{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:35:17Z","timestamp":1773203717517,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T00:00:00Z","timestamp":1361577600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00464-013-2861-3","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T10:08:34Z","timestamp":1361614114000},"page":"2940-2946","source":"Crossref","is-referenced-by-count":64,"title":["Refractory gastroesophageal reflux disease as diagnosed by impedance-pH monitoring can be cured by laparoscopic fundoplication"],"prefix":"10.1007","volume":"27","author":[{"given":"Marzio","family":"Frazzoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Piccoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Conigliaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Manta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Frazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Melotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,23]]},"reference":[{"key":"2861_CR1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2008.08.044","volume":"135","author":"PJ Kahrilas","year":"2008","unstructured":"Kahrilas PJ, Shaheen NJ, Vaezi MF (2008) American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease. Gastroenterology 135:1392\u20131413","journal-title":"Gastroenterology"},{"key":"2861_CR2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/gutjnl-2011-301897","volume":"61","author":"D Sifrim","year":"2012","unstructured":"Sifrim D, Zerbib F (2012) Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 61:1340\u20131354","journal-title":"Gut"},{"key":"2861_CR3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00464-005-0174-x","volume":"20","author":"B Dallemagne","year":"2006","unstructured":"Dallemagne B, Weerts J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, Jehaes C (2006) Clinical results of laparoscopic fundoplication at ten years after surgery. Surg Endosc 20:159\u2013165","journal-title":"Surg Endosc"},{"key":"2861_CR4","doi-asserted-by":"crossref","unstructured":"Stefanidis D, Hope WW, Kohn GP, Reardon PR, Richardson DS, Fanelli RD; The SAGES Guidelines Committee (2010) Guidelines for surgical treatment of gastroesophageal reflux disease. Surg Endosc 24:2647\u20132669","DOI":"10.1007\/s00464-010-1267-8"},{"issue":"Suppl 2","key":"2861_CR5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2036.2006.03039.x","volume":"24","author":"R Tutuian","year":"2006","unstructured":"Tutuian R, Castell DO (2006) Review article: complete gastro-oesophageal reflux monitoring\u2014combined pH and impedance. Aliment Pharmacol Ther 24(Suppl 2):27\u201337","journal-title":"Aliment Pharmacol Ther"},{"key":"2861_CR6","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.gie.2008.09.022","volume":"69","author":"JE Pandolfino","year":"2009","unstructured":"Pandolfino JE, Vela MF (2009) Esophageal reflux monitoring. Gastrointest Endosc 69:917\u2013930","journal-title":"Gastrointest Endosc"},{"key":"2861_CR7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10620-010-1381-4","volume":"56","author":"M Frazzoni","year":"2011","unstructured":"Frazzoni M, Conigliaro R, Melotti G (2011) Reflux parameters as modified by laparoscopic fundoplication in 40 patients with heartburn\/regurgitation persisting despite PPI therapy. A study using impedance-pH monitoring. Dig Dis Sci 56:1099\u20131106","journal-title":"Dig Dis Sci"},{"key":"2861_CR8","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s00464-011-2091-5","volume":"26","author":"M Frazzoni","year":"2012","unstructured":"Frazzoni M, Conigliaro R, Colli G, Melotti G (2012) Conventional versus robot-assisted laparoscopic Nissen fundoplication. A comparison of postoperative acid reflux parameters. Surg Endosc 26:1675\u20131681","journal-title":"Surg Endosc"},{"key":"2861_CR9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","volume":"45","author":"LR Lundell","year":"1999","unstructured":"Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GNJ, Wallin L (1999) Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 45:172\u2013180","journal-title":"Gut"},{"key":"2861_CR10","doi-asserted-by":"crossref","unstructured":"Frazzoni M, Conigliaro R, Mirante VG, Melotti G (2012) The added value of quantitative analysis of on-therapy impedance-pH parameters in distinguishing refractory non-erosive reflux disease from functional heartburn. Neurogastroenterol Motil 24:141-e87","DOI":"10.1111\/j.1365-2982.2011.01800.x"},{"key":"2861_CR11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1590-8658(02)80237-7","volume":"34","author":"M Frazzoni","year":"2002","unstructured":"Frazzoni M, Grisendi A, Lanzani A, Melotti G, De Micheli E (2002) Laparoscopic fundoplication versus lansoprazole for gastro-oesophageal reflux disease\u2014a pH-metric comparison. Dig Liver Dis 34:99\u2013104","journal-title":"Dig Liver Dis"},{"key":"2861_CR12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2036.2009.04063.x","volume":"30","author":"M Frazzoni","year":"2009","unstructured":"Frazzoni M, Savarino E, Manno M, Melotti G, Mirante VG, Mussetto A, Bertani H, Manta R, Conigliaro R (2009) Reflux patterns in patients with short segment Barrett\u2019s oesophagus: a study using impedance-pH monitoring off and on proton pump inhibitor therapy. Aliment Pharmacol Ther 30:508\u2013515","journal-title":"Aliment Pharmacol Ther"},{"key":"2861_CR13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2003.033290","volume":"53","author":"D Sifrim","year":"2004","unstructured":"Sifrim D, Castell D, Dent J, Kahrilas PJ (2004) Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 53:1024\u20131031","journal-title":"Gut"},{"key":"2861_CR14","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1572-0241.2006.00711.x","volume":"101","author":"F Zerbib","year":"2006","unstructured":"Zerbib F, Roman S, Ropert A, Bruley des Varannes S, Pouderoux P, Chaput U, Mion F, Verin E, Galmiche JP, Sifrim D (2006) Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 101:1956\u20131963","journal-title":"Am J Gastroenterol"},{"key":"2861_CR15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1442-2050.2009.00940.x","volume":"22","author":"A Agrawal","year":"2009","unstructured":"Agrawal A, Roberts J, Sharma N, Tutuian R, Vela M, Castell DO (2009) Symptoms with acid and nonacid reflux may be produced by different mechanisms. Dis Esophagus 22:467\u2013470","journal-title":"Dis Esophagus"},{"issue":"Suppl 3","key":"2861_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1440-1746.2012.07064.x","volume":"27","author":"R Fass","year":"2012","unstructured":"Fass R (2012) Therapeutic options for refractory gastroesophageal reflux disease. J Gastroenterol Hepatol 27(Suppl 3):3\u20137","journal-title":"J Gastroenterol Hepatol"},{"key":"2861_CR17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2036.2011.04677.x","volume":"34","author":"M Frazzoni","year":"2011","unstructured":"Frazzoni M, Conigliaro R, Manta R, Melotti G (2011) Reflux parameters as modified by EsophyX or laparoscopic fundoplication in refractory GERD. Aliment Pharmacol Ther 34:67\u201375","journal-title":"Aliment Pharmacol Ther"},{"key":"2861_CR18","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1007\/s00464-012-2324-2","volume":"26","author":"B Witteman","year":"2012","unstructured":"Witteman B, Strijkers R, de Vries E, Toemen L, Conchillo JM, Hameetemn W, Dagnelie PC, Koek GH, Bouvy ND (2012) Transoral incisionless fundoplication for treatment of gastroesophageal reflux disease in clinical practice. Surg Endosc 26:3307\u20133315","journal-title":"Surg Endosc"},{"key":"2861_CR19","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1001\/jama.2011.626","volume":"305","author":"JP Galmiche","year":"2011","unstructured":"Galmiche JP, Hatlebakk J, Attwood S, Ell C, Fiocca R, Eklund S, Langstrom G, Lind T, Lundell L (2011) Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD\u2014the LOTUS randomized clinical trial. JAMA 305:1969\u20131977","journal-title":"JAMA"},{"key":"2861_CR20","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/bjs.5493","volume":"93","author":"I Mainie","year":"2006","unstructured":"Mainie I, Tutuian R, Agrawal A, Adams D, Castell DO (2006) Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication. Br J Surg 93:1483\u20131487","journal-title":"Br J Surg"},{"key":"2861_CR21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/SLA.0b013e3181bcdaa7","volume":"250","author":"JA Broeders","year":"2009","unstructured":"Broeders JA, Rijnhart-de Jong HG, Draaisma WA, Bredenoord AJ, Smout AJ, Gooszen HG (2009) Ten-year outcome of laparoscopic and conventional Nissen fundoplication: randomized clinical trial. Ann Surg 250:698\u2013706","journal-title":"Ann Surg"},{"key":"2861_CR22","doi-asserted-by":"crossref","unstructured":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101:1900\u20131920","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"2861_CR23","doi-asserted-by":"crossref","unstructured":"Bytzer P (2004) Assessment of reflux symptom severity: methodological options and their attributes. Gut 53(Suppl 4):iv28\u2013iv34","DOI":"10.1136\/gut.2003.034298"},{"key":"2861_CR24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cgh.2011.07.009","volume":"9","author":"JC Slaughter","year":"2011","unstructured":"Slaughter JC, Goutte M, Rymer JA, Oranu AC, Schneider JA, Garrett CG, Hagaman D, Vaezi MF (2011) Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. Clin Gastroenterol Hepatol 9:868\u2013874","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2861_CR25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cgh.2009.02.022","volume":"7","author":"JM Pritchett","year":"2009","unstructured":"Pritchett JM, Aslam M, Slaughter JC, Ness RM, Garrett CG, Vaezi MF (2009) Efficacy of esophageal impedance\/pH monitoring in patients with refractory gastroesophageal reflux disease, on and off therapy. Clin Gastroenterol Hepatol 7:743\u2013748","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2861_CR26","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1365-2036.2010.04550.x","volume":"33","author":"M Frazzoni","year":"2011","unstructured":"Frazzoni M, Conigliaro R, Melotti G (2011) Weakly acidic refluxes have a major role in the pathogenesis of proton pump inhibitor\u2013resistant reflux oesophagitis. Aliment Pharmacol Ther 33:601\u2013606","journal-title":"Aliment Pharmacol Ther"},{"key":"2861_CR27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1053\/j.gastro.2012.05.005","volume":"143","author":"K Krishnan","year":"2012","unstructured":"Krishnan K, Pandolfino J, Kahrilas P, Keffer L, Boris L, Komandur S (2012) Increased risk for persistent intestinal metaplasia in patients with Barrett\u2019s esophagus and uncontrolled reflux exposure before radiofrequency ablation. Gastroenterology 143:576\u2013581","journal-title":"Gastroenterology"},{"key":"2861_CR28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/gut.2007.133298","volume":"57","author":"AJ Bredenoord","year":"2008","unstructured":"Bredenoord AJ, Draaisma WA, Weusten BLAM, Gooszen HG, Smout AJPM (2008) Mechanisms of acid, weakly acidic and gas reflux after anti-reflux surgery. Gut 57:161\u2013166","journal-title":"Gut"},{"key":"2861_CR29","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1007\/s00464-011-1688-z","volume":"25","author":"F Herbella","year":"2011","unstructured":"Herbella F, Vicentine F, Del Grande J, Patti MG (2011) Postprandial proximal gastric acid pocket in patients after laparoscopic Nissen fundoplication. Surg Endosc 25:3198\u20133201","journal-title":"Surg Endosc"},{"key":"2861_CR30","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1056\/NEJM200006223422506","volume":"342","author":"K Benson","year":"2000","unstructured":"Benson K, Hartz A (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342:1878\u20131886","journal-title":"N Engl J Med"},{"key":"2861_CR31","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJM200006223422507","volume":"342","author":"J Concato","year":"2000","unstructured":"Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342:1887\u20131892","journal-title":"N Engl J Med"},{"key":"2861_CR32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2982.2012.01977.x","volume":"24","author":"C Scarpignato","year":"2012","unstructured":"Scarpignato C (2012) Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end! Neurogastroenterol Motil 24:697\u2013704","journal-title":"Neurogastroenterol Motil"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-013-2861-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00464-013-2861-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-013-2861-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T02:01:12Z","timestamp":1562724072000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00464-013-2861-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,23]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["2861"],"URL":"https:\/\/doi.org\/10.1007\/s00464-013-2861-3","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,23]]}}}