{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:47:26Z","timestamp":1779893246544,"version":"3.53.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Previous studies suggest clinical effectiveness of endoscopic full-thickness plication in selected patients with gastroesophageal reflux disease (GERD). The aim of this study was to assess the clinical safety and efficiency of the GERDx\u2122 device by evaluating clinical parameters, reflux symptom scores, and quality of life (QoL).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Prospective one-arm trial evaluating the outcome of forty patients with GERD subjected to endoscopic plication with the GERDx\u2122 device. We included patients with at least one typical reflux symptom despite treatment with a PPI for &gt; 6 months, pathologic esophageal acid exposure, hiatal hernia of size &lt; 2\u00a0cm, and endoscopic Hill grade II\u2013III. Evaluation of Gastrointestinal Quality of Life Index (GIQLI), symptom scores, esophageal manometry, and impedance-pH-monitoring were performed at baseline and at 3 months after surgery. (Trial Registration: ClinicalTrials.gov NCT 01798212.)<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no intraoperative complications. Four out of forty patients experienced postoperative complications requiring intervention. Seven of forty patients were subjected to laparoscopic fundoplication 3 months after endoscopic plication due to persistent symptoms and were lost to further follow-up. Thirty out of forty patients were available at 3-month follow-up. There was an improvement of the GIQLI score, from a mean of 92.45\u2009\u00b1\u200918.47 to 112.03\u2009\u00b1\u200913.11 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The general reflux-specific score increased from a mean of 49.84\u2009\u00b1\u200924.83 to 23.93\u2009\u00b1\u200915.63 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and the DeMeester score from a mean of 46.48\u2009\u00b1\u200930.83 to 20.03\u2009\u00b1\u200923.62 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no significant change in manometric data after intervention. Three of thirty patients continued daily antireflux medication.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Endoscopic plication with the GERDx\u2122 device reduced distal acid exposure of the esophagus, reflux-related symptoms, and improved GIQLI scores with minimal side effects in a selected cohort of patients and may be a safe alternative in the treatment of GERD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-018-6153-9","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T10:54:53Z","timestamp":1522407293000},"page":"2541-2549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical feasibility of a new full-thickness endoscopic plication device (GERDx\u2122) for patients with GERD: results of a prospective trial"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1657-7405","authenticated-orcid":false,"given":"Michael","family":"Weitzendorfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg O.","family":"Spaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros A.","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Witzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Emmanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver O.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"6153_CR1","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S1542-3565(04)00288-5","volume":"2","author":"BB Dean","year":"2004","unstructured":"Dean BB, Gano AD Jr, Knight K, Ofman JJ, Fass R (2004) Effectiveness of proton pump inhibitors in nonerosive reflux disease. 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