{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:18:26Z","timestamp":1784715506004,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00464-018-6077-4","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T11:29:49Z","timestamp":1521804589000},"page":"3548-3556","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of premedication on lesion detection rate and visualization of the mucosa during upper gastrointestinal endoscopy: a multicenter large sample randomized controlled double-blind study"],"prefix":"10.1007","volume":"32","author":[{"given":"X.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. T.","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Y.","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. G.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. F.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Q.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-6949","authenticated-orcid":false,"given":"G. Q.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"6077_CR1","first-page":"892","volume":"93","author":"S Keeratichananont","year":"2010","unstructured":"Keeratichananont S, Sobhonslidsuk A, Kitiyakara T, Achalanan N, Soonthornpun S (2010) The role of liquid simethicone in enhancing endoscopic visibility prior to esophagogastroduodenoscopy (EGD): a prospective, randomized, double-blinded, placebo-controlled trial. J Med Assoc Thai 93:892\u2013897","journal-title":"J Med Assoc Thai"},{"key":"6077_CR2","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/00004836-199210000-00020","volume":"15","author":"B Banerjee","year":"1992","unstructured":"Banerjee B, Parker J, Waits W, Davis B (1992) Effectiveness of preprocedure simethicone drink in improving visibility during esophagogastroduodenoscopy: a double-blind, randomized study. J Clin Gastroenterol 15:264\u2013265","journal-title":"J Clin Gastroenterol"},{"key":"6077_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0016-5107(78)73542-X","volume":"24","author":"GB McDonald","year":"1978","unstructured":"McDonald GB, O\u2019Leary R, Stratton C (1978) Pre-endoscopic use of oral simethicone. Gastrointest Endosc 24:283","journal-title":"Gastrointest Endosc"},{"key":"6077_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1055\/s-2002-33220","volume":"34","author":"CH Kuo","year":"2002","unstructured":"Kuo CH, Sheu BS, Kao AW, Wu CH, Chuang CH (2002) A defoaming agent should be used with pronase premedication to improve visibility in upper gastrointestinal endoscopy. Endoscopy 34:531\u2013534","journal-title":"Endoscopy"},{"key":"6077_CR5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S0016-5107(98)70223-8","volume":"47","author":"T Fujii","year":"1998","unstructured":"Fujii T, Iishi H, Tatsuta M, Hirasawa R, Uedo N, Hifumi K, Omori M (1998) Effectiveness of premedication with pronase for improving visibility during gastroendoscopy: a randomized controlled trial. Gastrointest Endosc 47:382\u2013387","journal-title":"Gastrointest Endosc"},{"key":"6077_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3109\/00365520903483643","volume":"45","author":"P Bhandari","year":"2010","unstructured":"Bhandari P, Green S, Hamanaka H, Nakajima T, Matsuda T, Saito Y, Oda I, Gotoda T (2010) Use of Gascon and Pronase either as a pre-endoscopic drink or as targeted endoscopic flushes to improve visibility during gastroscopy: a prospective, randomized, controlled, blinded trial. Scand J Gastroenterol 45:357\u2013361","journal-title":"Scand J Gastroenterol"},{"key":"6077_CR7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.5946\/ce.2012.45.2.161","volume":"45","author":"GJ Lee","year":"2012","unstructured":"Lee GJ, Park SJ, Kim SJ, Kim HH, Park MI, Moon W (2012) Effectiveness of premedication with pronase for visualization of the mucosa during endoscopy: a randomized, controlled trial. Clin Endosc 45:161\u2013164","journal-title":"Clin Endosc"},{"key":"6077_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1055\/s-2004-826149","volume":"37","author":"M Lazzaroni","year":"2005","unstructured":"Lazzaroni M, Bianchi PG (2005) Preparation, premedication, and surveillance. Endoscopy 37:101\u2013109","journal-title":"Endoscopy"},{"key":"6077_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/MCG.0b013e3182758944","volume":"47","author":"JG Woo","year":"2013","unstructured":"Woo JG, Kim TO, Kim HJ, Shin BC, Seo EH, Heo NY, Park J, Park SH, Yang SY, Moon YS, Lee NY (2013) Determination of the optimal time for premedication with pronase, dimethylpolysiloxane, and sodium bicarbonate for upper gastrointestinal endoscopy. J Clin Gastroenterol 47:389\u2013392","journal-title":"J Clin Gastroenterol"},{"key":"6077_CR10","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.gie.2011.07.044","volume":"74","author":"JP Han","year":"2011","unstructured":"Han JP, Hong SJ, Moon JH, Lee GH, Byun JM, Kim HJ, Choi HJ, Ko BM, Lee MS (2011) Benefit of pronase in image quality during EUS. Gastrointest Endosc 74:1230\u20131237","journal-title":"Gastrointest Endosc"},{"key":"6077_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1046\/j.1365-2036.2003.01582.x","volume":"18","author":"N Sakai","year":"2003","unstructured":"Sakai N, Tatsuta M, Iishi H, Nakaizumi A (2003) Pre-medication with pronase reduces artefacts during endoscopic ultrasonography. Aliment Pharmacol Ther 18:327\u2013332","journal-title":"Aliment Pharmacol Ther"},{"key":"6077_CR12","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.3748\/wjg.v21.i8.2483","volume":"21","author":"GH Kim","year":"2015","unstructured":"Kim GH, Cho YK, Cha JM, Lee SY, Chung IK (2015) Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy. World J Gastroenterol 21:2483\u20132489","journal-title":"World J Gastroenterol"},{"key":"6077_CR13","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1007\/s10620-014-3218-z","volume":"59","author":"JM Cha","year":"2014","unstructured":"Cha JM, Won KY, Chung IK, Kim GH, Lee SY, Cho YK (2014) Effect of pronase premedication on narrow-band imaging endoscopy in patients with precancerous conditions of stomach. Dig Dis Sci 59:2735\u20132741","journal-title":"Dig Dis Sci"},{"key":"6077_CR14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4253\/wjge.v8.i5.267","volume":"8","author":"GH Kim","year":"2016","unstructured":"Kim GH, Cho YK, Cha JM, Lee SY, Chung IK (2016) Efforts to increase image quality during endoscopy: the role of pronase. World J Gastrointest Endosc 8:267\u2013272","journal-title":"World J Gastrointest Endosc"},{"key":"6077_CR15","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3748\/wjg.v13.i3.444","volume":"13","author":"CC Chang","year":"2007","unstructured":"Chang CC, Chen SH, Lin CP, Hsieh CR, Lou HY, Suk FM, Pan S, Wu MS, Chen JN, Chen YF (2007) Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: an endoscopist-blinded, prospective, randomized study. World J Gastroenterol 13:444\u2013447","journal-title":"World J Gastroenterol"},{"issue":"2","key":"6077_CR16","first-page":"139","volume":"49","author":"L Elvas","year":"2016","unstructured":"Elvas L, Areia M, Brito D, Alves S, Saraiva S, Cadime AT (2016) Premedication with simethicone and N-acetylcysteine in improving visibility during upper endoscopy: a double-blind randomized trial. Endoscopy 49(2):139\u2013145","journal-title":"Endoscopy"},{"key":"6077_CR17","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1055\/s-0042-113128","volume":"48","author":"R Bisschops","year":"2016","unstructured":"Bisschops R, Areia M, Coron E, Dobru D, Kaskas B, Kuvaev R, Pech O, Ragunath K, Weusten B, Familiari P, Domagk D, Valori R, Kaminski MF, Spada C, Bretthauer M, Bennett C, Senore C, Dinis-Ribeiro M, Rutter MD (2016) Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. Endoscopy 48:843\u2013864","journal-title":"Endoscopy"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00464-018-6077-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-018-6077-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-018-6077-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T21:21:28Z","timestamp":1553289688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00464-018-6077-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["6077"],"URL":"https:\/\/doi.org\/10.1007\/s00464-018-6077-4","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"21 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Drs. Liu X, Guan CT, Xue LY, He S, Zhang YM M.D., Zhao DL, Li Y, Liu FG, Li J, Liu YF, Ling AS, Wei WQ, and Wang GQ have no conflicts of interest of financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}