they fail. Cancer Prev Res 2(6):514\u2013517","journal-title":"Cancer Prev Res"},{"issue":"1","key":"2114_CR12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.canlet.2006.03.030","volume":"247","author":"JT Hwang","year":"2007","unstructured":"Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ (2007) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett 247(1):115\u2013121","journal-title":"Cancer Lett"},{"issue":"3","key":"2114_CR13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbrc.2005.06.182","volume":"334","author":"M Shimizu","year":"2005","unstructured":"Shimizu M, Deguchi A, Hara Y, Moriwaki H, Weinstein IB (2005) EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem Biophys Res Comm 334(3):947\u2013953","journal-title":"Biochem Biophys Res Comm"},{"issue":"4","key":"2114_CR14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1158\/1940-6207.CAPR-08-0045","volume":"1","author":"M Shimizu","year":"2008","unstructured":"Shimizu M, Shirakami Y, Sakai H, Adachi S, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H (2008) (\u2212)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL\/KsJ-db\/db mice. Cancer Prev Res 1(4):298\u2013304","journal-title":"Cancer Prev Res"},{"issue":"9\u201310","key":"2114_CR15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2119\/2007-00050.Yuan","volume":"14","author":"JH Yuan","year":"2008","unstructured":"Yuan JH, Li YQ, Yang XY (2008) Protective effects of epigallocatechin gallate on colon preneoplastic lesions induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Mol Med 14(9\u201310):590\u2013598","journal-title":"Mol Med"},{"issue":"1","key":"2114_CR16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000113648","volume":"15","author":"R Saller","year":"2008","unstructured":"Saller R, Brignoli R, Melzer J, Meier R (2008) An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forschende Komplementarmedizin 15(1):9\u201320","journal-title":"Forschende Komplementarmedizin"},{"issue":"2","key":"2114_CR17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1572-0241.1998.00139.x","volume":"93","author":"K Flora","year":"1998","unstructured":"Flora K, Hahn M, Rosen H, Benner K (1998) Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 93(2):139\u2013143","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"2114_CR18","first-page":"465","volume":"15","author":"K Wellington","year":"2001","unstructured":"Wellington K, Jarvis B (2001) Silymarin: a review of its clinical properties in the management of hepatic disorders. Bio Drugs 15(7):465\u2013489","journal-title":"Bio Drugs"},{"issue":"12","key":"2114_CR19","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/jnci\/djj231","volume":"98","author":"RP Singh","year":"2006","unstructured":"Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R (2006) Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 98(12):846\u2013855","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"2114_CR20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1158\/1078-0432.CCR-07-1565","volume":"14","author":"RP Singh","year":"2008","unstructured":"Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R (2008) Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 14(1):300\u2013308","journal-title":"Clin Cancer Res"},{"issue":"16","key":"2114_CR21","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3748\/wjg.15.1943","volume":"15","author":"W Cui","year":"2009","unstructured":"Cui W, Gu F, Hu KQ (2009) Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. World J Gastroenterol 15(16):1943\u20131950","journal-title":"World J Gastroenterol"},{"issue":"12","key":"2114_CR22","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/ijc.23879","volume":"123","author":"G Deep","year":"2008","unstructured":"Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R (2008) Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. Int J Cancer 123(12):2750\u20132758","journal-title":"Int J Cancer"},{"issue":"6","key":"2114_CR23","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1158\/0008-5472.CAN-07-6247","volume":"68","author":"RP Singh","year":"2008","unstructured":"Singh RP, Gu M, Agarwal R (2008) Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res 68(6):2043\u20132050","journal-title":"Cancer Res"},{"issue":"5","key":"2114_CR24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1593\/neo.10188","volume":"12","author":"M Kaur","year":"2010","unstructured":"Kaur M, Velmurugan B, Tyagi A, Agarwal C, Singh RP, Agarwal R (2010) Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia 12(5):415\u2013424","journal-title":"Neoplasia"},{"issue":"5","key":"2114_CR25","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1158\/0008-5472.CAN-05-3636","volume":"66","author":"N Khan","year":"2006","unstructured":"Khan N, Afaq F, Saleem M, Ahmad N, Mukhtar H (2006) Targeting multiple signaling pathways by green tea polyphenol (\u2212)-epigallocatechin-3-gallate. Cancer Res 66(5):2500\u20132505","journal-title":"Cancer Res"},{"issue":"2","key":"2114_CR26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.canlet.2008.03.053","volume":"269","author":"K Ramasamy","year":"2008","unstructured":"Ramasamy K, Agarwal R (2008) Multitargeted therapy of cancer by silymarin. Cancer Lett 269(2):352\u2013362","journal-title":"Cancer Lett"},{"issue":"2","key":"2114_CR27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jss.2005.05.006","volume":"129","author":"J Ko","year":"2005","unstructured":"Ko J, Ross J, Awad H, Hurwitz H, Klitzman B (2005) The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice. J Surg Res 129(2):251\u2013259","journal-title":"J Surg Res"},{"issue":"4","key":"2114_CR28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.surg.2004.12.016","volume":"137","author":"DA DuBay","year":"2005","unstructured":"DuBay DA, Wang X, Adamson B, Kuzon WM Jr, Dennis RG, Franz MG (2005) Progressive fascial wound failure impairs subsequent abdominal wall repairs: a new animal model of incisional hernia formation. Surgery 137(4):463\u2013471","journal-title":"Surgery"},{"key":"2114_CR29","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1158\/1078-0432.CCR-04-1435","volume":"10","author":"RP Singh","year":"2004","unstructured":"Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R (2004) Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemo combination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance. Clin Cancer Res 10:8641\u20138647","journal-title":"Clin Cancer Res"},{"key":"2114_CR30","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1200\/JCO.2008.21.1284","volume":"27","author":"TD Shanafelt","year":"2009","unstructured":"Shanafelt TD, Call TG, Zent CS, LaPlant B, Bowen DA, Roos M, Secreto CR, Ghosh AK, Kabat BF, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE (2009) Phase I trial of daily oral polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol 27:3808\u20133814","journal-title":"J Clin Oncol"},{"key":"2114_CR31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1055\/s-2007-969690","volume":"50","author":"H Hikino","year":"1984","unstructured":"Hikino H, Kiso Y, Wagner H, Fiebig M (1984) Anti-hepatotoxic actions of flavonolignans from Silybum marianum fruits. Planta Med 50:248\u2013250","journal-title":"Planta Med"},{"key":"2114_CR32","unstructured":"Indena (1992) IdB-1016 silybin phosphatidylcholine complex update. Drugs Future 17:248"},{"key":"2114_CR33","doi-asserted-by":"crossref","unstructured":"Marena C, Lampertico M (1991) Preliminary clinical development of silipide: a new complex of silybin in toxic liver disorders. Planta Med 57:A124\u2013A125","DOI":"10.1055\/s-2006-960420"},{"key":"2114_CR34","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/pros.21118","volume":"70","author":"TW Flaig","year":"2010","unstructured":"Flaig TW, Glode M, Gustafson D, van Bokhoven A, Tao Y, Wilson S, Su LJ, Li Y, Harrison G, Agarwal R, Crawford ED, Lucia MS, Pollak M (2010) A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 70:848\u2013855","journal-title":"Prostate"},{"key":"2114_CR35","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1200\/JCO.2008.20.5278","volume":"27","author":"S Kopetz","year":"2009","unstructured":"Kopetz S, Chang GJ, Overman MJ, Eng C, Sargent DJ, Larson DW, Grothey A, Vauthey JN, Nagorney DM, McWilliams RR (2009) Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 27:3677\u20133683","journal-title":"J Clin Oncol"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-011-2114-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00464-011-2114-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-011-2114-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T10:31:02Z","timestamp":1640514662000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00464-011-2114-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["2114"],"URL":"https:\/\/doi.org\/10.1007\/s00464-011-2114-2","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}