{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:13:51Z","timestamp":1782249231104,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,8,15]],"date-time":"2015-08-15T00:00:00Z","timestamp":1439596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00464-015-4468-3","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T13:53:27Z","timestamp":1439560407000},"page":"2103-2113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma: a single European center experience of 426 patients"],"prefix":"10.1007","volume":"30","author":[{"given":"Roberto","family":"Santambrogio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Barabino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Pisani","family":"Ceretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rachele","family":"Angiolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Zuin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Meloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Opocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,15]]},"reference":[{"key":"4468_CR1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","volume":"53","author":"J Bruix","year":"2011","unstructured":"Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 53:1020\u20131022","journal-title":"Hepatology"},{"key":"4468_CR2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jhep.2014.01.022","volume":"60","author":"A Vitale","year":"2014","unstructured":"Vitale A, Cucchetti A, Qiao GL, Cescon M, Li J, Ramirez-Morales R, Frigo AC, Xia Y, Tuci F, Shen F, Cillo U, Pinna AD (2014) Is resectable hepatocellular carcinoma a contraindication to liver transplantation? A novel decision model based on \u201cnumber of patients needed to transplant\u201d as measure of transplant benefit. J Hepatol 60:1165\u20131171","journal-title":"J Hepatol"},{"key":"4468_CR3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/hep.21933","volume":"47","author":"T Livraghi","year":"2008","unstructured":"Livraghi T, Meloni F, Di Stasi M, Rolle E, Solbiati L, Tinelli C, Rossi S (2008) Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice? Hepatology 47:82\u201389","journal-title":"Hepatology"},{"key":"4468_CR4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","volume":"379","author":"A Forner","year":"2012","unstructured":"Forner A, Llovet JM, Bruix J (2012) Hepatocellular carcinoma. Lancet 379:1245\u20131255","journal-title":"Lancet"},{"key":"4468_CR5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s002610000194","volume":"26","author":"R Lencioni","year":"2001","unstructured":"Lencioni R, Cioni D, Bartolozzi C (2001) Percutaneous radiofrequency thermal ablation of liver malignancies: techniques, indications, imaging findings, and clinical results. Abdom Imaging 26:345\u2013360","journal-title":"Abdom Imaging"},{"key":"4468_CR6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00000658-199804000-00013","volume":"227","author":"CM Lo","year":"1998","unstructured":"Lo CM, Lai ECS, Liu CL, Fan ST, Wong J (1998) Laparoscopy and laparoscopic ultrasonography avoid exploratory laparotomy in patients with hepatocellular carcinoma. Ann Surg 227:527\u2013532","journal-title":"Ann Surg"},{"key":"4468_CR7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jso.20204","volume":"89","author":"R Santambrogio","year":"2005","unstructured":"Santambrogio R, Opocher E, Costa M, Cappellani A, Montorsi M (2005) Survival and intra-hepatic recurrences after laparoscopic radiofrequency of hepatocellular carcinoma in patients with liver cirrhosis. J Surg Oncol 89:218\u2013226","journal-title":"J Surg Oncol"},{"key":"4468_CR8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/hpb.12379","volume":"17","author":"S Serna De la","year":"2015","unstructured":"De la Serna S, Vilana R, Sanchez-Cabus S, Calatayud D, Ferre J, Molina V, Fondevila C, Bruix J, Fuster J, Garcia Valdecasas JC (2015) Results of laparoscopic radiofrequency ablation for HCC. Could the location of the tumour influence a complete response to treatment? A single European centre experience. HPB 17:387\u2013393","journal-title":"HPB"},{"key":"4468_CR9","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1245\/s10434-009-0678-z","volume":"16","author":"R Santambrogio","year":"2009","unstructured":"Santambrogio R, Opocher E, Zuin M, Selmi C, Bertolini E, Costa M, Conti M, Montorsi M (2009) Surgical resection versus laparoscopic radiofrequency ablation in patients with hepatocellular carcinoma and Child\u2013Pugh class a liver cirrhosis. Ann Surg Oncol 16:3289\u20133298","journal-title":"Ann Surg Oncol"},{"key":"4468_CR10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","volume":"19","author":"JM Llovet","year":"1999","unstructured":"Llovet JM, Bru\u2019 C, Bruix J (1999) Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19:329\u2013338","journal-title":"Semin Liver Dis"},{"key":"4468_CR11","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/hep.20933","volume":"42","author":"J Bruix","year":"2005","unstructured":"Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208\u20131236","journal-title":"Hepatology"},{"key":"4468_CR12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s004640090082","volume":"16","author":"R Santambrogio","year":"2002","unstructured":"Santambrogio R, Bianchi P, Pasta A, Palmisano A, Montorsi M (2002) Ultrasound-guided interventional procedures of the liver during laparoscopy: technical considerations. Surg Endosc 16:349\u2013354","journal-title":"Surg Endosc"},{"key":"4468_CR13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ultrasmedbio.2010.10.007","volume":"37","author":"R Santambrogio","year":"2011","unstructured":"Santambrogio R, Costa M, Strada D, Bertolini E, Zuin M, Barabino M, Opocher E (2011) Intraoperative ultrasound score to predict recurrent hepatocellular carcinoma after radical treatments. Ultrasound Med Biol 37:7\u201315","journal-title":"Ultrasound Med Biol"},{"key":"4468_CR14","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1245\/s10434-011-2195-0","volume":"19","author":"Y Yamashita","year":"2012","unstructured":"Yamashita Y, Tsuijita E, Takeishi K, Fujiwara M, Kira S, Mori M, Aishima S, Taketomi A, Shirabe K, Ishida T, Maehara Y (2012) Predictors for microinvasion of small hepatocellular carcinoma\u00a0\u2264\u00a02 cm. Ann Surg Oncol 19:2027\u20132034","journal-title":"Ann Surg Oncol"},{"key":"4468_CR15","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00464-008-9751-0","volume":"22","author":"R Santambrogio","year":"2008","unstructured":"Santambrogio R, Costa M, Barabino M, Opocher E (2008) Laparoscopic radiofrequency of hepatocellular carcinoma using ultrasound-guided selective intrahepatic vascular occlusion. Surg Endosc 22:2051\u20132055","journal-title":"Surg Endosc"},{"key":"4468_CR16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1148\/radiol.14132958","volume":"273","author":"M Ahmed","year":"2014","unstructured":"Ahmed M (2014) Image-guided tumor ablation: standardization of terminology and reporting criteria\u2014a 10-year update. Radiology 273:241\u2013260","journal-title":"Radiology"},{"key":"4468_CR17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jvir.2011.12.026","volume":"23","author":"PN Kim","year":"2012","unstructured":"Kim PN, Choi D, Rhim H, Rha SE, Hong HP, Lee J, Choi J-II, Kim JW, Seo JW, Lee EJ, Lim HK (2012) Planning ultrasound for percutaneous radiofrequency ablation to treat (<3\u00a0cm) hepatocellular carcinomas detected on computed tomography or magnetic resonance imaging: a multicenter prospective study to assess factors affecting ultrasound visibility. J Vasc Interv Radiol 23:627\u2013634","journal-title":"J Vasc Interv Radiol"},{"key":"4468_CR18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ejso.2010.08.133","volume":"36","author":"ZW Peng","year":"2010","unstructured":"Peng ZW, Zhang YJ, Chen MS, Lin XJ, Liang HH, Shi M (2010) Radiofrequency ablation as first-line treatment for small solitary hepatocellular carcinoma: long-term results. EJSO 36:1054\u20131060","journal-title":"EJSO"},{"key":"4468_CR19","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jhep.2012.09.020","volume":"58","author":"YS Kim","year":"2013","unstructured":"Kim YS, Lim HK, Rhim H, Lee MW, Choi D, Lee WJ, Paik SW, Koh KC, Lee JH, Choi MS, Gwak GY, Yoo BC (2013) Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: analysis of prognostic factors. J Hepatol 58:89\u201397","journal-title":"J Hepatol"},{"key":"4468_CR20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/MEG.0b013e32835ee5f1","volume":"25","author":"F Brunello","year":"2013","unstructured":"Brunello F, Cantamessa A, Gaia S, Carucci P, Rolle E, Castiglione A, Ciccone G, Rizzetto M (2013) Radiofrequency ablation: technical and clinical long-term outcomes for single hepatocellular carcinoma up to 30 mm. Eur J Gastroenterol Hepatol 25:842\u2013849","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"4468_CR21","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1148\/radiology.214.3.r00mr02761","volume":"214","author":"T Livraghi","year":"2000","unstructured":"Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Ierace T, Solbiati L, Gazelle GS (2000) Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 214:761\u2013768","journal-title":"Radiology"},{"key":"4468_CR22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.amjsurg.2009.11.009","volume":"200","author":"A Ayav","year":"2010","unstructured":"Ayav A, Germain A, Marchal F, Tierris I, Laurent V, Bazin C, Yuan Y, Robert L, Brunaud L, Bresler L (2010) Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence. Am J Surg 200:435\u2013439","journal-title":"Am J Surg"},{"key":"4468_CR23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00270-007-9208-1","volume":"31","author":"E Paulet","year":"2008","unstructured":"Paulet E, Aub\u00e8 C, Peassaux P, Lebigot J, Lhermitte E, Oberti F, Ponthieux A, Cales P, Ridereau-Zins C, Pereira PL (2008) Factors limiting complete tumor ablation by radiofrequency ablation. Cardiovasc Intervent Radiol 31:107\u2013115","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4468_CR24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bpg.2014.08.011","volume":"28","author":"YS Kim","year":"2014","unstructured":"Kim YS, Lim HK, Rhim H, Lee MW (2014) Ablation of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 28:897\u2013908","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"4468_CR25","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/01.sla.0000171032.99149.fe","volume":"242","author":"S Mulier","year":"2005","unstructured":"Mulier S, Ni Y, Jamart J, Ruers T, Marchal G, Michel L (2005) Local recurrence after hepatic radiofrequency coagulation. Multivariate meta-analysis and review of contributing factors. Ann Surg 242:158\u2013171","journal-title":"Ann Surg"},{"key":"4468_CR26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archsurg.142.12.1136","volume":"142","author":"MR Khan","year":"2007","unstructured":"Khan MR, Poon RTP, Ng KK, Chan AC, Yuen J, Tung H, Tsang J, Fan ST (2007) Comparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinoma. Arch Surg 142:1136\u20131143","journal-title":"Arch Surg"},{"key":"4468_CR27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/hpb.12264","volume":"16","author":"U Cillo","year":"2014","unstructured":"Cillo U, Noaro G, Vitale A, Neri D, D\u2019Amico F, Gringeri E, Farinati F, Vincenzi V, Vigo M, Zanus G (2014) Laparoscopic microwave ablation in patients with hepatocellular carcinoma: a prospective cohort study. HPB 16:979\u2013986","journal-title":"HPB"},{"key":"4468_CR28","author":"T Vogl","year":"2015","unstructured":"Vogl T, Farshid P, Naguib NNN, Zangos S, Bodelle B, Paul J, Mbalisike EC, Beeres M, Nour-Eldin N-EA (2015) Ablation therapy of hepatocellular carcinoma: a comparative study between radiofrequency and microwave ablation. Abdom Imaging. doi: 10.1007\/s00261-015-0355-6","journal-title":"Abdom Imaging"},{"key":"4468_CR29","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1148\/radiol.13130940","volume":"270","author":"DH Lee","year":"2014","unstructured":"Lee DH, Lee JM, Lee JY, Kim SH, Yoon JH, Kim YJ, Han JK, Choi BI (2014) Radiofrequency ablation of hepatocellular carcinoma as first-line treatment: long-term results and prognostic factors in 162 patients with cirrhosis. Radiology 270:900\u2013909","journal-title":"Radiology"},{"key":"4468_CR30","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/SLA.0b013e31828329b8","volume":"257","author":"G Torzilli","year":"2013","unstructured":"Torzilli G, Belghiti J, Kokudo N, Takayama T, Capussotti L, Nuzzo G, Vauthey JN, Choti MA, De Santibanes E, Donadon M, Morenghi E, Makuuchi M (2013) A snapshot of the effective indications and results of surgery for hepatocellular carcinoma in tertiary referral centers: is it adherent to the EASL\/AASLD recommendations? An observational study of the HCC East\u2013West study group. Ann Surg 257:929\u2013937","journal-title":"Ann Surg"},{"key":"4468_CR31","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00268-001-0068-6","volume":"25","author":"M Shimada","year":"2001","unstructured":"Shimada M, Hamatsu T, Yamashita Y, Rikimaru T, Taguchi K, Utsunomiya T, Shirabe K, Sugimachi K (2001) Characteristics of multicentric hepatocellular carcinomas: comparison with intrahepatic metastasis. World J Surg 25:991\u2013995","journal-title":"World J Surg"},{"key":"4468_CR32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.7314\/APJCP.2013.14.1.217","volume":"14","author":"SL Li","year":"2013","unstructured":"Li SL, Su M, Peng T, Xiao K-Y, Shang LM, Xu BH, Su ZX, Ye XP, Peng N, Qin QL, Chen DF, Chen J, Li LQ (2013) Clinicopathologic characteristics and prognoses for multicentric occurrence and intrahepatic metastasis in synchronous multinodular hepatocellular carcinoma patients. Asian Pacific J Cancer Prev 14:217\u2013223","journal-title":"Asian Pacific J Cancer Prev"},{"key":"4468_CR33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1245\/s10434-011-1845-6","volume":"19","author":"R Santambrogio","year":"2012","unstructured":"Santambrogio R, Opocher E, Costa M, Barabino M, Zuin M, Bertolini E, De Filippi F, Bruno S (2012) Hepatic resection for \u201cBCLC stage A\u201d hepatocellular carcinoma. The prognostic role of alpha-fetoprotein. Ann Surg Oncol 19:426\u2013434","journal-title":"Ann Surg Oncol"},{"key":"4468_CR34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.dld.2008.11.008","volume":"41","author":"YH Yen","year":"2009","unstructured":"Yen YH, Changchien CS, Wang JH, Kee KM, Hung CH, Hu TH, Lee CM, Lin CY, Wang TY, Chen TY, Huang YJ, Lu SN (2009) A modified TNM-based Japan Integrated Score combined with AFP level may serve as a better staging system for early-stage predominant hepatocellular carcinoma patients. Dig Liver Dis 41:431\u2013441","journal-title":"Dig Liver Dis"},{"key":"4468_CR35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.dld.2012.10.022","volume":"45","author":"GP Francica","year":"2013","unstructured":"Francica GP, Saviano A, De Sio I, Nicoletta De Matthaeis, Franco Brunello, Cantamessa A, Giorgio A, Scognamiglio U, Fornari F, Giangregorio F, Piscaglia F, Gualandi S, Caturelli E, Roselli P, Rapaccini GL, Pompili M (2013) Long-term effectiveness of radiofrequency ablation for solitary small hepatocellular carcinoma: a retrospective analysis of 363 patients. Dig Liver Dis 45:336\u2013341","journal-title":"Dig Liver Dis"},{"key":"4468_CR36","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/hep.20465","volume":"40","author":"M Sala","year":"2004","unstructured":"Sala M, Llovet JM, Vilana R, Bianchi L, Sol\u00e8 M, Ayuso C, Bru C, Bruix J, For Barcelona Clinic Liver Cancer (BCLC) Group (2004) Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. Hepatology 40:1352\u20131360","journal-title":"Hepatology"},{"key":"4468_CR37","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1007\/s00464-011-2007-4","volume":"26","author":"R Santambrogio","year":"2012","unstructured":"Santambrogio R, Costa M, Barabino M, Zuin M, Bertolini E, De Filippi F, Bruno S, Opocher E (2012) Recurrent hepatocellular carcinoma successfully treated with laparoscopic thermal ablation. Surg Endosc 26:1108\u20131115","journal-title":"Surg Endosc"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-015-4468-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00464-015-4468-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-015-4468-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T20:23:19Z","timestamp":1559074999000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00464-015-4468-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,15]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["4468"],"URL":"https:\/\/doi.org\/10.1007\/s00464-015-4468-3","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,15]]}}}